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Nasdaq · USD

INCY

INCYTE CORP

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3182
SEC CIK
0000879169
Parsed reports
950

Last 12 months

Inside the activity.

0 purchase rows · 46 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
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MonthPurchasesSales
Nov 202507
Dec 202509
Jan 202602
Feb 202601
Mar 202601
Apr 202601
May 202602
Jun 202601
Jul 2026015
Aug 202605
Sep 202602
Oct 202600

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
June 01, 2017 Filed Jun 2, 2017 20:22 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,820 $0.00 Strike: $64.55 $0.00
Disclosure

SEC source: 0001209191-17-037245 · doc4.xml · derivative · entry 3

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,392

Underlying: Common Stock · 1,820 shares

Expires 2021-01-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Beginning January 21, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
June 01, 2017 Filed Jun 2, 2017 20:22 UTC
Siegel Eric H.EVP, General Counsel
SaleCommon Stock 1,820 $130.00 $236,600.00
Disclosure

SEC source: 0001209191-17-037245 · doc4.xml · nonDerivative · entry 2

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,924

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F2 · balance_after: This includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
June 01, 2017 Filed Jun 2, 2017 20:22 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionCommon Stock 1,820 $64.55 $117,481.00
Disclosure

SEC source: 0001209191-17-037245 · doc4.xml · nonDerivative · entry 1

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 31, 2017 Filed Jun 2, 2017 20:14 UTC PurchaseCommon Stock 500 $131.80 $65,900.00
Disclosure

SEC source: 0001209191-17-037215 · doc4.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,677

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
May 26, 2017 Filed May 31, 2017 20:33 UTC GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001209191-17-036456 · doc4.xml · derivative · entry 1

FRIEDMAN PAUL A · CIK 0001236927 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · derivative.exercise_date: This option vests in full on the first anniversary of the date of grant or, if earlier, the date of the next regular annual meeting of the Company's stockholders or upon change of control (as defined in option plan).

Read SEC document
May 26, 2017 Filed May 31, 2017 20:45 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001638599-17-000511 · doc4_4750.xml · derivative · entry 1

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · ownership.nature: 15,000 non-qualified stock options (the "Stock Options") convertible solely into common shares were granted to Julian C. Baker. The Stock Options have a strike price of $134.38 and vest on the first anniversary of the grant date or, if earlier, the date of the next regular annual meeting of Incyte Corporation (the "Issuer") stockholders or upon a change in control of the Issuer (as defined in the Issuer's Amended and Restated 2010 Stock Incentive Plan). Julian C. Baker serves on the Issuer's Board of Directors (the "Board") as a representative of 667, L.P. ("667"), Baker Brothers Life Sciences, L.P. ("Life Sciences"), 14159, L.P.("14159", and together with 667, and Life Sciences, the "Funds"). Pursuant to the policies of Baker Bros. Advisors LP (the "Adviser"), Julian C. Baker does not have any right to any of the Issuer's securities issued as part of his service on the Board and the Funds are entitled to receive all the pecuniary interest in the securities issued.

F2 · ownership.nature: The Funds each own an indirect proportionate pecuniary interest in the Stock Options. Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interest in the general partners of the general partners of the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Stock Options (i.e. no direct pecuniary interest).

F3 · ownership.nature: The Adviser serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

Read SEC document
May 26, 2017 Filed May 31, 2017 20:30 UTC GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001209191-17-036450 · doc4.xml · derivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · derivative.exercise_date: This option vests in full on the first anniversary of the date of grant or, if earlier, the date of the next regular annual meeting of the Company's stockholders or upon change of control (as defined in option plan).

Read SEC document
May 26, 2017 Filed May 31, 2017 20:26 UTC GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001209191-17-036443 · doc4.xml · derivative · entry 1

Clancy Paul J · CIK 0001409601 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · derivative.exercise_date: This option vests in full on the first anniversary of the date of grant or, if earlier, the date of the next regular annual meeting of the Company's stockholders or upon change of control (as defined in option plan).

Read SEC document
May 26, 2017 Filed May 31, 2017 20:22 UTC GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001209191-17-036437 · doc4.xml · derivative · entry 1

BROOKE PAUL A · CIK 0001175940 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · derivative.exercise_date: This option vests in full on the first anniversary of the date of grant or, if earlier, the date of the next regular annual meeting of the Company's stockholders or upon change of control (as defined in option plan).

Read SEC document
May 26, 2017 Filed May 31, 2017 20:19 UTC GrantNon-Qualified Stock Options (right to buy) · Derivative 15,000 $0.00 Strike: $134.38 $0.00
Disclosure

SEC source: 0001209191-17-036426 · doc4.xml · derivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2027-05-25

F1 · derivative.exercise_date: This option vests in full on the first anniversary of the date of grant or, if earlier, the date of the next regular annual meeting of the Company's stockholders or upon change of control (as defined in option plan).

Read SEC document
May 15, 2017 Filed May 17, 2017 20:18 UTC PurchaseCommon Stock 500 $115.00 $57,500.00
Disclosure

SEC source: 0001209191-17-033050 · doc4.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,177

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
May 08, 2017 Filed May 9, 2017 20:38 UTC
Huber Reid MEVP, Chief Scientific Officer
SaleCommon Stock 8,577 $119.21 $1,022,464.17
Disclosure

SEC source: 0001209191-17-030962 · doc4.xml · nonDerivative · entry 2

Huber Reid M · CIK 0001607052 · EVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,037

F2 · shares: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F3 · price: Represents weighted average sale price. Actual sale prices ranged from $117.45 - $121.72.

F4 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F5 · balance_after: Includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
May 05, 2017 Filed May 9, 2017 20:17 UTC
Trower PaulPrincipal Accounting Officer
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 3,000 $0.00 Strike: $17.79 $0.00
Disclosure

SEC source: 0001209191-17-030926 · doc4.xml · derivative · entry 3

Trower Paul · CIK 0001642041 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,187

Underlying: Common Stock · 3,000 shares

Expires 2019-01-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Beginning January 19, 2012, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years

Read SEC document
May 05, 2017 Filed May 9, 2017 20:17 UTC
Trower PaulPrincipal Accounting Officer
SaleCommon Stock 3,000 $121.70 $365,100.00
Disclosure

SEC source: 0001209191-17-030926 · doc4.xml · nonDerivative · entry 2

Trower Paul · CIK 0001642041 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,950

F1 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F2 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F3 · price: Represents weighted average sale price. Actual sale prices ranged from $121.00 - $124.15.

F4 · balance_after: This includes an 4,380 aggregate of shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
May 05, 2017 Filed May 9, 2017 20:17 UTC
Trower PaulPrincipal Accounting Officer
Exercise / conversionCommon Stock 3,000 $17.79 $53,370.00
Disclosure

SEC source: 0001209191-17-030926 · doc4.xml · nonDerivative · entry 1

Trower Paul · CIK 0001642041 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,950

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 05, 2017 Filed May 9, 2017 20:38 UTC
Huber Reid MEVP, Chief Scientific Officer
Tax withholdingCommon Stock 7,732 $125.00 $966,500.00
Disclosure

SEC source: 0001209191-17-030962 · doc4.xml · nonDerivative · entry 1

Huber Reid M · CIK 0001607052 · EVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,614

F1 · shares: Represents shares withheld to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock.

Read SEC document
May 05, 2017 Filed May 9, 2017 20:33 UTC
Wenqing YaoEVP, Head of Discovery Chem
Tax withholdingCommon Stock 4,413 $125.00 $551,625.00
Disclosure

SEC source: 0001209191-17-030952 · doc4.xml · nonDerivative · entry 1

Wenqing Yao · CIK 0001624033 · EVP, Head of Discovery Chem

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,767

F1 · shares: Represents shares withheld to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock.

F2 · balance_after: Includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
May 01, 2017 Filed May 2, 2017 22:01 UTC
Flannelly Barry PEVP & General Manager US
Exercise / conversionIncentive Stock Option (right to buy) · Derivative 2,064 $0.00 Strike: $48.44 $0.00
Disclosure

SEC source: 0001209191-17-029346 · doc4.xml · derivative · entry 4

Flannelly Barry P · CIK 0001615842 · EVP & General Manager US

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,720

Underlying: Common Stock · 2,064 shares

Expires 2021-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Beginning August 11, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years

Read SEC document
May 01, 2017 Filed May 2, 2017 22:01 UTC
Flannelly Barry PEVP & General Manager US
SaleCommon Stock 4,493 $124.75 $560,501.75
Disclosure

SEC source: 0001209191-17-029346 · doc4.xml · nonDerivative · entry 3

Flannelly Barry P · CIK 0001615842 · EVP & General Manager US

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,653

F1 · price: Reporting person undertakes to provide upon request by Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F2 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F4 · price: Represents weighted average sale price. Actual sale prices ranged from $123.92 - $125.47.

F5 · balance_after: Includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
May 01, 2017 Filed May 2, 2017 22:01 UTC
Flannelly Barry PEVP & General Manager US
SaleCommon Stock 803 $124.61 $100,061.83
Disclosure

SEC source: 0001209191-17-029346 · doc4.xml · nonDerivative · entry 2

Flannelly Barry P · CIK 0001615842 · EVP & General Manager US

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,146

F1 · price: Reporting person undertakes to provide upon request by Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F2 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F3 · price: Represents weighted average sale price. Actual sale prices ranged from $123.97 - $125.38.

Read SEC document
May 01, 2017 Filed May 2, 2017 22:01 UTC
Flannelly Barry PEVP & General Manager US
Exercise / conversionCommon Stock 2,064 $48.44 $99,980.16
Disclosure

SEC source: 0001209191-17-029346 · doc4.xml · nonDerivative · entry 1

Flannelly Barry P · CIK 0001615842 · EVP & General Manager US

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,949

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 01, 2017 Filed May 2, 2017 21:52 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,820 $0.00 Strike: $64.55 $0.00
Disclosure

SEC source: 0001209191-17-029326 · doc4.xml · derivative · entry 3

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,212

Underlying: Common Stock · 1,820 shares

Expires 2021-01-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Beginning January 21, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
May 01, 2017 Filed May 2, 2017 21:52 UTC
Siegel Eric H.EVP, General Counsel
SaleCommon Stock 1,820 $124.73 $227,008.60
Disclosure

SEC source: 0001209191-17-029326 · doc4.xml · nonDerivative · entry 2

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,924

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F2 · price: Represents weighted average sale price. Actual sale prices ranged from $123.97 - $125.37.

F3 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F4 · balance_after: This includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
May 01, 2017 Filed May 2, 2017 21:52 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionCommon Stock 1,820 $64.55 $117,481.00
Disclosure

SEC source: 0001209191-17-029326 · doc4.xml · nonDerivative · entry 1

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 28, 2017 Filed May 2, 2017 21:39 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,389 $0.00 Strike: $67.06 $0.00
Disclosure

SEC source: 0001209191-17-029297 · doc4.xml · derivative · entry 3

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,725

Underlying: Common Stock · 1,389 shares

Expires 2021-10-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Beginning October 31, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
April 28, 2017 Filed May 2, 2017 21:39 UTC
GRYSKA DAVID WExecutive Vice President, CFO
SaleCommon Stock 1,389 $124.26 $172,597.14
Disclosure

SEC source: 0001209191-17-029297 · doc4.xml · nonDerivative · entry 2

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,015

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F2 · balance_after: This includes an aggregate of 11,187 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested.

Read SEC document
April 28, 2017 Filed May 2, 2017 21:39 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionCommon Stock 1,389 $67.06 $93,146.34
Disclosure

SEC source: 0001209191-17-029297 · doc4.xml · nonDerivative · entry 1

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,404

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 28, 2017 Filed May 2, 2017 20:31 UTC PurchaseCommon Stock 500 $124.26 $62,130.00
Disclosure

SEC source: 0001209191-17-029204 · doc4.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,677

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionNon-Qualified Stock Options (right · Derivative 20,000 $0.00 Strike: $7.26 $0.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · derivative · entry 9

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2017-05-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · price: These non-qualified stock options are not priced.

F7 · ownership.nature: As a result of their ownership interest in 14159 Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by 14159, L.P. ("14159" and together with 667 and Life Sciences, the "Funds"), a limited partnership of which the sole general partner is 14159 Capital, L.P., a limited partnership of which the sole general partner is 14159 Capital (GP), LLC, due to 14159 Capital, L.P.'s right to receive an allocation of a portion of the profits from 14159. The policy of the Funds and the Adviser, does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionNon-Qualified Stock Options (right · Derivative 20,000 $0.00 Strike: $7.26 $0.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · derivative · entry 8

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2017-05-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · price: These non-qualified stock options are not priced.

F6 · ownership.nature: As a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by Baker Brothers Life Sciences, L.P. ("Life Sciences"), a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences. The policy of the Funds (defined below) and the Adviser, does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionNon-Qualified Stock Options (right · Derivative 20,000 $0.00 Strike: $7.26 $0.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · derivative · entry 7

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2017-05-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · price: These non-qualified stock options are not priced.

F4 · ownership.nature: As a result of their ownership interest in Baker Biotech Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by 667, L.P. ("667"), a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667. The policy of the Funds (defined below) and Baker Bros. Advisors LP (the "Adviser"), does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionCommon Stock 20,000 $7.26 $145,200.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · nonDerivative · entry 6

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 787,237

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · ownership.nature: The shares of common stock were received upon exercise of 20,000 stock options that were issued to Julian C. Baker in his capacity as a director of the Issuer. Julian C. Baker, pursuant to the policies of the Adviser, does not have any right to the pecuniary interest in the stock options issued for his service on the Board of Directors of the Issuer (the "Board") or the shares of common stock received upon exercise of such stock options. Each of the Funds owns an indirect proportionate pecuniary interest in the shares of common stock received upon exercise of the stock options issued in connection with Julian C. Baker's service on the Board less the exercise cost of those options. Solely as a result of their ownership interest in the general partners of the general partners of the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the shares issued upon exercise of the stock options (i.e. no direct pecuniary interest).

F7 · ownership.nature: As a result of their ownership interest in 14159 Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by 14159, L.P. ("14159" and together with 667 and Life Sciences, the "Funds"), a limited partnership of which the sole general partner is 14159 Capital, L.P., a limited partnership of which the sole general partner is 14159 Capital (GP), LLC, due to 14159 Capital, L.P.'s right to receive an allocation of a portion of the profits from 14159. The policy of the Funds and the Adviser, does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

F12 · ownership.nature: Includes beneficial ownership of 1,560 shares issued pursuant to the Stock Incentive Plan in lieu of director retainer fees and 95,000 shares, 75,000 of which were received previously, from exercise of 95,000 stock options of the Issuer that were issued to Julian C. Baker in his capacity as a director of the Issuer, of which the fund may be deemed to own a portion.

F13 · ownership.nature: After giving effect to the transactions reported herein, and as a result of their ownership interest in 14159 Capital (GP), LLC, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by 14159, a limited partnership of which the sole general partner is 14159 Capital, L.P., a limited partnership of which the sole general partner is 14159 Capital (GP), LLC, due to 14159, L.P.'s right to receive an allocation of a portion of the profits from 14159.

F14 · ownership.nature: The Adviser serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionCommon Stock 20,000 $7.26 $145,200.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · nonDerivative · entry 5

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 29,161,795

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · ownership.nature: The shares of common stock were received upon exercise of 20,000 stock options that were issued to Julian C. Baker in his capacity as a director of the Issuer. Julian C. Baker, pursuant to the policies of the Adviser, does not have any right to the pecuniary interest in the stock options issued for his service on the Board of Directors of the Issuer (the "Board") or the shares of common stock received upon exercise of such stock options. Each of the Funds owns an indirect proportionate pecuniary interest in the shares of common stock received upon exercise of the stock options issued in connection with Julian C. Baker's service on the Board less the exercise cost of those options. Solely as a result of their ownership interest in the general partners of the general partners of the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the shares issued upon exercise of the stock options (i.e. no direct pecuniary interest).

F6 · ownership.nature: As a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by Baker Brothers Life Sciences, L.P. ("Life Sciences"), a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences. The policy of the Funds (defined below) and the Adviser, does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

F11 · ownership.nature: After giving effect to the transactions reported herein, and as a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.

F12 · ownership.nature: Includes beneficial ownership of 1,560 shares issued pursuant to the Stock Incentive Plan in lieu of director retainer fees and 95,000 shares, 75,000 of which were received previously, from exercise of 95,000 stock options of the Issuer that were issued to Julian C. Baker in his capacity as a director of the Issuer, of which the fund may be deemed to own a portion.

F14 · ownership.nature: The Adviser serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

Read SEC document
April 27, 2017 Filed Apr 28, 2017 21:10 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
667, L.P.Director · 10% owner
BAKER FELIXDirector · 10% owner
BAKER JULIANDirector · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
Exercise / conversionCommon Stock 20,000 $7.26 $145,200.00
Disclosure

SEC source: 0001638599-17-000381 · doc4_4670.xml · nonDerivative · entry 4

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,374,099

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · ownership.nature: As a result of their ownership interest in Baker Biotech Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in 20,000 shares of Common Stock of the Issuer received upon the exercise of stock options of the Issuer held by 667, L.P. ("667"), a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667. The policy of the Funds (defined below) and Baker Bros. Advisors LP (the "Adviser"), does not permit employees or principals of the Adviser to receive compensation for serving as Directors of the Issuer.

F5 · ownership.nature: The shares of common stock were received upon exercise of 20,000 stock options that were issued to Julian C. Baker in his capacity as a director of the Issuer. Julian C. Baker, pursuant to the policies of the Adviser, does not have any right to the pecuniary interest in the stock options issued for his service on the Board of Directors of the Issuer (the "Board") or the shares of common stock received upon exercise of such stock options. Each of the Funds owns an indirect proportionate pecuniary interest in the shares of common stock received upon exercise of the stock options issued in connection with Julian C. Baker's service on the Board less the exercise cost of those options. Solely as a result of their ownership interest in the general partners of the general partners of the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the shares issued upon exercise of the stock options (i.e. no direct pecuniary interest).

F9 · ownership.nature: The disclosure of the exercise of directors options for shares of common stock reported on this form is a single exercise of 20,000 shares. The 20,000 shares is reported for each of the Funds as each has an indirect pecuniary interest.

F10 · ownership.nature: After giving effect to the transactions reported herein, and as a result of their ownership interest in Baker Biotech Capital (GP), LLC, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667. Includes beneficial ownership of 1,560 shares issued pursuant to the Stock Incentive Plan in lieu of director retainer fees and 95,000 shares, 75,000 of which were received previously, from exercise of 95,000 stock options of the Issuer that were issued to Julian C. Baker in his capacity as a director of the Issuer, of which the fund may be deemed to own a portion.

F14 · ownership.nature: The Adviser serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

Read SEC document
April 13, 2017 Filed Apr 17, 2017 20:56 UTC PurchaseCommon Stock 1,000 $139.66 $139,660.00
Disclosure

SEC source: 0001209191-17-027075 · doc4.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,177

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,820 $0.00 Strike: $64.55 $0.00
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · derivative · entry 6

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,032

Underlying: Common Stock · 1,820 shares

Expires 2021-01-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Beginning January 21, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 2,223 $0.00 Strike: $18.32 $0.00
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · derivative · entry 5

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,223 shares

Expires 2020-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Beginning February 9, 2013, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
SaleCommon Stock 1,820 $140.18 $255,127.60
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · nonDerivative · entry 4

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,785

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
SaleCommon Stock 2,223 $140.18 $311,620.14
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · nonDerivative · entry 3

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,605

F1 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionCommon Stock 1,820 $64.55 $117,481.00
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · nonDerivative · entry 2

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,828

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:19 UTC
Siegel Eric H.EVP, General Counsel
Exercise / conversionCommon Stock 2,223 $18.32 $40,725.36
Disclosure

SEC source: 0001209191-17-026567 · doc4.xml · nonDerivative · entry 1

Siegel Eric H. · CIK 0001527573 · EVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,008

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 39,789 $0.00 Strike: $67.06 $0.00
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · derivative · entry 6

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,114

Underlying: Common Stock · 39,789 shares

Expires 2021-10-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Beginning October 31, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionIncentive Stock Option (right to buy) · Derivative 1,739 $0.00 Strike: $67.06 $0.00
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · derivative · entry 5

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,734

Underlying: Common Stock · 1,739 shares

Expires 2021-10-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Beginning October 31, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
SaleCommon Stock 39,789 $138.00 $5,490,882.00
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · nonDerivative · entry 4

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,015

F1 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F2 · price: Represents weighted average sale price. Actual sale prices ranged from $136.10 - $140.71.

F3 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
SaleCommon Stock 1,739 $138.00 $239,982.00
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · nonDerivative · entry 3

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,804

F1 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F2 · price: Represents weighted average sale price. Actual sale prices ranged from $136.10 - $140.71.

F3 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionCommon Stock 39,789 $67.06 $2,668,250.34
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · nonDerivative · entry 2

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,543

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 10, 2017 Filed Apr 11, 2017 20:14 UTC
GRYSKA DAVID WExecutive Vice President, CFO
Exercise / conversionCommon Stock 1,739 $67.06 $116,617.34
Disclosure

SEC source: 0001209191-17-026564 · doc4.xml · nonDerivative · entry 1

GRYSKA DAVID W · CIK 0001202335 · Executive Vice President, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,754

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 07, 2017 Filed Apr 11, 2017 20:24 UTC
Stein Steven HEVP & Chief Medical Officer
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 5,000 $0.00 Strike: $95.76 $0.00
Disclosure

SEC source: 0001209191-17-026571 · doc4.xml · derivative · entry 6

Stein Steven H · CIK 0001673776 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,262

Underlying: Common Stock · 5,000 shares

Expires 2023-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Beginning January 7, 2016, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years

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April 07, 2017 Filed Apr 11, 2017 20:24 UTC
Stein Steven HEVP & Chief Medical Officer
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 27,000 $0.00 Strike: $88.68 $0.00
Disclosure

SEC source: 0001209191-17-026571 · doc4.xml · derivative · entry 5

Stein Steven H · CIK 0001673776 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,891

Underlying: Common Stock · 27,000 shares

Expires 2022-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Beginning March 2, 2015, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

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April 07, 2017 Filed Apr 11, 2017 20:24 UTC
Stein Steven HEVP & Chief Medical Officer
SaleCommon Stock 5,000 $137.91 $689,550.00
Disclosure

SEC source: 0001209191-17-026571 · doc4.xml · nonDerivative · entry 4

Stein Steven H · CIK 0001673776 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,648

F2 · price: Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated.

F3 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F4 · price: Represents weighted average sale price. Actual sale prices ranged from $136.61 - $139.85.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.