IOVA

SEC source: 0001104659-25-118170 · tm2532666-4_4seq1.xml · nonDerivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,640

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · derivative · entry 6

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,418

Underlying: Common stock · 10,417 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · nonDerivative · entry 4

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 464,522

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · nonDerivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 468,948

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · derivative · entry 6

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,517

Underlying: Common stock · 3,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · nonDerivative · entry 4

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,744

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · nonDerivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 107,530

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118167 · tm2532666-1_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,348

Underlying: Common stock · 5,469 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118167 · tm2532666-1_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 215,859

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118167 · tm2532666-1_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 218,326

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118170 · tm2532666-4_4seq1.xml · derivative · entry 5

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,949

Underlying: Common stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118170 · tm2532666-4_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,734

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118170 · tm2532666-4_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,198

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · derivative · entry 5

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,344

Underlying: Common stock · 41,669 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 458,531

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118168 · tm2532666-2_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 476,232

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · derivative · entry 5

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,949

Underlying: Common stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,014

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-118169 · tm2532666-3_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 108,478

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-087547 · tm2525186-3_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,817

Underlying: Common stock · 5,470 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087547 · tm2525186-3_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 212,857

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-087547 · tm2525186-3_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 215,324

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-087546 · tm2525186-2_4seq1.xml · derivative · entry 4

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,738

Underlying: Common stock · 8,790 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087546 · tm2525186-2_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,813

Underlying: Common stock · 3,907 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087546 · tm2525186-2_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,409

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-087546 · tm2525186-2_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,857

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-087549 · tm2525186-4_4seq1.xml · derivative · entry 4

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,013

Underlying: Common stock · 41,669 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087549 · tm2525186-4_4seq1.xml · derivative · entry 3

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,385

Underlying: Common stock · 10,417 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087549 · tm2525186-4_4seq1.xml · nonDerivative · entry 2

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 434,563

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-087549 · tm2525186-4_4seq1.xml · nonDerivative · entry 1

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 456,690

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-087545 · tm2525186-1_4seq1.xml · derivative · entry 4

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,738

Underlying: Common stock · 8,790 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087545 · tm2525186-1_4seq1.xml · derivative · entry 3

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,033

Underlying: Common stock · 3,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-087545 · tm2525186-1_4seq1.xml · nonDerivative · entry 2

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,689

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-087545 · tm2525186-1_4seq1.xml · nonDerivative · entry 1

BILINSKY IGOR · CIK 0001594604 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-075687 · tm2522878-2_4seq1.xml · derivative · entry 2

Roche Corleen M. · CIK 0001857905 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common stock · 150,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

F1 · derivative.expiration_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-075687 · tm2522878-2_4seq1.xml · derivative · entry 1

Roche Corleen M. · CIK 0001857905 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common stock · 300,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: Provided the Reporting Person is still employed with the Issuer on the following dates, the restricted stock units ("RSUs") and options are each exercisable as follows: (i) RSUs and options for the purchase of one-third of such shares shall vest on the one-year anniversary of the date of grant; and (ii) the remaining RSUs and options shall vest in eight equal quarterly installments over the next two years, commencing with the first quarter following the first anniversary of the date of grant.

SEC source: 0001104659-25-060245 · tm2518181-1_4seq1.xml · derivative · entry 1

YARNO WENDY L · CIK 0001181186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,546

Underlying: Common Stock · 67,546 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-25-060254 · tm2518181-5_4seq1.xml · derivative · entry 1

Countouriotis Athena · CIK 0001571469 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,546

Underlying: Common Stock · 67,546 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-25-060253 · tm2518181-4_4seq1.xml · derivative · entry 1

Maynard Ryan D · CIK 0001363984 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,546

Underlying: Common Stock · 67,546 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-25-060251 · tm2518181-3_4seq1.xml · derivative · entry 1

WEISER MICHAEL · CIK 0001221449 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,546

Underlying: Common Stock · 67,546 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-25-060249 · tm2518181-2_4seq1.xml · derivative · entry 1

Dukes Iain D. · CIK 0001681955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,092

Underlying: Common Stock · 135,092 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred restricted stock unit ("DRSU") represents a contingent right to receive one share of the Issuer's common stock and are granted pursuant to the Issuer's 2018 Equity Incentive Plan (as amended).

F2 · derivative.exercise_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

F2 · derivative.expiration_date: Provided the Reporting Person continues to be providing service to the Issuer on the following dates, the DRSUs shall vest on the earlier of: (i) the first anniversary of the Transaction Date; or (2) the day prior to the Issuer's next annual shareholder meeting. Notwithstanding the vesting, the issuance of the common stock will be deferred until the earlier of (i) three months after the Reported Person's resignation or removal from the Board of Directors or no longer providing service because of death or disability, (ii) a change in control (as defined in the DRSU agreement) or (iii) ten years from the Transaction Date.

SEC source: 0001104659-25-057310 · tm2517335-1_4seq1.xml · nonDerivative · entry 1

Kirby Daniel Gordon · CIK 0002055001 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

F1 · shares: Shares were acquired in the open market during a permitted trading window in accordance with the Issuer's Insider Trading Policy. A copy of the Insider Trading Policy is filed as Exhibit 19.1 to the Issuer's Annual Report on Form 10-K for the year ended December 31, 2024.

SEC source: 0001104659-25-056444 · tm2517077-5_4seq1.xml · derivative · entry 3

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,287

Underlying: Common Stock · 5,469 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056444 · tm2517077-5_4seq1.xml · nonDerivative · entry 2

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 209,854

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-056444 · tm2517077-5_4seq1.xml · nonDerivative · entry 1

Puri Raj K. · CIK 0002046483 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 212,321

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-056438 · tm2517077-3_4seq1.xml · derivative · entry 4

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,528

Underlying: Common stock · 8,789 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056438 · tm2517077-3_4seq1.xml · derivative · entry 3

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,720

Underlying: Common stock · 3,906 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F6 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 2, 2023, but does not include any other RSUs held by such Reporting Person.

SEC source: 0001104659-25-056438 · tm2517077-3_4seq1.xml · nonDerivative · entry 2

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,160

F2 · security: Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the RSUs. This is not an open market sale of securities.

F3 · balance_after: Represents the common stock remaining after deducting the common stock withheld for taxes.

SEC source: 0001104659-25-056438 · tm2517077-3_4seq1.xml · nonDerivative · entry 1

GRAF FINCKENSTEIN FRIEDRICH · CIK 0001782981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,608

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Represents such shares underlying the restricted stock units ("RSUs") which vested on the transaction date.

SEC source: 0001104659-25-056440 · tm2517077-4_4seq1.xml · derivative · entry 4

Vogt Frederick G · CIK 0001719678 · Director · Interim CEO & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 291,682

Underlying: Common stock · 41,668 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The remaining RSUs will vest in equal quarterly installments.

F5 · derivative.expiration_date: The remaining RSUs will vest in equal quarterly installments.

F7 · balance_after: Such aggregate number reflects the remainder of such RSUs granted on March 1, 2024, but does not include any other RSUs held by such Reporting Person.