HRTX

SEC source: 0001209191-23-003560 · doc4.xml · derivative · entry 5

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,750

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F4 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-23-003560 · doc4.xml · nonDerivative · entry 4

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,933

F3 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-23-003560 · doc4.xml · nonDerivative · entry 3

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,945

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-23-003560 · doc4.xml · nonDerivative · entry 2

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,381

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-062191 · doc4.xml · derivative · entry 2

Rodriguez Susan · CIK 0001812511 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

Underlying: Common Stock · 77,160 shares

Expires 2032-12-16

F2 · derivative.exercise_date: The stock options vest and become exercisable in 12 equal monthly installments beginning one month after the date of grant.

SEC source: 0001209191-22-062191 · doc4.xml · nonDerivative · entry 1

Rodriguez Susan · CIK 0001812511 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,282

F1 · shares: The shares were granted as restricted stock units which vest in full on December 16, 2023.

SEC source: 0001209191-22-062188 · doc4.xml · derivative · entry 2

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

Underlying: Common Stock · 77,160 shares

Expires 2032-12-16

F2 · derivative.exercise_date: The stock options vest and become exercisable in 12 equal monthly installments beginning one month after the date of grant.

SEC source: 0001209191-22-062188 · doc4.xml · nonDerivative · entry 1

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,872

F1 · shares: The shares were granted as restricted stock units which vest in full on December 16, 2023.

SEC source: 0001209191-22-062192 · doc4.xml · derivative · entry 2

Christian Waage · CIK 0001553179 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

Underlying: Common Stock · 77,160 shares

Expires 2032-12-16

F2 · derivative.exercise_date: The stock options vest and become exercisable in 12 equal monthly installments beginning one month after the date of grant.

SEC source: 0001209191-22-062192 · doc4.xml · nonDerivative · entry 1

Christian Waage · CIK 0001553179 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,232

F1 · shares: The shares were granted as restricted stock units which vest in full on December 16, 2023.

SEC source: 0001209191-22-062187 · doc4.xml · derivative · entry 2

Dissanaike Sharmila · CIK 0001885069 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

Underlying: Common Stock · 77,160 shares

Expires 2032-12-16

F2 · derivative.exercise_date: The stock options vest and become exercisable in 12 equal monthly installments beginning one month after the date of grant.

SEC source: 0001209191-22-062187 · doc4.xml · nonDerivative · entry 1

Dissanaike Sharmila · CIK 0001885069 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,282

F1 · shares: The shares were granted as restricted stock units which vest in full on December 16, 2023.

SEC source: 0001209191-22-062184 · doc4.xml · derivative · entry 2

DAVIS STEPHEN · CIK 0001131146 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

Underlying: Common Stock · 77,160 shares

Expires 2032-12-16

F2 · derivative.exercise_date: The stock options vest and become exercisable in 12 equal monthly installments beginning one month after the date of grant.

SEC source: 0001209191-22-062184 · doc4.xml · nonDerivative · entry 1

DAVIS STEPHEN · CIK 0001131146 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,032

F1 · shares: The shares were granted as restricted stock units which vest in full on December 16, 2023.

SEC source: 0001209191-23-003564 · doc4.xml · nonDerivative · entry 1

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,348

F1 · kind: Represents shares acquired under the Heron Therapeutics, Inc. 1997 Employee Stock Purchase Plan on October 31, 2022.

SEC source: 0001209191-23-003563 · doc4.xml · nonDerivative · entry 1

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,441

F1 · kind: Represents shares acquired under the Heron Therapeutics, Inc. 1997 Employee Stock Purchase Plan on October 31, 2022.

SEC source: 0001209191-23-003560 · doc4.xml · nonDerivative · entry 1

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,131

F1 · kind: Represents shares acquired under the Heron Therapeutics, Inc. 1997 Employee Stock Purchase Plan on October 31, 2022.

SEC source: 0001209191-22-053836 · doc4.xml · derivative · entry 5

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,064

Underlying: Common Stock · 4,564 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F4 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-053836 · doc4.xml · derivative · entry 4

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F3 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-053836 · doc4.xml · nonDerivative · entry 3

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,694

F2 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-053836 · doc4.xml · nonDerivative · entry 2

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053836 · doc4.xml · nonDerivative · entry 1

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,142

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053835 · doc4.xml · derivative · entry 5

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,929

Underlying: Common Stock · 16,122 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F4 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-053835 · doc4.xml · derivative · entry 4

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,166

Underlying: Common Stock · 3,646 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F3 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-053835 · doc4.xml · nonDerivative · entry 3

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,786

F2 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-053835 · doc4.xml · nonDerivative · entry 2

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 167,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053835 · doc4.xml · nonDerivative · entry 1

Quart Barry D · CIK 0001384243 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,883

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053834 · doc4.xml · derivative · entry 5

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,064

Underlying: Common Stock · 4,564 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F4 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-053834 · doc4.xml · derivative · entry 4

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F3 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-053834 · doc4.xml · nonDerivative · entry 3

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,044

F2 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-053834 · doc4.xml · nonDerivative · entry 2

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,056

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053834 · doc4.xml · nonDerivative · entry 1

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,492

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053832 · doc4.xml · derivative · entry 5

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,694

Underlying: Common Stock · 1,932 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F4 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-053832 · doc4.xml · derivative · entry 4

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,416

Underlying: Common Stock · 553 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F3 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-053832 · doc4.xml · nonDerivative · entry 3

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,589

F2 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-053832 · doc4.xml · nonDerivative · entry 2

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,450

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053832 · doc4.xml · nonDerivative · entry 1

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,518

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053827 · doc4.xml · derivative · entry 5

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,064

Underlying: Common Stock · 4,564 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F4 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-053827 · doc4.xml · derivative · entry 4

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F3 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-053827 · doc4.xml · nonDerivative · entry 3

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,476

F2 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-053827 · doc4.xml · nonDerivative · entry 2

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,488

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-053827 · doc4.xml · nonDerivative · entry 1

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,924

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-22-043292 · doc4.xml · derivative · entry 1

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,961

Underlying: Common Stock · 165,961 shares

Expires 2032-07-25

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 8 equal quarterly installments beginning one quarter after the date of grant (07/25/2022).

SEC source: 0001209191-22-043291 · doc4.xml · derivative · entry 1

POYHONEN JOHN · CIK 0001286100 · President & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,961

Underlying: Common Stock · 165,961 shares

Expires 2032-07-25

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 8 equal quarterly installments beginning one quarter after the date of grant (07/25/2022).

SEC source: 0001209191-22-043289 · doc4.xml · derivative · entry 1

Peraza Lisa · CIK 0001828266 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,902

Underlying: Common Stock · 60,902 shares

Expires 2032-07-25

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 8 equal quarterly installments beginning one quarter after the date of grant (07/25/2022).

SEC source: 0001209191-22-043288 · doc4.xml · derivative · entry 1

MANHARD KIMBERLY · CIK 0001202094 · Director · EVP, Drug Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,961

Underlying: Common Stock · 165,961 shares

Expires 2032-07-25

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 8 equal quarterly installments beginning one quarter after the date of grant (07/25/2022).

SEC source: 0001209191-22-042263 · doc4.xml · derivative · entry 6

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,628

Underlying: Common Stock · 4,564 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F5 · derivative.exercise_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

F5 · derivative.expiration_date: The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021).

SEC source: 0001209191-22-042263 · doc4.xml · derivative · entry 5

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

F4 · derivative.expiration_date: The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020).

SEC source: 0001209191-22-042263 · doc4.xml · nonDerivative · entry 4

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,892

F3 · acquired: Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions.

SEC source: 0001209191-22-042263 · doc4.xml · nonDerivative · entry 3

Szekeres David Leslie · CIK 0001602459 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,904

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.