EYPT

SEC source: 0000929638-23-003383 · form4.xml · nonDerivative · entry 5

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 5,028,386

F6 · price: Represents the weighted average sale price of shares purchased in a series of open market transactions on the transaction date at prices ranging from $22.30 to $23.29 per share.

F19 · price: The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were purchased by the Master Fund.

F1 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as General Partner of the Master Fund. Bihua Chen serves as manager of Cormorant, GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0000929638-23-003383 · form4.xml · nonDerivative · entry 4

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 5,000,296

F5 · price: Represents the weighted average sale price of shares purchased in a series of open market transactions on the transaction date at prices ranging from $21.30 to $22.29 per share.

F19 · price: The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were purchased by the Master Fund.

F1 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as General Partner of the Master Fund. Bihua Chen serves as manager of Cormorant, GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0000929638-23-003383 · form4.xml · nonDerivative · entry 3

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,920,491

F4 · price: Represents the weighted average sale price of shares purchased in a series of open market transactions on the transaction date at prices ranging from $20.30 to $21.29 per share.

F19 · price: The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were purchased by the Master Fund.

F1 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as General Partner of the Master Fund. Bihua Chen serves as manager of Cormorant, GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0000929638-23-003383 · form4.xml · nonDerivative · entry 2

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,797,866

F3 · price: Represents the weighted average sale price of shares purchased in a series of open market transactions on the transaction date at prices ranging from $19.30 to $20.30 per share.

F19 · price: The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were purchased by the Master Fund.

F1 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as General Partner of the Master Fund. Bihua Chen serves as manager of Cormorant, GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0000929638-23-003383 · form4.xml · nonDerivative · entry 1

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 3,852,202

F2 · price: Represents the weighted average sale price of Common Stock (the "shares") purchased in a series of open market transactions on the transaction date at prices ranging from $18.30 to $19.30 per share.

F19 · price: The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were purchased by the Master Fund.

F1 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as General Partner of the Master Fund. Bihua Chen serves as manager of Cormorant, GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0001562180-23-008273 · primarydocument.xml · derivative · entry 4

Pine Michael Craig · CIK 0001904458 · Chief Corp Dev.&Strat. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 45,000 shares

Expires 2032-01-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option to purchase will vest and become exercisable as follows: 25% at January 10th, 2023 and the remainder ratably, on a monthly basis, over the remaining three years.

SEC source: 0001562180-23-008273 · primarydocument.xml · nonDerivative · entry 3

Pine Michael Craig · CIK 0001904458 · Chief Corp Dev.&Strat. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,343

F2 · shares: This owned share transaction was inadvertently left off of the original Form 4 filing on December 6, 2023.

SEC source: 0001562180-23-008273 · primarydocument.xml · nonDerivative · entry 2

Pine Michael Craig · CIK 0001904458 · Chief Corp Dev.&Strat. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,343

SEC source: 0001562180-23-008273 · primarydocument.xml · nonDerivative · entry 1

Pine Michael Craig · CIK 0001904458 · Chief Corp Dev.&Strat. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,343

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Includes 2,159 shares acquired on January 31, 2023 and 2,184 shares acquired on July 31,2023 pursuant to EyePoint's 2019 Employee Stock Purchase Plan.

SEC source: 0001562180-23-007325 · primarydocument.xml · derivative · entry 1

Elston George · CIK 0001429932 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-10-15

F1 · derivative.exercise_date: The option to purchase will vest and become exercisable over a four year period as follows: 25% at the one year anniversary of grant and then ratably over the remainig thirty-six months

SEC source: 0001562180-23-007327 · primarydocument.xml · derivative · entry 1

Duty Stuart · CIK 0001970274 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2033-10-15

F1 · derivative.exercise_date: The option becomes exercisable in three ratable annual installments beginning on October 16, 2024.

SEC source: 0000899243-23-018661 · doc4a.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,490,921

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.73 to $10.11. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share total shown above is the aggregate amount of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP sold 19,226 shares of the amount shown above, and EWHP-A sold 774 shares of the amount shown above. EWHP now holds a total of 3,355,921 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,000 shares of Common Stock of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018658 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,490,921

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.73 to $10.11. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share total shown above is the aggregate amount of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP sold 19,226 shares of the amount shown above, and EWHP-A sold 774 shares of the amount shown above. EWHP now holds a total of 3,355,921 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,000 shares of Common Stock of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,510,921

F5 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.84 to $11.23. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,517,938

F4 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.83 to $10.76. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,589,416

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.35 to $11.37. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,589,743

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.32 to $11.29. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,650,392

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,650,957

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.30 to $11.29. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,738,246

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.28 to $12.00. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,799,104

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,853,760

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,799,104

F5 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.36 to $10.50. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,810,835

F4 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.5001 to $11.50. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,883,760

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,883,760

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.11 to $11.04. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,935,940

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.05 to $12.04. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018380 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,023,040

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 44,968 shares and 116,416 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively, and EWHP-A sold 1,810 shares and 4,687 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively. EWHP now holds a total of 3,867,447 shares of Common Stock of the Issuer and EWHP-A now holds a total of 155,593 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares"). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Scott Wiggins (collectively, the "Managers") and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018380 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,144,143

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 44,968 shares and 116,416 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively, and EWHP-A sold 1,810 shares and 4,687 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively. EWHP now holds a total of 3,867,447 shares of Common Stock of the Issuer and EWHP-A now holds a total of 155,593 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares"). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Scott Wiggins (collectively, the "Managers") and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0001562180-23-005879 · primarydocument.xml · derivative · entry 2

Zaderej Karen L. · CIK 0001530968 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning July 11, 2023.

F1 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning July 11, 2023.

SEC source: 0001562180-23-005879 · primarydocument.xml · nonDerivative · entry 1

Zaderej Karen L. · CIK 0001530968 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001562180-23-005880 · primarydocument.xml · derivative · entry 2

Lurker Nancy · CIK 0001450485 · Director · Executive Vice Chair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,666

Underlying: Common Stock · 66,666 shares

Expires 2033-07-10

F2 · derivative.exercise_date: The option to purchase will vest and become exercisable over a four year period as follows: 25% at the one year anniversary of grant and then ratably over the remaining thirty-six months

SEC source: 0001562180-23-005880 · primarydocument.xml · derivative · entry 1

Lurker Nancy · CIK 0001450485 · Director · Executive Vice Chair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,334

Underlying: Common Stock · 33,334 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest in three ratable annual installments beginning July 10, 2024.

F1 · derivative.expiration_date: The restricted stock units will vest in three ratable annual installments beginning July 10, 2024.

SEC source: 0001562180-23-005881 · primarydocument.xml · derivative · entry 2

Duker Jay S. · CIK 0001630864 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-07-10

F2 · derivative.exercise_date: The option to purchase will vest and become exercisable over a four year period as follows: 25% at the one year anniversary of grant and then ratably over the remaining thirty-six months

SEC source: 0001562180-23-005881 · primarydocument.xml · derivative · entry 1

Duker Jay S. · CIK 0001630864 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest in three ratable annual installments beginning July 10, 2024.

F1 · derivative.expiration_date: The restricted stock units will vest in three ratable annual installments beginning July 10, 2024.

SEC source: 0001562180-23-005502 · primarydocument.xml · derivative · entry 2

ADAMIS ANTHONY P · CIK 0001277479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The restricted stock units will vest in three equal annual installments beginning June 23, 2023.

F1 · derivative.expiration_date: The restricted stock units will vest in three equal annual installments beginning June 23, 2023.

SEC source: 0001562180-23-005502 · primarydocument.xml · nonDerivative · entry 1

ADAMIS ANTHONY P · CIK 0001277479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001562180-23-005448 · primarydocument.xml · derivative · entry 2

ANDO GORAN · CIK 0001110748 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,500

Underlying: Common Stock · 13,500 shares

Expires 2033-06-19

SEC source: 0001562180-23-005448 · primarydocument.xml · derivative · entry 1

ANDO GORAN · CIK 0001110748 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,100

Underlying: Common Stock · 27,100 shares

Expires 2033-06-19

SEC source: 0001562180-23-005444 · primarydocument.xml · derivative · entry 1

Jones David Scott · CIK 0001779458 · SVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,855

Underlying: Common Stock · 45,855 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

F1 · derivative.expiration_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

SEC source: 0001562180-23-005450 · primarydocument.xml · derivative · entry 2

Landis John B. · CIK 0001477283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,000

Underlying: Common Stock · 13,000 shares

Expires 2033-06-19

SEC source: 0001562180-23-005450 · primarydocument.xml · derivative · entry 1

Landis John B. · CIK 0001477283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,100

Underlying: Common Stock · 26,100 shares

Expires 2033-06-19

SEC source: 0001562180-23-005441 · primarydocument.xml · derivative · entry 1

Lurker Nancy · CIK 0001450485 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,400

Underlying: Common Stock · 225,400 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

F1 · derivative.expiration_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

SEC source: 0001562180-23-005442 · primarydocument.xml · derivative · entry 1

Elston George · CIK 0001429932 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,855

Underlying: Common Stock · 45,855 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

F1 · derivative.expiration_date: The restricted stock units will vest in three ratable annual installments beginning January 6, 2024.

SEC source: 0001562180-23-005449 · primarydocument.xml · derivative · entry 2

DICICCO WENDY F · CIK 0001225165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,000

Underlying: Common Stock · 13,000 shares

Expires 2033-06-19

SEC source: 0001562180-23-005449 · primarydocument.xml · derivative · entry 1

DICICCO WENDY F · CIK 0001225165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,100

Underlying: Common Stock · 26,100 shares

Expires 2033-06-19

SEC source: 0001562180-23-005451 · primarydocument.xml · derivative · entry 2

GUYER DAVID R · CIK 0001277476 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,000

Underlying: Common Stock · 13,000 shares

Expires 2033-06-19

SEC source: 0001562180-23-005451 · primarydocument.xml · derivative · entry 1

GUYER DAVID R · CIK 0001277476 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,100

Underlying: Common Stock · 26,100 shares

Expires 2033-06-19

SEC source: 0001562180-23-005447 · primarydocument.xml · derivative · entry 2

ADAMIS ANTHONY P · CIK 0001277479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,000

Underlying: Common Stock · 13,000 shares

Expires 2033-06-19

SEC source: 0001562180-23-005447 · primarydocument.xml · derivative · entry 1

ADAMIS ANTHONY P · CIK 0001277479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,100

Underlying: Common Stock · 26,100 shares

Expires 2033-06-19