ISRG

SEC source: 0001416180-25-000007 · edgardoc.xml · nonDerivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

F1 · kind: The filer gifted shares to a CRUT.

SEC source: 0001897642-25-000004 · edgardoc.xml · derivative · entry 13

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,929

Underlying: Common Stock · 636 shares

Expires 2031-08-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001897642-25-000004 · edgardoc.xml · derivative · entry 12

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,565 shares

Expires 2031-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001897642-25-000004 · edgardoc.xml · derivative · entry 11

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,898 shares

Expires 2030-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001897642-25-000004 · edgardoc.xml · derivative · entry 10

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,901 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 9

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,056

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 8

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,787

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 7

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,688

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 6

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,787

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 5

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,685

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 4

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,787

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 3

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 2

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,787

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001897642-25-000004 · edgardoc.xml · nonDerivative · entry 1

Charlton Henry L · CIK 0001897642 · EVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,423

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 1, 2026.

SEC source: 0001632901-25-000006 · edgardoc.xml · derivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,571

Underlying: Common Stock · 105 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F2 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001632901-25-000006 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001632901-25-000006 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0002010301-25-000004 · edgardoc.xml · derivative · entry 6

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,602

Underlying: Common Stock · 1,298 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

F3 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0002010301-25-000004 · edgardoc.xml · derivative · entry 5

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,115

Underlying: Common Stock · 2,202 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0002010301-25-000004 · edgardoc.xml · nonDerivative · entry 4

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,758

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0002010301-25-000004 · edgardoc.xml · nonDerivative · entry 3

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,960

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0002010301-25-000004 · edgardoc.xml · nonDerivative · entry 2

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,758

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0002010301-25-000004 · edgardoc.xml · nonDerivative · entry 1

Miller Brian Edward · CIK 0002010301 · EVP & Chief Digital Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,056

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0001897970-25-000003 · edgardoc.xml · derivative · entry 6

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,908 shares

Expires 2026-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001897970-25-000003 · edgardoc.xml · derivative · entry 5

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 159 shares

Expires 2026-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001897970-25-000003 · edgardoc.xml · nonDerivative · entry 4

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 473

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

SEC source: 0001897970-25-000003 · edgardoc.xml · nonDerivative · entry 3

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 632

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

SEC source: 0001897970-25-000003 · edgardoc.xml · nonDerivative · entry 2

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 473

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

SEC source: 0001897970-25-000003 · edgardoc.xml · nonDerivative · entry 1

Widman Fredrik · CIK 0001897970 · VP Corporate Controller

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,381

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 21, 2026.

SEC source: 0001519593-25-000006 · edgardoc.xml · nonDerivative · entry 1

Rosa David J. · CIK 0001519593 · Director · Chief Executive Officer (CEO)

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,802

F1 · kind: The filer gifted shares to The Rosa Donor Advised Fund.

SEC source: 0001632901-25-000004 · edgardoc.xml · derivative · entry 11

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 501

Underlying: Common Stock · 125 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 8

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001632901-25-000004 · edgardoc.xml · derivative · entry 13

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,030 shares

Expires 2030-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001632901-25-000004 · edgardoc.xml · derivative · entry 12

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,676

Underlying: Common Stock · 1,153 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F4 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001632901-25-000004 · edgardoc.xml · derivative · entry 10

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 626

Underlying: Common Stock · 1,379 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 353

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $545.57 to $551.71 as follows: 1,173 shares sold at $545.57 to $546.54; 2,460 shares sold at $546.69 to $547.63; 314 shares sold at $547.72 to $548.68; 2,610 shares sold at $549.26 to $550.21; 1,000 shares sold at $550.39 to $551.04; 5 shares sold at $551.71. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,732

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 353

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $545.57 to $551.71 as follows: 1,173 shares sold at $545.57 to $546.54; 2,460 shares sold at $546.69 to $547.63; 314 shares sold at $547.72 to $548.68; 2,610 shares sold at $549.26 to $550.21; 1,000 shares sold at $550.39 to $551.04; 5 shares sold at $551.71. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,506

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 353

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $545.57 to $551.71 as follows: 1,173 shares sold at $545.57 to $546.54; 2,460 shares sold at $546.69 to $547.63; 314 shares sold at $547.72 to $548.68; 2,610 shares sold at $549.26 to $550.21; 1,000 shares sold at $550.39 to $551.04; 5 shares sold at $551.71. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001632901-25-000004 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,383

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on July 29, 2026.

SEC source: 0001277620-25-000005 · edgardoc.xml · derivative · entry 4

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 750

Underlying: Common Stock · 2,193 shares

Expires 2026-04-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 29, 2026.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the Non-Employee Directors' Stock Option Plan. Option shall vest 100% one year after the date of grant or at the next Shareholders Meeting, whichever should take place first, provided that vesting will cease on termination of the Directors service to the Company.

SEC source: 0001277620-25-000005 · edgardoc.xml · nonDerivative · entry 2

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 29, 2026.

SEC source: 0001277620-25-000005 · edgardoc.xml · nonDerivative · entry 1

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,193

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 29, 2026.

SEC source: 0001280628-25-000004 · edgardoc.xml · derivative · entry 6

GUTHART GARY S · CIK 0001280628 · Director · Executive Chair of the Board o

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,000 shares

Expires 2027-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 28, 2026.

F5 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001280628-25-000004 · edgardoc.xml · nonDerivative · entry 4

GUTHART GARY S · CIK 0001280628 · Director · Executive Chair of the Board o

10b5-1 filing: Plan reported

Ownership: Indirect · Trust FBO Son

Disclosed balance after: 17,120

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 28, 2026.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $542.16 to $548.45 as follows: 190 shares sold at $542.16 to $542.98; 150 shares sold at $543.79 to $544.30; 190 shares sold at $545.00 to $545.33; 292 shares sold at $546.34 to $547.20; and 578 shares sold at $547.51 to $548.45. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001280628-25-000004 · edgardoc.xml · nonDerivative · entry 3

GUTHART GARY S · CIK 0001280628 · Director · Executive Chair of the Board o

10b5-1 filing: Plan reported

Ownership: Indirect · Trust FBO Daughter

Disclosed balance after: 17,120

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 28, 2026.

F3 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $542.74 to $548.48 as follows: 100 shares sold at $542.74; 205 shares sold at $543.97 to $544.45; 250 shares sold at $545.06 to $545.94; 200 shares sold at $546.46 to $546.75; and 645 shares sold at $547.49 to $548.48. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001280628-25-000004 · edgardoc.xml · nonDerivative · entry 2

GUTHART GARY S · CIK 0001280628 · Director · Executive Chair of the Board o

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,027

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 28, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $541.76 to $550.16 as follows: 800 shares sold at $541.76 to $542.59; 1,000 shares sold at $542.89 to $543.22; 2,563 shares sold at $544 to $545; 1,600 shares sold at $545.33 to $546.29; 2,770 shares sold at $546.34 to $547.19; 7,383 shares sold at $547.35 to $548.31; 9,068 shares sold at $548.36 to $549.35; and 3,616 shares sold at $549.485 to $550.16. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001280628-25-000004 · edgardoc.xml · nonDerivative · entry 1

GUTHART GARY S · CIK 0001280628 · Director · Executive Chair of the Board o

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,827

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 28, 2026.