IOVA

SEC source: 0001104659-24-080619 · tm2419709-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,160

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-080616 · tm2419709-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,626

Underlying: Common Stock · 2,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-080616 · tm2419709-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,143

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-080616 · tm2419709-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,571

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-071373 · tm2417165-4_4seq1.xml · derivative · entry 1

YARNO WENDY L · CIK 0001181186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,303

Underlying: Common Stock · 49,303 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-071374 · tm2417165-5_4seq1.xml · derivative · entry 1

Countouriotis Athena · CIK 0001571469 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,303

Underlying: Common Stock · 49,303 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-071372 · tm2417165-3_4seq1.xml · derivative · entry 1

WEISER MICHAEL · CIK 0001221449 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,303

Underlying: Common Stock · 49,303 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-071370 · tm2417165-2_4seq1.xml · derivative · entry 1

Maynard Ryan D · CIK 0001363984 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,303

Underlying: Common Stock · 49,303 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-071368 · tm2417165-1_4seq1.xml · derivative · entry 1

Dukes Iain D. · CIK 0001681955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,607

Underlying: Common Stock · 98,607 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-068773 · tm2416581-3_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,346

Underlying: Common stock · 3,906 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-068773 · tm2416581-3_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,486

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-068773 · tm2416581-3_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,468

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-068771 · tm2416581-1_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,921

Underlying: Common stock · 10,417 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-068771 · tm2416581-1_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,325

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-068771 · tm2416581-1_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,751

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-068772 · tm2416581-2_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,613

Underlying: Common stock · 3,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-068772 · tm2416581-2_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,758

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-068772 · tm2416581-2_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,542

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-048428 · tm2412101-2_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,439

Underlying: Common stock · 2,812 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-048428 · tm2412101-2_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,562

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-048428 · tm2412101-2_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,989

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-048429 · tm2412101-3_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,504

Underlying: Common stock · 20,834 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-048429 · tm2412101-3_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 141,334

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-048429 · tm2412101-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,185

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-048427 · tm2412101-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,439

Underlying: Common stock · 2,812 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-048427 · tm2412101-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,026

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-048427 · tm2412101-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,453

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-031578 · tm248073-3_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,252

Underlying: Common stock · 15,623 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-031578 · tm248073-3_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,177

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-031578 · tm248073-3_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,230

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-031576 · tm248073-2_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,338

Underlying: Common stock · 41,662 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-031576 · tm248073-2_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 129,351

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-031576 · tm248073-2_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,800

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-031575 · tm248073-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,129

Underlying: Common stock · 14,061 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-24-031575 · tm248073-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,641

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-24-031575 · tm248073-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,928

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-24-031115 · tm248017-11_4seq1.xml · derivative · entry 1

YARNO WENDY L · CIK 0001181186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031108 · tm248017-4_4seq1.xml · derivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,875

Underlying: Common stock · 46,875 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

F3 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

SEC source: 0001104659-24-031108 · tm248017-4_4seq1.xml · derivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,470

Underlying: Common stock · 105,470 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-24-031113 · tm248017-9_4seq1.xml · derivative · entry 2

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,750

Underlying: Common stock · 93,750 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

F3 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

SEC source: 0001104659-24-031113 · tm248017-9_4seq1.xml · derivative · entry 1

Vogt Frederick G · CIK 0001719678 · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common stock · 500,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-24-031114 · tm248017-10_4seq1.xml · derivative · entry 1

Rothbaum Wayne P. · CIK 0001423102 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031112 · tm248017d8_4seq1.xml · derivative · entry 1

Maynard Ryan D · CIK 0001363984 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031111 · tm248017-7_4seq1.xml · derivative · entry 1

WEISER MICHAEL · CIK 0001221449 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031110 · tm248017-6_4seq1.xml · derivative · entry 1

MCPEAK MERRILL A · CIK 0001210317 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031109 · tm248017-5_4seq1.xml · derivative · entry 1

Dukes Iain D. · CIK 0001681955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-24-031107 · tm248017-3_4seq1.xml · derivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,875

Underlying: Common stock · 46,875 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

F3 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

SEC source: 0001104659-24-031107 · tm248017-3_4seq1.xml · derivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,470

Underlying: Common stock · 105,470 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-24-031106 · tm248017-2_4seq1.xml · derivative · entry 2

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,875

Underlying: Common stock · 46,875 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

F3 · derivative.expiration_date: 50% of the RSUs will vest on the 6-month anniversary of the date of grant and the remaining RSUs will vest on the one-year anniversary of the date of grant.

SEC source: 0001104659-24-031106 · tm248017-2_4seq1.xml · derivative · entry 1

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,470

Underlying: Common stock · 105,470 shares

Expires not disclosed

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.