IMUX

SEC source: 0001280776-17-000065 · wf-form4_149739898026762.xml · derivative · entry 1

Henry Andrew · CIK 0001591104 · VP, Clinical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2027-06-09

F1 · derivative.exercise_date: One forty-eighth (1/48th) of the shares of common stock subject to the option shall vest monthly beginning on July 10, 2017, such that all of the shares of common stock subject to the option are vested by June 10, 2021, subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan (the "Plan")) through each vesting date; provided, that, 100% of the unvested portion of the option, if any, shall vest in the event of a termination without cause following a Change in Control (as defined in the Plan).

SEC source: 0001280776-17-000064 · wf-form4_149739888526652.xml · derivative · entry 1

DUNN JOHN MICHAEL · CIK 0001238648 · General Counsel and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2027-06-09

F1 · derivative.exercise_date: One forty-eighth (1/48th) of the shares of common stock subject to the option shall vest monthly beginning on July 10, 2017, such that all of the shares of common stock subject to the option are vested by June 10, 2021, subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan (the "Plan")) through each vesting date; provided, that, 100% of the unvested portion of the option, if any, shall vest in the event of a termination without cause following a Change in Control (as defined in the Plan).

SEC source: 0001280776-17-000063 · wf-form4_149739877852679.xml · derivative · entry 1

Ashley Robert A. · CIK 0001591017 · Chief Technical Officer, EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2027-06-09

F1 · derivative.exercise_date: One forty-eighth (1/48th) of the shares of common stock subject to the option shall vest monthly beginning on July 10, 2017, such that all of the shares of common stock subject to the option are vested by June 10, 2021, subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan (the "Plan")) through each vesting date; provided, that, 100% of the unvested portion of the option, if any, shall vest in the event of a termination without cause following a Change in Control (as defined in the Plan).

SEC source: 0001280776-17-000061 · wf-form4_149729794029409.xml · nonDerivative · entry 2

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 10,922,277

F1 · kind: All shares were purchased by Satter Medical Technology Partners, L.P.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.95 to $3.25. The reporting person undertakes to provide Vital Therapies, Inc., any security holder of Vital Therapies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price range set forth in this footnote (4) to this Form 4.

F3 · ownership.nature: The amount in Column 5 includes (a) 4,202,930 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 2,929,347 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (3), except to the extent of his pecuniary interest.

SEC source: 0001280776-17-000062 · wf-form4_149739868678115.xml · nonDerivative · entry 1

Ashley Robert A. · CIK 0001591017 · Chief Technical Officer, EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

SEC source: 0001280776-17-000059 · wf-form4_149703879137117.xml · nonDerivative · entry 1

Nash Duane · CIK 0001591098 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,224

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.10 to $3.15. The reporting person undertakes to provide Vital Therapies, Inc., any security holder of Vital Therapies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price range set forth in this footnote (1) to this Form 4.

SEC source: 0001280776-17-000061 · wf-form4_149729794029409.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 10,912,277

F1 · kind: All shares were purchased by Satter Medical Technology Partners, L.P.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.975 to $3.275. The reporting person undertakes to provide Vital Therapies, Inc., any security holder of Vital Therapies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price range set forth in this footnote (2) to this Form 4.

F3 · ownership.nature: The amount in Column 5 includes (a) 4,202,930 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 2,929,347 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (3), except to the extent of his pecuniary interest.

SEC source: 0001280776-17-000057 · wf-form4_149687731692993.xml · nonDerivative · entry 2

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 10,902,277

F1 · kind: All shares were purchased by Satter Medical Technology Partners, L.P.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.125 to $3.25. The reporting person undertakes to provide Vital Therapies, Inc., any security holder of Vital Therapies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price range set forth in this footnote (4) to this Form 4.

F3 · ownership.nature: The amount in Column 5 includes (a) 4,202,930 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 2,929,347 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (3), except to the extent of his pecuniary interest.

SEC source: 0001280776-17-000057 · wf-form4_149687731692993.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 10,892,277

F1 · kind: All shares were purchased by Satter Medical Technology Partners, L.P.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.675 to $3.45. The reporting person undertakes to provide Vital Therapies, Inc., any security holder of Vital Therapies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price range set forth in this footnote (2) to this Form 4.

F3 · ownership.nature: The amount in Column 5 includes (a) 4,202,930 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 2,929,347 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (3), except to the extent of his pecuniary interest.

SEC source: 0001280776-17-000047 · wf-form4_149574792815403.xml · derivative · entry 1

Godshall Douglas Evan · CIK 0001404227 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000049 · wf-form4_149574806715383.xml · derivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000053 · wf-form4_149574844517420.xml · derivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,031

Underlying: Common Stock · 63,031 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000052 · wf-form4_149574829041849.xml · derivative · entry 1

STEER RANDOLPH C · CIK 0001198762 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000051 · wf-form4_149574821641447.xml · derivative · entry 1

SEARS LOWELL · CIK 0001189160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000050 · wf-form4_149574814050757.xml · derivative · entry 1

Millis J. Michael · CIK 0001591498 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000048 · wf-form4_149574798992896.xml · derivative · entry 1

Halperin Errol R. · CIK 0001591095 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000046 · wf-form4_149574783170186.xml · derivative · entry 1

CROXFORD PHILIP M · CIK 0001307958 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000045 · wf-form4_149574771081552.xml · derivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000044 · wf-form4_149574762511530.xml · derivative · entry 1

Cohen Cheryl · CIK 0001529371 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,022

Underlying: Common Stock · 45,022 shares

Expires 2027-05-22

F1 · derivative.exercise_date: Subject to the reporting person's continuing to be a Service Provider (as defined in the 2014 Equity Incentive Plan) through the vesting date, 100% of the shares will vest upon the earlier of the one (1) year anniversary from May 23, 2017 or the day prior to the Company's 2018 annual meeting of stockholders.

SEC source: 0001280776-17-000017 · wf-form4_149065216093806.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 10,882,277

F1 · kind: All shares were purchased by Satter Medical Technology Partners, L.P. in connection with the Issuer's registered public offering of common stock.

F2 · ownership.nature: The amount in Column 5 includes (a) 4,202,930 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 2,929,347 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) 3,750,000 shares that are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (2), except to the extent of his pecuniary interest.

SEC source: 0001280776-17-000003 · wf-form5_148468690602702.xml · nonDerivative · entry 1

Nash Duane · CIK 0001591098 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,324

F1 · kind: Shares gifted by reporting person for no consideration.