CTMX

SEC source: 0001610717-26-000351 · form4.xml · derivative · entry 2

Carvajal Alejandra · CIK 0001645755 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2036-08-02

F3 · derivative.exercise_date: 25% of the shares subject to the option vest on the one-year anniversary measured from August 3, 2026 (the "Vesting Commencement Date"), and 1/48 monthly thereafter such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000351 · form4.xml · nonDerivative · entry 1

Carvajal Alejandra · CIK 0001645755 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 25% of the RSUs vest annually on September 15 of each year, with the first 25% vesting on September 15, 2027, subject to the Reporting Person's continued service to the Issuer through each such date.

F2 · balance_after: Includes 100,000 RSUs.

SEC source: 0001610717-26-000345 · form4.xml · derivative · entry 1

Fuchs Charles S. · CIK 0001719576 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,000

Underlying: Common Stock · 118,000 shares

Expires 2036-07-23

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 24, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000275 · form4.xml · derivative · entry 1

Ashworth Alan · CIK 0001886426 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000274 · form4.xml · derivative · entry 1

Jones Elaine V · CIK 0001296907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000277 · form4.xml · derivative · entry 1

Meyers James R · CIK 0001387521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000279 · form4.xml · derivative · entry 1

Young Matthew P. · CIK 0001601583 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000280 · form4.xml · derivative · entry 1

Su Zhen · CIK 0001991642 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000276 · form4.xml · derivative · entry 1

Gilbert Halley E · CIK 0001601360 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000278 · form4.xml · derivative · entry 1

Mohindru Mani · CIK 0001664708 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2036-06-16

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2027 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-26-000229 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 295,324

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 167,249 RSUs.

SEC source: 0001610717-26-000123 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,760

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 135,833 RSUs.

SEC source: 0001610717-26-000125 · form4.xml · nonDerivative · entry 1

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 189,446

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 149,833 RSUs.

SEC source: 0001610717-26-000124 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,078,922

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 457,500 RSUs.

SEC source: 0001610717-26-000122 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 296,948

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 173,082 RSUs.

SEC source: 0001610717-26-000043 · form4.xml · derivative · entry 3

Lester Rachael · CIK 0002094324 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-26-000043 · form4.xml · derivative · entry 2

Lester Rachael · CIK 0002094324 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000043 · form4.xml · nonDerivative · entry 1

Lester Rachael · CIK 0002094324 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 20,000 RSUs.

SEC source: 0001610717-26-000041 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000041 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 332,252

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 218,958 RSUs.

SEC source: 0001610717-26-000042 · form4.xml · derivative · entry 2

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000042 · form4.xml · nonDerivative · entry 1

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,725

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 206,000 RSUs.

SEC source: 0001610717-26-000040 · form4.xml · derivative · entry 2

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,000

Underlying: Common Stock · 325,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000040 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 316,271

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 239,987 RSUs.

SEC source: 0001610717-26-000039 · form4.xml · derivative · entry 3

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 980,000

Underlying: Common Stock · 980,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000039 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,197,891

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 698,750 RSUs.

SEC source: 0001610717-25-000372 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 987,891

F1 · kind: The transactions reported herein were effected pursuant to the Reporting Person's Rule 10b5-1 trading plan, adopted on August 27, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $4.50 to $4.62, inclusive. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

F3 · balance_after: Includes 488,750 restricted stock units.

SEC source: 0001610717-25-000370 · form4.xml · derivative · entry 1

Lester Rachael · CIK 0002094324 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 650,000

Underlying: Common Stock · 650,000 shares

Expires 2035-10-19

F1 · derivative.exercise_date: 25% of the shares subject to the option vest on the one year anniversary measured from October 20, 2025 (the "Vesting Commencement Date"), and 1/48th of the shares will vest monthly thereafter, such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000354 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,150

Underlying: Common Stock · 18,150 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000354 · form4.xml · derivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Common Stock · 36,300 shares

Expires 2035-09-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from September 26, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000356 · form4.xml · derivative · entry 2

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,750

Underlying: Common Stock · 43,750 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000356 · form4.xml · derivative · entry 1

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,500

Underlying: Common Stock · 87,500 shares

Expires 2035-09-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from September 26, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000357 · form4.xml · derivative · entry 2

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,000

Underlying: Common Stock · 285,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000357 · form4.xml · derivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 570,000

Underlying: Common Stock · 570,000 shares

Expires 2035-09-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from September 26, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000355 · form4.xml · derivative · entry 2

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,150

Underlying: Common Stock · 39,150 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000355 · form4.xml · derivative · entry 1

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,250

Underlying: Common Stock · 78,250 shares

Expires 2035-09-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from September 26, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000235 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 272,252

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 158,958 restricted stock units.

SEC source: 0001610717-25-000236 · form4.xml · nonDerivative · entry 3

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 226,271

F4 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 149,987 RSUs.

SEC source: 0001610717-25-000234 · form4.xml · nonDerivative · entry 2

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,089,684

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 488,750 restricted stock units.

SEC source: 0001610717-25-000235 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 37,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F4 · derivative.exercise_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F4 · derivative.expiration_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

SEC source: 0001610717-25-000235 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 286,136

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction represents the vesting of performance stock units ("PSUs") initially granted on February 2, 2023.

F2 · balance_after: Includes 158,958 restricted stock units.

SEC source: 0001610717-25-000236 · form4.xml · derivative · entry 4

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 37,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F5 · derivative.exercise_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F5 · derivative.expiration_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

SEC source: 0001610717-25-000236 · form4.xml · nonDerivative · entry 2

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 236,885

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This transaction represents the vesting of performance stock units ("PSUs") initially granted on February 2, 2023.

F2 · balance_after: Includes 149,987 RSUs.

SEC source: 0001610717-25-000236 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 199,385

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 149,987 RSUs.

SEC source: 0001610717-25-000234 · form4.xml · derivative · entry 4

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 150,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F5 · derivative.exercise_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F5 · derivative.expiration_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

SEC source: 0001610717-25-000234 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,145,195

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction represents the vesting of performance stock units ("PSUs") initially granted on February 2, 2023.

F2 · balance_after: Includes 488,750 restricted stock units.

SEC source: 0001610717-25-000209 · form4.xml · derivative · entry 1

Ashworth Alan · CIK 0001886426 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2026 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-25-000211 · form4.xml · derivative · entry 1

Jones Elaine V · CIK 0001296907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2026 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-25-000212 · form4.xml · derivative · entry 1

Meyers James R · CIK 0001387521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2026 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-25-000215 · form4.xml · derivative · entry 1

Su Zhen · CIK 0001991642 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2026 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.