DNTH

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 8

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,031

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 7

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 81,781

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 6

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,287

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

SEC source: 0001992260-25-000008 · ownership.xml · derivative · entry 11

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,471

Underlying: Common Stock · 3,529 shares

Expires 2034-01-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

F6 · derivative.exercise_date: The shares of common stock underlying this stock option award vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001992260-25-000008 · ownership.xml · derivative · entry 10

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,996

Underlying: Common Stock · 83,978 shares

Expires 2032-06-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

F5 · derivative.exercise_date: The shares of common stock underlying this stock option award vested as to 25% of the shares on April 25, 2023, with the remaining three quarters vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 5

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,000

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $37.48 to $38.22, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 4

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,576

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $36.48 to $37.47, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 3

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,341

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.48 to $36.48, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 2

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 91,507

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

SEC source: 0001992260-25-000008 · ownership.xml · nonDerivative · entry 1

Randhawa Simrat · CIK 0001992260 · EVP, Head of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,978

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 14, 2025.

SEC source: 0001669866-25-000004 · ownership.xml · derivative · entry 1

Garcia Marino · CIK 0001669866 · Director · CEO AND PRESIDENT

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2035-09-30

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after September 30, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001992260-25-000005 · ownership.xml · derivative · entry 1

Randhawa Simrat · CIK 0001992260 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2035-09-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after September 23, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001992324-25-000003 · ownership.xml · derivative · entry 1

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2035-09-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after September 23, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-114293 · ownership.xml · derivative · entry 3

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 104,766

Underlying: Common Stock · 20,000 shares

Expires 2032-06-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 31, 2025.

F2 · derivative.exercise_date: The shares of common stock underlying this stock option award vested as to 25% of the shares on June 2, 2023, with the remaining three quarters vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-114293 · ownership.xml · nonDerivative · entry 2

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 31, 2025.

SEC source: 0000950170-25-114293 · ownership.xml · nonDerivative · entry 1

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 31, 2025.

SEC source: 0000950170-25-076410 · ownership.xml · derivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-25-076412 · ownership.xml · derivative · entry 1

Violin Jonathan · CIK 0001730615 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-25-076406 · ownership.xml · derivative · entry 1

McGeorge Anne · CIK 0001779934 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-25-076408 · ownership.xml · derivative · entry 1

Romano Steven J. · CIK 0001639860 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-25-076403 · ownership.xml · derivative · entry 1

Lawton Alison Frances · CIK 0001542650 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-25-076400 · ownership.xml · derivative · entry 1

Read Simon · CIK 0001688199 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest as to one-third of the shares subject to the option on each of the first, second and third anniversaries of the date of grant, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-033808 · ownership.xml · derivative · entry 1

KANGO SUJAY · CIK 0001336503 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-03-04

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest as to one-third of the shares subject to the option on each of the first, second and third anniversaries of the date of grant, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-013485 · ownership.xml · derivative · entry 1

Randhawa Simrat · CIK 0001992260 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-013516 · ownership.xml · derivative · entry 1

CARR EDWARD · CIK 0001273351 · CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-013488 · ownership.xml · derivative · entry 1

Veness Adam M · CIK 0001778623 · SVP, General Counsel and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-013471 · ownership.xml · derivative · entry 1

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-25-013443 · ownership.xml · derivative · entry 1

Garcia Marino · CIK 0001669866 · Director · CEO AND PRESIDENT

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 340,000

Underlying: Common Stock · 340,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001104659-24-105106 · tm2425346-1_4seq1.xml · nonDerivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Kiselak Tomas · CIK 0001830177 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Fairmount SPV III, LLC

Disclosed balance after: 0

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Fairmount SPV III, LLC ("Fairmount SPV") to its membership interest investors.

F2 · ownership.nature: Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund II L.P. ("Fund II") and the Class A Member for Fairmount SPV. The general partner of Fairmount is Fairmount Funds Management GP LLC ("Fairmount GP"), of which Peter Harwin and Tomas Kiselak are the managing members. Fairmount, Fairmount GP, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0000950170-24-107900 · ownership.xml · derivative · entry 1

Romano Steven J. · CIK 0001639860 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-09-15

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest as to one-third of the shares subject to the option on each of the first, second and third anniversaries of the date of grant, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065565 · ownership.xml · derivative · entry 1

Randhawa Simrat · CIK 0001992260 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after May 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065545 · ownership.xml · derivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-24-065566 · ownership.xml · derivative · entry 1

Veness Adam M · CIK 0001778623 · SVP, General Counsel and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after May 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065567 · ownership.xml · derivative · entry 1

CARR EDWARD · CIK 0001273351 · CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after May 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065564 · ownership.xml · derivative · entry 1

Savitz Ryan · CIK 0001992324 · CFO & CBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after May 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065562 · ownership.xml · derivative · entry 1

Garcia Marino · CIK 0001669866 · Director · CEO AND PRESIDENT

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 243,000

Underlying: Common Stock · 243,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after May 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-065560 · ownership.xml · derivative · entry 1

Violin Jonathan · CIK 0001730615 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-24-065543 · ownership.xml · derivative · entry 1

MOULDER LEON O JR · CIK 0001228865 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-24-065541 · ownership.xml · derivative · entry 1

McGeorge Anne · CIK 0001779934 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-24-065540 · ownership.xml · derivative · entry 1

Lawton Alison Frances · CIK 0001542650 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer through the vesting date.

SEC source: 0000950170-24-065539 · ownership.xml · derivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Kiselak Tomas · CIK 0001830177 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2034-05-22

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in full on the date that is the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's 2025 Annual Meeting of Stockholders, subject to Tomas Kiselak's continued service to the Issuer through the vesting date.

F2 · ownership.nature: Under Mr. Kiselak's arrangement with Fairmount Funds Management LLC ("Fairmount"), Mr. Kiselak holds the option for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Kiselak is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Kiselak therefore disclaims beneficial ownership of the option and underlying common stock. Fairmount disclaims beneficial ownership of any of the reported securities, except to the extent of its pecuniary interest therin.

SEC source: 0000950170-24-039590 · ownership.xml · nonDerivative · entry 2

Fairmount Funds Management LLC · CIK 0001802528 · Director

Kiselak Tomas · CIK 0001830177 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Fairmount Healthcare Fund II LP

Disclosed balance after: 2,700,691

F1 · kind: On April 1, 2024, in connection with the wind down of Fairmount Healthcare Fund LP ("Fund I"), all shares of common stock held by Fund I were transferred to Fairmount Healthcare Fund II LP ("Fund II").

F1 · price: On April 1, 2024, in connection with the wind down of Fairmount Healthcare Fund LP ("Fund I"), all shares of common stock held by Fund I were transferred to Fairmount Healthcare Fund II LP ("Fund II").

F3 · ownership.nature: Fairmount is the investment manager for Fund II. Fairmount, Fairmount GP, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the securities held by Fund II for purposes of Rule 16a-1(a)(2), except to the extent of their pecuniary interest therein.

SEC source: 0000950170-24-039590 · ownership.xml · nonDerivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Kiselak Tomas · CIK 0001830177 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Fairmount Healthcare Fund LP

Disclosed balance after: 0

F1 · kind: On April 1, 2024, in connection with the wind down of Fairmount Healthcare Fund LP ("Fund I"), all shares of common stock held by Fund I were transferred to Fairmount Healthcare Fund II LP ("Fund II").

F1 · price: On April 1, 2024, in connection with the wind down of Fairmount Healthcare Fund LP ("Fund I"), all shares of common stock held by Fund I were transferred to Fairmount Healthcare Fund II LP ("Fund II").

F2 · ownership.nature: Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fund I. The general partner of Fairmount is Fairmount Funds Management GP LLC ("Fairmount GP"), of which Peter Harwin and Tomas Kiselak are the managing members. Fairmount, Fairmount GP, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the securities held by Fund I for purposes of Rule 16a-1(a)(2), except to the extent of their pecuniary interest therein.

SEC source: 0000950170-24-007990 · ownership.xml · derivative · entry 1

Randhawa Simrat · CIK 0001992260 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-008000 · ownership.xml · derivative · entry 1

CARR EDWARD · CIK 0001273351 · CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-007994 · ownership.xml · derivative · entry 1

Veness Adam M · CIK 0001778623 · SVP, General Counsel and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-007979 · ownership.xml · derivative · entry 1

Garcia Marino · CIK 0001669866 · Director · CEO AND PRESIDENT

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,000

Underlying: Common Stock · 275,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-007986 · ownership.xml · derivative · entry 1

Savitz Ryan · CIK 0001992324 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: The shares of common stock underlying this stock option award will vest in equal monthly installments over the four years after January 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-007130 · ownership.xml · derivative · entry 2

Meng Lei · CIK 0001992281 · Director

Avidity Partners Management LP · CIK 0001791827 · Director

Gregory Michael David · CIK 0001993963 · Director

Avidity Partners Management (GP) LLC · CIK 0001993910 · Director

Witzke David Roy · CIK 0001994125 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 1,833,333

Underlying: Common Stock · 1,833,333 shares

Expires not disclosed

F3 · shares: Consists of Pre-Funded Warrants to purchase up to an aggregate of 1,833,333 shares of common stock purchased by clients of Avidity Partners Management LP from the Issuer in a private placement, which transaction is exempt from Section 16(b) in accordance with Rule 16b-3(d)(1) promulgated under the Exchange Act.

F4 · derivative.exercise_date: The Pre-Funded Warrants have no expiration date and are exercisable at any time after the date of issuance. A holder of Pre-Funded Warrants may not exercise the Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 9.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise.

F4 · derivative.expiration_date: The Pre-Funded Warrants have no expiration date and are exercisable at any time after the date of issuance. A holder of Pre-Funded Warrants may not exercise the Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 9.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise.

F2 · ownership.nature: The reported securities are held by clients of Avidity Partners Management LP and may be deemed to beneficially owned by (i) Avidity Partners Management LP, (ii) Avidity Partners Management (GP) LLC, the general partner of Avidity Partners Management LP and (iii) each of David Witzke and Michael Gregory, the managing members of Avidity Partners Management (GP) LLC. Lei Meng, an employee of Avidity Partners Management LP, is a director of the Issuer. Avidity Partners Management LP, Avidity Partners Management (GP) LLC, Mr. Witzke and Mr. Gregory may be considered directors by deputization due to their affiliation with Ms. Meng. Each Reporting Person disclaims beneficial ownership of these shares except to the extent of its, his or her pecuniary interest, if any, therein, and this report shall not be deemed to be an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

SEC source: 0000950170-24-007130 · ownership.xml · nonDerivative · entry 1

Meng Lei · CIK 0001992281 · Director

Avidity Partners Management LP · CIK 0001791827 · Director

Gregory Michael David · CIK 0001993963 · Director

Avidity Partners Management (GP) LLC · CIK 0001993910 · Director

Witzke David Roy · CIK 0001994125 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 2,717,554

F1 · shares: Consists of an aggregate of 1,500,000 shares of common stock purchased by clients of Avidity Partners Management LP from the Issuer in a private placement, which transaction is exempt from Section 16(b) in accordance with Rule 16b-3(d)(1) promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F2 · ownership.nature: The reported securities are held by clients of Avidity Partners Management LP and may be deemed to beneficially owned by (i) Avidity Partners Management LP, (ii) Avidity Partners Management (GP) LLC, the general partner of Avidity Partners Management LP and (iii) each of David Witzke and Michael Gregory, the managing members of Avidity Partners Management (GP) LLC. Lei Meng, an employee of Avidity Partners Management LP, is a director of the Issuer. Avidity Partners Management LP, Avidity Partners Management (GP) LLC, Mr. Witzke and Mr. Gregory may be considered directors by deputization due to their affiliation with Ms. Meng. Each Reporting Person disclaims beneficial ownership of these shares except to the extent of its, his or her pecuniary interest, if any, therein, and this report shall not be deemed to be an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.