EDIT

SEC source: 0001650664-24-000103 · wk-form4_1725653893.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 313,724

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $3.4246 to $3.4503. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000090 · wk-form4_1722027729.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,136

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on July 3, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on July 24, 2024. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-24-000087 · wk-form4_1721682068.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 134,413

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on July 18, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.1650 to $5.2058. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000076 · wk-form4_1717705020.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 315,279

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-24-000075 · wk-form4_1717704962.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,032

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-24-000058 · wk-form4_1717446440.xml · derivative · entry 1

Levy Elliott M. · CIK 0001858745 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000054 · wk-form4_1717446166.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000068 · wk-form4_1717449062.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000071 · wk-form4_1717449268.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000072 · wk-form4_1717449318.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025

SEC source: 0001650664-24-000070 · wk-form4_1717449223.xml · derivative · entry 1

Chatterjee Meeta · CIK 0001835388 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000060 · wk-form4_1717446617.xml · derivative · entry 1

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025

SEC source: 0001650664-24-000056 · wk-form4_1717446325.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-05-29

F1 · derivative.exercise_date: This option was granted on May 30, 2024 and is scheduled to vest in full on May 30, 2025.

SEC source: 0001650664-24-000044 · wk-form4_1716409797.xml · nonDerivative · entry 1

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,829

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on May 12, 2023, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on May 17, 2024. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-24-000039 · wk-form4_1715717825.xml · nonDerivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,700

F1 · price: This transaction was executed in multiple trades at prices ranging from $5.43 to $5.83. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000015 · wk-form4_1709686792.xml · nonDerivative · entry 4

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 327,470

F4 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $9.1036 to $9.4298. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000013 · wk-form4_1709686469.xml · nonDerivative · entry 4

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,543

F4 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022 and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on March 2, 2024. The sale does not represent a discretionary trade by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $9.1036 to $9.4298. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-24-000019 · wk-form4_1709687193.xml · derivative · entry 3

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,000

Underlying: Common Stock · 106,000 shares

Expires 2034-03-01

F3 · derivative.exercise_date: This option was granted on March 2, 2024 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2024 through March 2, 2028.

SEC source: 0001650664-24-000019 · wk-form4_1709687193.xml · nonDerivative · entry 2

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 139,166

F2 · kind: Reflects the acquisition, upon the achievement of a specified business development milestone, of a portion of a performance-based restricted stock unit award originally granted on May 17, 2023. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on May 17, 2024, subject to continued service.

SEC source: 0001650664-24-000019 · wk-form4_1709687193.xml · nonDerivative · entry 1

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,200

F1 · kind: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2025 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2028.

SEC source: 0001650664-24-000017 · wk-form4_1709686999.xml · derivative · entry 3

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,400

Underlying: Common Stock · 74,400 shares

Expires 2034-03-01

F3 · derivative.exercise_date: This option was granted on March 2, 2024 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2024 through March 2, 2028.

SEC source: 0001650664-24-000017 · wk-form4_1709686999.xml · nonDerivative · entry 2

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,022

F2 · kind: Reflects the acquisition, upon the achievement of a specified business development milestone, of a portion of a performance-based restricted stock unit award originally granted on July 24, 2023. The shares subject to the restricted stock unit award remain subject to time-based vesting conditions and will vest on July 24, 2024, subject to continued service.

SEC source: 0001650664-24-000017 · wk-form4_1709686999.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,967

F1 · kind: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2025 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2028.

SEC source: 0001650664-24-000015 · wk-form4_1709686792.xml · derivative · entry 5

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 392,100

Underlying: Common Stock · 392,100 shares

Expires 2034-03-01

F6 · derivative.exercise_date: This option was granted on March 2, 2024 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2024 through March 2, 2028.

SEC source: 0001650664-24-000015 · wk-form4_1709686792.xml · nonDerivative · entry 3

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 405,294

F3 · kind: Reflects the vesting, upon the achievement of a business development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 2, 2022.

SEC source: 0001650664-24-000015 · wk-form4_1709686792.xml · nonDerivative · entry 2

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 333,082

F2 · kind: Reflects the vesting, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on June 2, 2022.

SEC source: 0001650664-24-000015 · wk-form4_1709686792.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260,869

F1 · kind: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2025 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2028.

SEC source: 0001650664-24-000013 · wk-form4_1709686469.xml · derivative · entry 5

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 152,800

Underlying: Common Stock · 152,800 shares

Expires 2034-03-01

F6 · derivative.exercise_date: This option was granted on March 2, 2024 and is scheduled to vest over four years in equal monthly installments beginning on April 2, 2024 through March 2, 2028.

SEC source: 0001650664-24-000013 · wk-form4_1709686469.xml · nonDerivative · entry 3

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 161,870

F3 · kind: Reflects the vesting, upon the achievement of a business development milestone, of a portion of a performance-based restricted stock unit award originally granted on July 18, 2022.

SEC source: 0001650664-24-000013 · wk-form4_1709686469.xml · nonDerivative · entry 2

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 142,413

F2 · kind: Reflects the vesting, upon the achievement of a specified research and development milestone, of a portion of a performance-based restricted stock unit award originally granted on July 18, 2022.

SEC source: 0001650664-24-000013 · wk-form4_1709686469.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,955

F1 · kind: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years with 25% of the units vesting on March 2, 2025 and the remaining 75% of the units scheduled to vest in equal quarterly installments thereafter through March 2, 2028.

SEC source: 0001650664-23-000029 · wk-form4_1701984627.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,791

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on December 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $10.6149 to $10.9000. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001650664-23-000022 · wk-form4_1700170220.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,894

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on November 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-23-000019 · wk-form4_1699565469.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,589

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on November 6, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001650664-23-000002 · wk-form4_1694120355.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,728

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on September 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-012264 · form4-08152023_040803.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,831

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on August 10, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-012049 · form4-08102023_040848.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,533

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on August 6, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-011455 · form4-07252023_040701.xml · derivative · entry 2

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,500

Underlying: Common Stock · 135,500 shares

Expires 2033-07-23

F2 · derivative.exercise_date: This option was granted on July 24, 2023 and is scheduled to vest over four years, with 25% of the shares to vest on July 24, 2024 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through July 24, 2027.

SEC source: 0001415889-23-011455 · form4-07252023_040701.xml · nonDerivative · entry 1

Burkly Linda · CIK 0001985604 · EVP, CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,167

F1 · security: The common stock received by the Reporting Person was in connection with the grant of a restricted stock unit award to the Reporting Person, for no consideration, and which is scheduled to vest over four years in equal yearly installments of one-fourth of the shares, with the first such installment to vest on July 24, 2024 continuing through July 24, 2027.

SEC source: 0001415889-23-011382 · form4-07212023_040701.xml · nonDerivative · entry 1

Mei Baisong · CIK 0001938499 · SVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,055

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 14, 2022 and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on July 18, 2023. The sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-23-009368 · form4-06072023_040602.xml · nonDerivative · entry 1

Eaton Bruce · CIK 0001874831 · EVP, CBO AND CTO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,674

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on June 15, 2019, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.4618 to $9.5034. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-009369 · form4-06072023_040605.xml · nonDerivative · entry 1

O'Neill Gilmore Neil · CIK 0001742084 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130,169

F1 · kind: Sale was effected pursuant to a durable automatic sales instruction plan adopted by the Reporting Person on April 13, 2022, and represents the sale of shares by the Issuer necessary to meet tax withholding obligations as a result of vesting in restricted stock units on June 2, 2023. The sale does not represent a discretionary trade by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.4600 to $9.5034. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request, to the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-009234 · form4-06052023_040619.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-009231 · form4-06052023_040604.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-009232 · form4-06052023_040609.xml · derivative · entry 1

Hopfield Jessica · CIK 0001648715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and will vest in full on June 1, 2024.

SEC source: 0001415889-23-009236 · form4-06052023_040621.xml · derivative · entry 1

Connaughton Bernadette · CIK 0001662521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-009237 · form4-06052023_040625.xml · derivative · entry 1

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-009233 · form4-06052023_040614.xml · derivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-009230 · form4-06052023_040602.xml · derivative · entry 1

Chatterjee Meeta · CIK 0001835388 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-05-31

F1 · derivative.exercise_date: This option was granted on June 1, 2023 and is scheduled to vest in full on June 1, 2024.

SEC source: 0001415889-23-008293 · form4-05182023_090554.xml · derivative · entry 2

Lucera Erick · CIK 0001697616 · EVP, CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,800

Underlying: Common Stock · 155,800 shares

Expires 2033-05-16

F2 · derivative.exercise_date: This option was granted on May 17, 2023 and is scheduled to vest over four years, with 25% of the shares to vest on May 17, 2024 and the remaining 75% of the shares scheduled to vest in equal monthly installments thereafter through May 17, 2027.