CSTL

SEC source: 0001447362-20-000082 · wf-form4_159052388689095.xml · derivative · entry 2

Monzon Federico A. · CIK 0001783133 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,584

Underlying: Common Stock · 20,000 shares

Expires 2026-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the option are fully vested.

SEC source: 0001447362-20-000082 · wf-form4_159052388689095.xml · nonDerivative · entry 1

Monzon Federico A. · CIK 0001783133 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,459

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001447362-20-000078 · wf-form4_159052360680850.xml · nonDerivative · entry 4

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,670,218

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $38.04 to $38.28, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000078 · wf-form4_159052360680850.xml · nonDerivative · entry 3

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,671,089

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.98, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000076 · wf-form4_159017812288427.xml · nonDerivative · entry 4

BRADBURY DANIEL · CIK 0001236397 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By LLC

Disclosed balance after: 893,578

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by BioBrit, LLC (the "LLC") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $37.150 to $37.915, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the LLC, of which the Reporting Person is the managing member and has voting and investment power over the shares.

SEC source: 0001447362-20-000076 · wf-form4_159017812288427.xml · nonDerivative · entry 3

BRADBURY DANIEL · CIK 0001236397 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By LLC

Disclosed balance after: 895,829

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by BioBrit, LLC (the "LLC") on March 13, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $36.140 to $37.140, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the LLC, of which the Reporting Person is the managing member and has voting and investment power over the shares.

SEC source: 0001447362-20-000078 · wf-form4_159052360680850.xml · nonDerivative · entry 2

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,681,414

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $38.10 to $38.58, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000078 · wf-form4_159052360680850.xml · nonDerivative · entry 1

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,682,214

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.99, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000070 · wf-form4_159009171514660.xml · nonDerivative · entry 2

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,692,836

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.39, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000076 · wf-form4_159017812288427.xml · nonDerivative · entry 2

BRADBURY DANIEL · CIK 0001236397 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By LLC

Disclosed balance after: 897,328

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by BioBrit, LLC (the "LLC") on March 13, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $37.170 to $37.390, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the LLC, of which the Reporting Person is the managing member and has voting and investment power over the shares.

SEC source: 0001447362-20-000076 · wf-form4_159017812288427.xml · nonDerivative · entry 1

BRADBURY DANIEL · CIK 0001236397 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By LLC

Disclosed balance after: 898,979

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by BioBrit, LLC (the "LLC") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $36.145 to $37.145, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the LLC, of which the Reporting Person is the managing member and has voting and investment power over the shares.

SEC source: 0001447362-20-000070 · wf-form4_159009171514660.xml · nonDerivative · entry 1

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,702,920

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.13, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000068 · wf-form4_158992074087636.xml · nonDerivative · entry 5

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,703,820

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000068 · wf-form4_158992074087636.xml · nonDerivative · entry 4

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,703,920

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $38.00 to $38.99, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000068 · wf-form4_158992074087636.xml · nonDerivative · entry 3

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,708,821

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.99, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-20-013561 · doc4.xml · nonDerivative · entry 2

MGC Venture Partners 2013 GP, LLC · CIK 0001783292 · 10% owner

MGC Venture Partners 2013, L.P. · CIK 0001572764 · 10% owner

MGC Venture Partners 2018 GP, LLC · CIK 0001783291 · 10% owner

MGC VENTURE PARTNERS 2018, L.P. · CIK 0001745133 · 10% owner

MGC VENTURE PARTNERS QP 2018, L.P. · CIK 0001749814 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,464,020

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.50, inclusive. The price reported above reflects the weighted-average sale price. MGC 2013 LP hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F7 · balance_after: Reflects number of shares owned as of May 15, 2020.

F3 · ownership.nature: Held directly by MGC 2013 LP.

F4 · ownership.nature: MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC QP 2018 LP"). Each of MGC 2013 LP, MGC 2013 GP, MGC 2018 LP, MGC QP 2018 LP and MGC 2018 GP directly (whether through ownership or position) or indirectly through one or more intermediaries, may be deemed for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, to be the indirect beneficial owner of some or all of the shares owned by MGC 2013 LP, MGC 2018 LP and MGC QP 2018 LP and, therefore, a "ten percent holder" hereunder.

F5 · ownership.nature: Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton and Byron W. Smith are managing directors of MGC 2013 GP and share voting and investment power over the shares held by MGC 2013 LP. Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton, Byron W. Smith, Jay Ferguson and Rob Readnour are managing partners of MGC 2018 GP and share voting and investment power over the shares held by MGC 2018 LP and MGC QP 2018 LP. Each of the reporting persons disclaims beneficial ownership of the shares held by any other reporting persons reported herein, except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-20-013561 · doc4.xml · nonDerivative · entry 1

MGC Venture Partners 2013 GP, LLC · CIK 0001783292 · 10% owner

MGC Venture Partners 2013, L.P. · CIK 0001572764 · 10% owner

MGC Venture Partners 2018 GP, LLC · CIK 0001783291 · 10% owner

MGC VENTURE PARTNERS 2018, L.P. · CIK 0001745133 · 10% owner

MGC VENTURE PARTNERS QP 2018, L.P. · CIK 0001749814 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,472,137

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.98, inclusive. The price reported above reflects the weighted-average sale price. MGC 2013 LP hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held directly by MGC 2013 LP.

F4 · ownership.nature: MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC QP 2018 LP"). Each of MGC 2013 LP, MGC 2013 GP, MGC 2018 LP, MGC QP 2018 LP and MGC 2018 GP directly (whether through ownership or position) or indirectly through one or more intermediaries, may be deemed for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, to be the indirect beneficial owner of some or all of the shares owned by MGC 2013 LP, MGC 2018 LP and MGC QP 2018 LP and, therefore, a "ten percent holder" hereunder.

F5 · ownership.nature: Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton and Byron W. Smith are managing directors of MGC 2013 GP and share voting and investment power over the shares held by MGC 2013 LP. Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton, Byron W. Smith, Jay Ferguson and Rob Readnour are managing partners of MGC 2018 GP and share voting and investment power over the shares held by MGC 2018 LP and MGC QP 2018 LP. Each of the reporting persons disclaims beneficial ownership of the shares held by any other reporting persons reported herein, except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000068 · wf-form4_158992074087636.xml · nonDerivative · entry 2

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,714,020

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.50, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000068 · wf-form4_158992074087636.xml · nonDerivative · entry 1

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,722,137

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.98, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000066 · wf-form4_158983217168260.xml · nonDerivative · entry 1

MAETZOLD DEREK J · CIK 0001239501 · Director · Pres. & Chief Exec. Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,632,348

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 18, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $32.00 to $33.00, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-20-013082 · doc4.xml · nonDerivative · entry 3

MGC Venture Partners 2013 GP, LLC · CIK 0001783292 · 10% owner

MGC Venture Partners 2013, L.P. · CIK 0001572764 · 10% owner

MGC Venture Partners 2018 GP, LLC · CIK 0001783291 · 10% owner

MGC VENTURE PARTNERS 2018, L.P. · CIK 0001745133 · 10% owner

MGC VENTURE PARTNERS QP 2018, L.P. · CIK 0001749814 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,485,936

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.45, inclusive. The price reported above reflects the weighted-average sale price. MGC 2013 LP hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held directly by MGC 2013 LP.

F4 · ownership.nature: MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC QP 2018 LP"). Each of MGC 2013 LP, MGC 2013 GP, MGC 2018 LP, MGC QP 2018 LP and MGC 2018 GP directly (whether through ownership or position) or indirectly through one or more intermediaries, may be deemed for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, to be the indirect beneficial owner of some or all of the shares owned by MGC 2013 LP, MGC 2018 LP and MGC QP 2018 LP and, therefore, a "ten percent holder" hereunder.

F5 · ownership.nature: Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton and Byron W. Smith are managing directors of MGC 2013 GP and share voting and investment power over the shares held by MGC 2013 LP. Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton, Byron W. Smith, Jay Ferguson and Rob Readnour are managing partners of MGC 2018 GP and share voting and investment power over the shares held by MGC 2018 LP and MGC QP 2018 LP. Each of the reporting persons disclaims beneficial ownership of the shares held by any other reporting persons reported herein, except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000063 · wf-form4_158948687358607.xml · nonDerivative · entry 3

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,735,936

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.45, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-20-013082 · doc4.xml · nonDerivative · entry 2

MGC Venture Partners 2013 GP, LLC · CIK 0001783292 · 10% owner

MGC Venture Partners 2013, L.P. · CIK 0001572764 · 10% owner

MGC Venture Partners 2018 GP, LLC · CIK 0001783291 · 10% owner

MGC VENTURE PARTNERS 2018, L.P. · CIK 0001745133 · 10% owner

MGC VENTURE PARTNERS QP 2018, L.P. · CIK 0001749814 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,487,067

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.98, inclusive. The price reported above reflects the weighted-average sale price. MGC 2013 LP hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held directly by MGC 2013 LP.

F4 · ownership.nature: MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC QP 2018 LP"). Each of MGC 2013 LP, MGC 2013 GP, MGC 2018 LP, MGC QP 2018 LP and MGC 2018 GP directly (whether through ownership or position) or indirectly through one or more intermediaries, may be deemed for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, to be the indirect beneficial owner of some or all of the shares owned by MGC 2013 LP, MGC 2018 LP and MGC QP 2018 LP and, therefore, a "ten percent holder" hereunder.

F5 · ownership.nature: Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton and Byron W. Smith are managing directors of MGC 2013 GP and share voting and investment power over the shares held by MGC 2013 LP. Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton, Byron W. Smith, Jay Ferguson and Rob Readnour are managing partners of MGC 2018 GP and share voting and investment power over the shares held by MGC 2018 LP and MGC QP 2018 LP. Each of the reporting persons disclaims beneficial ownership of the shares held by any other reporting persons reported herein, except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-20-013082 · doc4.xml · nonDerivative · entry 1

MGC Venture Partners 2013 GP, LLC · CIK 0001783292 · 10% owner

MGC Venture Partners 2013, L.P. · CIK 0001572764 · 10% owner

MGC Venture Partners 2018 GP, LLC · CIK 0001783291 · 10% owner

MGC VENTURE PARTNERS 2018, L.P. · CIK 0001745133 · 10% owner

MGC VENTURE PARTNERS QP 2018, L.P. · CIK 0001749814 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,491,668

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.96, inclusive. The price reported above reflects the weighted-average sale price. MGC 2013 LP hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held directly by MGC 2013 LP.

F4 · ownership.nature: MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC QP 2018 LP"). Each of MGC 2013 LP, MGC 2013 GP, MGC 2018 LP, MGC QP 2018 LP and MGC 2018 GP directly (whether through ownership or position) or indirectly through one or more intermediaries, may be deemed for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, to be the indirect beneficial owner of some or all of the shares owned by MGC 2013 LP, MGC 2018 LP and MGC QP 2018 LP and, therefore, a "ten percent holder" hereunder.

F5 · ownership.nature: Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton and Byron W. Smith are managing directors of MGC 2013 GP and share voting and investment power over the shares held by MGC 2013 LP. Each of Joseph C. Cook, Jr., Joseph C. Cook III, Steven D. Singleton, Byron W. Smith, Jay Ferguson and Rob Readnour are managing partners of MGC 2018 GP and share voting and investment power over the shares held by MGC 2018 LP and MGC QP 2018 LP. Each of the reporting persons disclaims beneficial ownership of the shares held by any other reporting persons reported herein, except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,433,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F5 · price: This transaction was executed in multiple trades at prices ranging from $35.1750 to $35.6650, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,533,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F4 · price: This transaction was executed in multiple trades at prices ranging from $34.0861 to $34.6399, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,633,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · price: This transaction was executed in multiple trades at prices ranging from $33.0340 to $33.0400, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000064 · wf-form4_158948696880092.xml · nonDerivative · entry 1

Anderson Bonnie H · CIK 0001588970 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By trust

Disclosed balance after: 30,723

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2020.

F2 · ownership.nature: Held by the Bonnie H. Anderson Living Trust, or the Anderson Trust. The Reporting Person is the trustee of the Anderson Trust.

SEC source: 0001447362-20-000063 · wf-form4_158948687358607.xml · nonDerivative · entry 2

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,737,067

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $37.00 to $37.98, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000063 · wf-form4_158948687358607.xml · nonDerivative · entry 1

Cook Joseph C. III · CIK 0001783205 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,741,668

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by MGC Venture Partners 2013, L.P. ("MGC 2013 LP") on March 13, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $36.00 to $36.96, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by MGC 2013 LP, MGC Venture Partners 2018, L.P. ("MGC 2018 LP") and MGC Venture Partners QP 2018, L.P. ("MGC 2018 QP LP"). MGC Venture Partners 2013 GP, LLC ("MGC 2013 GP") is the general partner of MGC 2013 LP. MGC Venture Partners 2018 GP, LLC ("MGC 2018 GP") is the general partner of MGC 2018 LP and MGC 2018 QP LP.

F4 · ownership.nature: The Reporting Person is a managing director of MGC 2013 GP and a managing partner of MGC 2018 GP, and shares voting and investment power over the shares held by MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP. The Reporting Person disclaims beneficial ownership of the shares held by MGC 2013 GP, MGC 2018 GP, MGC 2013 LP, MGC 2018 LP and MGC 2018 QP LP as reported herein, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001447362-20-000061 · wf-form4_158948664897633.xml · derivative · entry 3

MAETZOLD DEREK J · CIK 0001239501 · Director · Pres. & Chief Exec. Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 65,627 shares

Expires 2020-06-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option are fully vested.

SEC source: 0001447362-20-000061 · wf-form4_158948664897633.xml · nonDerivative · entry 1

MAETZOLD DEREK J · CIK 0001239501 · Director · Pres. & Chief Exec. Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,642,348

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-061078 · tm209687d1_form4.xml · nonDerivative · entry 1

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · 10% owner

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · 10% owner

Kong Garheng · CIK 0001435183 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,433,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · price: Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 12, 2020. The actual sale prices ranged from a low of $33.034 to a high of $35.665, inclusive. Each Reporting Person undertakes to provide upon request of the SEC Staff, Castle Biosciences, Inc. or a Castle Biosciences, Inc. security holder full information regarding the number of shares sold at each price within the range.

F3 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-063888 · tm2019858-1_4a.xml · nonDerivative · entry 3

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · See Remarks

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · See Remarks

Kong Garheng · CIK 0001435183 · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,433,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F5 · price: Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 12, 2020. The actual sale prices ranged from a low of $35.175 to a high of $35.665, inclusive. Each Reporting Person undertakes to provide upon request of the SEC Staff, Castle Biosciences, Inc. or a Castle Biosciences, Inc. security holder full information regarding the number of shares sold at each price within the range.

F3 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-063888 · tm2019858-1_4a.xml · nonDerivative · entry 2

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · See Remarks

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · See Remarks

Kong Garheng · CIK 0001435183 · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,533,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F4 · price: Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 12, 2020. The actual sale prices ranged from a low of $34.0861 to a high of $34.6399, inclusive. Each Reporting Person undertakes to provide upon request of the SEC Staff, Castle Biosciences, Inc. or a Castle Biosciences, Inc. security holder full information regarding the number of shares sold at each price within the range.

F3 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-063888 · tm2019858-1_4a.xml · nonDerivative · entry 1

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · See Remarks

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · See Remarks

Kong Garheng · CIK 0001435183 · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,633,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · price: Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 12, 2020. The actual sale prices ranged from a low of $33.034 to a high of $33.04, inclusive. Each Reporting Person undertakes to provide upon request of the SEC Staff, Castle Biosciences, Inc. or a Castle Biosciences, Inc. security holder full information regarding the number of shares sold at each price within the range.

F3 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000055 · wf-form4_158931513579119.xml · derivative · entry 2

Spiess Bernhard E. · CIK 0001782994 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,867

Underlying: Common Stock · 32,233 shares

Expires 2026-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25% of the 169,592 shares originally subject to the option vested on May 2, 2017, and the remaining shares vested in 36 equal monthly installments thereafter.

SEC source: 0001447362-20-000055 · wf-form4_158931513579119.xml · nonDerivative · entry 1

Spiess Bernhard E. · CIK 0001782994 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,859

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001447362-20-000045 · wf-form4_158862515278176.xml · nonDerivative · entry 2

Anderson Bonnie H · CIK 0001588970 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By trust

Disclosed balance after: 34,723

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $30.73 to $31.52, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the Bonnie H. Anderson Living Trust, or the Anderson Trust. The Reporting Person is the trustee of the Anderson Trust.

SEC source: 0001447362-20-000045 · wf-form4_158862515278176.xml · nonDerivative · entry 1

Anderson Bonnie H · CIK 0001588970 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By trust

Disclosed balance after: 35,185

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on March 17, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $29.59 to $30.38, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by the Bonnie H. Anderson Living Trust, or the Anderson Trust. The Reporting Person is the trustee of the Anderson Trust.

SEC source: 0001447362-20-000037 · wf-form4_158592173021395.xml · derivative · entry 1

Harrison Miles · CIK 0001808228 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2030-03-31

F1 · derivative.exercise_date: One-third of the shares shall vest on April 15, 2021, and the remaining shares shall vest in 24 equal monthly installments thereafter.

SEC source: 0001447362-20-000015 · wf-form4_158232544082709.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,683,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-023968 · tm209687-1_4.xml · nonDerivative · entry 1

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · 10% owner

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · 10% owner

Kong Garheng · CIK 0001435183 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,683,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000012 · wf-form4_158206493466077.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,708,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-022494 · tm209325-1_4.xml · nonDerivative · entry 1

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · 10% owner

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · 10% owner

Kong Garheng · CIK 0001435183 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,708,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000010 · wf-form4_158137118397757.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,733,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-014010 · tm207324-1_4.xml · nonDerivative · entry 1

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · 10% owner

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · 10% owner

Kong Garheng · CIK 0001435183 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,733,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000008 · wf-form4_158084850505165.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,758,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001104659-20-010543 · tm206618d1_4.xml · nonDerivative · entry 2

Sofinnova HealthQuest Partners, L.P. · CIK 0001579382 · 10% owner

HealthQuest Venture Management, L.L.C. · CIK 0001783696 · 10% owner

Kong Garheng · CIK 0001435183 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,758,577

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Sofinnova Healthquest Partners, L.P. on December 17, 2019.

F2 · ownership.direct: The shares are directly held by Sofinnova HealthQuest Partners, L.P. ("HealthQuest"). HealthQuest Venture Management, L.L.C. ("HQVM"), the general partner of HealthQuest, and Garheng Kong, the managing member of HQVM, may be deemed to have sole voting and dispositive power with respect to the shares held of record by HealthQuest. Mr. Kong and HQVM disclaim beneficial ownership over all shares owned by HealthQuest except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000008 · wf-form4_158084850505165.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,783,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.