INVA

SEC source: 0000899140-23-000696 · form4.xml · nonDerivative · entry 2

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 7,080,000

F2 · price: On May 26, 2023, the Reporting Persons acquired 30,000 shares of Common Stock at a weighted average price of $13.1243 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.011 to $13.14 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F4 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F5 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein.

SEC source: 0000899140-23-000696 · form4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 7,050,000

F1 · price: On May 25, 2023, the Reporting Persons acquired 50,000 shares of Common Stock at a weighted average price of $13.0866 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.015 to $13.14 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F4 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F5 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein.

SEC source: 0001104659-23-064215 · tm2316873-6_4seq1.xml · derivative · entry 2

Srivastava Sapna · CIK 0001569226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064215 · tm2316873-6_4seq1.xml · nonDerivative · entry 1

Srivastava Sapna · CIK 0001569226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,173

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064214 · tm2316873-5_4seq1.xml · derivative · entry 2

Birx Deborah · CIK 0001849673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064214 · tm2316873-5_4seq1.xml · nonDerivative · entry 1

Birx Deborah · CIK 0001849673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,984

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064213 · tm2316873-4_4seq1.xml · derivative · entry 2

Schlesinger Sarah J. · CIK 0001579873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064213 · tm2316873-4_4seq1.xml · nonDerivative · entry 1

Schlesinger Sarah J. · CIK 0001579873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,706

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064212 · tm2316873-3_4seq1.xml · derivative · entry 2

Haimovitz Jules · CIK 0001340855 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064212 · tm2316873-3_4seq1.xml · nonDerivative · entry 1

Haimovitz Jules · CIK 0001340855 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,906

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064210 · tm2316873-2_4seq1.xml · derivative · entry 2

DiPaolo Mark · CIK 0001669816 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064210 · tm2316873-2_4seq1.xml · nonDerivative · entry 1

DiPaolo Mark · CIK 0001669816 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,706

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064209 · tm2316873-1_4seq1.xml · derivative · entry 2

Odysseas Kostas D · CIK 0001483080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2033-05-21

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001104659-23-064209 · tm2316873-1_4seq1.xml · nonDerivative · entry 1

Odysseas Kostas D · CIK 0001483080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 108,702

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2023 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0000899140-23-000672 · form4.xml · nonDerivative · entry 3

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 7,000,000

F3 · price: On May 19, 2023, the Reporting Persons acquired 36,000 shares of Common Stock at a weighted average price of $13.4763 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.47 to $13.49 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F4 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F5 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein

SEC source: 0000899140-23-000678 · form4.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,937

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-23-000672 · form4.xml · nonDerivative · entry 2

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,964,000

F2 · price: On May 18, 2023, the Reporting Persons acquired 10,000 shares of Common Stock at a weighted average price of $13.0538 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.01 to $13.07 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F4 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F5 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein

SEC source: 0000899140-23-000667 · form4.xml · nonDerivative · entry 2

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,964,000

F2 · price: On May 18, 2023, the Reporting Persons acquired 10,000 shares of Common Stock at a weighted average price of $13.0538 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.01 to $13.07 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F3 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F4 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein

SEC source: 0000899140-23-000672 · form4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,954,000

F1 · price: On May 17, 2023, the Reporting Persons acquired 50,000 shares of Common Stock at a weighted average price of $13.0738 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.00 to $13.13 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F4 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F5 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein

SEC source: 0000899140-23-000667 · form4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,954,000

F1 · price: On May 17, 2023, the Reporting Persons acquired 50,000 shares of Common Stock at a weighted average price of $13.0738 per share. The shares were purchased in multiple open market transactions at prices ranging from $13.00 to $13.13 per share, inclusive. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F3 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F4 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein

SEC source: 0000899140-23-000678 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,721

F1 · shares: Includes 1,576 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2023.

SEC source: 0000899140-23-000656 · form4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,904,000

F1 · price: On May 11, 2023, the Reporting Persons acquired 290,000 shares of Common Stock at a weighted average price of $12.3359 per share. The shares were purchased in multiple open market transactions at prices ranging from $12.25 to $12.43. The Reporting Persons undertake to provide, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote to this Form 4.

F2 · ownership.nature: Sarissa Capital Management LP ("Sarissa Capital") is the investment advisor to Sarissa Capital Offshore Master Fund LP, Sarissa Capital Catapult Fund LLC, Sarissa Capital Hawkeye Fund LP and Sarissa Capital Master Fund II LP (collectively, the "Sarissa Funds") and may be deemed to beneficially own the shares of Common Stock directly beneficially owned by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the shares of Common Stock. Alexander J. Denner, Ph.D., a citizen of the United States of America ("Dr. Denner"), is the Chief Investment Officer and ultimate general partner of Sarissa Capital and is the ultimate general partner, or controls the managing member, of each of the Sarissa Funds; accordingly, Dr. Denner may be deemed to beneficially own the shares of Common Stock directly held by the Sarissa Funds by virtue of such positions.

F3 · ownership.nature: Each of Dr. Denner, Sarissa Capital and each of the Sarissa Funds disclaims beneficial ownership of the shares of Common Stock reported herein except, in each case, to the extent of their pecuniary interest therein.

SEC source: 0000899140-23-000540 · form4.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 20,000 shares

Expires 2033-04-12

F2 · derivative.exercise_date: The Reporting Person was granted options. Twenty-five percent of the options shall vest on February 20, 2024, 6.25% on May 20, 2024, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0000899140-23-000540 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,145

F1 · shares: The Reporting Person was granted a one time-based restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU shall vest on February 20, 2024, 6.25% on May 20, 2024, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-23-005055 · doc1.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,799

F1 · shares: The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions in the open market at prices ranging from $10.865 to $10.87, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote 1 to this Form 4.

F1 · price: The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions in the open market at prices ranging from $10.865 to $10.87, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote 1 to this Form 4.

F2 · balance_after: Includes (1) 2,266 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 13, 2022, and (2) 3,000 shares of common stock acquired in multiple transactions in the open market on March 10, 2023, as described in greater detail in footnote 1 to this Form 4.

SEC source: 0001567619-23-003505 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,801

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-020775 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,653

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-020775 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,481

F1 · shares: Includes 433 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2022.

SEC source: 0001567619-22-016563 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,048

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-011518 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,878

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-011518 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,706

F1 · shares: Includes 1,834 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 13, 2022.

SEC source: 0001567619-22-009512 · doc1.xml · derivative · entry 2

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 150,000 shares

Expires 2032-05-01

F2 · derivative.exercise_date: 25% of the options will vest on May 20, 2023 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) or in the event that Mr. Raifeld experiences an "involuntary termination" (as defined in Mr. Raifeld's option agreement) within 24 months following a "change in control."

SEC source: 0001567619-22-009046 · doc1.xml · derivative · entry 2

Birx Deborah · CIK 0001849673 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2032-04-24

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009046 · doc1.xml · nonDerivative · entry 1

Birx Deborah · CIK 0001849673 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,489

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009043 · doc1.xml · derivative · entry 2

DiPaolo Mark · CIK 0001669816 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2032-04-24

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009043 · doc1.xml · nonDerivative · entry 1

DiPaolo Mark · CIK 0001669816 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,211

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009045 · doc1.xml · derivative · entry 2

Bickerstaff George · CIK 0001329646 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2032-04-24

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009045 · doc1.xml · nonDerivative · entry 1

Bickerstaff George · CIK 0001329646 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,207

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009044 · doc1.xml · derivative · entry 2

Haimovitz Jules · CIK 0001340855 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2032-04-24

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009044 · doc1.xml · nonDerivative · entry 1

Haimovitz Jules · CIK 0001340855 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,411

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009042 · doc1.xml · derivative · entry 2

Schlesinger Sarah J. · CIK 0001579873 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2032-04-24

F1 · derivative.exercise_date: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009042 · doc1.xml · nonDerivative · entry 1

Schlesinger Sarah J. · CIK 0001579873 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,211

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-009041 · doc1.xml · derivative · entry 2

Odysseas Kostas D · CIK 0001483080 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 0 shares

Expires 2032-04-24

SEC source: 0001567619-22-009041 · doc1.xml · nonDerivative · entry 1

Odysseas Kostas D · CIK 0001483080 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,207

F1 · shares: The Reporting Person was granted restricted stock units ("RSUs") and options upon the conclusion of the Issuer's 2022 annual meeting of stockholders. 100% of the RSUs and options will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date.

SEC source: 0001567619-22-006130 · doc1.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 15,000 shares

Expires 2032-02-28

F2 · derivative.exercise_date: The Reporting Person was granted options. Twenty-five percent of the options shall vest on February 20, 2023, 6.25% on May 20, 2023, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-22-006130 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,872

F1 · shares: The Reporting Person was granted a time-based restricted stock award ("RSA"). Twenty-five percent of the shares subject to the RSA shall vest on February 20, 2023, 6.25% on May 20, 2023, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-22-005277 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,181

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-21-020984 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,458

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

F2 · balance_after: Includes 612 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2021.

SEC source: 0001567619-21-016236 · doc1.xml · nonDerivative · entry 3

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,604

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-21-016236 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,364