EDIT

SEC source: 0001415889-22-001224 · form4-02112022_010249.xml · nonDerivative · entry 1

Shearman Mark S · CIK 0001643799 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,494

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on February 10, 2023 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through February 10, 2026.

SEC source: 0001415889-22-001195 · form4-02102022_010215.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,196

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 6, 2022. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $17.61 to $17.82. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-22-000470 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,462

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on January 9, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-22-000112 · edgar.xml · nonDerivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,898

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on March 4, 2021, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 22, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-21-011227 · edgar.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,498

F1 · kind: Reflects the acquisition, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 2, 2021. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on June 2, 2022, subject to continued service.

SEC source: 0001179110-21-011224 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,206

F1 · kind: Reflects the acquisition, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 2, 2021. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on June 2, 2022, subject to continued service.

SEC source: 0001179110-21-011223 · edgar.xml · nonDerivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,150

F1 · kind: Reflects the vesting, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on March 2, 2021.

SEC source: 0001179110-21-011225 · edgar.xml · nonDerivative · entry 1

Shearman Mark S · CIK 0001643799 · EVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,785

F1 · kind: Reflects the acquisition, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 14, 2021. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on June 14, 2022, subject to continued service.

SEC source: 0001179110-21-011226 · edgar.xml · nonDerivative · entry 1

Michaels Lisa Anne · CIK 0001830610 · EVP/Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,675

F1 · kind: Reflects the acquisition, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 2, 2021. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on June 2, 2022, subject to continued service.

SEC source: 0001179110-21-010113 · edgar.xml · nonDerivative · entry 1

Michaels Lisa Anne · CIK 0001830610 · EVP/Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,432

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on November 11, 2021, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on November 9, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-21-010059 · edgar.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,026

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on November 6, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-21-009688 · edgar.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,732

Underlying: Common Stock · 24,732 shares

Expires 2031-10-25

F1 · derivative.exercise_date: This option was granted on October 26, 2021 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on October 26, 2022 through October 26, 2024.

SEC source: 0001179110-21-009557 · edgar.xml · nonDerivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,673

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on March 4, 2021, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 30, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-21-009149 · edgar.xml · nonDerivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,478

F1 · kind: Reflects the vesting, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on March 2, 2021.

SEC source: 0001179110-21-008671 · edgar.xml · derivative · entry 1

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,736

Underlying: Common Stock · 13,736 shares

Expires 2031-09-02

F1 · derivative.exercise_date: This option was granted on September 3, 2021 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on September 3, 2022 through September 3, 2024.

SEC source: 0001179110-21-008086 · edgar.xml · derivative · entry 3

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Stock · 2,500 shares

Expires 2030-01-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

F2 · derivative.exercise_date: This option was granted on January 9, 2020 and is scheduled to vest over four years, with 25% of the shares having vested on January 9, 2021, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through January 9, 2024.

SEC source: 0001179110-21-008086 · edgar.xml · nonDerivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,735

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

SEC source: 0001179110-21-008086 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,235

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

SEC source: 0001415889-22-003709 · form4-04042022_040401.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,099

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on August 6, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-21-007175 · edgar.xml · derivative · entry 3

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,500

Underlying: Common Stock · 2,500 shares

Expires 2030-01-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

F2 · derivative.exercise_date: This option was granted on January 9, 2020 and is scheduled to vest over four years, with 25% of the shares having vested on January 9, 2021, and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through January 9, 2024.

SEC source: 0001179110-21-007175 · edgar.xml · nonDerivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,735

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

SEC source: 0001179110-21-007175 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,235

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on March 12, 2021.

SEC source: 0001179110-21-006780 · edgar.xml · derivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,989

Underlying: Common Stock · 170,989 shares

Expires 2031-03-01

F1 · derivative.exercise_date: Reflects the vesting, upon the achievement of a specified organizational milestone, of a portion of a performance-based stock option originally granted on March 2, 2021.

SEC source: 0001179110-21-006778 · edgar.xml · derivative · entry 2

Shearman Mark S · CIK 0001643799 · EVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,718

Underlying: Common Stock · 52,718 shares

Expires 2031-06-13

F2 · derivative.exercise_date: This option was granted on June 14, 2021 and is scheduled to vest over four years, with 25% of the shares to vest on June 14, 2022 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through June 14, 2025.

SEC source: 0001179110-21-006778 · edgar.xml · nonDerivative · entry 1

Shearman Mark S · CIK 0001643799 · EVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,701

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years in equal yearly installments of one-fourth of the shares, with the first such installment to vest on June 14, 2022 continuing through June 14, 2025.

SEC source: 0001179110-21-006458 · edgar.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,538

Underlying: Common Stock · 11,538 shares

Expires 2031-06-02

F1 · derivative.exercise_date: This option was granted on June 3, 2021 and is scheduled to vest in full on June 3, 2022.

SEC source: 0001179110-21-006451 · edgar.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,538

Underlying: Common Stock · 11,538 shares

Expires 2031-06-02

F1 · derivative.exercise_date: This option was granted on June 3, 2021 and is scheduled to vest in full on June 3, 2022.

SEC source: 0001179110-21-006450 · edgar.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,538

Underlying: Common Stock · 11,538 shares

Expires 2031-06-02

F1 · derivative.exercise_date: This option was granted on June 3, 2021 and is scheduled to vest in full on June 3, 2022.

SEC source: 0001179110-21-006454 · edgar.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,538

Underlying: Common Stock · 11,538 shares

Expires 2031-06-02

F1 · derivative.exercise_date: This option was granted on June 3, 2021 and is scheduled to vest in full on June 3, 2022.

SEC source: 0001179110-21-006452 · edgar.xml · derivative · entry 1

Chatterjee Meeta · CIK 0001835388 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,538

Underlying: Common Stock · 11,538 shares

Expires 2031-06-02

F1 · derivative.exercise_date: This option was granted on June 3, 2021 and is scheduled to vest in full on June 3, 2022.

SEC source: 0001179110-21-002936 · edgar.xml · nonDerivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,700

F1 · price: This transaction was executed in multiple trades at prices ranging from $45.48 to $45.59. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-21-002870 · edgar.xml · derivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,197

Underlying: Common Stock · 32,197 shares

Expires 2031-03-01

F2 · derivative.exercise_date: This option was granted on March 2, 2021 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2021 through March 2, 2025.

SEC source: 0001179110-21-002870 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,735

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2022 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2025.

SEC source: 0001179110-21-002869 · edgar.xml · derivative · entry 2

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 196,637

Underlying: Common Stock · 196,637 shares

Expires 2031-03-01

F2 · derivative.exercise_date: This option was granted on March 2, 2021 and is scheduled to vest as to one-third of the shares underlying the option when the closing price of the Issuer's common stock, as reported on the Nasdaq Global Select Market, has for 15 consecutive trading days in the five year period following the grant date equaled or exceeded $80.00, $100.00 and $120.00 per share, respectively.

SEC source: 0001179110-21-002869 · edgar.xml · nonDerivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

F1 · price: This transaction was executed in multiple trades at prices ranging from $46.27 to $46.44. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-21-001512 · edgar.xml · nonDerivative · entry 1

Collins Cynthia · CIK 0001405692 · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,760

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on May 11, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 6, 2021. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $66.47 to $66.66. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-21-000574 · edgar.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,432

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on January 9, 2021. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001179110-20-012101 · edgar.xml · derivative · entry 1

Chatterjee Meeta · CIK 0001835388 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,076

Underlying: Common Stock · 23,076 shares

Expires 2030-12-16

F1 · derivative.exercise_date: This option was granted on December 17, 2020 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on December 17, 2021 through December 17, 2023.

SEC source: 0001179110-20-012070 · edgar.xml · derivative · entry 5

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,000

Underlying: Common Stock · 10,000 shares

Expires 2026-09-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F4 · derivative.exercise_date: This option was granted on September 9, 2016 and vested over four years with 25% of the shares having vested on August 22, 2017, and the remaining 75% of the shares having vested in equal monthly installments thereafter through August 22, 2020.

SEC source: 0001179110-20-012070 · edgar.xml · nonDerivative · entry 4

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,907

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

SEC source: 0001179110-20-012070 · edgar.xml · nonDerivative · entry 3

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,107

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $63.24 to $64.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-20-012070 · edgar.xml · nonDerivative · entry 2

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,131

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $62.18 to $63.12. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-20-012070 · edgar.xml · nonDerivative · entry 1

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

SEC source: 0001179110-20-011830 · edgar.xml · derivative · entry 3

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,000

Underlying: Common Stock · 10,000 shares

Expires 2026-09-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F2 · derivative.exercise_date: This option was granted on September 9, 2016 and vested over four years with 25% of the shares having vested on August 22, 2017, and the remaining 75% of the shares having vested in equal monthly installments thereafter through August 22, 2020.

SEC source: 0001179110-20-011830 · edgar.xml · nonDerivative · entry 2

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,907

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

SEC source: 0001179110-20-011830 · edgar.xml · nonDerivative · entry 1

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

SEC source: 0001179110-20-011752 · edgar.xml · derivative · entry 3

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,000

Underlying: Common Stock · 20,000 shares

Expires 2026-09-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F3 · derivative.exercise_date: This option was granted on September 9, 2016 and vested over four years with 25% of the shares having vested on August 22, 2017, and the remaining 75% of the shares having vested in equal monthly installments thereafter through August 22, 2020.

SEC source: 0001179110-20-011752 · edgar.xml · nonDerivative · entry 2

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,907

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $40.00 to $40.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001179110-20-011752 · edgar.xml · nonDerivative · entry 1

Albright Charles · CIK 0001682323 · EVP/Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sale reported in this Form 4 was effected pursuant to a 10b5-1 plan adopted by the Reporting Person on May 15, 2020.

SEC source: 0001179110-20-010969 · edgar.xml · derivative · entry 2

Michaels Lisa Anne · CIK 0001830610 · EVP/Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2030-11-08

F2 · derivative.exercise_date: This option was granted on November 9, 2020 and is scheduled to vest over four years, with 25% of the shares to vest on November 9, 2021 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through November 9, 2024.