ISRG

SEC source: 0001035267-24-000226 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,704

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 33

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,625 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F8 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 32

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,336 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 31

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,336

Underlying: Common Stock · 2,414 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 30

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,625 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 29

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,750 shares

Expires 2028-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F8 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 28

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 422 shares

Expires 2027-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 27

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 422

Underlying: Common Stock · 5,203 shares

Expires 2027-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 26

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 468 shares

Expires 2027-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F8 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 25

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 456 shares

Expires 2026-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F9 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · derivative · entry 24

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 459 shares

Expires 2026-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F8 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Awards Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 23

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,001

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F7 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.23 to $493.36 as follows: 939 shares sold at $480.23 to $480.84; 525 shares sold at $481.27 to $482.25; 100 shares sold at $482.45; 1,067 shares sold at $483.58 to $484.58; 542 shares sold at $484.68 to $485.59; 96 shares sold at $485.78; 144 shares sold at $486.91 to $487.14; 588 shares sold at $488.11 to $488.66; 790 shares sold at $489.22 to $490.08; 600 shares sold at $490.28 to $491.22; 1,015 shares sold at $491.37 to $492.05; and 423 shares sold at $492.52 to $493.36. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 22

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,830

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F6 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.53 to $493.48 as follows: 1,082 shares sold at $480.53 to $481.48; 383 shares sold at $481.63 to $482.25; 342 shares sold at $482.69 to $483.61; 952 shares sold at $483.95 to $484.84; 603 shares sold at $485.01 to $485.64; 488 shares sold at $488.17 to $489.00; 908 shares sold at $489.19 to $490.16; 684 shares sold at $490.22 to $490.97; 958 shares sold at $491.41 to $492.01; 409 shares sold at $492.45 to $493.04; and 19 shares sold at $493.48. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 21

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,658

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F5 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $492.62 as follows: 1,134 shares sold at $480.29 to $481.24; 344 shares sold at $481.40 to $482.25; 317 shares sold at $482.69 to $483.61; 832 shares sold at $483.90 to $484.82; 713 shares sold at $485.04 to $485.96; 100 shares sold at $486.95; 755 shares sold at $488.42 to $489.31; 1,198 shares sold at $489.60 to $490.50; 428 shares sold at $490.77 to $491.74; and 1,007 shares sold at $491.79 to $492.62. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 20

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.30 to $493.00 as follows: 836 shares sold at $480.30 to $480.96; 597 shares sold at $481.40 to $482.40; 285 shares sold at $482.45 to $483.37; 784 shares sold at $483.63 to $484.62; 714 shares sold at $484.80 to $485.64; 100 shares sold at $486.95; 476 shares sold at $488.11 to $488.58; 1,034 shares sold at $489.30 to $490.30; 364 shares sold at $490.38 to $491.17; 1,038 shares sold at $491.41 to $492.28; and 358 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 19

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,945

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 18

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.30 to $493.00 as follows: 836 shares sold at $480.30 to $480.96; 597 shares sold at $481.40 to $482.40; 285 shares sold at $482.45 to $483.37; 784 shares sold at $483.63 to $484.62; 714 shares sold at $484.80 to $485.64; 100 shares sold at $486.95; 476 shares sold at $488.11 to $488.58; 1,034 shares sold at $489.30 to $490.30; 364 shares sold at $490.38 to $491.17; 1,038 shares sold at $491.41 to $492.28; and 358 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 17

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,942

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 16

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.30 to $493.00 as follows: 836 shares sold at $480.30 to $480.96; 597 shares sold at $481.40 to $482.40; 285 shares sold at $482.45 to $483.37; 784 shares sold at $483.63 to $484.62; 714 shares sold at $484.80 to $485.64; 100 shares sold at $486.95; 476 shares sold at $488.11 to $488.58; 1,034 shares sold at $489.30 to $490.30; 364 shares sold at $490.38 to $491.17; 1,038 shares sold at $491.41 to $492.28; and 358 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 15

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,954

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 14

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F3 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $493.00 as follows: 1,080 shares sold at $480.29 to $481.27; 443 shares sold at $481.40 to $482.25; 199 shares sold at $482.81 to $483.33; 812 shares sold at $483.90 to $484.62; 708 shares sold at $484.91 to $485.78; 559 shares sold at $488.03 to $488.73; 809 shares sold at $489.20 to $490.09; 655 shares sold at $490.22 to $491.21; 948 shares sold at $491.41 to $492.25; and 373 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 13

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,908

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 12

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.30 to $493.00 as follows: 836 shares sold at $480.30 to $480.96; 597 shares sold at $481.40 to $482.40; 285 shares sold at $482.45 to $483.37; 784 shares sold at $483.63 to $484.62; 714 shares sold at $484.80 to $485.64; 100 shares sold at $486.95; 476 shares sold at $488.11 to $488.58; 1,034 shares sold at $489.30 to $490.30; 364 shares sold at $490.38 to $491.17; 1,038 shares sold at $491.41 to $492.28; and 358 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 11

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 10

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F3 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $493.00 as follows: 1,080 shares sold at $480.29 to $481.27; 443 shares sold at $481.40 to $482.25; 199 shares sold at $482.81 to $483.33; 812 shares sold at $483.90 to $484.62; 708 shares sold at $484.91 to $485.78; 559 shares sold at $488.03 to $488.73; 809 shares sold at $489.20 to $490.09; 655 shares sold at $490.22 to $491.21; 948 shares sold at $491.41 to $492.25; and 373 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 9

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,236

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 8

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $492.95 as follows: 886 shares sold at $480.29 to $481.00; 578 shares sold at $481.46 to $482.25; 284 shares sold at $482.94 to $483.61; 933 shares sold at $483.95 to $484.73; 467 shares sold at $485.00 to $485.78; 180 shares sold at $486.07 to $486.95; 560 shares sold at $488.11 to $488.74; 1,036 shares sold at $489.35 to $490.35; 488 shares sold at $490.52 to $491.52; 866 shares sold at $491.57 to $492.45; and 308 shares sold at $492.62 to $492.95. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 7

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,822

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 6

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F3 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $493.00 as follows: 1,080 shares sold at $480.29 to $481.27; 443 shares sold at $481.40 to $482.25; 199 shares sold at $482.81 to $483.33; 812 shares sold at $483.90 to $484.62; 708 shares sold at $484.91 to $485.78; 559 shares sold at $488.03 to $488.73; 809 shares sold at $489.20 to $490.09; 655 shares sold at $490.22 to $491.21; 948 shares sold at $491.41 to $492.25; and 373 shares sold at $492.62 to $493.00. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 5

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,900

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 4

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $492.95 as follows: 886 shares sold at $480.29 to $481.00; 578 shares sold at $481.46 to $482.25; 284 shares sold at $482.94 to $483.61; 933 shares sold at $483.95 to $484.73; 467 shares sold at $485.00 to $485.78; 180 shares sold at $486.07 to $486.95; 560 shares sold at $488.11 to $488.74; 1,036 shares sold at $489.35 to $490.35; 488 shares sold at $490.52 to $491.52; 866 shares sold at $491.57 to $492.45; and 308 shares sold at $492.62 to $492.95. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 3

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,111

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 2

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,486

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $480.29 to $492.95 as follows: 886 shares sold at $480.29 to $481.00; 578 shares sold at $481.46 to $482.25; 284 shares sold at $482.94 to $483.61; 933 shares sold at $483.95 to $484.73; 467 shares sold at $485.00 to $485.78; 180 shares sold at $486.07 to $486.95; 560 shares sold at $488.11 to $488.74; 1,036 shares sold at $489.35 to $490.35; 488 shares sold at $490.52 to $491.52; 866 shares sold at $491.57 to $492.45; and 308 shares sold at $492.62 to $492.95. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000224 · edgardoc.xml · nonDerivative · entry 1

Charlton Henry L · CIK 0001897642 · SVP & Chief Commercial and Mkt

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,111

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 26, 2025.

SEC source: 0001035267-24-000221 · edgardoc.xml · derivative · entry 6

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,591

Underlying: Common Stock · 120 shares

Expires 2030-08-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F3 · derivative.exercise_date: 7/48th of the shares subject to the option vest on the one-month anniversary measured from August 10, 2023, and 1/48th of the total number of shares vest in forty-one (41) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000221 · edgardoc.xml · derivative · entry 5

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,591

Underlying: Common Stock · 120 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F2 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000221 · edgardoc.xml · nonDerivative · entry 4

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000221 · edgardoc.xml · nonDerivative · entry 3

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,626

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000221 · edgardoc.xml · nonDerivative · entry 2

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000221 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,626

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001610717-24-000412 · form4.xml · derivative · entry 3

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,943 shares

Expires 2026-04-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 2, 2025.

F2 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001610717-24-000412 · form4.xml · nonDerivative · entry 2

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,275

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 2, 2025.

SEC source: 0001610717-24-000412 · form4.xml · nonDerivative · entry 1

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 2, 2025.

SEC source: 0001035267-24-000219 · edgardoc.xml · derivative · entry 6

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 25,200 shares

Expires 2025-02-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

F6 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000219 · edgardoc.xml · nonDerivative · entry 5

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust FBO Son

Disclosed balance after: 23,640

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

F5 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $443.66 to $447.85 as follows: 1,552 shares sold at $443.66 to $444.62; 1,400 shares sold at $444.84.00 to $445.29; 568 shares sold at $446.46 to $447.33; and 200 shares sold at $447.76 to $447.85. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000219 · edgardoc.xml · nonDerivative · entry 4

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust FBO Daughte

Disclosed balance after: 23,640

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

F4 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $443.66 to $447.85 as follows: 1,465 shares sold at $443.66 to $444.31; 1,601 shares sold at $444.93 to $445.80; 554 shares sold at $446.46 to $447.08; and 100 shares sold at $447.85. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000219 · edgardoc.xml · nonDerivative · entry 3

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 1,191,144

F3 · kind: The shares were donated to a Donor Advised Fund (DAF) in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

SEC source: 0001035267-24-000219 · edgardoc.xml · nonDerivative · entry 2

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,170

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $437.94 to $447.76 as follows: 1,797 shares sold at $437.94 to $438.93; 1,345 shares sold at $439.00 to $440.00; 3,108 shares sold at $440.11 to $441.10; 5,000 shares sold at $442.35 to $443.29; 5,182 shares sold at $443.38 to $444.36; 4,556 shares sold at $444.39 to $445.25; 800 shares sold at $445.62 to $445.80; and 1,600 shares sold at $447.00 to $447.76. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000219 · edgardoc.xml · nonDerivative · entry 1

GUTHART GARY S · CIK 0001280628 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,558

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2025.

SEC source: 0001035267-24-000217 · edgardoc.xml · derivative · entry 22

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,572

Underlying: Common Stock · 188 shares

Expires 2029-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F4 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.