IOVA

SEC source: 0001104659-25-056440 · tm2517077-4_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,252

Underlying: Common stock · 10,417 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056440 · tm2517077-4_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 404,604

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-056440 · tm2517077-4_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 426,731

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-056437 · tm2517077-2_4seq1.xml · derivative · entry 4

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,528

Underlying: Common stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056437 · tm2517077-2_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,549

Underlying: Common stock · 3,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056437 · tm2517077-2_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,633

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-056437 · tm2517077-2_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,883

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-056432 · tm2517077-1_4seq1.xml · derivative · entry 3

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,528

Underlying: Common Stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F6 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F6 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056432 · tm2517077-1_4seq1.xml · nonDerivative · entry 2

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,529

F3 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F4 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-056432 · tm2517077-1_4seq1.xml · nonDerivative · entry 1

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,993

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

F2 · balance_after: Represents common stock owned by the Reporting Person, excluding common stock purchased pursuant to the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001104659-25-052968 · tm2516237-1_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 206,852

F1 · shares: Shares were acquired in the open market during a permitted trading window in accordance with the Issuer's Insider Trading Policy. A copy of the Insider Trading Policy is filed as Exhibit 19.1 to the Issuer's Annual Report on Form 10-K for the year ended December 31, 2024.

SEC source: 0001104659-25-049999 · tm2515393-1_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 374,646

F1 · shares: Shares were acquired in the open market during a permitted trading window in accordance with the Issuer's Insider Trading Policy. A copy of the Insider Trading Policy is filed as Exhibit 19.1 to the Issuer's Annual Report on Form 10-K for the year ended December 31, 2024.

SEC source: 0001104659-25-025216 · tm259584-1_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 8,334 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-025216 · tm259584-1_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 201,252

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-025216 · tm259584-1_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 203,761

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-021871 · tm258333-9_4seq1.xml · derivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,190

Underlying: Common stock · 117,190 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-021869 · tm258333-8_4seq1.xml · derivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,750

Underlying: Common stock · 93,750 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-021872 · tm258333-10_4seq1.xml · derivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,500

Underlying: Common stock · 187,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-021868 · tm258333-7_4seq1.xml · derivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,750

Underlying: Common stock · 93,750 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-021866 · tm258333-6_4seq1.xml · derivative · entry 1

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,750

Underlying: Common stock · 93,750 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F2 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the RSUs shall vest over three years, with (i) one-third of the RSUs vesting on the one-year anniversary of the date of grant and (ii) the remaining RSUs shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-021056 · tm258333-2_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,756

Underlying: Common stock · 59,999 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021056 · tm258333-2_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 195,427

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-021056 · tm258333-2_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 215,411

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-021055 · tm258333-1_4seq1.xml · derivative · entry 4

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,317

Underlying: Common stock · 58,590 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021055 · tm258333-1_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,626

Underlying: Common stock · 3,907 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021055 · tm258333-1_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,913

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-021055 · tm258333-1_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,383

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-021057 · tm258333-3_4seq1.xml · derivative · entry 4

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 333,350

Underlying: Common stock · 213,525 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021057 · tm258333-3_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,669

Underlying: Common stock · 10,418 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021057 · tm258333-3_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 349,646

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-021057 · tm258333-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 445,059

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-021062 · tm258333-5_4seq1.xml · derivative · entry 3

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,317

Underlying: Common Stock · 58,590 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F6 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F6 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021062 · tm258333-5_4seq1.xml · nonDerivative · entry 2

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,204

F3 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F4 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-021062 · tm258333-5_4seq1.xml · nonDerivative · entry 1

Bellemin Jean-Marc · CIK 0001754253 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,938

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

F2 · balance_after: Represents common stock owned by the Reporting Person, excluding common stock purchased pursuant to the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001104659-25-021058 · tm258333-4_4seq1.xml · derivative · entry 4

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,317

Underlying: Common stock · 58,590 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021058 · tm258333-4_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,065

Underlying: Common stock · 3,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-021058 · tm258333-4_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,578

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-021058 · tm258333-4_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-012273 · tm256127d2_4seq1.xml · derivative · entry 3

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common stock · 150,000 shares

Expires not disclosed

F3 · derivative.exercise_price: Each performance stock unit ("PSU") converts into one share of the Issuer's common stock.

F4 · shares: Up to 150,000 shares of the Issuer's common stock underlying the PSUs may be earned subject to achievement of certain financial milestones.

F5 · derivative.exercise_date: Such earned PSUs shall vest on the date that the Issuer publicly announces its 2025 financial results by filing its Form 10-K with the U.S. Securities and Exchange Commission.

F5 · derivative.expiration_date: Such earned PSUs shall vest on the date that the Issuer publicly announces its 2025 financial results by filing its Form 10-K with the U.S. Securities and Exchange Commission.

SEC source: 0001104659-25-012273 · tm256127d2_4seq1.xml · derivative · entry 2

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common stock · 120,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F1 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-012273 · tm256127d2_4seq1.xml · derivative · entry 1

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common stock · 35,000 shares

Expires 2035-02-10

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-004204 · tm253469-2_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-004204 · tm253469-2_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,886

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-004204 · tm253469-2_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,464

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-004205 · tm253469-3_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 20,835 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-004205 · tm253469-3_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 221,116

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-004205 · tm253469-3_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 231,071

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-004202 · tm253469-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,813 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on January 14, 2022, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-004202 · tm253469-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,774

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-004202 · tm253469-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.