ISRG

SEC source: 0001035267-20-000046 · edgardoc.xml · nonDerivative · entry 5

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 384,425

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000046 · edgardoc.xml · nonDerivative · entry 4

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 383,008

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000046 · edgardoc.xml · nonDerivative · entry 3

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 384,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000046 · edgardoc.xml · nonDerivative · entry 2

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 382,000

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000046 · edgardoc.xml · nonDerivative · entry 1

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 382,620

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · derivative · entry 13

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,749

Underlying: Common Stock · 584 shares

Expires 2023-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-20-000050 · edgardoc.xml · derivative · entry 12

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Common Stock · 1,000 shares

Expires 2022-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-20-000050 · edgardoc.xml · derivative · entry 11

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 999

Underlying: Common Stock · 1,000 shares

Expires 2021-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 6

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,368

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 5

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,864

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 4

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,864

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 3

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,154

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 2

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,570

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000050 · edgardoc.xml · nonDerivative · entry 1

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,066

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · derivative · entry 13

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,082

Underlying: Common Stock · 584 shares

Expires 2023-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

F3 · derivative.exercise_date: Each Restricted Stock Unit, granted pursuant to the 2010 Employee Stock Option Plan, represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period of time.

SEC source: 0001035267-20-000052 · edgardoc.xml · derivative · entry 12

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 708 shares

Expires 2022-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-20-000052 · edgardoc.xml · derivative · entry 10

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,250 shares

Expires 2020-02-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 6

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,727

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 5

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,017

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 4

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,433

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 3

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,785

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 2

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,077

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000052 · edgardoc.xml · nonDerivative · entry 1

MOHR MARSHALL · CIK 0001252986 · Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,697

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-20-000038 · edgardoc.xml · nonDerivative · entry 3

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 298,523

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000038 · edgardoc.xml · nonDerivative · entry 2

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,714

F2 · kind: These shares were were transferred to a Fidelity charitable account in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000038 · edgardoc.xml · nonDerivative · entry 1

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,414

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000034 · edgardoc.xml · derivative · entry 3

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,545 shares

Expires 2027-04-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on October 30, 2020.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the Non-Employee Directors' Stock Option Plan. Option shall vest 100% one year after the date of grant or at the next Shareholders Meeting, whichever should take place first, provided that vesting will cease on termination of the Directors service to the Company.

SEC source: 0001035267-20-000034 · edgardoc.xml · nonDerivative · entry 2

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on October 30, 2020.

SEC source: 0001035267-20-000034 · edgardoc.xml · nonDerivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,877

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on October 30, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · derivative · entry 9

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,118

Underlying: Common Stock · 332 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-20-000036 · edgardoc.xml · derivative · entry 8

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 898

Underlying: Common Stock · 827 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-20-000036 · edgardoc.xml · derivative · entry 7

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,117

Underlying: Common Stock · 333 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 6

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 5

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,034

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 4

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 3

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 539

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 2

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000036 · edgardoc.xml · nonDerivative · entry 1

Samath Jamie · CIK 0001330269 · SVP of Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 540

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000037 · edgardoc.xml · nonDerivative · entry 9

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 311,060

F3 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000037 · edgardoc.xml · nonDerivative · entry 4

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 297,077

F4 · kind: These shares were were transferred to a Fidelity charitable account in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000037 · edgardoc.xml · nonDerivative · entry 3

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 298,377

F3 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on March 13, 2020.

SEC source: 0001035267-20-000037 · edgardoc.xml · nonDerivative · entry 8

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 314,523

F6 · kind: The shares were sold from the Lonnie M. Smith 2013 Charitable Remainder Unitrust, from which Mr. Smith is not an Investment Advisor.

SEC source: 0001035267-20-000028 · edgardoc.xml · derivative · entry 3

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 4,250 shares

Expires 2021-04-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 15, 2020.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the Non-Employee Directors' Stock Option Plan. Option shall vest 100% one year after the date of grant or at the next Shareholders Meeting, whichever should take place first, provided that vesting will cease on termination of the Directors service to the Company.

SEC source: 0001035267-20-000028 · edgardoc.xml · nonDerivative · entry 2

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,206

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 15, 2020.

F2 · price: The average selling price for the transaction was $577.433231. Shares sold at $574.381 - $574.951 = 500; shares sold at $575.05 - $575.79 = 1,059; shares sold at $576.40 - $576.449 = 557; shares sold at $577.958 - $578.82 = 358; shares sold at $579.09 - $579.882 = 1,495; shares sold at $580.6 - $581.36 = 281.

SEC source: 0001035267-20-000028 · edgardoc.xml · nonDerivative · entry 1

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,456

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 15, 2020.

SEC source: 0001035267-20-000030 · edgardoc.xml · derivative · entry 3

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,875

Underlying: Common Stock · 31,875 shares

Expires 2021-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 1/8 six months after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-20-000030 · edgardoc.xml · nonDerivative · entry 2

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 381,370

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

F2 · price: The average selling price for the transactions was $576.560879.The shares sold at:$573.48 to $573.98 = 834 shares;$574 to 574.98 = 5,880 shares; $575 to $575.95 = 3,512 shares; $576.05 to $576.93 = 2,457 shares; $577.09 to $599.99 = 5,591 shares; $578.16 to $578.87 = 528 shares; $579.03 to $579.96 = 2,320 shares; $580.29 to $580.94 = 700 shares; $581.36 to $582 = 411 shares.

SEC source: 0001035267-20-000030 · edgardoc.xml · nonDerivative · entry 1

GUTHART GARY S · CIK 0001280628 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 403,603

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 5, 2020.

SEC source: 0001035267-20-000021 · edgardoc.xml · derivative · entry 9

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,750

Underlying: Common Stock · 750 shares

Expires 2027-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 15, 2020.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-20-000021 · edgardoc.xml · derivative · entry 8

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 750

Underlying: Common Stock · 750 shares

Expires 2026-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on June 15, 2020.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.