CRNX

SEC source: 0001628280-26-019498 · wk-form4_1773868275.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,342

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-019488 · wk-form4_1773867929.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 404,778

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-019488 · wk-form4_1773867929.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 413,563

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-019503 · wk-form4_1773868401.xml · nonDerivative · entry 2

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,018

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-019503 · wk-form4_1773868401.xml · nonDerivative · entry 1

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,979

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-017797 · wk-form4_1773438366.xml · nonDerivative · entry 2

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,300

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $36.77 per share. The range of sales prices on the transaction date was $36.69 to $36.89 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-017797 · wk-form4_1773438366.xml · nonDerivative · entry 1

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,823

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $36.08 per share. The range of sales prices on the transaction date was $35.65 to $36.53 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-014775 · wk-form4_1772664285.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,300

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $39.67 per share.

SEC source: 0001628280-26-014772 · wk-form4_1772664230.xml · nonDerivative · entry 1

Schilke Tobin · CIK 0001678984 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,121

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 10, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $39.67 per share. The range of sales prices on the transaction date was $39.67 to $39.74 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0001628280-26-011718 · wk-form4_1772055248.xml · derivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires 2036-02-23

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

SEC source: 0001628280-26-011718 · wk-form4_1772055248.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,713

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2027.

SEC source: 0001628280-26-011730 · wk-form4_1772055418.xml · derivative · entry 7

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,000

Underlying: Common Stock · 228,000 shares

Expires 2036-02-23

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

SEC source: 0001628280-26-011730 · wk-form4_1772055418.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 426,759

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2027.

SEC source: 0001628280-26-011728 · wk-form4_1772055379.xml · derivative · entry 2

Schilke Tobin · CIK 0001678984 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2036-02-23

F3 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

SEC source: 0001628280-26-011728 · wk-form4_1772055379.xml · nonDerivative · entry 1

Schilke Tobin · CIK 0001678984 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,834

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2027.

F2 · balance_after: Includes 834 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-26-011723 · wk-form4_1772055288.xml · derivative · entry 2

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2036-02-23

F3 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

SEC source: 0001628280-26-011723 · wk-form4_1772055288.xml · nonDerivative · entry 1

Knight Jeff E. · CIK 0001881007 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,929

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2027.

F2 · balance_after: Includes 438 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-26-011715 · wk-form4_1772055157.xml · derivative · entry 2

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2036-02-23

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

SEC source: 0001628280-26-011715 · wk-form4_1772055157.xml · nonDerivative · entry 1

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,834

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 1, 2027.

SEC source: 0001628280-26-001230 · wk-form4_1767823884.xml · derivative · entry 3

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 2,500 shares

Expires 2035-01-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on December 16, 2025, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-26-001230 · wk-form4_1767823884.xml · nonDerivative · entry 2

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 834

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 7, 2025.

F3 · price: The common stock was sold by the Reporting Person in an open market transaction on the transaction date, at a sale price of $55.00 per share.

SEC source: 0001628280-26-001230 · wk-form4_1767823884.xml · nonDerivative · entry 1

Kalofonos Isabel · CIK 0001975163 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,334

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 834 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-25-059009 · wk-form4_1767044199.xml · derivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,514

Underlying: Common Stock · 18,000 shares

Expires 2028-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The option vested in 48 equal monthly installments beginning on April 16, 2018.

SEC source: 0001628280-25-059009 · wk-form4_1767044199.xml · nonDerivative · entry 1

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,713

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-058056 · wk-form4_1766102083.xml · derivative · entry 9

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 259,058

Underlying: Common Stock · 28,400 shares

Expires 2031-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vested on April 16, 2018, and 1/48th of the shares subject to the option vested monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-058056 · wk-form4_1766102083.xml · derivative · entry 8

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,342 shares

Expires 2028-05-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vested on June 25, 2018, and 1/48th of the shares subject to the option vested monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-058056 · wk-form4_1766102083.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 364,759

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-058056 · wk-form4_1766102083.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 336,359

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,837

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $45.02 per share. The range of sale prices on the transaction date was $44.59 to $45.51. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,837

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 567 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · derivative · entry 4

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $43.27 per share for 100 shares.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,370

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $42.65 per share. The range of sale prices on the transaction date was $42.14 to $43.09. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 79,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $41.81 per share. The range of sales prices on the transaction date was $41.34 to $42.16 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: On September 4, 2025, the Reporting Person filed a Form 4 (the "Prior Form 4") which inadvertently reported that, following the transactions reported in the Prior Form 4, the Reporting Person directly owned 96,270 shares of the Issuer's common stock. In fact, the Reporting Person directly owned 66,270 shares of the Issuer's common stock following the transactions reported in the Prior Form 4.

SEC source: 0001658247-25-000011 · wk-form4_1759264973.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By Family Trust 2

Disclosed balance after: 106,000

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $45.00 per share.

SEC source: 0001658247-25-000010 · wk-form4_1759264890.xml · derivative · entry 3

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,092

Underlying: Common Stock · 10,000 shares

Expires 2028-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/3rd of the options vested on February 16, 2019, and 1/36th of the options vested monthly thereafter.

SEC source: 0001658247-25-000010 · wk-form4_1759264890.xml · nonDerivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,836

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 3, 2024.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $44.75 per share.

SEC source: 0001658247-25-000010 · wk-form4_1759264890.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 38,836

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001948238-25-000009 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001948238-25-000009 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $32.10 per share. The range of sales prices on the transaction date was $32.00 to $32.24 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001948238-25-000009 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001948238-25-000007 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,042

Underlying: Common Stock · 30,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001948238-25-000007 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $30.43 per share. The range of sales prices on the transaction date was $30.00 to $30.98 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001948238-25-000007 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001948238-25-000005 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $29.18 per share. The range of sales prices on the transaction date was $28.94 to $29.47 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

F3 · balance_after: Includes 529 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-086804 · ownership.xml · derivative · entry 5

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,198

Underlying: Common Stock · 16,645 shares

Expires 2028-05-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option vested in 48 equal monthly installments beginning on June 25, 2018.