CYTK

SEC source: 0001061983-21-000109 · edgardoc.xml · nonDerivative · entry 3

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,920

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 10, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000109 · edgardoc.xml · nonDerivative · entry 2

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 920

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 10, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000109 · edgardoc.xml · nonDerivative · entry 1

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,127

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 10, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000106 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,348

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000100 · edgardoc.xml · nonDerivative · entry 1

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 920

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · derivative · entry 10

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,100 shares

Expires 2021-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

SEC source: 0001061983-21-000102 · edgardoc.xml · derivative · entry 9

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,100

Underlying: Common Stock · 1,100 shares

Expires 2021-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

SEC source: 0001061983-21-000102 · edgardoc.xml · derivative · entry 8

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,200

Underlying: Common Stock · 1,133 shares

Expires 2021-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 6

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,410

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 5

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,510

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 4

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,410

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 3

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,510

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 2

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,410

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000102 · edgardoc.xml · nonDerivative · entry 1

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,543

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 2, 2021

F2 · balance_after: Amount includes 511 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000101 · edgardoc.xml · nonDerivative · entry 1

Wysenski Nancy · CIK 0001294596 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 459

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 459 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000099 · edgardoc.xml · nonDerivative · entry 1

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 920

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000098 · edgardoc.xml · nonDerivative · entry 1

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 920

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000097 · edgardoc.xml · nonDerivative · entry 1

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,529

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 1,725 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000096 · edgardoc.xml · nonDerivative · entry 1

Califf Robert · CIK 0001574557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 459

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $24.44, representing the Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 459 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001209191-22-007845 · doc4a.xml · nonDerivative · entry 1

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,819

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all of part of directors' annual base retainer program. Shares are fully vested from the moment of grant. Shares issued at a per share price of $24.44, representing Issuer's closing stock price on April 1, 2021.

F2 · balance_after: Amount includes 920 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000095 · edgardoc.xml · derivative · entry 1

Callos Andrew · CIK 0001852129 · EVP, Chief Commercial Officers

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2031-03-31

F1 · derivative.exercise_date: Stock options will vest over 4 years from the date of the grant, with 1/4th of the shares underlying the reporting person's option vesting on the one-year anniversary of the grant date and the remaining shares thereafter vesting monthly at a rate of 1/48th of the shares underlying the reporting person's option over the subsequent 36 months, subject to the reporting person's continued employment with the Issuer.

SEC source: 0001061983-21-000087 · edgardoc.xml · derivative · entry 8

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,065

Underlying: Common Stock · 566 shares

Expires 2022-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000087 · edgardoc.xml · derivative · entry 7

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,434 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000087 · edgardoc.xml · nonDerivative · entry 4

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,859

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000087 · edgardoc.xml · nonDerivative · entry 3

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 357,425

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000087 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,859

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000087 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 361,293

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000085 · edgardoc.xml · derivative · entry 4

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2022-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000085 · edgardoc.xml · nonDerivative · entry 2

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,762

SEC source: 0001061983-21-000085 · edgardoc.xml · nonDerivative · entry 1

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,762

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000083 · edgardoc.xml · derivative · entry 7

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,333 shares

Expires 2021-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000083 · edgardoc.xml · derivative · entry 6

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 7,006 shares

Expires 2022-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000083 · edgardoc.xml · nonDerivative · entry 4

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,762

SEC source: 0001061983-21-000083 · edgardoc.xml · nonDerivative · entry 3

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000083 · edgardoc.xml · nonDerivative · entry 2

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,762

SEC source: 0001061983-21-000083 · edgardoc.xml · nonDerivative · entry 1

GAGE L PATRICK · CIK 0001196903 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,768

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000081 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,348

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000064 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,434

Underlying: Common Stock · 5,000 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000064 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,658

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000064 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 385,658

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000078 · edgardoc.xml · nonDerivative · entry 1

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,850

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

SEC source: 0001061983-21-000079 · edgardoc.xml · nonDerivative · entry 1

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,879

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes up to 5,238 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000077 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 166,348

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000076 · edgardoc.xml · nonDerivative · entry 1

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,492

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 727 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000075 · edgardoc.xml · nonDerivative · entry 1

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,625

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes up to 13,132 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000074 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,859

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/06/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000061 · edgardoc.xml · derivative · entry 3

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,871

Underlying: Common Stock · 34,871 shares

Expires 2031-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000061 · edgardoc.xml · derivative · entry 2

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,129

Underlying: Common Stock · 10,129 shares

Expires 2031-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000061 · edgardoc.xml · nonDerivative · entry 1

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,000

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

SEC source: 0001061983-21-000062 · edgardoc.xml · derivative · entry 3

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,092

Underlying: Common Stock · 8,092 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.