EDIT

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 6

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $34.82 to $35.79. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 5

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

SEC source: 0001179110-18-002253 · edgar.xml · derivative · entry 8

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,662

Underlying: Common Stock · 6,000 shares

Expires 2025-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

F5 · derivative.exercise_date: This option was granted on September 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 4

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $34.50 to $34.79. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 3

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

SEC source: 0001179110-18-002258 · edgar.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,076

Underlying: Common Stock · 23,076 shares

Expires 2028-02-13

F1 · derivative.exercise_date: This option was granted on February 14, 2018 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on February 14, 2019 through February 14, 2021.

SEC source: 0001179110-18-002253 · edgar.xml · derivative · entry 7

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,662

Underlying: Common Stock · 6,000 shares

Expires 2025-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

F5 · derivative.exercise_date: This option was granted on September 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 2

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $32.27 to $33.07. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-002253 · edgar.xml · nonDerivative · entry 1

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 15, 2017.

SEC source: 0001179110-18-001908 · edgar.xml · derivative · entry 1

Cox Gerald Frank · CIK 0001686130 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2028-02-06

F1 · derivative.exercise_date: This option was granted on February 7, 2018 and is scheduled to vest over four years in equal monthly installments beginning on February 7, 2018 through February 7, 2022.

SEC source: 0001179110-18-001909 · edgar.xml · derivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 275,000

Underlying: Common Stock · 275,000 shares

Expires 2028-02-06

F1 · derivative.exercise_date: This option was granted on February 7, 2018 and is scheduled to vest over four years in equal monthly installments beginning on February 7, 2018 through February 7, 2022.

SEC source: 0001179110-18-001906 · edgar.xml · derivative · entry 1

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2028-02-06

F1 · derivative.exercise_date: This option was granted on February 7, 2018 and is scheduled to vest over four years in equal monthly installments beginning on February 7, 2018 through February 7, 2022.

SEC source: 0001179110-18-001907 · edgar.xml · derivative · entry 1

Albright Charles · CIK 0001682323 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,500

Underlying: Common Stock · 71,500 shares

Expires 2028-02-06

F1 · derivative.exercise_date: This option was granted on February 7, 2018 and is scheduled to vest over four years in equal monthly installments beginning on February 7, 2018 through February 7, 2022.

SEC source: 0001179110-18-001570 · edgar.xml · nonDerivative · entry 3

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,336,098

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $37.32 to $37.9. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-001570 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,336,798

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $36.35 to $37.29. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-001570 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,338,898

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $35.34 to $36.31. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-001288 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,344,431

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $40 to $40.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-001288 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,354,431

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $37.5 to $37.63. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-001072 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,364,431

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $35.21 to $35.33. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-000486 · edgar.xml · nonDerivative · entry 5

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,367,769

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F6 · price: This transaction was executed in multiple trades at prices ranging from $35 to $35.7. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-000486 · edgar.xml · nonDerivative · entry 4

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,374,431

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F5 · price: This transaction was executed in multiple trades at prices ranging from $33.89 to $34.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-000486 · edgar.xml · nonDerivative · entry 3

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,378,368

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $32.89 to $33.87. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-000486 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,380,561

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $31.79 to $32.37. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-18-000486 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,382,264

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $30.75 to $31.71. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-015633 · edgar.xml · derivative · entry 9

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,427

Underlying: Common Stock · 4,649 shares

Expires 2025-07-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F5 · derivative.exercise_date: This option was granted on July 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 6

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $24.75 to $25.73. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 5

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,649

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

SEC source: 0001179110-17-015633 · edgar.xml · derivative · entry 8

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,076

Underlying: Common Stock · 5,000 shares

Expires 2025-07-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F5 · derivative.exercise_date: This option was granted on July 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 4

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $24.50 to $25.24. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 3

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

SEC source: 0001179110-17-015633 · edgar.xml · derivative · entry 7

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,076

Underlying: Common Stock · 5,000 shares

Expires 2025-07-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F5 · derivative.exercise_date: This option was granted on July 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 2

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $24.20 to $24.49. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-015633 · edgar.xml · nonDerivative · entry 1

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

SEC source: 0001179110-17-014870 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,382,764

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $29.56 to $30.27. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-014870 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,387,897

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $28.54 to $29.47. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-014413 · edgar.xml · derivative · entry 6

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,076

Underlying: Common Stock · 5,000 shares

Expires 2025-07-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F4 · derivative.exercise_date: This option was granted on July 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-17-014413 · edgar.xml · nonDerivative · entry 4

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $25.04 to $25.78. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-014413 · edgar.xml · nonDerivative · entry 3

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

SEC source: 0001179110-17-014413 · edgar.xml · derivative · entry 5

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,076

Underlying: Common Stock · 5,000 shares

Expires 2025-07-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F4 · derivative.exercise_date: This option was granted on July 14, 2015 and is scheduled to vest over four years with 25% of the shares having vested on July 1, 2016, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 1, 2019.

SEC source: 0001179110-17-014413 · edgar.xml · nonDerivative · entry 2

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $24.68 to $25.04. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-014413 · edgar.xml · nonDerivative · entry 1

Hack Andrew A. F. · CIK 0001657434 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2017.

SEC source: 0001179110-17-013743 · edgar.xml · nonDerivative · entry 3

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,391,097

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $24.99 to $25.15. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-013743 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,391,397

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $23.99 to $24.64. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-013743 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,393,322

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $22.88 to $23.85. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-013103 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,399,430

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $25.32 to $25.34. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected

SEC source: 0001179110-17-013103 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,399,630

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $24.2 to $25.17. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected

SEC source: 0001179110-17-012109 · edgar.xml · nonDerivative · entry 3

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,407,763

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F4 · price: This transaction was executed in multiple trades at prices ranging from $20.00 to $20.85. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-012109 · edgar.xml · nonDerivative · entry 2

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,414,429

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $21.13 to $21.26. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-17-012109 · edgar.xml · nonDerivative · entry 1

Bosley Katrine · CIK 0001592469 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,414,629

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2017.

F2 · price: This transaction was executed in multiple trades at prices ranging from $20.09 to $21.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001012975-17-000637 · edgar.xml · nonDerivative · entry 1

Cole Douglas G. · CIK 0001486373 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,171

F1 · kind: On August 17, 2017, Flagship Ventures Fund IV, L.P. ("Flagship IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship IV-Rx") distributed to its limited partners and sole general partner, Flagship Ventures Fund IV General Partner, LLC ("Flagship IV LLC"), pro rata and without consideration, 1,361,400 shares and 340,349 shares, respectively, of the Issuer's common stock. Flagship IV LLC, in turn, distributed to its members, pro rata and without consideration, the 57,022 shares and 11 shares it received from Flagship IV and Flagship IV-Rx, respectively. Mr. Cole, a member of Flagship IV LLC, received 1,686 shares through such distribution.

F1 · price: On August 17, 2017, Flagship Ventures Fund IV, L.P. ("Flagship IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship IV-Rx") distributed to its limited partners and sole general partner, Flagship Ventures Fund IV General Partner, LLC ("Flagship IV LLC"), pro rata and without consideration, 1,361,400 shares and 340,349 shares, respectively, of the Issuer's common stock. Flagship IV LLC, in turn, distributed to its members, pro rata and without consideration, the 57,022 shares and 11 shares it received from Flagship IV and Flagship IV-Rx, respectively. Mr. Cole, a member of Flagship IV LLC, received 1,686 shares through such distribution.