EDIT

SEC source: 0002149618-26-000006 · wk-form4_1788987497.xml · derivative · entry 1

Ory Daniel Scott · CIK 0002149618 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 950,000

Underlying: Common Stock · 950,000 shares

Expires 2036-09-07

F1 · derivative.exercise_date: This option was granted on September 8, 2026 and is scheduled to vest over four years, with 25% of the shares to vest on October 15, 2027 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through October 15, 2030.

SEC source: 0001985604-26-000003 · wk-form4_1788553659.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,660

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $3.0050 to $3.0372. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0002063082-26-000006 · wk-form4_1788553522.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,839

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001742084-26-000003 · wk-form4_1788553359.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 243,189

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $3.0050 to $3.0372. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0002137699-26-000004 · wk-form4_1786137389.xml · derivative · entry 1

Ellinor Patrick Thomas II · CIK 0002137699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,400

Underlying: Common Stock · 103,400 shares

Expires 2036-08-05

F1 · derivative.exercise_date: This option was granted on August 6, 2026 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on August 6, 2027 through August 6, 2029.

SEC source: 0002063082-26-000003 · wk-form4_1785960474.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,292

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on August 1, 2026. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-26-000076 · wk-form4_1785358259.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,369

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on July 24, 2026. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-26-000068 · wk-form4_1782160133.xml · derivative · entry 1

Levy Elliott M. · CIK 0001858745 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,700

Underlying: Common Stock · 51,700 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2026 and is scheduled to vest in full on June 17, 2027.

SEC source: 0001650664-26-000070 · wk-form4_1782160207.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,700

Underlying: Common Stock · 51,700 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2026 and is scheduled to vest in full on June 17, 2027.

SEC source: 0001650664-26-000071 · wk-form4_1782160247.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,700

Underlying: Common Stock · 51,700 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2026 and is scheduled to vest in full on June 17, 2027.

SEC source: 0001650664-26-000069 · wk-form4_1782160170.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,700

Underlying: Common Stock · 51,700 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2026 and is scheduled to vest in full on June 17, 2027.

SEC source: 0001650664-26-000072 · wk-form4_1782160274.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,700

Underlying: Common Stock · 51,700 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2026 and is scheduled to vest in full on June 17, 2027.

SEC source: 0001650664-26-000057 · wk-form4_1780691609.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,970

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.7010 to $2.7049. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-26-000055 · wk-form4_1780691552.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,297

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.7010 to $2.7050. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-26-000056 · wk-form4_1780691579.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 248,313

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.7010 to $2.7250. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-26-000021 · wk-form4_1773693286.xml · derivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 292,856

Underlying: Common Stock · 292,856 shares

Expires 2036-03-11

F1 · derivative.exercise_date: This option was granted on March 12, 2026 and is scheduled to vest over four years in equal monthly installments beginning on April 12, 2026 through March 12, 2030.

SEC source: 0001650664-26-000023 · wk-form4_1773693426.xml · derivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,015,200

Underlying: Common Stock · 1,015,200 shares

Expires 2036-03-11

F1 · derivative.exercise_date: This option was granted on March 12, 2026 and is scheduled to vest over four years in equal monthly installments beginning on April 12, 2026 through March 12, 2030.

SEC source: 0001650664-26-000022 · wk-form4_1773693348.xml · derivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 292,856

Underlying: Common Stock · 292,856 shares

Expires 2036-03-11

F1 · derivative.exercise_date: This option was granted on March 12, 2026 and is scheduled to vest over four years in equal monthly installments beginning on April 12, 2026 through March 12, 2030.

SEC source: 0001650664-26-000009 · wk-form4_1772661358.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,693

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.0050 to $2.0204 The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-26-000007 · wk-form4_1772660958.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,434

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.0050 to $2.0204. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-26-000006 · wk-form4_1772660918.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,028

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2026. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.0041 to $2.0204. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected

SEC source: 0001650664-25-000163 · wk-form4_1764884348.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,777

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000162 · wk-form4_1764884318.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 269,087

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000161 · wk-form4_1764884284.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,908

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000142 · wk-form4_1757017244.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,369

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000143 · wk-form4_1757017284.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,490

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

F2 · balance_after: The amount of securities beneficially owned following the reported transaction includes 5,802 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001650664-25-000141 · wk-form4_1757017197.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 274,690

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000118 · wk-form4_1754684878.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,827

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 6, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000113 · wk-form4_1754340586.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,398

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on July 24, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-25-000101 · wk-form4_1749586723.xml · derivative · entry 1

Levy Elliott M. · CIK 0001858745 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-06-05

F1 · derivative.exercise_date: This option was granted on June 6, 2025 and is scheduled to vest in full on June 6, 2026.

SEC source: 0001650664-25-000099 · wk-form4_1749586673.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-06-05

F1 · derivative.exercise_date: This option was granted on June 6, 2025 and is scheduled to vest in full on June 6, 2026.

SEC source: 0001650664-25-000103 · wk-form4_1749586773.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-06-05

F1 · derivative.exercise_date: This option was granted on June 6, 2025 and is scheduled to vest in full on June 6, 2026.

SEC source: 0001650664-25-000102 · wk-form4_1749586749.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-06-05

F1 · derivative.exercise_date: This option was granted on June 6, 2025 and is scheduled to vest in full on June 6, 2026.

SEC source: 0001650664-25-000100 · wk-form4_1749586697.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-06-05

F1 · derivative.exercise_date: This option was granted on June 6, 2025 and is scheduled to vest in full on June 6, 2026.

SEC source: 0001650664-25-000093 · wk-form4_1749076755.xml · nonDerivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,506

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 7, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2025. The sale does not represent a discretionary trade by the Reporting Person

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.7239 to $1.7522. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-25-000091 · wk-form4_1749076666.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,519

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.7239 to $1.7522. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-25-000089 · wk-form4_1749076593.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 280,282

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.7239 to $1.7566 . The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-25-000052 · wk-form4_1744144175.xml · derivative · entry 1

Parison Amy · CIK 0002063082 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,672

Underlying: Common Stock · 34,672 shares

Expires 2035-04-07

F1 · derivative.exercise_date: This option was granted on April 8, 2025 and is scheduled to vest over four years, with 25% of the shares to vest on April 8, 2026 and the remaining 75% of the shares scheduled to vest in equal monthly monthly installments thereafter through April 8, 2029.

SEC source: 0001650664-25-000040 · wk-form4_1743108110.xml · derivative · entry 2

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2035-03-07

F2 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest in full on September 8, 2026.

SEC source: 0001650664-25-000040 · wk-form4_1743108110.xml · derivative · entry 1

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,100

Underlying: Common Stock · 275,100 shares

Expires 2035-03-07

F1 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest over four years in equal monthly installments beginning on April 8, 2025 through March 8, 2029.

SEC source: 0001650664-25-000037 · wk-form4_1743107853.xml · derivative · entry 2

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2035-03-07

F2 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest in full on September 8, 2026.

SEC source: 0001650664-25-000037 · wk-form4_1743107853.xml · derivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 828,000

Underlying: Common Stock · 828,000 shares

Expires 2035-03-07

F1 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest over four years in equal monthly installments beginning on April 8, 2025 through March 8, 2029.

SEC source: 0001650664-25-000034 · wk-form4_1743107610.xml · derivative · entry 2

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2035-03-07

F2 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest in full on September 8, 2026.

SEC source: 0001650664-25-000034 · wk-form4_1743107610.xml · derivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,100

Underlying: Common Stock · 275,100 shares

Expires 2035-03-07

F1 · derivative.exercise_date: This option was granted on March 8, 2025 and is scheduled to vest over four years in equal monthly installments beginning on April 8, 2025 through March 8, 2029.

SEC source: 0001650664-25-000027 · wk-form4_1741211041.xml · nonDerivative · entry 1

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,720

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on May 12, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 3, 2025. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.7107 to $1.7150 . The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-25-000026 · wk-form4_1741210979.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 295,474

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 3, 2025. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $1.7107 to $1.7125 . The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-25-000025 · wk-form4_1741210903.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 70,245

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2025. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-24-000126 · wk-form4_1733434825.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 312,106

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.0550 to $2.0783. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000124 · wk-form4_1733434638.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 133,354

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $2.0507 to $2.0783. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000105 · wk-form4_1725654028.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 133,895

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $3.4246 to $3.4501. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.