CYTK

SEC source: 0001061983-22-000029 · edgardoc.xml · nonDerivative · entry 2

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,291

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000029 · edgardoc.xml · nonDerivative · entry 1

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,041

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000028 · edgardoc.xml · nonDerivative · entry 2

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,875

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000028 · edgardoc.xml · nonDerivative · entry 1

SCHLOSSBERG MARK A · CIK 0001520533 · SVP - Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,750

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000027 · edgardoc.xml · nonDerivative · entry 2

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,462

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000027 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,087

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000026 · edgardoc.xml · nonDerivative · entry 2

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,151

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000026 · edgardoc.xml · nonDerivative · entry 1

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,026

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000025 · edgardoc.xml · nonDerivative · entry 2

Cragg David · CIK 0001316459 · Chief HR & Admin Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 144,161

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000025 · edgardoc.xml · nonDerivative · entry 1

Cragg David · CIK 0001316459 · Chief HR & Admin Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,036

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000024 · edgardoc.xml · nonDerivative · entry 2

Callos Andrew · CIK 0001852129 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,196

F2 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000024 · edgardoc.xml · nonDerivative · entry 1

Callos Andrew · CIK 0001852129 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,071

F1 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000031 · edgardoc.xml · derivative · entry 7

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,208

Underlying: Common Stock · 10,000 shares

Expires 2025-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

SEC source: 0001061983-22-000031 · edgardoc.xml · nonDerivative · entry 4

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 375,118

F3 · kind: Comprised of restricted stock units (RSUs) issued upon conversion of certain PSUs granted to the Reporting Person on May 11, 2021. The satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into RSUs of the Issuer. These RSUs will vest in whole on February 16, 2023.

SEC source: 0001061983-22-000031 · edgardoc.xml · nonDerivative · entry 3

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 366,368

F2 · kind: On or about May 11, 2021, the Reporting Person was granted performance-based stock units (PSUs) of the Issuer, which upon satisfaction and certification of the performance metric resulted in a portion of the PSUs being converted into fully-vested shares of common stock of the Issuer.

SEC source: 0001061983-22-000031 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 360,644

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

SEC source: 0001061983-22-000031 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 370,644

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

SEC source: 0001061983-22-000017 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,208

Underlying: Common Stock · 10,000 shares

Expires 2025-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

SEC source: 0001061983-22-000017 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 360,644

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

F2 · balance_after: Includes 6,276 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-22-000017 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 370,644

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on December 22, 2021.

F2 · balance_after: Includes 6,276 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-22-000014 · edgardoc.xml · nonDerivative · entry 1

Wysenski Nancy · CIK 0001294596 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,003

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 1,003 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000013 · edgardoc.xml · nonDerivative · entry 1

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,887

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 1,887 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000012 · edgardoc.xml · nonDerivative · entry 1

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,887

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 1,887 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000011 · edgardoc.xml · nonDerivative · entry 1

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,009

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 2,009 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000010 · edgardoc.xml · nonDerivative · entry 1

HENDERSON JOHN T · CIK 0001226488 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,499

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 2,009 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000008 · edgardoc.xml · nonDerivative · entry 1

Bhanji Muna · CIK 0001846905 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,244

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 244 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-22-000009 · edgardoc.xml · nonDerivative · entry 1

Califf Robert · CIK 0001574557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,003

F1 · kind: Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Shares are full vested from the moment of grant. Shares issued at per share price of $46.00, representing the Issuer's closing stock price on January 3, 2022.

F2 · balance_after: Amount includes 1,003 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · derivative · entry 9

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,834

Underlying: Common Stock · 4,166 shares

Expires 2031-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000268 · edgardoc.xml · derivative · entry 8

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2030-05-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000268 · edgardoc.xml · derivative · entry 7

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,124 shares

Expires 2030-02-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 6

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 5

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,889

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 4

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 3

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,765

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 2

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000268 · edgardoc.xml · nonDerivative · entry 1

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,931

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000269 · edgardoc.xml · derivative · entry 3

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,166 shares

Expires 2022-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000269 · edgardoc.xml · nonDerivative · entry 2

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on November 24, 2021.

F2 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000269 · edgardoc.xml · nonDerivative · entry 1

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,931

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on November 24, 2021.

F2 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000265 · edgardoc.xml · derivative · entry 3

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2026-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000265 · edgardoc.xml · nonDerivative · entry 2

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on November 12, 2021.

F2 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000265 · edgardoc.xml · nonDerivative · entry 1

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,765

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on November 12, 2021.

F2 · balance_after: Amount includes 1,765 shares of common stock received at Reporting Person's election pursuant Issuer's stock in lieu of cash for all or part of directors' annual base retainer program.

SEC source: 0001061983-21-000263 · edgardoc.xml · derivative · entry 6

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,427 shares

Expires 2022-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000263 · edgardoc.xml · derivative · entry 5

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 22,739 shares

Expires 2022-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000263 · edgardoc.xml · nonDerivative · entry 4

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,314

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 2,436 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000263 · edgardoc.xml · nonDerivative · entry 3

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 172,053

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 2,436 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000263 · edgardoc.xml · nonDerivative · entry 2

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,314

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 2,436 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000263 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,741

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan meeting the requirements of Rule 10b5-1(c) under the Exchange Act entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 2,436 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000261 · edgardoc.xml · derivative · entry 9

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2027-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000261 · edgardoc.xml · derivative · entry 8

SMITH SANDFORD D · CIK 0001243004 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,032 shares

Expires 2027-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.