INSM

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 25

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 0

Underlying: Common Stock · 57,000 shares

Expires 2023-10-31

F6 · kind: The reported transactions involve transfers of options from the reporting person's spouse to a family trust, ARTICLE 4 TRUST UNDER KATIE PROCTER DYNASTY TRUST, of which the reporting person is a trustee. The reporting person and members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 21

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 0

Underlying: Common Stock · 67,257 shares

Expires 2023-05-23

F6 · kind: The reported transactions involve transfers of options from the reporting person's spouse to a family trust, ARTICLE 4 TRUST UNDER KATIE PROCTER DYNASTY TRUST, of which the reporting person is a trustee. The reporting person and members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 17

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 0

Underlying: Common Stock · 83,333 shares

Expires 2023-05-23

F6 · kind: The reported transactions involve transfers of options from the reporting person's spouse to a family trust, ARTICLE 4 TRUST UNDER KATIE PROCTER DYNASTY TRUST, of which the reporting person is a trustee. The reporting person and members of the reporting person's immediate family are the sole beneficiaries of the trust.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 13

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 0

Underlying: Common Stock · 83,334 shares

Expires 2023-05-23

F6 · kind: The reported transactions involve transfers of options from the reporting person's spouse to a family trust, ARTICLE 4 TRUST UNDER KATIE PROCTER DYNASTY TRUST, of which the reporting person is a trustee. The reporting person and members of the reporting person's immediate family are the sole beneficiaries of the trust.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001608 · tm211774d7_4seq1.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,577

F1 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001104659-21-001607 · tm211774d6_4.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,532

F1 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001104659-21-001605 · tm211774d4_4seq1.xml · nonDerivative · entry 2

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,756

F2 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001104659-21-001606 · tm211774d5_4seq1.xml · nonDerivative · entry 1

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,264

F1 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001104659-21-001604 · tm211774d3_4seq1.xml · nonDerivative · entry 1

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 132,188

F1 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001104659-21-001602 · tm211774-2_4seq1.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,484

F1 · shares: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

F2 · balance_after: Includes 206 shares acquired through the Company's 2018 Employee Stock Purchase Plan.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 28

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 245,950

Underlying: Common Stock · 245,950 shares

Expires 2026-05-19

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 27

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 245,950 shares

Expires 2026-05-19

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 24

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 57,000

Underlying: Common Stock · 57,000 shares

Expires 2023-10-31

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 23

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 123,456

Underlying: Common Stock · 57,000 shares

Expires 2023-10-31

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 20

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 67,257

Underlying: Common Stock · 67,257 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 19

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 67,257 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 16

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 83,333

Underlying: Common Stock · 83,333 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 15

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 83,333 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 12

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 83,334

Underlying: Common Stock · 83,334 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 11

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 83,334 shares

Expires 2023-05-23

F4 · kind: The reported transactions involve a gift of securities by the reporting person to his spouse.

F5 · derivative.exercise_date: These options became exercisable upon the achievement of certain performance criteria.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 10

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 175,530

Underlying: Common Stock · 175,530 shares

Expires 2027-01-05

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F3 · derivative.exercise_date: The options were granted on January 9, 2017 and become exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 9

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 175,530 shares

Expires 2027-01-05

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F3 · derivative.exercise_date: The options were granted on January 9, 2017 and become exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 8

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2024-06-02

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2024-06-02

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 55,500

Underlying: Common Stock · 55,500 shares

Expires 2023-10-31

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,456

Underlying: Common Stock · 55,500 shares

Expires 2023-10-31

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 186,170

Underlying: Common Stock · 186,170 shares

Expires 2022-09-28

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 186,170 shares

Expires 2022-09-28

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 30,630

Underlying: Common Stock · 30,630 shares

Expires 2022-09-10

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-21-001601 · tm211774-1_4seq1.xml · derivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 30,360 shares

Expires 2022-09-10

F1 · kind: The reported transactions involve the reporting person's transfer of options to a family trust, ARTICLE 4 TRUST UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020. Members of the reporting person's immediate family are the sole beneficiaries of the trust.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001104659-20-139098 · tm2039285d1_4.xml · derivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,630

Underlying: Common Stock · 50,000 shares

Expires 2022-09-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-139098 · tm2039285d1_4.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,787

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 11,633 shares sold at prices ranging from $36.83 to $37.46 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-139098 · tm2039285d1_4.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,420

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 38,367 shares sold at prices ranging from $35.83 to $36.82 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-139098 · tm2039285d1_4.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,787

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-133640 · tm2036583-3_4seq1.xml · nonDerivative · entry 1

ALTOMARI ALFRED · CIK 0001285644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,938

F1 · kind: The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 20,000 shares sold at prices ranging from $39.01 to $40.14 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-129005 · a4.xml · nonDerivative · entry 2

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,890

F3 · price: This is the weighted average sales price representing 4,000 shares sold at prices ranging from $39.04 to $39.17 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-129005 · a4.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Baby Gator LLC

Disclosed balance after: 5,900

F1 · price: This is the weighted average sales price representing 4,000 shares sold at prices ranging from $38.92 to $39.05 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F2 · ownership.nature: The Reporting Person is a managing member of Baby Gator LLC.

SEC source: 0001104659-20-127949 · a4.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by The Sharoky Family Foundation, Inc.

Disclosed balance after: 7,714

F1 · price: This is the weighted average sales price representing 4,000 shares sold at prices ranging from $39.42 to $39.53 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F2 · ownership.nature: The Reporting Person is Chairman of The Sharoky Family Foundation, Inc. and is one of three individuals who currently share voting and investment power over the shares held by The Sharoky Family Foundation, Inc. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.

SEC source: 0001104659-20-122622 · a4.xml · derivative · entry 37

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,880 shares

Expires 2024-01-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-122622 · a4.xml · derivative · entry 36

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,044 shares

Expires 2023-10-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-122622 · a4.xml · derivative · entry 35

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,076 shares

Expires 2023-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-122622 · a4.xml · nonDerivative · entry 24

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,787

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-122622 · a4.xml · nonDerivative · entry 23

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 159,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-122622 · a4.xml · nonDerivative · entry 22

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,863

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · derivative · entry 38

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,750 shares

Expires 2024-01-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-121948 · a4.xml · derivative · entry 37

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 35,904 shares

Expires 2023-07-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 25

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,002

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 24

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,252

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · derivative · entry 36

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,665 shares

Expires 2024-06-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-121948 · a4.xml · derivative · entry 35

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,665

Underlying: Common Stock · 2,024 shares

Expires 2024-06-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.