CYPH

SEC source: 0001104659-21-001647 · tm211724-3_4seq1.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,300

Underlying: Common Stock · 32,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

SEC source: 0001104659-21-001646 · tm211724-2_4seq1.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,300

Underlying: Common Stock · 32,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

SEC source: 0001104659-21-001644 · tm211724-1_4seq1.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,300

Underlying: Common Stock · 32,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

SEC source: 0001104659-21-001652 · tm211724-5_4seq1.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,300

Underlying: Common Stock · 32,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

SEC source: 0001104659-21-001649 · tm211724d4_4seq1.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,300

Underlying: Common Stock · 37,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

SEC source: 0001104659-20-140672 · tm2039504d1_4seq1.xml · nonDerivative · entry 1

HealthCare Ventures VIII, L.P. · CIK 0001358990 · 10% owner

HealthCare Partners VIII, LLC · CIK 0001358992 · 10% owner

HealthCare Partners VIII, L.P. · CIK 0001358991 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: On December 28, 2020, HealthCare Ventures VIII, L.P. ("HCV VIII") transferred, for no consideration, all 2,618,406 shares it held (the "Transfer") to HCV VIII Liquidating Trust (the "Trust"). The Transfer was effected in connection with the process of winding-down, liquidating and dissolving HCV VIII. HCV VIII is a venture capital fund with a standard 10-year term. In accordance with the limited partnership agreement of HCV VIII, that term was previously extended for consecutive one-year periods, and the fund is currently in liquidation. The general partner of HCV VIII has begun taking the requisite steps to wind-up, liquidate and dissolve HCV VIII.

F2 · kind: The general partner of HCV VIII has made the decision not to distribute to the partners of HCV VIII any of the 2,618,406 shares held by HCV VIII at this time. Instead, the general partner of HCV VIII has decided to transfer all of such 2,618,406 shares to the Trust, a liquidating trust that will be managed by Augustine Lawlor, as trustee. Mr. Lawlor is one of the Managing Directors of the general partner of HCV VIII. The Trust will hold all of the 2,618,406 shares transferred to it pursuant to the Transfer until such time as the trustee of the Trust determines in his discretion to either sell such shares or distribute such shares to the former partners of HCV VIII for no consideration and on a pro rata basis in accordance with the limited partnership agreement of HCV VIII.

F3 · kind: For so long as the Trust owns such shares, the trustee of the Trust shall have the power to cause the Trust to exercise its voting rights as the record or beneficial owner of such shares in such manner as the trustee shall determine in his discretion.

F4 · ownership.direct: All 2,618,406 shares were held of record by HCV VIII. Christopher K. Mirabelli, James H. Cavanaugh, John W. Littlechild, Harold Werner and Augustine Lawlor (collectively, the "HCVVIII Directors") are the Managing Directors of HealthCare Partners VIII, LLC ("HCPVIII LLC"), which is the General Partner of HealthCare Partners, VIII, L.P. ("HCPVIII"), which is the General Partner of HCV VIII. Each of the HCVVIII Directors, HCPVIII LLC and HCPVIII indirectly beneficially owned and shared voting and dispositive power with respect to all of the securities owned by HCV VIII, and disclaimed beneficial ownership of these shares except to the extent of his or its proportionate pecuniary interest therein.

F5 · ownership.direct: Following the Transfer, each of the HCVVIII Directors, HCPVIII LLC and HCPVIII will maintain the same proportionate pecuniary interest in the 2,618,406 shares held by the Trust as the proportionate pecuniary interest each such person and entity maintained in those shares when they were held by HCV VIII, and likewise disclaims beneficial ownership of such shares as held by the Trust, except to the extent of his or its proportionate pecuniary interest therein.

SEC source: 0001104659-20-094195 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094203 · a4.xml · derivative · entry 1

Sirard Cynthia · CIK 0001808408 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094193 · a4.xml · derivative · entry 1

O'Mahony John Mark · CIK 0001808556 · Chief Manufacturing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094191 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094204 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · Director · CEO, Pres.,GC, Treas., & Sec. · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094201 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094192 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · Chairman of the Board · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094197 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094199 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0001104659-20-094194 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

SEC source: 0000899243-20-017581 · doc4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 8,476,496

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001104659-20-046077 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046080 · a4.xml · derivative · entry 1

Sirard Cynthia · CIK 0001808408 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046079 · a4.xml · derivative · entry 1

O'Mahony John Mark · CIK 0001808556 · Chief Manufacturing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046076 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046072 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046073 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046074 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046075 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-046078 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

SEC source: 0001104659-20-035911 · a4.xml · derivative · entry 2

ONSI DOUGLAS E · CIK 0001270185 · Director · CFO,GC,Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 660,606

Underlying: Common Stock · 660,606 shares

Expires not disclosed

F2 · derivative.exercise_price: The Restricted Stock Units were awarded pursuant to Leap's 2016 Equity Incentive Plan for no consideration. Restricted Stock Units may be settled in common stock, cash or a combination of the two at Leap's election.

F2 · price: The Restricted Stock Units were awarded pursuant to Leap's 2016 Equity Incentive Plan for no consideration. Restricted Stock Units may be settled in common stock, cash or a combination of the two at Leap's election.

F3 · derivative.exercise_date: The Restricted Stock Units will cliff vest and be settled after three years of continuous service or upon a change of control of Leap, whichever is earlier.

F3 · derivative.expiration_date: The Restricted Stock Units will cliff vest and be settled after three years of continuous service or upon a change of control of Leap, whichever is earlier.

SEC source: 0001104659-20-035911 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · Director · CFO,GC,Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 500,000 shares

Expires 2030-03-18

F1 · derivative.exercise_date: The Stock Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in equal monthly installments over a three-year period from the date of grant.

SEC source: 0001104659-20-029235 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-20-029242 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-20-029237 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-20-029241 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-20-029239 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-20-029236 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

SEC source: 0001104659-19-035076 · a4.xml · derivative · entry 1

CAVANAUGH JAMES H · CIK 0001013473 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035075 · a4.xml · derivative · entry 1

LITTLECHILD JOHN W · CIK 0001013469 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035072 · a4.xml · derivative · entry 1

LI WILLIAM · CIK 0001273806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035077 · a4.xml · derivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO,GC,Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035079 · a4.xml · derivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035073 · a4.xml · derivative · entry 1

Mirabelli Christopher · CIK 0001262326 · Director · Pres., CEO & Chairman of Board · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035081 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035078 · a4.xml · derivative · entry 1

Mashiach Nissim · CIK 0001357777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-035074 · a4.xml · derivative · entry 1

Dietz Thomas John · CIK 0001574218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

SEC source: 0001104659-19-005835 · a4.xml · derivative · entry 2

HealthCare Ventures IX, L.P. · CIK 0001490245 · 10% owner

Healthcare Partners IX, L.P. · CIK 0001697027 · 10% owner

Healthcare Partners IX, LLC · CIK 0001698828 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 571,428

Underlying: Common Stock, $0.001 par value per share · 571,428 shares

Expires 2026-02-05

F2 · price: The reported securities were included with the 571,428 shares of common stock purchased by the reporting persons for $1.75 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.direct: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX indirectly beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. and each disclaims beneficial ownership of these shares except to the extent of his or its proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005835 · a4.xml · nonDerivative · entry 1

HealthCare Ventures IX, L.P. · CIK 0001490245 · 10% owner

Healthcare Partners IX, L.P. · CIK 0001697027 · 10% owner

Healthcare Partners IX, LLC · CIK 0001698828 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,144,804

F1 · ownership.direct: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX indirectly beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. and each disclaims beneficial ownership of these shares except to the extent of his or its proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005838 · a4.xml · derivative · entry 3

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC, Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 592,797

Underlying: Common Stock, $0.001 par value per share · 571,428 shares

Expires 2026-02-05

F3 · price: The reported securities were included with the 571,428 shares of common stock purchased by HealthCare Ventures IX, L.P. for $1.75 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Douglas E. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005838 · a4.xml · nonDerivative · entry 1

ONSI DOUGLAS E · CIK 0001270185 · CFO, GC, Treasurer & Secretary · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,114,804

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Douglas E. Onsi disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005837 · a4.xml · derivative · entry 4

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 592,797

Underlying: Common Stock, $0.001 par value per share · 571,428 shares

Expires 2026-02-05

F4 · price: The reported securities were included with the 571,428 shares of common stock purchased by HealthCare Ventures IX, L.P. for $1.75 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Augustine Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005837 · a4.xml · nonDerivative · entry 1

LAWLOR AUGUSTINE · CIK 0001262327 · Chief Operating Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,114,804

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Augustine Lawlor disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.

SEC source: 0001104659-19-005836 · a4.xml · derivative · entry 4

Mirabelli Christopher · CIK 0001262326 · Director · CEO, President, Chairman · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 592,797

Underlying: Common Stock, $0.001 par value per share · 571,428 shares

Expires 2026-02-05

F4 · price: The reported securities were included with the 571,428 shares of common stock purchased by HealthCare Ventures IX, L.P. for $1.75 per share. Each such purchased share of common stock was issued with a warrant to purchase one share of common stock.

F1 · ownership.nature: The shares are owned directly by HealthCare Ventures IX, L.P. Christopher K. Mirabelli, Douglas E. Onsi and Augustine Lawlor (collectively, the "HCVIX Directors") are the Managing Directors of HealthCare Partners IX, LLC ("HCPIX LLC"), which is the General Partner of HealthCare Partners IX, L.P. ("HCPIX"), which is the General Partner of HealthCare Ventures IX, L.P. Each of the HCVIX Directors, HCPIX LLC and HCPIX beneficially own and share voting and dispositive power with respect to all of the securities owned by HealthCare Ventures IX, L.P. Christopher Mirabelli disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest in these securities.