GPCR

SEC source: 0001415889-25-018213 · form4-06252025_050601.xml · derivative · entry 1

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,804

Underlying: Ordinary Shares · 51,804 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-018217 · form4-06252025_050609.xml · derivative · entry 1

LOVE TED W · CIK 0001188919 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,804

Underlying: Ordinary Shares · 51,804 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-018215 · form4-06252025_050605.xml · derivative · entry 1

DOBMEIER ERIC · CIK 0001202785 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,804

Underlying: Ordinary Shares · 51,804 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-018214 · form4-06252025_050603.xml · derivative · entry 1

TETLOW SHARON · CIK 0001328565 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,804

Underlying: Ordinary Shares · 51,804 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-018218 · form4-06252025_050611.xml · derivative · entry 1

Russell Angus C. · CIK 0001534002 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,833

Underlying: Ordinary Shares · 42,833 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-018216 · form4-06252025_050607.xml · derivative · entry 1

Waldstreicher Joanne · CIK 0001962413 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,804

Underlying: Ordinary Shares · 51,804 shares

Expires 2035-06-22

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 23, 2025, provided that the grant will in any case be fully vested on the date immediately prior to the date of the Issuer's 2026 annual shareholder meeting,

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-019354 · form4-07032025_050709.xml · derivative · entry 4

Coll Crespo Blas · CIK 0002037144 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,157

Underlying: Ordinary Shares · 1,287 shares

Expires not disclosed

F4 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F5 · kind: Voluntary reporting of the acquisition of 429 ADSs by the Reporting Person on May 21, 2025 pursuant to the Issuer's Employee Share Purchase Plan.

F4 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F4 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-019350 · form4-07032025_050702.xml · derivative · entry 5

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,000

Underlying: Ordinary Shares · 3,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F6 · kind: Voluntary reporting of the acquisition of 1,000 ADSs by the Reporting Person on May 21, 2025 pursuant to the Issuer's Employee Share Purchase Plan.

F5 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F5 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-019351 · form4-07032025_050704.xml · derivative · entry 5

Yoon Jun · CIK 0001962414 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,946

Underlying: Ordinary Shares · 2,963 shares

Expires not disclosed

F5 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F5 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F5 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001801842-26-000002 · form4-03052026_060304.xml · derivative · entry 2

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225

Underlying: Ordinary Shares · 675 shares

Expires not disclosed

F3 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F4 · kind: Voluntary reporting of the acquisition of 225 ADSs by the Reporting Person on May 20, 2025 pursuant to the Issuer's Employee Share Purchase Plan.

F3 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F3 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008555 · form4-03182025_080313.xml · derivative · entry 2

Coll Crespo Blas · CIK 0002037144 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 284,241

Underlying: Ordinary Shares · 284,241 shares

Expires 2035-03-14

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008555 · form4-03182025_080313.xml · nonDerivative · entry 1

Coll Crespo Blas · CIK 0002037144 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,588

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one Ordinary Share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-008554 · form4-03182025_080311.xml · derivative · entry 2

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,032

Underlying: Ordinary Shares · 124,032 shares

Expires 2035-03-15

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008554 · form4-03182025_080311.xml · nonDerivative · entry 1

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,338

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one ordinary share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-008550 · form4-03182025_080301.xml · derivative · entry 3

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 826,890

Underlying: Ordinary Shares · 826,890 shares

Expires 2035-03-14

F4 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F5 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008550 · form4-03182025_080301.xml · nonDerivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,133,678

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one Ordinary Share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-008553 · form4-03182025_080308.xml · derivative · entry 2

Ma Yingli · CIK 0001963664 · CHIEF TECHNOLOGY OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,040

Underlying: Ordinary Shares · 155,040 shares

Expires 2035-03-15

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008553 · form4-03182025_080308.xml · nonDerivative · entry 1

Ma Yingli · CIK 0001963664 · CHIEF TECHNOLOGY OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,539

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one ordinary share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-008552 · form4-03182025_080306.xml · derivative · entry 2

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,386

Underlying: Ordinary Shares · 196,386 shares

Expires 2035-03-15

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008552 · form4-03182025_080306.xml · nonDerivative · entry 1

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 166,536

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one ordinary share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-008551 · form4-03182025_080303.xml · derivative · entry 3

Yoon Jun · CIK 0001962414 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 413,445

Underlying: Ordinary Shares · 413,445 shares

Expires 2035-03-14

F4 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F5 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest March 1, 2026, and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through each such vesting date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008551 · form4-03182025_080303.xml · nonDerivative · entry 1

Yoon Jun · CIK 0001962414 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,293,299

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · kind: Represents the grant of restricted stock units ("RSUs"), each of which represents a contingent right to receive one Ordinary Share of the Issuer. The RSUs vest 1/4th annually on each anniversary of March 1, 2025, subject to Reporting Person's continued service on such dates.

SEC source: 0001415889-25-019354 · form4-07032025_050709.xml · nonDerivative · entry 1

Coll Crespo Blas · CIK 0002037144 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 218,355

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

SEC source: 0001415889-25-019350 · form4-07032025_050702.xml · nonDerivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,121,183

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

SEC source: 0001415889-25-019353 · form4-07032025_050708.xml · nonDerivative · entry 1

Ma Yingli · CIK 0001963664 · CHIEF TECHNOLOGY OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,715

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

SEC source: 0001415889-25-019352 · form4-07032025_050706.xml · nonDerivative · entry 1

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,095

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

SEC source: 0001415889-25-019351 · form4-07032025_050704.xml · nonDerivative · entry 1

Yoon Jun · CIK 0001962414 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,287,359

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

SEC source: 0000950170-25-016705 · ownership.xml · derivative · entry 4

FMR LLC · CIK 0000315066 · 10% owner · See Remark 1

10b5-1 filing: No plan indicated

Ownership: Indirect · FIMM, LLC

Disclosed balance after: 0

Underlying: Ordinary Shares · 123 shares

Expires not disclosed

F1 · derivative.exercise_price: Reported securities are American Depositary Shares, each of which represents three Ordinary Shares of the Issuer. Any one American Depositary Share may be converted into three Ordinary Shares, and any three Ordinary Shares into one American Depositary Share, at any time at the election of the holder upon notice.

F1 · derivative.exercise_date: Reported securities are American Depositary Shares, each of which represents three Ordinary Shares of the Issuer. Any one American Depositary Share may be converted into three Ordinary Shares, and any three Ordinary Shares into one American Depositary Share, at any time at the election of the holder upon notice.

F1 · derivative.expiration_date: Reported securities are American Depositary Shares, each of which represents three Ordinary Shares of the Issuer. Any one American Depositary Share may be converted into three Ordinary Shares, and any three Ordinary Shares into one American Depositary Share, at any time at the election of the holder upon notice.

SEC source: 0001415889-25-008555 · form4-03182025_080313.xml · derivative · entry 3

Coll Crespo Blas · CIK 0002037144 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 728

Underlying: Ordinary Shares · 1,089 shares

Expires not disclosed

F5 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F6 · kind: Voluntary reporting of the acquisition of 363 ADSs by the Reporting Person on Novembery 20, 2024 pursuant to the Issuer's Employee Share Purchase Plan.

F5 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F5 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-25-008551 · form4-03182025_080303.xml · derivative · entry 5

Yoon Jun · CIK 0001962414 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,115

Underlying: Ordinary Shares · 2,463 shares

Expires not disclosed

F6 · derivative.exercise_price: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F8 · kind: Voluntary reporting of the acquisition of 821 ADSs by the Reporting Person on Novembery 20, 2024 pursuant to the Issuer's Employee Share Purchase Plan.

F6 · derivative.exercise_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F6 · derivative.expiration_date: Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-023791 · form4-09202024_090935.xml · derivative · entry 2

Coll Crespo Blas · CIK 0002037144 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,000

Underlying: Ordinary Shares · 111,000 shares

Expires 2034-09-17

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: One-fourth of the shares vest on the first anniversary of September 18, 2024, and the remaining shares shall vest in thirty-six (36) equal monthly installments thereafter.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-023791 · form4-09202024_090935.xml · nonDerivative · entry 1

Coll Crespo Blas · CIK 0002037144 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,600

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ('ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents restricted stock unit award granted under the Issuer's 2023 Equity Incentive Plan.

SEC source: 0001415889-24-023794 · form4-09202024_090932.xml · derivative · entry 2

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,890

Underlying: Ordinary Shares · 82,890 shares

Expires 2034-09-17

F3 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's ADSs.

F4 · derivative.exercise_date: One-fourth of the shares vest on the first anniversary of September 18, 2024, and the remaining shares shall vest in thirty-six (36) equal monthly installments thereafter.

F1 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-023794 · form4-09202024_090932.xml · nonDerivative · entry 1

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,290

F1 · security: The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

F2 · shares: Represents restricted stock unit award granted under the Issuer's 2023 Equity Incentive Plan.

SEC source: 0001415889-24-022457 · form4-08282024_080826.xml · derivative · entry 1

Russell Angus C. · CIK 0001534002 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Ordinary Shares · 75,000 shares

Expires 2034-08-25

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over a three-year period such that the option is fully vested on the third anniversary of August 26, 2024.

F3 · derivative.underlying: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-018324 · form4-06272024_040601.xml · derivative · entry 1

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Ordinary Shares · 37,500 shares

Expires 2034-06-24

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 25, 2024.

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-018328 · form4-06272024_040609.xml · derivative · entry 1

LOVE TED W · CIK 0001188919 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,595

Underlying: Ordinary Shares · 33,595 shares

Expires 2034-06-24

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 25, 2024.

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-018326 · form4-06272024_040605.xml · derivative · entry 1

DOBMEIER ERIC · CIK 0001202785 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Ordinary Shares · 37,500 shares

Expires 2034-06-24

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 25, 2024.

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-018325 · form4-06272024_040603.xml · derivative · entry 1

TETLOW SHARON · CIK 0001328565 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Ordinary Shares · 37,500 shares

Expires 2034-06-24

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 25, 2024.

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-018327 · form4-06272024_040607.xml · derivative · entry 1

Waldstreicher Joanne · CIK 0001962413 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Ordinary Shares · 37,500 shares

Expires 2034-06-24

F1 · derivative.exercise_price: The option exercise price per share is equal to the fair market value per Ordinary Share on the grant date based on the trading price of the Issuer's American Depositary Shares ("ADSs").

F2 · derivative.exercise_date: The shares vest in equal monthly installments over the 12 months following June 25, 2024.

F3 · derivative.underlying_shares: The Ordinary Shares of the Issuer may be represented by ADSs. Each ADS represents three Ordinary Shares of the Issuer.

SEC source: 0001415889-24-017040 · form4-06152024_120647.xml · derivative · entry 5

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 488,766

Underlying: Ordinary Shares · 50,001 shares

Expires 2031-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares vest in a series of 48 successive equal monthly installments beginning one month after January 22, 2021.

SEC source: 0001415889-24-017040 · form4-06152024_120647.xml · derivative · entry 4

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1

Underlying: Ordinary Shares · 99,999 shares

Expires 2030-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-017040 · form4-06152024_120647.xml · nonDerivative · entry 2

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 793,346

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-017040 · form4-06152024_120647.xml · nonDerivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 743,345

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-016510 · form4-06122024_080615.xml · derivative · entry 4

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 555,000 shares

Expires not disclosed

F3 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F4 · price: The weighted average sale price for the transaction was $52.7965, and the range of prices was $52.43 and $53.075. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

F3 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F3 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001415889-24-016510 · form4-06122024_080615.xml · derivative · entry 3

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Ordinary Shares · 555,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F3 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F3 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001415889-24-016510 · form4-06122024_080615.xml · nonDerivative · entry 1

Stevens Raymond C · CIK 0001698149 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 643,346

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The Ordinary Shares were converted into American Depositary Shares as reported in Table II above.

SEC source: 0001415889-24-015683 · form4-06052024_110646.xml · derivative · entry 6

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 53,100 shares

Expires not disclosed

F4 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F6 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on December 28, 2023.

F7 · price: The weighted average sale price for the transaction reported was $50.004, and the range of prices were between $50.00 and $50.16. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each price will be provided.

F4 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F4 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001415889-24-015683 · form4-06052024_110646.xml · derivative · entry 5

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,700

Underlying: Ordinary Shares · 53,100 shares

Expires not disclosed

F4 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F6 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on December 28, 2023.

F4 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F4 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

SEC source: 0001415889-24-015683 · form4-06052024_110646.xml · derivative · entry 4

Lin Xichen · CIK 0001962926 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,400

Underlying: Ordinary Shares · 106,200 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F5 · shares: 106,200 Ordinary Shares, which were acquired upon exercise of a share option, were converted into 35,400 American Depositary Shares.

F4 · derivative.exercise_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

F4 · derivative.expiration_date: Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.