Last 12 months
Inside the activity.
0 purchase rows · 59 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 13 |
| Dec 2025 | 0 | 3 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 15 |
| Mar 2026 | 0 | 4 |
| Apr 2026 | 0 | 3 |
| May 2026 | 0 | 5 |
| Jun 2026 | 0 | 3 |
| Jul 2026 | 0 | 1 |
| Aug 2026 | 0 | 7 |
| Sep 2026 | 0 | 3 |
| Oct 2026 | 0 | 2 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| October 06, 2026 Filed Oct 7, 2026 21:44 UTC |
GALA RENEE DDirector · President & CEO
|
SaleOrdinary Shares | 2,000 | $236.40 | $472,800.00 |
DisclosureSEC source: 0001607737-26-000016 · edgardoc.xml · nonDerivative · entry 1 GALA RENEE D · CIK 0001607737 · Director · President & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 141,394 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| October 01, 2026 Filed Oct 5, 2026 20:18 UTC |
COZADD BRUCE CDirector
|
SaleOrdinary Shares | 6,000 | $230.33 | $1,381,980.00 |
DisclosureSEC source: 0001193210-26-000028 · edgardoc.xml · nonDerivative · entry 1 COZADD BRUCE C · CIK 0001193210 · Director 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 345,875 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| September 10, 2026 Filed Sep 14, 2026 22:38 UTC |
Patil Neena MEVP & Chief Legal Officer
|
SaleOrdinary Shares | 1,200 | $240.94 | $289,128.00 |
DisclosureSEC source: 0001783908-26-000022 · edgardoc.xml · nonDerivative · entry 1 Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 47,671 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on February 26, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| September 08, 2026 Filed Sep 10, 2026 20:33 UTC |
GALA RENEE DPresident & CEO
|
SaleOrdinary Shares | 2,000 | $243.03 | $486,060.00 |
DisclosureSEC source: 0001607737-26-000013 · edgardoc.xml · nonDerivative · entry 2 GALA RENEE D · CIK 0001607737 · President & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 143,394 F2 · kind: This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| September 08, 2026 Filed Sep 10, 2026 20:33 UTC |
GALA RENEE DPresident & CEO
|
Tax withholdingOrdinary Shares | 1,967 | $246.81 | $485,475.27 |
DisclosureSEC source: 0001607737-26-000013 · edgardoc.xml · nonDerivative · entry 1 GALA RENEE D · CIK 0001607737 · President & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 145,394 F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units. Read SEC document |
| September 08, 2026 Filed Sep 10, 2026 20:28 UTC |
Henderson Mary ElizabethSVP, Technical Operations
|
Tax withholdingOrdinary Shares | 15 | $241.20 | $3,618.00 |
DisclosureSEC source: 0001989533-26-000019 · edgardoc.xml · nonDerivative · entry 2 Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 23,815 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| September 08, 2026 Filed Sep 10, 2026 20:28 UTC |
Henderson Mary ElizabethSVP, Technical Operations
|
Tax withholdingOrdinary Shares | 1,412 | $243.03 | $343,158.22 |
DisclosureSEC source: 0001989533-26-000019 · edgardoc.xml · nonDerivative · entry 1 Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 23,830 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| September 01, 2026 Filed Sep 2, 2026 21:03 UTC |
COZADD BRUCE CDirector
|
SaleOrdinary Shares | 6,000 | $250.13 | $1,500,780.00 |
DisclosureSEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 3 COZADD BRUCE C · CIK 0001193210 · Director 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 351,875 F3 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:38 UTC |
Henderson Mary ElizabethSVP, Technical Operations
|
Tax withholdingOrdinary Shares | 16 | $244.64 | $3,914.31 |
DisclosureSEC source: 0001989533-26-000015 · edgardoc.xml · nonDerivative · entry 2 Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 25,242 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:38 UTC |
Henderson Mary ElizabethSVP, Technical Operations
|
Tax withholdingOrdinary Shares | 2,076 | $241.39 | $501,125.64 |
DisclosureSEC source: 0001989533-26-000015 · edgardoc.xml · nonDerivative · entry 1 Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 25,258 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:34 UTC |
Smith Mark DouglasDirector
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001756253-26-000009 · edgardoc.xml · nonDerivative · entry 2 Smith Mark Douglas · CIK 0001756253 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 9,579 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:34 UTC |
Smith Mark DouglasDirector
|
Tax withholdingOrdinary Shares | 14 | $244.64 | $3,425.02 |
DisclosureSEC source: 0001756253-26-000009 · edgardoc.xml · nonDerivative · entry 1 Smith Mark Douglas · CIK 0001756253 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 11,271 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:31 UTC |
RIEDEL NORBERT GDirector
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001161662-26-000008 · edgardoc.xml · nonDerivative · entry 2 RIEDEL NORBERT G · CIK 0001161662 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 6,923 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:31 UTC |
RIEDEL NORBERT GDirector
|
Tax withholdingOrdinary Shares | 14 | $244.64 | $3,425.02 |
DisclosureSEC source: 0001161662-26-000008 · edgardoc.xml · nonDerivative · entry 1 RIEDEL NORBERT G · CIK 0001161662 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 8,615 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:28 UTC |
LOVE TED WDirector
|
Tax withholdingOrdinary Shares | 737 | $241.39 | $177,904.36 |
DisclosureSEC source: 0001188919-26-000015 · edgardoc.xml · nonDerivative · entry 2 LOVE TED W · CIK 0001188919 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 2,389 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:28 UTC |
LOVE TED WDirector
|
Tax withholdingOrdinary Shares | 6 | $244.06 | $1,464.38 |
DisclosureSEC source: 0001188919-26-000015 · edgardoc.xml · nonDerivative · entry 1 LOVE TED W · CIK 0001188919 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 3,126 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:24 UTC |
Hamill LauraDirector
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001751804-26-000005 · edgardoc.xml · nonDerivative · entry 2 Hamill Laura · CIK 0001751804 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 6,832 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:24 UTC |
Hamill LauraDirector
|
Tax withholdingOrdinary Shares | 14 | $244.06 | $3,416.90 |
DisclosureSEC source: 0001751804-26-000005 · edgardoc.xml · nonDerivative · entry 1 Hamill Laura · CIK 0001751804 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 8,524 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:20 UTC |
Cook Jennifer E.Director
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001754371-26-000007 · edgardoc.xml · nonDerivative · entry 2 Cook Jennifer E. · CIK 0001754371 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 10,736 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:20 UTC |
Cook Jennifer E.Director
|
Tax withholdingOrdinary Shares | 14 | $244.06 | $3,416.90 |
DisclosureSEC source: 0001754371-26-000007 · edgardoc.xml · nonDerivative · entry 1 Cook Jennifer E. · CIK 0001754371 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 12,428 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:17 UTC |
ENRIGHT PATRICK GDirector
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001253886-26-000011 · edgardoc.xml · nonDerivative · entry 2 ENRIGHT PATRICK G · CIK 0001253886 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 21,278 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:17 UTC |
ENRIGHT PATRICK GDirector
|
Tax withholdingOrdinary Shares | 14 | $244.64 | $3,425.02 |
DisclosureSEC source: 0001253886-26-000011 · edgardoc.xml · nonDerivative · entry 1 ENRIGHT PATRICK G · CIK 0001253886 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 22,970 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:13 UTC |
McSharry Heather AnnDirector
|
Tax withholdingOrdinary Shares | 1,840 | $241.39 | $444,157.60 |
DisclosureSEC source: 0001576068-26-000009 · edgardoc.xml · nonDerivative · entry 2 McSharry Heather Ann · CIK 0001576068 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 18,199 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:13 UTC |
McSharry Heather AnnDirector
|
Tax withholdingOrdinary Shares | 15 | $244.64 | $3,669.67 |
DisclosureSEC source: 0001576068-26-000009 · edgardoc.xml · nonDerivative · entry 1 McSharry Heather Ann · CIK 0001576068 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 20,039 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:09 UTC |
Kennedy PatrickDirector
|
Tax withholdingOrdinary Shares | 1,840 | $241.39 | $444,157.60 |
DisclosureSEC source: 0002013944-26-000006 · edgardoc.xml · nonDerivative · entry 2 Kennedy Patrick · CIK 0002013944 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 6,452 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:09 UTC |
Kennedy PatrickDirector
|
Tax withholdingOrdinary Shares | 15 | $244.06 | $3,660.97 |
DisclosureSEC source: 0002013944-26-000006 · edgardoc.xml · nonDerivative · entry 1 Kennedy Patrick · CIK 0002013944 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 8,292 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:06 UTC |
Winningham Rick EDirector
|
Tax withholdingOrdinary Shares | 14 | $244.64 | $3,425.02 |
DisclosureSEC source: 0001302443-26-000015 · edgardoc.xml · nonDerivative · entry 2 Winningham Rick E · CIK 0001302443 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 9,466 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:06 UTC |
Winningham Rick EDirector
|
Tax withholdingOrdinary Shares | 1,692 | $241.39 | $408,431.88 |
DisclosureSEC source: 0001302443-26-000015 · edgardoc.xml · nonDerivative · entry 1 Winningham Rick E · CIK 0001302443 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 9,480 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:03 UTC |
COZADD BRUCE CDirector
|
Tax withholdingOrdinary Shares | 1,209 | $241.39 | $291,840.39 |
DisclosureSEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 2 COZADD BRUCE C · CIK 0001193210 · Director 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 357,875 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Read SEC document |
| August 31, 2026 Filed Sep 2, 2026 21:03 UTC |
COZADD BRUCE CDirector
|
Tax withholdingOrdinary Shares | 10 | $244.06 | $2,440.64 |
DisclosureSEC source: 0001193210-26-000025 · edgardoc.xml · nonDerivative · entry 1 COZADD BRUCE C · CIK 0001193210 · Director 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 359,084 F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. F2 · balance_after: Includes the November 3, 2025 disposition of 3,193 shares for the withholding of restricted stock units by the Issuer to satisfy FICA taxes arising from the Reporting Person being retirement eligible which was previously inadvertently not reported; not an open market transaction. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative | 27,584 | $0.00 Strike: $137.12 | $0.00 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 14 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 27,584 shares Expires 2029-08-07 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F8 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of May 29, 2019, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative | 26,116 | $0.00 Strike: $113.10 | $0.00 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 13 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 26,116 shares Expires 2030-02-26 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F7 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionIncentive Stock Option (right to buy) · Derivative | 2,916 | $0.00 Strike: $137.12 | $0.00 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 12 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 2,916 shares Expires 2029-08-07 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F8 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of May 29, 2019, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionIncentive Stock Option (right to buy) · Derivative | 884 | $0.00 Strike: $113.10 | $0.00 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · derivative · entry 11 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 884 shares Expires 2030-02-26 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F7 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 300 | $252.76 | $75,828.00 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 10 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 65,686 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 9,259 | $251.95 | $2,332,804.12 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 9 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 65,986 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F6 · price: Reflects the sale of ordinary shares executed in multiple transactions at prices ranging from $251.37 to $252.31. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 19,639 | $250.60 | $4,921,596.24 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 8 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 75,245 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F5 · price: Reflects the sale of ordinary shares executed in multiple transactions at prices ranging from $250.33 to $251.29. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 18,113 | $250.02 | $4,528,572.41 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 7 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 94,884 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F4 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $249.33 to $250.325 The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 11,423 | $248.67 | $2,840,516.29 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 6 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 112,997 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $248.29 to $249.24. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
SaleOrdinary Shares | 18,187 | $247.86 | $4,507,780.72 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 5 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 124,420 F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $247.29 to $248.24. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionOrdinary Shares | 2,916 | $137.12 | $399,841.92 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 4 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 142,607 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionOrdinary Shares | 27,584 | $137.12 | $3,782,318.08 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 3 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 139,691 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionOrdinary Shares | 884 | $113.10 | $99,980.40 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 2 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 112,107 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 27, 2026 Filed Aug 31, 2026 22:45 UTC |
Iannone RobertEVP, Global Head of R&D & CMO
|
Exercise / conversionOrdinary Shares | 26,116 | $113.10 | $2,953,719.60 |
DisclosureSEC source: 0001737329-26-000016 · edgardoc.xml · nonDerivative · entry 1 Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 111,223 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 22:01 UTC |
Pearce SamanthaEVP, Chief Commercial Officer
|
Tax withholdingOrdinary Shares | 780 | $261.62 | $204,063.60 |
DisclosureSEC source: 0001805688-26-000014 · edgardoc.xml · nonDerivative · entry 1 Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 47,131 F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 21:33 UTC |
RIEDEL NORBERT GDirector
|
GrantOrdinary Shares | 1,605 | $0.00 | $0.00 |
DisclosureSEC source: 0001161662-26-000005 · edgardoc.xml · nonDerivative · entry 1 RIEDEL NORBERT G · CIK 0001161662 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 8,629 F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027. F2 · balance_after: Shares beneficially owned by NORBERT G. RIEDEL 2023 TRUST, an entity owned and controlled by the reporting person and his immediate family. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 21:48 UTC |
Kennedy PatrickDirector
|
GrantOrdinary Shares | 1,605 | $0.00 | $0.00 |
DisclosureSEC source: 0002013944-26-000003 · edgardoc.xml · nonDerivative · entry 1 Kennedy Patrick · CIK 0002013944 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 8,307 F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 21:39 UTC |
McSharry Heather AnnDirector
|
GrantOrdinary Shares | 1,605 | $0.00 | $0.00 |
DisclosureSEC source: 0001576068-26-000004 · edgardoc.xml · nonDerivative · entry 1 McSharry Heather Ann · CIK 0001576068 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 20,054 F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 21:57 UTC |
Winningham Rick EDirector
|
GrantOrdinary Shares | 1,605 | $0.00 | $0.00 |
DisclosureSEC source: 0001302443-26-000010 · edgardoc.xml · nonDerivative · entry 1 Winningham Rick E · CIK 0001302443 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 11,172 F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027. Read SEC document |
| August 05, 2026 Filed Aug 7, 2026 21:55 UTC |
LOVE TED WDirector
|
GrantOrdinary Shares | 1,605 | $0.00 | $0.00 |
DisclosureSEC source: 0001188919-26-000012 · edgardoc.xml · nonDerivative · entry 1 LOVE TED W · CIK 0001188919 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 3,132 F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.