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GYRE

GYRE THERAPEUTICS, INC.

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5247
SEC CIK
0001124105
Parsed reports
309

Last 12 months

Inside the activity.

0 purchase rows · 18 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202500
Jan 202600
Feb 202600
Mar 202600
Apr 202600
May 2026010
Jun 202608
Jul 202600
Aug 202600
Sep 202600
Oct 202600

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
May 21, 2019 Filed May 22, 2019 16:23 UTC
Levy HowardChief Medical Officer
Exercise / conversionCommon Stock 4,400 $4.63 $20,372.00
Disclosure

SEC source: 0001209191-19-031947 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,094

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 20, 2019 Filed May 22, 2019 18:17 UTC
USMAN NASSIMDirector · President & CEO
Exercise / conversionStock Option (Right to Buy) · Derivative 4,400 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-19-031970 · doc4.xml · derivative · entry 5

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,783

Underlying: Common Stock · 4,400 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
May 20, 2019 Filed May 22, 2019 16:23 UTC
Levy HowardChief Medical Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 4,400 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-19-031947 · doc4.xml · derivative · entry 3

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,218

Underlying: Common Stock · 4,400 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
April 01, 2019 Filed Apr 2, 2019 20:38 UTC GrantCommon Stock 1,364 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-022543 · doc4.xml · nonDerivative · entry 1

Williams Eddie · CIK 0001725276 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,036

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
April 01, 2019 Filed Apr 2, 2019 20:38 UTC GrantCommon Stock 2,414 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-022537 · doc4.xml · nonDerivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,146

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
April 01, 2019 Filed Apr 2, 2019 20:37 UTC
Hunt AndreaDirector
GrantCommon Stock 717 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-022530 · doc4.xml · nonDerivative · entry 1

Hunt Andrea · CIK 0001720487 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,528

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
April 01, 2019 Filed Apr 2, 2019 20:36 UTC GrantCommon Stock 1,504 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-022525 · doc4.xml · nonDerivative · entry 1

DESOUZA ERROL B · CIK 0001213895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,448

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
February 11, 2019 Filed Feb 14, 2019 00:19 UTC
Payne FletcherChief Financial Officer
GrantCommon Stock 1,002 $7.04 $7,054.08
Disclosure

SEC source: 0001209191-19-009885 · doc4.xml · nonDerivative · entry 1

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,731

F1 · shares: Shares purchased under the Catalyst Biosciences, Inc. 2018 Employee Stock Purchase Plan ("ESPP") on February 11, 2019.

Read SEC document
February 11, 2019 Filed Feb 13, 2019 22:01 UTC
USMAN NASSIMDirector · President & CEO
GrantCommon Stock 350 $7.04 $2,464.00
Disclosure

SEC source: 0001209191-19-009705 · doc4.xml · nonDerivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,167

F1 · shares: Shares purchased under the Catalyst Biosciences, Inc. 2018 Employee Stock Purchase Plan ("ESPP") on February 11, 2019.

Read SEC document
February 11, 2019 Filed Feb 13, 2019 22:00 UTC
Levy HowardChief Medical Officer
GrantCommon Stock 2,485 $7.04 $17,494.40
Disclosure

SEC source: 0001209191-19-009704 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,867

F1 · shares: Shares purchased under the Catalyst Biosciences, Inc. 2018 Employee Stock Purchase Plan ("ESPP") on February 11, 2019.

Read SEC document
February 04, 2019 Filed Feb 4, 2019 21:52 UTC
Payne FletcherChief Financial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 1,503 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-19-006858 · doc4.xml · derivative · entry 2

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,497

Underlying: Common Stock · 1,503 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
February 04, 2019 Filed Feb 4, 2019 21:52 UTC
Payne FletcherChief Financial Officer
Exercise / conversionCommon Stock 1,503 $4.63 $6,958.89
Disclosure

SEC source: 0001209191-19-006858 · doc4.xml · nonDerivative · entry 1

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,230

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 31, 2019 Filed Feb 4, 2019 21:53 UTC
Levy HowardChief Medical Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 1,500 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-19-006862 · doc4.xml · derivative · entry 2

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,500

Underlying: Common Stock · 1,500 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
January 31, 2019 Filed Feb 4, 2019 21:53 UTC
Levy HowardChief Medical Officer
Exercise / conversionCommon Stock 1,500 $4.63 $6,945.00
Disclosure

SEC source: 0001209191-19-006862 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,382

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 31, 2019 Filed Feb 4, 2019 21:51 UTC
USMAN NASSIMDirector · President & CEO
Exercise / conversionStock Option (Right to Buy) · Derivative 5,729 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-19-006857 · doc4.xml · derivative · entry 2

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 269,271

Underlying: Common Stock · 5,729 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017

Read SEC document
January 31, 2019 Filed Feb 4, 2019 21:51 UTC
USMAN NASSIMDirector · President & CEO
Exercise / conversionCommon Stock 5,729 $4.63 $26,525.27
Disclosure

SEC source: 0001209191-19-006857 · doc4.xml · nonDerivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,041

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 24, 2019 Filed Jan 28, 2019 23:58 UTC
USMAN NASSIMDirector · President and CEO
GrantStock Option (Right to Buy) · Derivative 80,000 $0.00 Strike: $7.97 $0.00
Disclosure

SEC source: 0001209191-19-005668 · doc4.xml · derivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2029-01-24

F1 · derivative.exercise_date: Award vests over a four (4) year period on each monthly anniversary commencing January 24, 2019.

Read SEC document
January 24, 2019 Filed Jan 28, 2019 23:54 UTC
Levy HowardChief Medical Officer
GrantStock Option (Right to Buy) · Derivative 35,000 $0.00 Strike: $7.97 $0.00
Disclosure

SEC source: 0001209191-19-005666 · doc4.xml · derivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2029-01-24

F1 · derivative.exercise_date: Award vests over a four (4) year period on each monthly anniversary commencing January 24, 2019.

Read SEC document
January 24, 2019 Filed Jan 28, 2019 23:56 UTC
Payne FletcherChief Financial Officer
GrantStock Option (Right to Buy) · Derivative 38,000 $0.00 Strike: $7.97 $0.00
Disclosure

SEC source: 0001209191-19-005667 · doc4.xml · derivative · entry 1

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2029-01-24

F1 · derivative.exercise_date: Award vests over a four (4) year period on each monthly anniversary commencing January 24, 2019.

Read SEC document
December 31, 2018 Filed Jan 3, 2019 22:45 UTC GrantCommon Stock 1,544 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-001224 · doc4.xml · nonDerivative · entry 1

Williams Eddie · CIK 0001725276 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,672

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
December 31, 2018 Filed Jan 3, 2019 22:44 UTC GrantCommon Stock 2,732 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-001221 · doc4.xml · nonDerivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,732

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
December 31, 2018 Filed Jan 3, 2019 22:44 UTC
Hunt AndreaDirector
GrantCommon Stock 811 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-001219 · doc4.xml · nonDerivative · entry 1

Hunt Andrea · CIK 0001720487 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 811

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
December 31, 2018 Filed Jan 3, 2019 22:43 UTC GrantCommon Stock 1,703 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-001218 · doc4.xml · nonDerivative · entry 1

DESOUZA ERROL B · CIK 0001213895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,944

F1 · shares: Represents shares of stock received in lieu of fees.

Read SEC document
November 26, 2018 Filed Nov 27, 2018 22:01 UTC
Levy HowardChief Medical Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 149 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-18-060006 · doc4.xml · derivative · entry 2

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,118

Underlying: Common Stock · 149 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
November 26, 2018 Filed Nov 27, 2018 22:01 UTC
Levy HowardChief Medical Officer
Exercise / conversionCommon Stock 149 $4.63 $689.87
Disclosure

SEC source: 0001209191-18-060006 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,709

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 16, 2018 Filed Nov 16, 2018 22:56 UTC
Levy HowardChief Medical Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 173 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-18-059044 · doc4.xml · derivative · entry 3

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,267

Underlying: Common Stock · 173 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
November 16, 2018 Filed Nov 16, 2018 22:56 UTC
Levy HowardChief Medical Officer
SaleCommon Stock 173 $11.00 $1,903.00
Disclosure

SEC source: 0001209191-18-059044 · doc4.xml · nonDerivative · entry 2

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,560

F1 · shares: Sale of shares made pursuant to and in accordance with the requirements of Rule 10b5-1 under the Securities Exchange Act of 1934, as amended, under a plan adopted by the Reporting Person on September 5, 2018.

Read SEC document
November 16, 2018 Filed Nov 16, 2018 22:56 UTC
Levy HowardChief Medical Officer
Exercise / conversionCommon Stock 173 $4.63 $800.99
Disclosure

SEC source: 0001209191-18-059044 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,733

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
September 06, 2018 Filed Sep 7, 2018 01:41 UTC Disposition to issuerCommon Stock 190 $10.07 $1,913.30
Disclosure

SEC source: 0001209191-18-049987 · doc4.xml · nonDerivative · entry 1

HILL STEPHEN A · CIK 0001237404 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,190

Read SEC document
July 30, 2018 Filed Aug 1, 2018 21:48 UTC
USMAN NASSIMDirector · President & CEO
GrantStock Option (Right to Buy) · Derivative 75,000 $0.00 Strike: $9.68 $0.00
Disclosure

SEC source: 0001209191-18-044791 · doc4.xml · derivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2028-07-30

F1 · derivative.exercise_date: Award vests monthly over four (4) years starting June 13, 2018.

Read SEC document
July 30, 2018 Filed Aug 1, 2018 21:48 UTC
Payne FletcherChief Financial Officer
GrantStock Option (Right to Buy) · Derivative 25,000 $0.00 Strike: $9.68 $0.00
Disclosure

SEC source: 0001209191-18-044790 · doc4.xml · derivative · entry 1

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-07-30

F1 · derivative.exercise_date: Award vests monthly over four (4) years starting June 13, 2018.

Read SEC document
July 30, 2018 Filed Aug 1, 2018 21:47 UTC
Levy HowardChief Medical Officer
GrantStock Option (Right to Buy) · Derivative 35,000 $0.00 Strike: $9.68 $0.00
Disclosure

SEC source: 0001209191-18-044788 · doc4.xml · derivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2028-07-30

F1 · derivative.exercise_date: Award vests monthly over four (4) years starting June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:57 UTC GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038139 · doc4.xml · derivative · entry 1

Williams Eddie · CIK 0001725276 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:56 UTC GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038138 · doc4.xml · derivative · entry 1

Richard John P · CIK 0001296528 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:53 UTC GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038137 · doc4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:53 UTC
Hunt AndreaDirector
GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038136 · doc4.xml · derivative · entry 1

Hunt Andrea · CIK 0001720487 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:52 UTC GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038134 · doc4.xml · derivative · entry 1

DESOUZA ERROL B · CIK 0001213895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing June 13, 2018.

Read SEC document
June 13, 2018 Filed Jun 15, 2018 21:52 UTC GrantStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $24.94 $0.00
Disclosure

SEC source: 0001209191-18-038135 · doc4.xml · derivative · entry 1

HILL STEPHEN A · CIK 0001237404 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option shall vest monthly over a period of 12 months commencing 06/13/2018.

Read SEC document
May 03, 2018 Filed May 4, 2018 20:58 UTC
Levy HowardChief Medical Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 7,560 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-18-028135 · doc4.xml · derivative · entry 2

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,440

Underlying: Common Stock · 7,560 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

F2 · derivative.expiration_date: Due to clerical error, the expiration date of the grant was erroneously reported on the Form 4 filed July 13, 2017 as "07/11/2017". This filing corrects that error.

Read SEC document
May 03, 2018 Filed May 4, 2018 20:58 UTC
Levy HowardChief Medical Officer
Exercise / conversionCommon Stock 7,560 $4.63 $35,002.80
Disclosure

SEC source: 0001209191-18-028135 · doc4.xml · nonDerivative · entry 1

Levy Howard · CIK 0001672333 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,560

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 09, 2018 Filed Apr 12, 2018 00:00 UTC
USMAN NASSIMDirector · President & CEO
GiftCommon Stock 88 $0.00 $0.00
Disclosure

SEC source: 0001209191-18-024695 · doc4.xml · nonDerivative · entry 2

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Usman Family Trust

Disclosed balance after: 4,144

F1 · balance_after: Reflects a 1:15 reverse stock split effected on February 10, 2017.

Read SEC document
April 09, 2018 Filed Apr 12, 2018 00:00 UTC
USMAN NASSIMDirector · President & CEO
GiftCommon Stock 88 $0.00 $0.00
Disclosure

SEC source: 0001209191-18-024695 · doc4.xml · nonDerivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Read SEC document
April 04, 2018 Filed Apr 6, 2018 21:03 UTC
USMAN NASSIMDirector · President & CEO
Exercise / conversionStock Option (Right to Buy) · Derivative 88 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-18-024224 · doc4.xml · derivative · entry 4

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 274,912

Underlying: Common Stock · 88 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
April 04, 2018 Filed Apr 6, 2018 21:03 UTC
USMAN NASSIMDirector · President & CEO
Exercise / conversionCommon Stock 88 $4.63 $407.44
Disclosure

SEC source: 0001209191-18-024224 · doc4.xml · nonDerivative · entry 1

USMAN NASSIM · CIK 0001206872 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 26, 2018 Filed Mar 28, 2018 20:11 UTC
Payne FletcherChief Financial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 59 $0.00 Strike: $4.63 $0.00
Disclosure

SEC source: 0001209191-18-021896 · doc4.xml · derivative · entry 3

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,941

Underlying: Common Stock · 59 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The Option vests monthly over a period of four years commencing June 15, 2017.

Read SEC document
March 26, 2018 Filed Mar 28, 2018 20:11 UTC
Payne FletcherChief Financial Officer
Exercise / conversionCommon Stock 59 $4.63 $273.17
Disclosure

SEC source: 0001209191-18-021896 · doc4.xml · nonDerivative · entry 1

Payne Fletcher · CIK 0001650476 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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March 08, 2018 Filed Mar 8, 2018 22:18 UTC
Flynn James E10% owner · Possible Member of 10% Group
Deerfield Mgmt L.P.10% owner · Possible Member of 10% Group
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner · Possible Member of 10% Group
Deerfield Special Situations Fund, L.P.10% owner · Possible Member of 10% Group
SaleCommon Stock 8,123 $29.03 $235,810.69
Disclosure

SEC source: 0001193805-18-000371 · e617783_4-catalyst.xml · nonDerivative · entry 5

Flynn James E · CIK 0001352546 · 10% owner · Possible Member of 10% Group

Deerfield Mgmt L.P. · CIK 0001010823 · 10% owner · Possible Member of 10% Group

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner · Possible Member of 10% Group

Deerfield Special Situations Fund, L.P. · CIK 0001354395 · 10% owner · Possible Member of 10% Group

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Through Deerfield Special Situations Fund, L.P.

Disclosed balance after: 1,113,222

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.00 to $29.75, inclusive.

F4 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (the "Fund"). Deerfield Management Company, L.P. is the investment manager of the Fund. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

F5 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Fund is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

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March 08, 2018 Filed Mar 8, 2018 22:18 UTC
Flynn James E10% owner · Possible Member of 10% Group
Deerfield Mgmt L.P.10% owner · Possible Member of 10% Group
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner · Possible Member of 10% Group
Deerfield Special Situations Fund, L.P.10% owner · Possible Member of 10% Group
SaleCommon Stock 1,194 $30.00 $35,820.00
Disclosure

SEC source: 0001193805-18-000371 · e617783_4-catalyst.xml · nonDerivative · entry 4

Flynn James E · CIK 0001352546 · 10% owner · Possible Member of 10% Group

Deerfield Mgmt L.P. · CIK 0001010823 · 10% owner · Possible Member of 10% Group

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner · Possible Member of 10% Group

Deerfield Special Situations Fund, L.P. · CIK 0001354395 · 10% owner · Possible Member of 10% Group

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Through Deerfield Special Situations Fund, L.P.

Disclosed balance after: 1,121,345

F4 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (the "Fund"). Deerfield Management Company, L.P. is the investment manager of the Fund. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

F5 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Fund is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

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March 08, 2018 Filed Mar 21, 2018 20:12 UTC Amendment
Flynn James E10% owner · Possible Member of 10% Group
Deerfield Mgmt L.P.10% owner · Possible Member of 10% Group
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner · Possible Member of 10% Group
Deerfield Special Situations Fund, L.P.10% owner · Possible Member of 10% Group
DEERFIELD PARTNERS, L.P.10% owner · Possible Member of 10% Group
SaleCommon Stock 2,233 $29.03 $64,823.99
Disclosure

SEC source: 0001193805-18-000436 · e617828_4a-catalyst.xml · nonDerivative · entry 10

Flynn James E · CIK 0001352546 · 10% owner · Possible Member of 10% Group

Deerfield Mgmt L.P. · CIK 0001010823 · 10% owner · Possible Member of 10% Group

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner · Possible Member of 10% Group

Deerfield Special Situations Fund, L.P. · CIK 0001354395 · 10% owner · Possible Member of 10% Group

DEERFIELD PARTNERS, L.P. · CIK 0001301041 · 10% owner · Possible Member of 10% Group

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Through Deerfield Special Situations Fund, L.P.

Disclosed balance after: 305,965

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.00 to $29.75, inclusive.

F4 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

F5 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

F6 · ownership.nature: This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the "Original Filing") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged.

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March 08, 2018 Filed Mar 21, 2018 20:12 UTC Amendment
Flynn James E10% owner · Possible Member of 10% Group
Deerfield Mgmt L.P.10% owner · Possible Member of 10% Group
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner · Possible Member of 10% Group
Deerfield Special Situations Fund, L.P.10% owner · Possible Member of 10% Group
DEERFIELD PARTNERS, L.P.10% owner · Possible Member of 10% Group
SaleCommon Stock 5,890 $29.03 $170,986.70
Disclosure

SEC source: 0001193805-18-000436 · e617828_4a-catalyst.xml · nonDerivative · entry 9

Flynn James E · CIK 0001352546 · 10% owner · Possible Member of 10% Group

Deerfield Mgmt L.P. · CIK 0001010823 · 10% owner · Possible Member of 10% Group

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner · Possible Member of 10% Group

Deerfield Special Situations Fund, L.P. · CIK 0001354395 · 10% owner · Possible Member of 10% Group

DEERFIELD PARTNERS, L.P. · CIK 0001301041 · 10% owner · Possible Member of 10% Group

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Through Deerfield Partners, L.P.

Disclosed balance after: 807,257

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.00 to $29.75, inclusive.

F4 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

F5 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

F6 · ownership.nature: This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the "Original Filing") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.