CYPH

SEC source: 0001104659-19-005836 · a4.xml · nonDerivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · CEO, President, Chairman · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,114,804

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Christopher Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-000514 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000507 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000509 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000512 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO,GC,Treasurer and Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000511 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000513 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · Pres,CEO Chairman of Board · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000506 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000504 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-19-000508 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,375

Underlying: Common Stock · 9,375 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

SEC source: 0001104659-18-048858 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,137

Underlying: Common Stock · 2,137 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P., of which the reporting person is a limited partner. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock.

SEC source: 0001104659-18-048859 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,137

Underlying: Common Stock · 2,137 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P., of which the reporting person is a limited partner. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock.

SEC source: 0001104659-18-048857 · a4.xml · derivative · entry 1

WERNER HAROLD R · CIK 0001013603 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,137

Underlying: Common Stock · 2,137 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P. to its limited partner, Werner Family Investment L.P. Harold R. Werner is the general partner of Werner Family Investment L.P. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock.

F1 · ownership.direct: Pro rata distribution from HealthCare Ventures IX, L.P. to its limited partner, Werner Family Investment L.P. Harold R. Werner is the general partner of Werner Family Investment L.P. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock.

F1 · ownership.nature: Pro rata distribution from HealthCare Ventures IX, L.P. to its limited partner, Werner Family Investment L.P. Harold R. Werner is the general partner of Werner Family Investment L.P. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock.

SEC source: 0001104659-18-048864 · a4.xml · derivative · entry 1

HealthCare Ventures IX, L.P. · CIK 0001490245 · 10% owner

Healthcare Partners IX, L.P. · CIK 0001697027 · 10% owner

Healthcare Partners IX, LLC · CIK 0001698828 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,057,769 shares

Expires 2024-11-14

F1 · kind: HealthCare Ventures IX, L.P. ("HCV IX") distributed these warrants to its limited partners on a pro rata basis, for no consideration. In the distribution, Eli Lilly and Company, a 5% or greater stockholder of the Company and limited partner of HCV IX, received a warrant to purchase 331,221 shares of common stock. No shares of outstanding common stock were distributed. HCV IX continues to hold 3,573,376 shares of common stock, which represents 24.3% of the outstanding common stock.

SEC source: 0001104659-18-048863 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC, Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 21,369

Underlying: Common Stock · 21,369 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities. The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX and (ii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF").

F2 · kind: HCV IX continues to hold 3,573,376 shares of common stock and HCV SF continues to hold 343,889 shares of common stock, representing 24.3% and 2.3% respectively, and 26.6% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.direct: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities. The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX and (ii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF").

F2 · ownership.direct: HCV IX continues to hold 3,573,376 shares of common stock and HCV SF continues to hold 343,889 shares of common stock, representing 24.3% and 2.3% respectively, and 26.6% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.nature: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities. The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX and (ii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF").

F2 · ownership.nature: HCV IX continues to hold 3,573,376 shares of common stock and HCV SF continues to hold 343,889 shares of common stock, representing 24.3% and 2.3% respectively, and 26.6% in the aggregate, of the outstanding shares of common stock.

SEC source: 0001104659-18-048861 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 21,369

Underlying: Common Stock · 21,369 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · kind: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.direct: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · ownership.direct: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.nature: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Mr. Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · ownership.nature: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

SEC source: 0001104659-18-048862 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · CEO, President and COB · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 21,369

Underlying: Common Stock · 21,369 shares

Expires 2024-11-14

F1 · kind: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Dr. Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · kind: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.direct: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Dr. Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · ownership.direct: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

F1 · ownership.nature: Pro rata distribution from HealthCare Ventures IX, L.P. ("HCV IX") to its limited partner, Nine Capital Partners, LLC. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor are the Managing Members of Nine Capital Partners, LLC, and as such, beneficially own and share voting and dispositive power with respect to all of the securities owned by Nine Capital Partners, LLC. Dr. Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

F2 · ownership.nature: The reporting person is also (i) a Managing Director of HealthCare Partners IX, LLC, which is the General Partner of HealthCare Partners IX, L.P., which is the General Partner of HCV IX, (ii) a Managing Director of HealthCare Partners VIII, LLC, which is the General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"), and (iii) a Managing Director of HCV Strategic LLC, which is the General Partner of HealthCare Ventures Strategic Fund, L.P. ("HCV SF"). HCV IX continues to hold 3,573,376 shares of common stock, HCV VIII continues to hold 2,618,406 shares of common stock, and HCV SF continues to hold 343,889 shares of common stock, representing 24.3%, 17.8%, and 2.3%, respectively, and 44.5% in the aggregate, of the outstanding shares of common stock.

SEC source: 0000059478-18-000198 · wf-form4_153419584098663.xml · derivative · entry 1

LILLY ELI & CO · CIK 0000059478 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 331,221

Underlying: Common Stock, $0.001 par value per share · 331,221 shares

Expires 2024-11-14

SEC source: 0001104659-18-025617 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025612 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025620 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025610 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock, $0.001 par value per share · 50,000 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025611 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock, $0.001 par value per share · 50,000 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025615 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · President, CEO & COB · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock, $0.001 par value per share · 50,000 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025622 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025619 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-18-025613 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock, $0.001 par value per share · 11,250 shares

Expires 2028-04-17

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 18, 2018, the Vesting Start Date.

SEC source: 0001104659-17-069120 · a4.xml · derivative · entry 2

HealthCare Ventures IX, L.P. · CIK 0001490245 · 10% owner

Healthcare Partners IX, L.P. · CIK 0001697027 · 10% owner

Healthcare Partners IX, LLC · CIK 0001698828 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,057,769

Underlying: Common Stock, $0.001 par value per share · 1,057,769 shares

Expires 2024-11-14

F2 · price: The reported securities were included with the 1,057,759 shares of common stock purchased by the reporting persons for $6.085 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.direct: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX indirectly beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. and each disclaims beneficial ownership of these shares except to the extent of his or its proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069120 · a4.xml · nonDerivative · entry 1

HealthCare Ventures IX, L.P. · CIK 0001490245 · 10% owner

Healthcare Partners IX, L.P. · CIK 0001697027 · 10% owner

Healthcare Partners IX, LLC · CIK 0001698828 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,573,376

F1 · ownership.direct: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX indirectly beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. and each disclaims beneficial ownership of these shares except to the extent of his or its proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069119 · a4.xml · derivative · entry 3

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC, Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,057,769

Underlying: Common Stock, $0.001 par value per share · 1,057,769 shares

Expires 2024-11-14

F3 · price: The reported securities were included with the 1,057,759 shares of common stock purchased by HealthCare Ventures IX, L.P. for $6.085 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Douglas E. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069119 · a4.xml · nonDerivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC, Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 3,573,376

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Douglas E. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069118 · a4.xml · derivative · entry 4

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,057,769

Underlying: Common Stock, $0.001 par value per share · 1,057,769 shares

Expires 2024-11-14

F4 · price: The reported securities were included with the 1,057,759 shares of common stock purchased by HealthCare Ventures IX, L.P. for $6.085 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Augustine Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069118 · a4.xml · nonDerivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,573,376

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Augustine Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069117 · a4.xml · derivative · entry 4

Mirabelli Christopher · CIK 0001262326 · Director · CEO, President, COB · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,057,769

Underlying: Common Stock, $0.001 par value per share · 1,057,769 shares

Expires 2024-11-14

F4 · price: The reported securities were included with the 1,057,759 shares of common stock purchased by HealthCare Ventures IX, L.P. for $6.085 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Christopher Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-069117 · a4.xml · nonDerivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · CEO, President, COB · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,573,376

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Christopher Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-17-003613 · a4.xml · derivative · entry 2

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F2 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F2 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

SEC source: 0001104659-17-003613 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock, $0.001 par value per share · 11,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

SEC source: 0001104659-17-003610 · a4.xml · derivative · entry 2

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F2 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F2 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

SEC source: 0001104659-17-003610 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock, $0.001 par value per share · 11,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

SEC source: 0001104659-17-003608 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO,Gen Counsel,Treas, Sec. · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,303

Underlying: Common Stock, $0.001 par value per share · 330,303 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

SEC source: 0001104659-17-003609 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,303

Underlying: Common Stock, $0.001 par value per share · 330,303 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

SEC source: 0001104659-17-003607 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · CEO,Pres,Chairman of the Board · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,303

Underlying: Common Stock, $0.001 par value per share · 330,303 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and become exercisable with respect to 33 1/3% of the Option Shares on the one-year anniversary of January 23, 2017, the Vesting Start Date (the "First Vesting Date"), after which it shall vest in a series of 24 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of the First Vesting Date.

SEC source: 0001104659-17-003611 · a4.xml · derivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F2 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F2 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

SEC source: 0001104659-17-003611 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock, $0.001 par value per share · 11,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and is fully vested as of the grant date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and shall vest and is fully vested as of the grant date.

SEC source: 0001104659-17-003612 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

SEC source: 0001104659-17-003614 · a4.xml · derivative · entry 2

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F2 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F2 · derivative.underlying_shares: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

SEC source: 0001104659-17-003614 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock, $0.001 par value per share · 11,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

F1 · derivative.underlying_shares: The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and is fully vested as of the grant date.

SEC source: 0001104659-17-004067 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock, $0.001 par value per share · 15,000 shares

Expires 2027-01-22

F1 · derivative.exercise_date: The Option shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.

F1 · derivative.underlying_shares: The Option shall vest and become exercisable in a series of 12 equal quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 23, 2017, the Vesting Start Date.