EDIT

SEC source: 0001415889-23-008293 · form4-05182023_090554.xml · nonDerivative · entry 1

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 77,900

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years in equal yearly installments of one-fourth of the shares, with the first such installment to vest on May 17, 2024 continuing through May 17, 2027.

SEC source: 0001415889-23-007989 · form4-05152023_040501.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,779

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on May 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-007990 · form4-05152023_040503.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,610

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on May 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-007816 · form4-05112023_040501.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,447

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on May 6, 2023. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.5100 to $9.5150.The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006521 · form4-04132023_080436.xml · derivative · entry 1

Levy Elliott M. · CIK 0001858745 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-04-10

F1 · derivative.exercise_date: This option was granted on April 11, 2023 and is scheduled to vest over three years in equal yearly installments of one-third of the shares beginning on April 11, 2024 through April 11, 2026.

SEC source: 0001415889-23-004312 · form4-03062023_040302.xml · nonDerivative · entry 2

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,582

F2 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-004315 · form4-03062023_040309.xml · nonDerivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,559

F2 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-004312 · form4-03062023_040302.xml · derivative · entry 3

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-03-01

F3 · derivative.exercise_date: This option was granted on March 2, 2023 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2023 through March 2, 2027.

SEC source: 0001415889-23-004312 · form4-03062023_040302.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,683

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2024 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2027.

SEC source: 0001415889-23-004315 · form4-03062023_040309.xml · derivative · entry 3

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,500

Underlying: Common Stock · 94,500 shares

Expires 2033-03-01

F3 · derivative.exercise_date: This option was granted on March 2, 2023 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2023 through March 2, 2027.

SEC source: 0001415889-23-004315 · form4-03062023_040309.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,743

F1 · security: The common stock received by the Reporting person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2024 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2027.

SEC source: 0001415889-23-004314 · form4-03062023_040307.xml · derivative · entry 2

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,000

Underlying: Common Stock · 54,000 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option was granted on March 2, 2023 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2023 through March 2, 2027.

SEC source: 0001415889-23-004314 · form4-03062023_040307.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,372

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2024 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2027.

SEC source: 0001415889-23-004313 · form4-03062023_040304.xml · derivative · entry 2

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option was granted on March 2, 2023 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2023 through March 2, 2027.

SEC source: 0001415889-23-004313 · form4-03062023_040304.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,655

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2024 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2027.

SEC source: 0001415889-23-002602 · form4-02152023_040201.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,983

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-002603 · form4-02152023_040208.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,243

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-002604 · form4-02152023_040213.xml · nonDerivative · entry 1

Shearman Mark S · CIK 0001643799 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,559

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 19, 2021 and represents the sale of shares necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-002218 · form4-02092023_040202.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,290

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on February 6, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-000875 · form4-01122023_040101.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,530

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30,2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on January 9,2023. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.1600 to $8.1911. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012131 · form4-12062022_041201.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,636

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-012132 · form4-12062022_041206.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,282

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-011242 · form4-11092022_041141.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,738

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on November 6, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-009448 · form4-09082022_040901.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,027

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-009449 · form4-09082022_040910.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,475

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-008463 · form4-08102022_040801.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,128

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on August 6, 2022. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.0525 to $18.61. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-007838 · form4-07202022_010742.xml · derivative · entry 2

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 171,602

Underlying: Common Stock · 171,602 shares

Expires 2032-07-17

F2 · derivative.exercise_date: This option was granted on July 18, 2022 and is scheduled to vest over four years, with 25% of the shares to vest on July 18, 2023 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 18, 2026.

SEC source: 0001415889-22-007838 · form4-07202022_010742.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,372

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years in equal yearly installments of one-fourth of the shares, with the first such installment to vest on July 18, 2023 continuing through July 18, 2026.

SEC source: 0001415889-22-006631 · form4-06162022_040601.xml · nonDerivative · entry 1

Shearman Mark S · CIK 0001643799 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,349

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 19, 2021 and represents the sale of shares necessary to meet tax withholding obligations as a result of vesting in restricted stock units and in performance stock units on June 14, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-006492 · form4-06132022_040621.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006489 · form4-06132022_040606.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023

SEC source: 0001415889-22-006490 · form4-06132022_040611.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006494 · form4-06132022_040635.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006493 · form4-06132022_040629.xml · derivative · entry 1

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006491 · form4-06132022_040616.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006488 · form4-06132022_040601.xml · derivative · entry 1

Chatterjee Meeta · CIK 0001835388 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2022 and is scheduled to vest in full on June 9, 2023.

SEC source: 0001415889-22-006162 · form4-06062022_010614.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,421

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units and in performance stock units on June 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-006161 · form4-06062022_010617.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,667

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units and in performance stock units on June 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-006159 · form4-06062022_010612.xml · derivative · entry 2

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 950,209

Underlying: Common Stock · 950,209 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This option was granted on June 2, 2022 and is scheduled to vest over four years, with 25% of the shares scheduled to vest on June 2, 2023 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through June 2, 2026.

SEC source: 0001415889-22-006159 · form4-06062022_010612.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,655

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years in equal yearly installments of one-fourth of the shares, with the first such installment to vest on June 2, 2023 continuing through June 2, 2026.

SEC source: 0001415889-22-004837 · form4-05112022_040501.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,544

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on May 6, 2022. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.8768 to $13.12. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-004098 · form4-04182022_040401.xml · derivative · entry 1

MULLEN JAMES C · CIK 0001226288 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,989

Underlying: Common Stock · 170,989 shares

Expires 2031-03-01

F1 · derivative.exercise_date: Reflects the vesting, upon the satisfaction of the performance criteria, of a portion of a performance-based stock option originally granted on March 2, 2021.

SEC source: 0001415889-22-003709 · form4-04042022_040401.xml · nonDerivative · entry 2

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,841

F2 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 31, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-002656 · form4-03072022_040308.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,386

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-002655 · form4-03072022_040301.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,194

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on December 30, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2022. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-22-001225 · form4-02112022_010246.xml · derivative · entry 2

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,732

Underlying: Common Stock · 110,732 shares

Expires 2032-02-09

F2 · derivative.exercise_date: This option was granted on February 10, 2022 and is scheduled to vest over four years in equal monthly installments beginning on March 10, 2022 through February 10, 2026.

SEC source: 0001415889-22-001225 · form4-02112022_010246.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CHIEF BUSINESS OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,789

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on February 10, 2023 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through February 10, 2026.

SEC source: 0001415889-22-001223 · form4-02112022_010242.xml · derivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,580

Underlying: Common Stock · 157,580 shares

Expires 2032-02-09

F2 · derivative.exercise_date: This option was granted on February 10, 2022 and is scheduled to vest over four years in equal monthly installments beginning on March 10, 2022 through February 10, 2026.

SEC source: 0001415889-22-001223 · form4-02112022_010242.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,961

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on February 10, 2023 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through February 10, 2026.

SEC source: 0001415889-22-001224 · form4-02112022_010249.xml · derivative · entry 2

Shearman Mark S · CIK 0001643799 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,398

Underlying: Common Stock · 93,398 shares

Expires 2032-02-09

F2 · derivative.exercise_date: This option was granted on February 10, 2022 and is scheduled to vest over four years in equal monthly installments beginning on March 10, 2022 through February 10, 2026.