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Nasdaq · USD

IONS

IONIS PHARMACEUTICALS INC

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1182
SEC CIK
0000874015
Parsed reports
834

Last 12 months

Inside the activity.

2 purchase rows · 116 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 2025015
Dec 202502
Jan 2026029
Feb 202607
Mar 2026031
Apr 202609
May 202606
Jun 2026011
Jul 202626
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
April 08, 2019 Filed Apr 10, 2019 22:24 UTC
Geary Richard SSVP, Development
Exercise / conversionCommon Stock 24,000 $47.34 $1,136,160.00
Disclosure

SEC source: 0000874015-19-000059 · edgar.xml · nonDerivative · entry 1

Geary Richard S · CIK 0001442730 · SVP, Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,442

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/7/2019.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/7/2019.

Read SEC document
April 05, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 2,252 $0.00 Strike: $61.68 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 24

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,969

Underlying: Common Stock · 2,252 shares

Expires 2023-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 05, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 2,252 $84.75 $190,857.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 18

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,673

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 05, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 2,252 $61.68 $138,903.36
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 17

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,925

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 8,000 $0.00 Strike: $49.25 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 23

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,638

Underlying: Common Stock · 8,000 shares

Expires 2025-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 5,600 $0.00 Strike: $47.34 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 22

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,825

Underlying: Common Stock · 5,600 shares

Expires 2024-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 2,657 $0.00 Strike: $61.57 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 21

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,657 shares

Expires 2022-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 20,365 $0.00 Strike: $61.68 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 20

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,221

Underlying: Common Stock · 20,365 shares

Expires 2023-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 1,878 $84.25 $158,221.50
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 16

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,673

F8 · kind: The sale was made pursuant to shares owned.

F8 · shares: The sale was made pursuant to shares owned.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 1,122 $82.01 $92,015.22
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 15

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,551

F8 · kind: The sale was made pursuant to shares owned.

F8 · shares: The sale was made pursuant to shares owned.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.00 to $82.02, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (9) on this Form 4.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 8,000 $84.29 $674,320.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 14

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.20 to $84.35, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (7) on this Form 4.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 8,000 $49.25 $394,000.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 13

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,673

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 3,600 $82.10 $295,560.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 12

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 3,600 $47.34 $170,424.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 11

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 2,000 $84.20 $168,400.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 10

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 2,000 $47.34 $94,680.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 9

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,673

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 2,657 $82.03 $217,953.71
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 8

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.00 to $82.05, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (6) on this Form 4.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 2,657 $61.57 $163,591.49
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 7

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,330

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

F5 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 4,873 $82.19 $400,511.87
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plans adopted by the reporting person on 8/29/2018 and 3/5/2019.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plans adopted by the reporting person on 8/29/2018 and 3/5/2019.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.05 to $82.30, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 4,873 $61.68 $300,566.64
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,546

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plans adopted by the reporting person on 8/29/2018 and 3/5/2019.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plans adopted by the reporting person on 8/29/2018 and 3/5/2019.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 15,492 $84.75 $1,312,947.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
April 04, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 15,492 $61.68 $955,546.56
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,165

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
April 03, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 7,654 $0.00 Strike: $61.68 $0.00
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · derivative · entry 19

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,586

Underlying: Common Stock · 7,654 shares

Expires 2023-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 03, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 7,654 $84.83 $649,288.82
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.75 to $85.025, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
April 03, 2019 Filed Apr 5, 2019 23:29 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 7,654 $61.68 $472,098.72
Disclosure

SEC source: 0000874015-19-000057 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,327

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
March 19, 2019 Filed Mar 20, 2019 22:05 UTC SaleCommon Stock 10,000 $79.63 $796,258.00
Disclosure

SEC source: 0000874015-19-000053 · edgar.xml · nonDerivative · entry 1

WENDER JOSEPH H · CIK 0001073384 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Joseph H. Wender Trust

Disclosed balance after: 58,916

F1 · kind: The sale was made pursuant to shares owned.

F1 · shares: The sale was made pursuant to shares owned.

Read SEC document
March 18, 2019 Filed Mar 20, 2019 22:15 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 28,800 $0.00 Strike: $61.57 $0.00
Disclosure

SEC source: 0000874015-19-000055 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,657

Underlying: Common Stock · 28,800 shares

Expires 2022-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 18, 2019 Filed Mar 20, 2019 22:15 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 28,800 $78.79 $2,269,186.56
Disclosure

SEC source: 0000874015-19-000055 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.75 to $78.895, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
March 18, 2019 Filed Mar 20, 2019 22:15 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 28,800 $61.57 $1,773,216.00
Disclosure

SEC source: 0000874015-19-000055 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,473

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
March 12, 2019 Filed Mar 14, 2019 22:24 UTC Exercise / conversionEmployee Stock Option (right to buy) · Derivative 8,334 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000051 · edgar.xml · derivative · entry 3

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,500

Underlying: Common Stock · 8,334 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 12, 2019 Filed Mar 14, 2019 22:24 UTC SaleCommon Stock 8,334 $75.00 $625,050.00
Disclosure

SEC source: 0000874015-19-000051 · edgar.xml · nonDerivative · entry 2

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,677

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

Read SEC document
March 12, 2019 Filed Mar 14, 2019 22:24 UTC Exercise / conversionCommon Stock 8,334 $39.87 $332,276.58
Disclosure

SEC source: 0000874015-19-000051 · edgar.xml · nonDerivative · entry 1

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,011

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:56 UTC Exercise / conversionEmployee Stock Option (right to buy) · Derivative 8,333 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000049 · edgar.xml · derivative · entry 3

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,834

Underlying: Common Stock · 8,333 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:56 UTC SaleCommon Stock 8,333 $70.00 $583,310.00
Disclosure

SEC source: 0000874015-19-000049 · edgar.xml · nonDerivative · entry 2

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,677

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:56 UTC Exercise / conversionCommon Stock 8,333 $39.87 $332,236.71
Disclosure

SEC source: 0000874015-19-000049 · edgar.xml · nonDerivative · entry 1

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,010

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/8/2017.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 8,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · derivative · entry 8

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 18,800 $0.00 Strike: $47.34 $0.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · derivative · entry 7

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,755

Underlying: Common Stock · 18,800 shares

Expires 2024-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 8,000 $68.75 $550,000.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 8,000 $39.87 $318,960.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,673

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 14,100 $68.75 $969,375.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 14,100 $47.34 $667,494.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,773

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 4,700 $64.51 $303,204.52
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.50 to $64.55, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
February 27, 2019 Filed Mar 1, 2019 22:40 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 4,700 $47.34 $222,498.00
Disclosure

SEC source: 0000874015-19-000047 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,373

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 26, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 37,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · derivative · entry 7

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,500

Underlying: Common Stock · 37,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 26, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
SaleCommon Stock 37,000 $61.54 $2,276,798.70
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · nonDerivative · entry 4

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,634

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.45 to $61.68, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

Read SEC document
February 26, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
Exercise / conversionCommon Stock 37,000 $39.87 $1,475,190.00
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · nonDerivative · entry 3

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,634

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

Read SEC document
February 25, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 40,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · derivative · entry 6

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,500

Underlying: Common Stock · 40,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 25, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
SaleCommon Stock 40,000 $60.07 $2,402,700.00
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · nonDerivative · entry 2

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,634

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.02 to $60.15, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
February 25, 2019 Filed Feb 28, 2019 00:31 UTC
CROOKE STANLEY TDirector · Chairman and CEO
Exercise / conversionCommon Stock 40,000 $39.87 $1,594,800.00
Disclosure

SEC source: 0000874015-19-000042 · edgar.xml · nonDerivative · entry 1

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,634

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016.

Read SEC document
February 13, 2019 Filed Feb 14, 2019 22:57 UTC
CROOKE STANLEY TDirector · Chairman and CEO
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 5,300 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000038 · edgar.xml · derivative · entry 10

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By wife

Disclosed balance after: 3,200

Underlying: Common Stock · 5,300 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.