CRNX

SEC source: 0000950170-25-086804 · ownership.xml · derivative · entry 4

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,514

Underlying: Common Stock · 71,525 shares

Expires 2028-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested in 48 equal monthly installments beginning on April 16, 2018.

SEC source: 0000950170-25-086804 · ownership.xml · nonDerivative · entry 3

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 99,713

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $32.23 per share. The range of sales prices on the transaction date was $31.67 to $32.65 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0000950170-25-086804 · ownership.xml · nonDerivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 197,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-086804 · ownership.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 180,551

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 438 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-086269 · ownership.xml · derivative · entry 2

Deardorf Caren · CIK 0001871152 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086269 · ownership.xml · nonDerivative · entry 1

Deardorf Caren · CIK 0001871152 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,300

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086267 · ownership.xml · derivative · entry 2

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086267 · ownership.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,300

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086268 · ownership.xml · derivative · entry 2

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086268 · ownership.xml · nonDerivative · entry 1

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,300

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086266 · ownership.xml · derivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086266 · ownership.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,836

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086265 · ownership.xml · derivative · entry 2

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086265 · ownership.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,300

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086264 · ownership.xml · derivative · entry 2

Nichols Weston · CIK 0001746376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086264 · ownership.xml · nonDerivative · entry 1

Nichols Weston · CIK 0001746376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,300

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086260 · ownership.xml · derivative · entry 2

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,350

Underlying: Common Stock · 10,350 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-086260 · ownership.xml · nonDerivative · entry 1

WIERENGA WENDALL · CIK 0001235945 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,146

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0000950170-25-073605 · ownership.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 1

Disclosed balance after: 661,205

F1 · kind: Bona fide gift made by the Reporting person for no consideration.

SEC source: 0000950170-25-073605 · ownership.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 320,017

F1 · kind: Bona fide gift made by the Reporting person for no consideration.

SEC source: 0000950170-25-051170 · ownership.xml · derivative · entry 7

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 81,270 shares

Expires 2028-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vested on April 16, 2018, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-051170 · ownership.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 410,417

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-043407 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,233

F3 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.83 per share. The range of sales prices on the transaction date was $34.78 to $35.00 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043407 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,360

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.17 per share. The range of sales prices on the transaction date was $33.78 to $34.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043402 · ownership.xml · nonDerivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,588

F3 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.83 per share. The range of sales prices on the transaction date was $34.78 to $35.00 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043402 · ownership.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,879

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.17 per share. The range of sales prices on the transaction date was $33.78 to $34.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043401 · ownership.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 329,147

F3 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.83 per share. The range of sales prices on the transaction date was $34.78 to $35.00 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043401 · ownership.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 330,022

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.17 per share. The range of sales prices on the transaction date was $33.78 to $34.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043404 · ownership.xml · nonDerivative · entry 2

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,491

F3 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.83 per share. The range of sales prices on the transaction date was $34.78 to $35.00 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043404 · ownership.xml · nonDerivative · entry 1

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,852

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.17 per share. The range of sales prices on the transaction date was $33.78 to $34.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-037200 · ownership.xml · derivative · entry 2

Schilke Tobin · CIK 0001678984 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2035-03-09

F2 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on February 28, 2026, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-037200 · ownership.xml · nonDerivative · entry 1

Schilke Tobin · CIK 0001678984 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,000

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2026.

SEC source: 0000950170-25-025665 · ownership.xml · derivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 20, 2025.

SEC source: 0000950170-25-025665 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,748

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2026.

SEC source: 0000950170-25-025664 · ownership.xml · derivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 20, 2025.

SEC source: 0000950170-25-025664 · ownership.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,358

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2026.

SEC source: 0000950170-25-025667 · ownership.xml · derivative · entry 7

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 313,000

Underlying: Common Stock · 313,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 20, 2025.

SEC source: 0000950170-25-025667 · ownership.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 346,485

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2026.

SEC source: 0000950170-25-025666 · ownership.xml · derivative · entry 2

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 20, 2025.

SEC source: 0000950170-25-025666 · ownership.xml · nonDerivative · entry 1

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,653

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2026.

SEC source: 0000950170-25-014557 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-014557 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,748

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $39.07 per share. The range of sales prices on the transaction date was $38.89 to $39.49 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-014557 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,748

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-004855 · ownership.xml · derivative · entry 1

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-01-09

F1 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on December 16, 2025, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-002869 · ownership.xml · derivative · entry 5

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 2,500 shares

Expires 2033-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 1/48th of the shares subject to the option vested on April 1, 2023, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,748

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-002869 · ownership.xml · derivative · entry 4

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 124,042

Underlying: Common Stock · 15,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,248

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $52.09 per share. The range of sales prices on the transaction date was $51.60 to $52.60 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

F3 · balance_after: Includes 741 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,248

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-137923 · ownership.xml · derivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 180,039

Underlying: Common Stock · 2,331 shares

Expires 2028-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vested on April 16, 2018, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.