CRBP

SEC source: 0001193125-26-392093 · ownership.xml · nonDerivative · entry 1

Ben Yong · CIK 0001967669 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,383

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 12, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.80 to $7.90. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 3,800 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-354145 · ownership.xml · derivative · entry 2

Nicacio Leonardo Viana · CIK 0002064901 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,676

Underlying: Common Stock · 191,676 shares

Expires 2036-08-16

F3 · derivative.exercise_date: This option award was made in accordance with the terms of the issuer's 2026 Inducement Award Plan. 25% of the option vests on August 3, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on September 3, 2027.

SEC source: 0001193125-26-354145 · ownership.xml · nonDerivative · entry 1

Nicacio Leonardo Viana · CIK 0002064901 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,333

F1 · shares: On August 16, 2026, the Reporting Person was granted 58,333 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth annual anniversary beginning on August 16, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a prorata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardee's termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 58,333 unvested RSUs granted on August 16, 2026.

SEC source: 0001193125-26-346966 · ownership.xml · nonDerivative · entry 1

Saxena Nishant C · CIK 0002136365 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 77,900

F1 · balance_after: This amount includes 58,300 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-342479 · ownership.xml · nonDerivative · entry 1

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,694

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.00 to $10.25. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 68,795 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-342485 · ownership.xml · nonDerivative · entry 1

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 157,316

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.00 to $10.18. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 138,049 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-267671 · ownership.xml · nonDerivative · entry 1

Jenkins John Kenneth · CIK 0001742557 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,833

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.71 to $7.97. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 3,800 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-267672 · ownership.xml · nonDerivative · entry 1

Kung Winston · CIK 0001666963 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,140

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.71 to $7.97. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 3,800 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-267655 · ownership.xml · nonDerivative · entry 1

Altmeyer Anne · CIK 0001947086 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,579

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2026.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.71 to $7.97. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 3,800 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-255834 · ownership.xml · nonDerivative · entry 2

Saxena Nishant C · CIK 0002136365 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,300

F2 · balance_after: This amount includes 58,300 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-255834 · ownership.xml · nonDerivative · entry 1

Saxena Nishant C · CIK 0002136365 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,300

F1 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.33 to $7.34. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F2 · balance_after: This amount includes 58,300 unvested RSUs subject to the grant's vesting schedule as previously reported.

SEC source: 0001193125-26-237103 · ownership.xml · derivative · entry 2

Saxena Nishant C · CIK 0002136365 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,300

Underlying: Common Stock · 192,300 shares

Expires 2036-05-21

F3 · derivative.exercise_date: The annual option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. 25% of the option vests on May 21, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on June 21, 2027.

SEC source: 0001193125-26-237103 · ownership.xml · nonDerivative · entry 1

Saxena Nishant C · CIK 0002136365 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,800

F1 · shares: On May 21, 2026, the Reporting Person was granted 58,300 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth annual anniversary beginning on May 21, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a prorata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardees termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 58,300 unvested RSUs granted on May 21, 2026.

SEC source: 0001193125-26-234850 · ownership.xml · derivative · entry 2

Ben Yong · CIK 0001967669 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,300

Underlying: Common Stock · 12,300 shares

Expires 2026-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest 100% on the one-year anniversary from the date of grant.

SEC source: 0001193125-26-234850 · ownership.xml · nonDerivative · entry 1

Ben Yong · CIK 0001967669 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,383

F1 · shares: On May 19, 2026, 3,800 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest 100% on the one-year anniversary from the date of grant.

F2 · balance_after: This amount includes 8,600 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-234853 · ownership.xml · derivative · entry 2

Jenkins John Kenneth · CIK 0001742557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,300

Underlying: Common Stock · 12,300 shares

Expires 2026-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest 100% on the one-year anniversary from the date of grant.

SEC source: 0001193125-26-234853 · ownership.xml · nonDerivative · entry 1

Jenkins John Kenneth · CIK 0001742557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,633

F1 · shares: On May 19, 2026, 3,800 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest 100% on the one-year anniversary from the date of grant.

F2 · balance_after: This amount includes 8,600 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-234860 · ownership.xml · derivative · entry 2

Kung Winston · CIK 0001666963 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,300

Underlying: Common Stock · 12,300 shares

Expires 2026-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest 100% on the one-year anniversary from the date of grant.

SEC source: 0001193125-26-234860 · ownership.xml · nonDerivative · entry 1

Kung Winston · CIK 0001666963 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,166

F1 · shares: On May 19, 2026, 3,800 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest 100% on the one-year anniversary from the date of grant.

F2 · balance_after: This amount includes 8,600 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-234857 · ownership.xml · derivative · entry 2

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,300

Underlying: Common Stock · 12,300 shares

Expires 2026-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest 100% on the one-year anniversary from the date of grant.

SEC source: 0001193125-26-234857 · ownership.xml · nonDerivative · entry 1

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,383

F1 · shares: On May 19, 2026, 3,800 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest 100% on the one-year anniversary from the date of grant.

F2 · balance_after: This amount includes 8,600 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-234851 · ownership.xml · derivative · entry 2

Altmeyer Anne · CIK 0001947086 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,300

Underlying: Common Stock · 12,300 shares

Expires 2026-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest 100% on the one-year anniversary from the date of grant.

SEC source: 0001193125-26-234851 · ownership.xml · nonDerivative · entry 1

Altmeyer Anne · CIK 0001947086 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,991

F1 · shares: On May 19, 2026, 3,800 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest 100% on the one-year anniversary from the date of grant.

F2 · balance_after: This amount includes 8,600 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-234813 · ownership.xml · derivative · entry 2

Pfeiffenberger Brent · CIK 0002001162 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,700

Underlying: Common Stock · 24,700 shares

Expires 2036-05-19

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. The option will vest in three equal annual installments on each of the first three anniversaries of the grant date, subject to continued service to the Company through each applicable vesting date.

SEC source: 0001193125-26-234813 · ownership.xml · nonDerivative · entry 1

Pfeiffenberger Brent · CIK 0002001162 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

F1 · shares: On May 19, 2026, 7,500 restricted stock units ("RSUs") were granted, which will be settled in shares of common stock, par value $0.0001. The RSUs will vest in three equal annual installments on each of the first three anniversaries of the grant date, subject to continued service to the Company through each applicable vesting date.

F2 · balance_after: This amount includes 7,500 unvested RSUs that were granted on May 19, 2026 and will vest in three equal annual installments on each of the first three anniversaries of the grant date, subject to continued service to the Company through each applicable vesting date.

SEC source: 0001193125-26-091647 · ownership.xml · nonDerivative · entry 1

Smethurst Dominic · CIK 0001820549 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,790

F1 · kind: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.20 to $8.35. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 73,765 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-057174 · ownership.xml · nonDerivative · entry 1

Hodgson Ian · CIK 0002057525 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,080

F1 · kind: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.37 to $7.42. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 46,362 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-057168 · ownership.xml · nonDerivative · entry 1

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,694

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 14, 2025 and the sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.58 to $7.96. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 68,795 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-057159 · ownership.xml · nonDerivative · entry 1

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,316

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 14, 2025 and the sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.58 to $7.96. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 138,049 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-037643 · ownership.xml · nonDerivative · entry 1

Hodgson Ian · CIK 0002057525 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,927

F1 · kind: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.01 to $8.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 48,108 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-037647 · ownership.xml · nonDerivative · entry 1

Smethurst Dominic · CIK 0001820549 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,887

F1 · kind: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.01 to $8.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: This amount includes 86,265 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-015430 · ownership.xml · derivative · entry 2

Hodgson Ian · CIK 0002057525 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,095

Underlying: Common Stock · 85,095 shares

Expires 2036-01-14

F3 · derivative.exercise_date: The annual option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. 25% of the option vests on January 14, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on February 14, 2027.

SEC source: 0001193125-26-015430 · ownership.xml · nonDerivative · entry 1

Hodgson Ian · CIK 0002057525 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,342

F1 · shares: On January 14, 2026, the Reporting Person was granted 28,365 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth anniversary beginning on January 14, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a pro rata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardees termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 53,108 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-015427 · ownership.xml · derivative · entry 2

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,247

Underlying: Common Stock · 84,247 shares

Expires 2036-01-14

F3 · derivative.exercise_date: The annual option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. 25% of the option vests on January 14, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on February 14, 2027.

SEC source: 0001193125-26-015427 · ownership.xml · nonDerivative · entry 1

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 101,395

F1 · shares: On January 14, 2026, the Reporting Person was granted 28,082 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth anniversary beginning on January 14, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a pro rata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardees termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 85,714 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-015426 · ownership.xml · derivative · entry 2

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2036-01-14

F3 · derivative.exercise_date: The annual option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. 25% of the option vests on January 14, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on February 14, 2027.

SEC source: 0001193125-26-015426 · ownership.xml · nonDerivative · entry 1

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 188,187

F1 · shares: On January 14, 2026, the Reporting Person was granted 50,000 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth anniversary beginning on January 14, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a prorata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardees termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 173,561 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-26-015429 · ownership.xml · derivative · entry 2

Smethurst Dominic · CIK 0001820549 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,095

Underlying: Common Stock · 85,095 shares

Expires 2036-01-14

F3 · derivative.exercise_date: The annual option award was made in accordance with the terms of the issuer's 2024 Equity Compensation Plan. 25% of the option vests on January 14, 2027, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on February 14, 2027.

SEC source: 0001193125-26-015429 · ownership.xml · nonDerivative · entry 1

Smethurst Dominic · CIK 0001820549 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,172

F1 · shares: On January 14, 2026, the Reporting Person was granted 28,365 restricted stock units ("RSUs"), which will be settled in shares of common stock, par value $0.0001. 25% of the RSUs shall vest on each of the first, second, third and fourth anniversary beginning on January 14, 2027. Notwithstanding the foregoing, upon termination of the Reporting Person's Service by the Company without cause, provided that such termination occurs after the first Vesting Date, then a pro rata portion of the RSUs shall accelerate in an amount equal to the product of (x) the number of RSUs scheduled to vest on the next Vesting Date and (y) a fraction, the numerator of which is the number of completed months of service the Awardee worked since the most recent Vesting Date through the date of Awardees termination of Service and the denominator of which is 12. The RSUs, to the extent not accelerated in accordance with this paragraph shall be forfeited upon such Reporting Person's termination of service.

F2 · balance_after: This amount includes 93,065 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0000929638-25-004597 · form4.xml · nonDerivative · entry 1

Cormorant Asset Management, LP · CIK 0001583977 · 10% owner

Cormorant Global Healthcare Master Fund, LP · CIK 0001618442 · 10% owner

Chen Bihua · CIK 0001599214 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 2,344,971

F1 · price: The reported price represents the weighted average sale price of Common Stock (the "shares") sold in a series of open market transactions on the transaction date at prices ranging from $11.20 to $12.15 per share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price. All of the shares reported herein were sold by the Master Fund.

F2 · ownership.nature: Cormorant Asset Management, LP ("Cormorant") serves as the investment manager of Cormorant Global Healthcare Master Fund, LP (the "Master Fund"). Cormorant Global Healthcare GP, LLC ("GP LLC") serves as the general partner of the Master Fund. Bihua Chen serves as the managing member of Cormorant, GP LLC and the Master Fund. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or her pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0001193125-25-251639 · ownership.xml · derivative · entry 6

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,106

Underlying: Common Stock · 8,973 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · security: The annual option award was made in accordance with the terms of the issuer's 2014 Equity Compensation Plan. 25% of the option vested on February 13, 2024, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on March 13, 2024.

SEC source: 0001193125-25-251639 · ownership.xml · nonDerivative · entry 4

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 138,187

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 14, 2025.

F4 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.00 to $17.31. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F1 · balance_after: This amount includes 123,561 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-251639 · ownership.xml · nonDerivative · entry 3

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 147,160

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: This amount includes 123,561 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-251635 · ownership.xml · derivative · entry 3

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,386

Underlying: Common Stock · 12,981 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · security: The annual option award was made in accordance with the terms of the issuer's 2014 Equity Compensation Plan. 25% of the option vested on February 13, 2024, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on March 13, 2024.

SEC source: 0001193125-25-251635 · ownership.xml · nonDerivative · entry 2

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,313

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 14, 2025.

F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.79 to $17.38. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F1 · balance_after: This amount includes 57,632 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-251635 · ownership.xml · nonDerivative · entry 1

Moran Sean F. · CIK 0001451495 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 86,294

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: This amount includes 57,632 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-251639 · ownership.xml · derivative · entry 5

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,079

Underlying: Common Stock · 18,660 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · security: The annual option award was made in accordance with the terms of the issuer's 2014 Equity Compensation Plan. 25% of the option vested on February 13, 2024, with the remaining 75% of the option vesting in equal monthly installments over a period of 36 months commencing on March 13, 2024.

SEC source: 0001193125-25-251639 · ownership.xml · nonDerivative · entry 2

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 138,187

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 14, 2025.

F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.79 to $17.38. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F1 · balance_after: This amount includes 123,561 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-251639 · ownership.xml · nonDerivative · entry 1

Cohen Yuval · CIK 0001626003 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 156,847

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: This amount includes 123,561 unvested RSUs subject to each grant's vesting schedule as previously reported.

SEC source: 0001193125-25-245262 · ownership.xml · derivative · entry 3

Altmeyer Anne · CIK 0001947086 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,247

Underlying: Common Stock · 1,060 shares

Expires 2032-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · security: The option award was made in accordance with the terms of the issuer's 2014 Equity Compensation Plan and is fully vested.

F3 · derivative.exercise_date: The option award was made in accordance with the terms of the issuer's 2014 Equity Compensation Plan and is fully vested.