GPCR

SEC source: 0000315066-23-002162 · primary_doc.xml · nonDerivative · entry 4

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Life Sciences Advisors Fund VI LP

Disclosed balance after: 75,088

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000315066-23-002162 · primary_doc.xml · nonDerivative · entry 3

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Life Sciences Advisors Fund VI LP

Disclosed balance after: 67,677

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000315066-23-002162 · primary_doc.xml · nonDerivative · entry 2

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Life Sciences Advisors Fund VI LP

Disclosed balance after: 57,523

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000315066-23-002162 · primary_doc.xml · nonDerivative · entry 1

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Life Sciences Fund VI LP

Disclosed balance after: 965,115

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 18

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare IV, LP

Disclosed balance after: 0

Underlying: Ordinary Shares · 624,239 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 17

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare V, LP

Disclosed balance after: 0

Underlying: Ordinary Shares · 494,035 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 16

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 0

Underlying: Ordinary Shares · 7,411 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 15

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 0

Underlying: Ordinary Shares · 10,154 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 14

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 0

Underlying: Ordinary Shares · 71,636 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 13

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 0

Underlying: Ordinary Shares · 179,242 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 12

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 0

Underlying: Ordinary Shares · 452,867 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 11

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 0

Underlying: Ordinary Shares · 620,499 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · derivative · entry 10

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,013,678 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.exercise_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

F1 · derivative.expiration_date: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 9

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare IV, LP

Disclosed balance after: 624,239

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 8

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare V, LP

Disclosed balance after: 494,035

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 7

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 89,201

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 6

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 81,790

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 5

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · ERVC Healthcare Advisors IV, LP

Disclosed balance after: 71,636

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 4

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 5,266,286

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 3

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 5,087,044

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 2

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 4,634,177

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0000318989-23-000054 · primary_doc.xml · nonDerivative · entry 1

FIL Ltd · CIK 0000318989 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Eight Roads Investments

Disclosed balance after: 4,013,678

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On February 7, 2023, in connection with the completion of the issuer's initial public offering, each share of Series A, A+, B, and B-1 Preferred Shares converted on a 1-for-1 basis into Ordinary Shares.

SEC source: 0001209191-23-008163 · doc4.xml · derivative · entry 1

Bach Mark Allen · CIK 0001962610 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,500

Underlying: Ordinary Shares · 4,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F2 · kind: The American Depositary Shares were purchased in the Issuer's initial public offering.

F1 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001209191-23-008159 · doc4.xml · derivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,000

Underlying: Ordinary Shares · 12,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F2 · kind: The American Depositary Shares were purchased in the Issuer's initial public offering.

F1 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F3 · ownership.nature: By Raymond Stevens and Vivian Urena-Stevens, as Co-Trustees of the Stevens 2001 Revocable Trust, dated March 28, 2001.

SEC source: 0001209191-23-008168 · doc4.xml · derivative · entry 2

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 0

Underlying: Ordinary Shares · 123,508 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · derivative.exercise_date: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · derivative.expiration_date: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

SEC source: 0001209191-23-008168 · doc4.xml · nonDerivative · entry 1

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By spouse

Disclosed balance after: 123,508

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

SEC source: 0001209191-23-008166 · doc4.xml · derivative · entry 3

Farid Ramy · CIK 0001797707 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schrodinger, Inc.

Disclosed balance after: 275,000

Underlying: Ordinary Shares · 825,000 shares

Expires not disclosed

F3 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F4 · kind: The American Depositary Shares were purchased in the Issuer's initial public offering.

F3 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F3 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F2 · ownership.nature: The Reporting Person is President, Chief Executive Officer and a member of the board of directors of Schrodinger, Inc. ("Schrodinger") and may be deemed to share voting and dispositive power over the shares held by Schrodinger. The Reporting Person disclaims beneficial ownership of the shares held by Schrodinger.

SEC source: 0001209191-23-008166 · doc4.xml · derivative · entry 2

Farid Ramy · CIK 0001797707 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schrodinger, Inc.

Disclosed balance after: 0

Underlying: Ordinary Shares · 642,245 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · derivative.exercise_date: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F1 · derivative.expiration_date: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F2 · ownership.nature: The Reporting Person is President, Chief Executive Officer and a member of the board of directors of Schrodinger, Inc. ("Schrodinger") and may be deemed to share voting and dispositive power over the shares held by Schrodinger. The Reporting Person disclaims beneficial ownership of the shares held by Schrodinger.

SEC source: 0001209191-23-008166 · doc4.xml · nonDerivative · entry 1

Farid Ramy · CIK 0001797707 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schrodinger, Inc.

Disclosed balance after: 3,260,495

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: All outstanding Preferred Shares automatically converted into Ordinary Shares immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one Ordinary Share for each one Preferred Share, based on the conversion price currently in effect. The Preferred Shares have no expiration date.

F2 · ownership.nature: The Reporting Person is President, Chief Executive Officer and a member of the board of directors of Schrodinger, Inc. ("Schrodinger") and may be deemed to share voting and dispositive power over the shares held by Schrodinger. The Reporting Person disclaims beneficial ownership of the shares held by Schrodinger.

SEC source: 0001209191-23-008164 · doc4.xml · derivative · entry 1

Jung Melita Sun · CIK 0001962407 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000

Underlying: Ordinary Shares · 3,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F2 · kind: The American Depositary Shares were purchased in the Issuer's initial public offering.

F1 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001209191-23-008160 · doc4.xml · derivative · entry 1

Yoon Jun · CIK 0001962414 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 600

Underlying: Ordinary Shares · 1,800 shares

Expires not disclosed

F1 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F2 · kind: The American Depositary Shares were purchased in the Issuer's initial public offering.

F1 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001209191-23-007314 · doc4.xml · derivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,600,000

Underlying: Ordinary Shares · 1,600,000 shares

Expires 2033-02-01

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on the first anniversary of February 2, 2023, and the remaining shares shall vest in 36 equal monthly installments thereafter.

SEC source: 0001209191-23-007317 · doc4.xml · derivative · entry 1

Yoon Jun · CIK 0001962414 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 750,000

Underlying: Ordinary Shares · 750,000 shares

Expires 2033-02-01

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on the first anniversary of February 2, 2023, and the remaining shares shall vest in 36 equal monthly installments thereafter.