IOVA

SEC source: 0001104659-26-113342 · tm2626734-2_4seq1.xml · derivative · entry 3

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common stock · 135,000 shares

Expires not disclosed

F3 · derivative.exercise_price: Each performance stock unit ("PSU") converts into one share of the Issuer's common stock.

F4 · shares: Up to 135,000 shares of the Issuer's common stock underlying the PSUs may be earned subject to achievement of certain regulatory milestones.

F5 · derivative.exercise_date: Such earned PSUs shall vest on the date that the Issuer publicly discloses on a Form 8-K with the U.S. Securities and Exchange Commission its receipt of certain regulatory milestones.

F5 · derivative.expiration_date: Such earned PSUs shall vest on the date that the Issuer publicly discloses on a Form 8-K with the U.S. Securities and Exchange Commission its receipt of certain regulatory milestones.

SEC source: 0001104659-26-113342 · tm2626734-2_4seq1.xml · derivative · entry 2

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 180,000

Underlying: Common stock · 180,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F1 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-26-113342 · tm2626734-2_4seq1.xml · derivative · entry 1

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common stock · 135,000 shares

Expires 2036-09-30

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-26-106752 · tm2625111-3_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,756

Underlying: Common stock · 15,626 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-106752 · tm2625111-3_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 595,447

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-106752 · tm2625111-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,085

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-106750 · tm2625111-2_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,878

Underlying: Common stock · 7,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-106750 · tm2625111-2_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,074

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-106750 · tm2625111-2_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 146,050

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-106748 · tm2625111-1_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,599

Underlying: Common stock · 9,766 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-106748 · tm2625111-1_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 256,364

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-106748 · tm2625111-1_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,842

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-105101 · tm2624648-3_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,338

Underlying: Common stock · 41,669 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-105101 · tm2624648-3_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 586,459

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-105101 · tm2624648-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 604,161

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-105100 · tm2624648-2_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,939

Underlying: Common stock · 5,470 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-105100 · tm2624648-2_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,076

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-105100 · tm2624648-2_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,584

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-105099 · tm2624648-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,580

Underlying: Common stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-105099 · tm2624648-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,237

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-105099 · tm2624648-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,709

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-095040 · tm2622903-1_4seq1.xml · derivative · entry 3

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,003

Underlying: Common Stock · 10,001 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on February 10, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-095040 · tm2622903-1_4seq1.xml · nonDerivative · entry 2

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,511

F2 · date: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-095040 · tm2622903-1_4seq1.xml · nonDerivative · entry 1

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 156,947

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · date: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-093482 · tm2622610-1_4seq1.xml · derivative · entry 3

Roche Corleen M. · CIK 0001857905 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,005

Underlying: Common Stock · 49,995 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on August 6, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-093482 · tm2622610-1_4seq1.xml · nonDerivative · entry 2

Roche Corleen M. · CIK 0001857905 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,757

F2 · date: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-093482 · tm2622610-1_4seq1.xml · nonDerivative · entry 1

Roche Corleen M. · CIK 0001857905 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,995

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · date: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-075854 · tm2618145-1_4seq1.xml · derivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common stock · 15,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-26-075863 · tm2618145-5_4seq1.xml · derivative · entry 1

WEISER MICHAEL · CIK 0001221449 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,316

Underlying: Common Stock · 90,316 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-26-075856 · tm2618145-2_4seq1.xml · derivative · entry 1

Maynard Ryan D · CIK 0001363984 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,316

Underlying: Common Stock · 90,316 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-26-075861 · tm2618145-4_4seq1.xml · derivative · entry 1

Dukes Iain D. · CIK 0001681955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 180,632

Underlying: Common Stock · 180,632 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-26-075858 · tm2618145-3_4seq1.xml · derivative · entry 1

Countouriotis Athena · CIK 0001571469 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,316

Underlying: Common Stock · 90,316 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (ii) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reporting Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-26-071895 · tm2617137-2_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,365

Underlying: Common stock · 9,766 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-071895 · tm2617137-2_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,114

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-071895 · tm2617137-2_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,957

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-071897 · tm2617137-3_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,691

Underlying: Common stock · 7,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-071897 · tm2617137-3_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,111

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-071897 · tm2617137-3_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,087

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-071899 · tm2617137-4_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,382

Underlying: Common stock · 15,625 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-071899 · tm2617137-4_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 562,492

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-071899 · tm2617137-4_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 569,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-071891 · tm2617137-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,691

Underlying: Common stock · 7,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 5, 2025, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-071891 · tm2617137-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,920

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-071891 · tm2617137-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,896

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-070153 · tm2616710-3_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,409

Underlying: Common stock · 5,469 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-070153 · tm2616710-3_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 242,191

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-070153 · tm2616710-3_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 244,699

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-26-070152 · tm2616710-2_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,369

Underlying: Common stock · 8,790 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-26-070152 · tm2616710-2_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,274

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-26-070152 · tm2616710-2_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.