Tapewire

Nasdaq · USD

JAZZ

Jazz Pharmaceuticals plc

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Tapewire entity
818
SEC CIK
0001232524
Parsed reports
624

Last 12 months

Inside the activity.

0 purchase rows · 59 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 2025013
Dec 202503
Jan 202600
Feb 2026015
Mar 202604
Apr 202603
May 202605
Jun 202603
Jul 202601
Aug 202607
Sep 202603
Oct 202602

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
October 06, 2026 Filed Oct 7, 2026 21:44 UTC
GALA RENEE DDirector · President & CEO
SaleOrdinary Shares 2,000 $236.40 $472,800.00
Disclosure

SEC source: 0001607737-26-000016 · edgardoc.xml · nonDerivative · entry 1

GALA RENEE D · CIK 0001607737 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,394

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
October 01, 2026 Filed Oct 5, 2026 20:18 UTC SaleOrdinary Shares 6,000 $230.33 $1,381,980.00
Disclosure

SEC source: 0001193210-26-000028 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 345,875

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
September 10, 2026 Filed Sep 14, 2026 22:38 UTC
Patil Neena MEVP & Chief Legal Officer
SaleOrdinary Shares 1,200 $240.94 $289,128.00
Disclosure

SEC source: 0001783908-26-000022 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,671

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on February 26, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
September 08, 2026 Filed Sep 10, 2026 20:33 UTC
GALA RENEE DPresident & CEO
SaleOrdinary Shares 2,000 $243.03 $486,060.00
Disclosure

SEC source: 0001607737-26-000013 · edgardoc.xml · nonDerivative · entry 2

GALA RENEE D · CIK 0001607737 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 143,394

F2 · kind: This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
September 08, 2026 Filed Sep 10, 2026 20:33 UTC
GALA RENEE DPresident & CEO
Tax withholdingOrdinary Shares 1,967 $246.81 $485,475.27
Disclosure

SEC source: 0001607737-26-000013 · edgardoc.xml · nonDerivative · entry 1

GALA RENEE D · CIK 0001607737 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 145,394

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

Read SEC document
September 08, 2026 Filed Sep 10, 2026 20:28 UTC
Henderson Mary ElizabethSVP, Technical Operations
Tax withholdingOrdinary Shares 15 $241.20 $3,618.00
Disclosure

SEC source: 0001989533-26-000019 · edgardoc.xml · nonDerivative · entry 2

Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,815

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
September 08, 2026 Filed Sep 10, 2026 20:28 UTC
Henderson Mary ElizabethSVP, Technical Operations
Tax withholdingOrdinary Shares 1,412 $243.03 $343,158.22
Disclosure

SEC source: 0001989533-26-000019 · edgardoc.xml · nonDerivative · entry 1

Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,830

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
September 01, 2026 Filed Sep 2, 2026 21:03 UTC SaleOrdinary Shares 6,000 $250.13 $1,500,780.00
Disclosure

SEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 3

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 351,875

F3 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:38 UTC
Henderson Mary ElizabethSVP, Technical Operations
Tax withholdingOrdinary Shares 16 $244.64 $3,914.31
Disclosure

SEC source: 0001989533-26-000015 · edgardoc.xml · nonDerivative · entry 2

Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,242

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:38 UTC
Henderson Mary ElizabethSVP, Technical Operations
Tax withholdingOrdinary Shares 2,076 $241.39 $501,125.64
Disclosure

SEC source: 0001989533-26-000015 · edgardoc.xml · nonDerivative · entry 1

Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,258

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:34 UTC Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001756253-26-000009 · edgardoc.xml · nonDerivative · entry 2

Smith Mark Douglas · CIK 0001756253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,579

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:34 UTC Tax withholdingOrdinary Shares 14 $244.64 $3,425.02
Disclosure

SEC source: 0001756253-26-000009 · edgardoc.xml · nonDerivative · entry 1

Smith Mark Douglas · CIK 0001756253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,271

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:31 UTC Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001161662-26-000008 · edgardoc.xml · nonDerivative · entry 2

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,923

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:31 UTC Tax withholdingOrdinary Shares 14 $244.64 $3,425.02
Disclosure

SEC source: 0001161662-26-000008 · edgardoc.xml · nonDerivative · entry 1

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,615

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:28 UTC
LOVE TED WDirector
Tax withholdingOrdinary Shares 737 $241.39 $177,904.36
Disclosure

SEC source: 0001188919-26-000015 · edgardoc.xml · nonDerivative · entry 2

LOVE TED W · CIK 0001188919 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,389

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:28 UTC
LOVE TED WDirector
Tax withholdingOrdinary Shares 6 $244.06 $1,464.38
Disclosure

SEC source: 0001188919-26-000015 · edgardoc.xml · nonDerivative · entry 1

LOVE TED W · CIK 0001188919 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,126

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:24 UTC
Hamill LauraDirector
Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001751804-26-000005 · edgardoc.xml · nonDerivative · entry 2

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,832

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:24 UTC
Hamill LauraDirector
Tax withholdingOrdinary Shares 14 $244.06 $3,416.90
Disclosure

SEC source: 0001751804-26-000005 · edgardoc.xml · nonDerivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,524

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:20 UTC Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001754371-26-000007 · edgardoc.xml · nonDerivative · entry 2

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,736

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:20 UTC Tax withholdingOrdinary Shares 14 $244.06 $3,416.90
Disclosure

SEC source: 0001754371-26-000007 · edgardoc.xml · nonDerivative · entry 1

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,428

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:17 UTC Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001253886-26-000011 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,278

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:17 UTC Tax withholdingOrdinary Shares 14 $244.64 $3,425.02
Disclosure

SEC source: 0001253886-26-000011 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,970

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:13 UTC Tax withholdingOrdinary Shares 1,840 $241.39 $444,157.60
Disclosure

SEC source: 0001576068-26-000009 · edgardoc.xml · nonDerivative · entry 2

McSharry Heather Ann · CIK 0001576068 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,199

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:13 UTC Tax withholdingOrdinary Shares 15 $244.64 $3,669.67
Disclosure

SEC source: 0001576068-26-000009 · edgardoc.xml · nonDerivative · entry 1

McSharry Heather Ann · CIK 0001576068 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,039

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:09 UTC Tax withholdingOrdinary Shares 1,840 $241.39 $444,157.60
Disclosure

SEC source: 0002013944-26-000006 · edgardoc.xml · nonDerivative · entry 2

Kennedy Patrick · CIK 0002013944 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,452

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:09 UTC Tax withholdingOrdinary Shares 15 $244.06 $3,660.97
Disclosure

SEC source: 0002013944-26-000006 · edgardoc.xml · nonDerivative · entry 1

Kennedy Patrick · CIK 0002013944 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,292

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:06 UTC Tax withholdingOrdinary Shares 14 $244.64 $3,425.02
Disclosure

SEC source: 0001302443-26-000015 · edgardoc.xml · nonDerivative · entry 2

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,466

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:06 UTC Tax withholdingOrdinary Shares 1,692 $241.39 $408,431.88
Disclosure

SEC source: 0001302443-26-000015 · edgardoc.xml · nonDerivative · entry 1

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,480

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:03 UTC Tax withholdingOrdinary Shares 1,209 $241.39 $291,840.39
Disclosure

SEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 2

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 357,875

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Read SEC document
August 31, 2026 Filed Sep 2, 2026 21:03 UTC Tax withholdingOrdinary Shares 10 $244.06 $2,440.64
Disclosure

SEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 359,084

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

F2 · balance_after: Includes the November 3, 2025 disposition of 3,193 shares for the withholding of restricted stock units by the Issuer to satisfy FICA taxes arising from the Reporting Person being retirement eligible which was previously inadvertently not reported; not an open market transaction.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 27,584 $0.00 Strike: $137.12 $0.00
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 14

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 27,584 shares

Expires 2029-08-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F8 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of May 29, 2019, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 26,116 $0.00 Strike: $113.10 $0.00
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 13

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 26,116 shares

Expires 2030-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F7 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionIncentive Stock Option (right to buy) · Derivative 2,916 $0.00 Strike: $137.12 $0.00
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 12

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 2,916 shares

Expires 2029-08-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F8 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of May 29, 2019, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionIncentive Stock Option (right to buy) · Derivative 884 $0.00 Strike: $113.10 $0.00
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 11

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 884 shares

Expires 2030-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F7 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 300 $252.76 $75,828.00
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 10

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,686

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 9,259 $251.95 $2,332,804.12
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 9

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,986

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F6 · price: Reflects the sale of ordinary shares executed in multiple transactions at prices ranging from $251.37 to $252.31. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 19,639 $250.60 $4,921,596.24
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 8

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,245

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F5 · price: Reflects the sale of ordinary shares executed in multiple transactions at prices ranging from $250.33 to $251.29. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 18,113 $250.02 $4,528,572.41
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 7

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 94,884

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F4 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $249.33 to $250.325 The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 11,423 $248.67 $2,840,516.29
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 6

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,997

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $248.29 to $249.24. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Read SEC document
August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
SaleOrdinary Shares 18,187 $247.86 $4,507,780.72
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 5

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 124,420

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $247.29 to $248.24. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

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August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionOrdinary Shares 2,916 $137.12 $399,841.92
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 4

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 142,607

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

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August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionOrdinary Shares 27,584 $137.12 $3,782,318.08
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 3

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,691

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

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August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionOrdinary Shares 884 $113.10 $99,980.40
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 2

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,107

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

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August 27, 2026 Filed Aug 31, 2026 22:45 UTC
Iannone RobertEVP, Global Head of R&D & CMO
Exercise / conversionOrdinary Shares 26,116 $113.10 $2,953,719.60
Disclosure

SEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 1

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,223

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

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August 05, 2026 Filed Aug 7, 2026 22:01 UTC
Pearce SamanthaEVP, Chief Commercial Officer
Tax withholdingOrdinary Shares 780 $261.62 $204,063.60
Disclosure

SEC source: 0001805688-26-000014 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,131

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

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August 05, 2026 Filed Aug 7, 2026 21:33 UTC GrantOrdinary Shares 1,605 $0.00 $0.00
Disclosure

SEC source: 0001161662-26-000005 · edgardoc.xml · nonDerivative · entry 1

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,629

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

F2 · balance_after: Shares beneficially owned by NORBERT G. RIEDEL 2023 TRUST, an entity owned and controlled by the reporting person and his immediate family.

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August 05, 2026 Filed Aug 7, 2026 21:48 UTC GrantOrdinary Shares 1,605 $0.00 $0.00
Disclosure

SEC source: 0002013944-26-000003 · edgardoc.xml · nonDerivative · entry 1

Kennedy Patrick · CIK 0002013944 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,307

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

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August 05, 2026 Filed Aug 7, 2026 21:39 UTC GrantOrdinary Shares 1,605 $0.00 $0.00
Disclosure

SEC source: 0001576068-26-000004 · edgardoc.xml · nonDerivative · entry 1

McSharry Heather Ann · CIK 0001576068 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,054

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

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August 05, 2026 Filed Aug 7, 2026 21:57 UTC GrantOrdinary Shares 1,605 $0.00 $0.00
Disclosure

SEC source: 0001302443-26-000010 · edgardoc.xml · nonDerivative · entry 1

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,172

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

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August 05, 2026 Filed Aug 7, 2026 21:55 UTC
LOVE TED WDirector
GrantOrdinary Shares 1,605 $0.00 $0.00
Disclosure

SEC source: 0001188919-26-000012 · edgardoc.xml · nonDerivative · entry 1

LOVE TED W · CIK 0001188919 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,132

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.