GOSS

SEC source: 0001728117-23-000018 · wf-form4_167951967938039.xml · nonDerivative · entry 3

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By family trust

Disclosed balance after: 4,495,897

F3 · price: This transaction was executed in multiple trades at prices ranging from $1.06 to $1.20 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-23-000018 · wf-form4_167951967938039.xml · nonDerivative · entry 2

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By family trust

Disclosed balance after: 4,055,397

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.155 to $1.21 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-23-000028 · wf-form4_167952019155286.xml · derivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2033-03-19

F1 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000018 · wf-form4_167951967938039.xml · derivative · entry 5

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 544,500

Underlying: Common Stock · 544,500 shares

Expires 2033-03-19

F4 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000018 · wf-form4_167951967938039.xml · nonDerivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By family trust

Disclosed balance after: 3,786,008

F1 · price: This transaction was executed in multiple trades at prices ranging from $0.97 to 1.09 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-23-000022 · wf-form4_167951991888150.xml · derivative · entry 4

Christian Waage · CIK 0001553179 · EVP, Tech Ops and Admin

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2033-03-19

F1 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000022 · wf-form4_167951991888150.xml · nonDerivative · entry 1

Christian Waage · CIK 0001553179 · EVP, Tech Ops and Admin

10b5-1 filing: No plan indicated

Ownership: Indirect · By family trust

Disclosed balance after: 32,388

SEC source: 0001728117-23-000026 · wf-form4_167952007605605.xml · derivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2033-03-19

F1 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000024 · wf-form4_167951999562246.xml · derivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2033-03-19

F1 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000020 · wf-form4_167951981146427.xml · derivative · entry 3

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 211,500

Underlying: Common Stock · 211,500 shares

Expires 2033-03-19

F1 · derivative.exercise_date: 25% of the total number of shares subject to the option will vest on March 20, 2024 and 1/48th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-23-000020 · wf-form4_167951981146427.xml · nonDerivative · entry 1

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: No plan indicated

Ownership: Indirect · By family trust

Disclosed balance after: 70,990

SEC source: 0001728117-23-000016 · wf-form4_167931855307436.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,263

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.08 to $1.10 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-23-000014 · wf-form4_167931846505758.xml · nonDerivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 199,388

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.08 to $1.10 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-23-000012 · wf-form4_167931838708022.xml · nonDerivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,851

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.08 to $1.10 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000114 · wf-form4_167062448909309.xml · derivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000104 · wf-form4_167062400607119.xml · derivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 544,500

Underlying: Common Stock · 544,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000108 · wf-form4_167062422822547.xml · derivative · entry 1

Christian Waage · CIK 0001553179 · EVP, Tech Ops and Admin

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000110 · wf-form4_167062432335745.xml · derivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000112 · wf-form4_167062440627546.xml · derivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,500

Underlying: Common Stock · 157,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000106 · wf-form4_167062410024328.xml · derivative · entry 1

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,500

Underlying: Common Stock · 211,500 shares

Expires 2032-12-06

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on December 7, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000090 · wf-form4_166673142835218.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,292

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $11.881 to $12.078 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold.Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000088 · wf-form4_166673132619628.xml · nonDerivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 205,430

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $11.881 to $12.078 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold.Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000092 · wf-form4_166673154182049.xml · nonDerivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,415

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $11.881 to $12.078 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000094 · wf-form4a_166690466548859.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,292

F1 · kind: The Reporting Person's purchase of 6,934 shares of common stock at a price of $7.21 per share on July 15, 2022 was matchable under Section 16(b) of the Securities Exchange Act of 1934, with the Reporting Person's sale of common stock reported herein and, to the extent of 2,058 shares, the Reporting Person's sale of common stock at a price of $8.278 per share on March 16, 2022. The Reporting Person has agreed top pay to the Issuer $18,558.51, which, together with the $7,351.42 previously paid to the Issuer on July 15, 2022, represents the full amount of the profit realized in connection with the short-swing transaction.

F2 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F3 · price: This transaction was executed in multiple trades at prices ranging from $11.881 to $12.078 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold.Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000065 · wf-form4_165791682751110.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,168

F1 · kind: The Reporting Person's purchase of common stock reported herein was matchable under Section 16(b) of the Securities Exchange Act of 1934, to the extent of 6,934 shares, with the Reporting Person's sale of 6,934 shares of common stock at a price ranging from $8.278 to $8.25 per share on July 1, 2022 and March 16, 2022. The Reporting Person paid to the Issuer $7,351.42, representing the full amount of the profit realized in connection with the short-swing transaction.

SEC source: 0001728117-22-000059 · wf-form4_165791646217786.xml · nonDerivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By family trust

Disclosed balance after: 3,617,325

F1 · kind: The Reporting Person's purchase of common stock reported herein was matchable under Section 16(b) of the Securities Exchange Act of 1934, to the extent of 19,035 shares, with the Reporting Person's sale of 19,035 shares of common stock at a price of $8.915 per share on March 23, 2022. The Reporting Person paid to the Issuer $32,454.68, representing the full amount of the profit realized in connection with the short-swing transaction.

SEC source: 0001728117-22-000063 · wf-form4_165791671885890.xml · nonDerivative · entry 1

Christian Waage · CIK 0001553179 · EVP, Tech Ops and Admin

10b5-1 filing: Not disclosed

Ownership: Indirect · By family trust

Disclosed balance after: 13,888

F1 · kind: The Reporting Person's purchase of common stock reported herein was matchable under Section 16(b) of the Securities Exchange Act of 1934, to the extent of 6,934 shares, with the Reporting Person's sale of 6,934 shares of common stock at a price of $8.915 per share on March 23, 2022. The Reporting Person paid to the Issuer $11,882.47, representing the full amount of the profit realized in connection with the short-swing transaction.

SEC source: 0001728117-22-000061 · wf-form4_165791656527611.xml · nonDerivative · entry 1

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: Not disclosed

Ownership: Indirect · By family trust

Disclosed balance after: 20,990

F1 · kind: The Reporting Person's purchase of common stock reported herein was matchable under Section 16(b) of the Securities Exchange Act of 1934, to the extent of 10,722 shares, with the Reporting Person's sale of 10,722 shares of common stock at a price of $8.915 per share on March 23, 2022. The Reporting Person paid to the Issuer $18,281.01, representing the full amount of the profit realized in connection with the short-swing transaction.

SEC source: 0001728117-22-000053 · wf-form4_165705352176346.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,234

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.01 to 8.25 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000051 · wf-form4_165602440770532.xml · nonDerivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,897

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $6.88 to 7.13 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000071 · wf-form4_165791912081771.xml · derivative · entry 1

Bilenker Joshua H. · CIK 0001612312 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · shares: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer'sstockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001728117-22-000069 · wf-form4_165791902180593.xml · derivative · entry 1

Milligan Sandra · CIK 0001859810 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · shares: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date

SEC source: 0001728117-22-000073 · wf-form4_165791919498991.xml · derivative · entry 1

Cox Russell J. · CIK 0001512984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · kind: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer'sstockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001728117-22-000076 · wf-form4_165791970616328.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · shares: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer'sstockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001728117-22-000078 · wf-form4_165792005588771.xml · derivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · kind: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer'sstockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001728117-22-000067 · wf-form4_165791832433011.xml · derivative · entry 1

GALA RENEE D · CIK 0001607737 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-08

F1 · shares: Award made pursuant to Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The entire number of shares subject to this option becomes fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date

SEC source: 0001728117-22-000041 · wf-form4_165178888025620.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,042

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001728117-22-000031 · wf-form4_164815532088964.xml · nonDerivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,465

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001728117-22-000033 · wf-form4_164815543637815.xml · nonDerivative · entry 1

Christian Waage · CIK 0001553179 · EVP, Tech Ops and Admin

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 579,008

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001728117-22-000029 · wf-form4_164815518548512.xml · nonDerivative · entry 1

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,167

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001728117-22-000027 · wf-form4_164755094113540.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,304

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.27 to $8.41 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000025 · wf-form4_164755080313319.xml · nonDerivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,172

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.27 to $8.41 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000023 · wf-form4_164755066150082.xml · nonDerivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,675

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.27 to $8.42 per share. The price reported above reflects the weighted average sale price for the entire number of shares sold. Information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001728117-22-000011 · wf-form4_164184919646960.xml · derivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000002 · wf-form4_164184855665829.xml · derivative · entry 1

Hasnain Faheem · CIK 0001352620 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 650,000

Underlying: Common Stock · 650,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000005 · wf-form4_164184879849201.xml · derivative · entry 1

Christian Waage · CIK 0001553179 · EVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000009 · wf-form4_164184907106908.xml · derivative · entry 1

Peterson Caryn · CIK 0001857256 · EVP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000004 · wf-form4_164184871170973.xml · derivative · entry 1

Giraudo Bryan · CIK 0001740847 · COO/CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,000

Underlying: Common Stock · 265,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-22-000007 · wf-form4_164184894330645.xml · derivative · entry 1

Aranda Richard · CIK 0001867872 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2032-01-05

F1 · derivative.exercise_date: One-third of the total number of shares subject to the option will vest on January 6, 2023 and 1/36th of the total number of shares subject to the option vest on the last day of each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001728117-21-000098 · wf-form4_163528202672533.xml · nonDerivative · entry 1

Carter Laura · CIK 0001858178 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,306

F1 · shares: Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.