JBIO

SEC source: 0001415889-24-009364 · form4-03282024_060301.xml · nonDerivative · entry 2

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,291

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.95 to $28.18, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-009364 · form4-03282024_060301.xml · nonDerivative · entry 1

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,359

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

SEC source: 0001415889-24-009243 · form4-03272024_060301.xml · derivative · entry 3

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,068

Underlying: Common Stock · 3,432 shares

Expires 2031-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F3 · derivative.exercise_date: A total of 58,000 shares subject to an employee stock option were granted on December 14, 2021, with the first installment vested on January 14, 2022, and with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-009243 · form4-03272024_060301.xml · nonDerivative · entry 2

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,291

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.95 to $28.385, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-009243 · form4-03272024_060301.xml · nonDerivative · entry 1

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,723

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

SEC source: 0001415889-24-008772 · form4-03202024_060317.xml · derivative · entry 4

Verwijs Marinus · CIK 0001916553 · CHIEF TECHNICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,700

Underlying: Common Stock · 5,300 shares

Expires 2032-03-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 17, 2023.

F4 · derivative.exercise_date: 25% of this option vested and became exercisable on March 21, 2023, with the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-008772 · form4-03202024_060317.xml · nonDerivative · entry 3

Verwijs Marinus · CIK 0001916553 · CHIEF TECHNICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 17, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.30 to $26.71, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008772 · form4-03202024_060317.xml · nonDerivative · entry 2

Verwijs Marinus · CIK 0001916553 · CHIEF TECHNICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,764

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 17, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.255 to $26.125, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008772 · form4-03202024_060317.xml · nonDerivative · entry 1

Verwijs Marinus · CIK 0001916553 · CHIEF TECHNICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 17, 2023.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · derivative · entry 6

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,500

Underlying: Common Stock · 14,500 shares

Expires 2031-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F5 · derivative.exercise_date: A total of 58,000 shares subject to an employee stock option were granted on December 14, 2021, with the first installment vested on January 14, 2022, and with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · derivative · entry 5

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 102,789

Underlying: Common Stock · 20,557 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F4 · derivative.exercise_date: A total of 328,921 shares subject to an employee stock option were granted on April 2, 2021, with the first installment vested on July 4, 2021, and with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · nonDerivative · entry 4

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,291

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.25 to $26.88, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · nonDerivative · entry 3

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,872

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.235 to $26.234, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · nonDerivative · entry 2

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,348

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

SEC source: 0001415889-24-008770 · form4-03202024_060307.xml · nonDerivative · entry 1

Dake Benjamin T · CIK 0001869248 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,848

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 16, 2023.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · derivative · entry 6

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,510

Underlying: Common Stock · 3,000 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F5 · derivative.exercise_date: A total of 109,640 shares subject to an employee stock option were granted on April 2, 2021, with the first installment vested on July 4, 2021, with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · derivative · entry 5

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,036

Underlying: Common Stock · 4,000 shares

Expires 2030-09-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F4 · derivative.exercise_date: A total of 16,097 shares subject to an employee stock option were granted on September 4, 2020, with 10% of this option vested on May 1, 2020, 22.5% vested on May 1 2021, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · nonDerivative · entry 4

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,251

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.25 to $26.75, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · nonDerivative · entry 3

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,864

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.25 to $26.18, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · nonDerivative · entry 2

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,251

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-008771 · form4-03202024_060312.xml · nonDerivative · entry 1

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,251

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · derivative · entry 6

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,263

Underlying: Common Stock · 2,016 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F4 · derivative.exercise_date: A total of 98,676 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on June 4, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · nonDerivative · entry 4

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.00 to $25.08, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · nonDerivative · entry 3

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,976

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · derivative · entry 5

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,279

Underlying: Common Stock · 2,051 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F4 · derivative.exercise_date: A total of 98,676 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on June 4, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · nonDerivative · entry 2

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.00 to $25.19, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-008033 · form4-03142024_060304.xml · nonDerivative · entry 1

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,011

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · derivative · entry 11

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,330

Underlying: Common Stock · 3,433 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F5 · derivative.exercise_date: A total of 98,676 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on June 4, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 7

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 6

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,970

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.00 to $25.88, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 5

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,393

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · derivative · entry 10

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,763

Underlying: Common Stock · 114 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F5 · derivative.exercise_date: A total of 98,676 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on June 4, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 4

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 3

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,074

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007533 · form4-03112024_060304.xml · derivative · entry 4

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,510

Underlying: Common Stock · 8,030 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F3 · derivative.exercise_date: A total of 109,640 shares subject to an employee stock option were granted on April 2, 2021, with the first installment vested on July 4, 2021, with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-007533 · form4-03112024_060304.xml · derivative · entry 3

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,324

Underlying: Common Stock · 945 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F2 · derivative.exercise_date: A total of 16,294 shares subject to an employee stock option were granted on April 2, 2021, with the first installment vested on May 2, 2021, with shares vesting in 48 substantially equal monthly installments.

SEC source: 0001415889-24-007533 · form4-03112024_060304.xml · nonDerivative · entry 2

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,251

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-007533 · form4-03112024_060304.xml · nonDerivative · entry 1

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,226

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · derivative · entry 9

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,877

Underlying: Common Stock · 20,986 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F5 · derivative.exercise_date: A total of 98,676 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on June 4, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · derivative · entry 8

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,263

Underlying: Common Stock · 1,400 shares

Expires 2031-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F4 · derivative.exercise_date: A total of 50,850 shares subject to an employee stock option were granted on April 2, 2021, with 25% of this option vested on March 22, 2022, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 2

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.00 to $25.289, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-007534 · form4-03112024_060307.xml · nonDerivative · entry 1

Eldridge George A · CIK 0001413006 · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,346

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 17, 2023.

SEC source: 0001415889-24-007100 · form4-03062024_060321.xml · derivative · entry 1

Dable Habib J · CIK 0001690773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,531

Underlying: Common Stock · 1,531 shares

Expires 2034-03-04

F1 · kind: This option was awarded in lieu of cash compensation pursuant to the Issuer's Non-Employee Director Compensation Policy. The shares underlying such option shall vest and become exercisable in four equal installments, with the first installment vesting on March 31, 2024, the second installment vesting on June 30, 2024, the third installment vesting on September 30, 2024, and the fourth installment vesting on December 31, 2024.

F1 · derivative.exercise_date: This option was awarded in lieu of cash compensation pursuant to the Issuer's Non-Employee Director Compensation Policy. The shares underlying such option shall vest and become exercisable in four equal installments, with the first installment vesting on March 31, 2024, the second installment vesting on June 30, 2024, the third installment vesting on September 30, 2024, and the fourth installment vesting on December 31, 2024.

SEC source: 0001415889-24-005571 · form4-02272024_060201.xml · derivative · entry 3

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,014

Underlying: Common Stock · 511 shares

Expires 2030-09-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F2 · derivative.exercise_date: A total of 24,108 shares subject to an employee stock option were granted on September 4, 2020, with 25% of the shares vested on August 1, 2021, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-005571 · form4-02272024_060201.xml · nonDerivative · entry 2

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,251

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-005571 · form4-02272024_060201.xml · nonDerivative · entry 1

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,762

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

SEC source: 0001415889-24-004903 · form4-02222024_060201.xml · derivative · entry 5

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,036

Underlying: Common Stock · 987 shares

Expires 2030-09-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F5 · derivative.exercise_date: A total of 16,097 shares subject to an employee stock option were granted on September 4, 2020, with 10% of this option vested on May 1, 2020, 22.5% vested on May 1 2021, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-004903 · form4-02222024_060201.xml · derivative · entry 4

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,525

Underlying: Common Stock · 2,502 shares

Expires 2030-09-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F4 · derivative.exercise_date: A total of 24,108 shares subject to an employee stock option were granted on September 4, 2020, with 25% of the shares vested on August 1, 2021, and the remainder vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001415889-24-004903 · form4-02222024_060201.xml · nonDerivative · entry 3

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,251

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.55 to $20.67, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001415889-24-004903 · form4-02222024_060201.xml · nonDerivative · entry 2

Gillies Hunter · CIK 0001868997 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,149

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 19, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.53 to $20.515, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.