COLL

SEC source: 0001192482-21-000212 · edgar.xml · derivative · entry 4

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,205

Underlying: Common Stock · 48,616 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 48,616 shares under the option are exercisable. The option, initially representing a right to purchase a total of 259,283 shares, vests and becomes exercisable over a four-year period commencing on May 31, 2017. Twenty-five percent (25%) of the option vested and became exercisable on May 31, 2018 and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) at the end of each quarterly period over the remaining three years of the four-year period, subject to the reporting person's continued service with the Issuer.

SEC source: 0001192482-21-000212 · edgar.xml · nonDerivative · entry 3

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 278,307

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2020.

F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.00 to $23.54, inclusive.

SEC source: 0001192482-21-000212 · edgar.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,116

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2020.

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.01 to $22.98, inclusive. The reporting person undertakes to provide to the Issuer, any securityholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) and (3).

SEC source: 0001192482-21-000212 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 343,075

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001192482-21-000151 · edgar.xml · nonDerivative · entry 4

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,258

F3 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 19, 2020

F5 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.01 to $25.95, inclusive.

SEC source: 0001192482-21-000151 · edgar.xml · nonDerivative · entry 3

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,056

F3 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 19, 2020

F4 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.66 to $25.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (4) and (5).

SEC source: 0001192482-21-000150 · edgar.xml · nonDerivative · entry 2

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,724

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000150 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,419

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000149 · edgar.xml · nonDerivative · entry 2

Fleming Alison B · CIK 0001640701 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,164

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000149 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,209

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000148 · edgar.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 294,459

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000148 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 309,747

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000151 · edgar.xml · nonDerivative · entry 2

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,156

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000151 · edgar.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,439

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000147 · edgar.xml · nonDerivative · entry 2

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,428

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000147 · edgar.xml · nonDerivative · entry 1

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 221,355

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000146 · edgar.xml · nonDerivative · entry 2

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,677

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000146 · edgar.xml · nonDerivative · entry 1

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,219

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000085 · edgar.xml · nonDerivative · entry 3

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,582

F3 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 23, 2020.

SEC source: 0001192482-21-000094 · edgar.xml · nonDerivative · entry 3

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,582

F3 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 23, 2020.

SEC source: 0001192482-21-000085 · edgar.xml · derivative · entry 4

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 129,600

Underlying: Common Stock · 129,600 shares

Expires 2031-01-19

F4 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000085 · edgar.xml · nonDerivative · entry 2

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,663

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,772 performance share units granted in two prior years.

SEC source: 0001192482-21-000085 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,891

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000086 · edgar.xml · derivative · entry 3

Fleming Alison B · CIK 0001640701 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 129,600

Underlying: Common Stock · 129,600 shares

Expires 2031-01-19

F3 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000086 · edgar.xml · nonDerivative · entry 2

Fleming Alison B · CIK 0001640701 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,308

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,529 performance share units granted in two prior years.

SEC source: 0001192482-21-000086 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,779

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000083 · edgar.xml · derivative · entry 3

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 420,000

Underlying: Common Stock · 420,000 shares

Expires 2031-01-19

F3 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000083 · edgar.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,245

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 28,989 performance share units granted in two prior years.

SEC source: 0001192482-21-000083 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 289,256

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000087 · edgar.xml · derivative · entry 3

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,800

Underlying: Common Stock · 130,800 shares

Expires 2031-01-19

F3 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000087 · edgar.xml · nonDerivative · entry 2

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,340

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,165 performance share units granted in two prior years.

SEC source: 0001192482-21-000087 · edgar.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,175

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000088 · edgar.xml · derivative · entry 3

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,600

Underlying: Common Stock · 105,600 shares

Expires 2031-01-19

F3 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000088 · edgar.xml · nonDerivative · entry 2

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,977

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 2,187 performance share units granted in a prior year.

SEC source: 0001192482-21-000088 · edgar.xml · nonDerivative · entry 1

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,790

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000084 · edgar.xml · derivative · entry 3

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2031-01-19

F3 · derivative.exercise_date: Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2022, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer.

SEC source: 0001192482-21-000084 · edgar.xml · nonDerivative · entry 2

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 223,919

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 8,161 performance share units granted in two prior years.

SEC source: 0001192482-21-000084 · edgar.xml · nonDerivative · entry 1

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,758

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000094 · edgar.xml · nonDerivative · entry 2

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,663

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,772 performance share units granted in two prior years.

SEC source: 0001192482-21-000094 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,891

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000101 · edgar.xml · nonDerivative · entry 2

Fleming Alison B · CIK 0001640701 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,308

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,529 performance share units granted in two prior years.

SEC source: 0001192482-21-000101 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,779

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000103 · edgar.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,245

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 28,989 performance share units granted in two prior years.

SEC source: 0001192482-21-000103 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 289,256

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000098 · edgar.xml · nonDerivative · entry 2

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,340

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 6,165 performance share units granted in two prior years.

SEC source: 0001192482-21-000098 · edgar.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,175

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000096 · edgar.xml · nonDerivative · entry 2

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 223,919

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 8,161 performance share units granted in two prior years.

SEC source: 0001192482-21-000096 · edgar.xml · nonDerivative · entry 1

Brannelly Paul · CIK 0001394936 · Executive Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,758

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000092 · edgar.xml · nonDerivative · entry 2

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,977

F2 · price: On January 19, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 2,187 performance share units granted in a prior year.

SEC source: 0001192482-21-000092 · edgar.xml · nonDerivative · entry 1

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,790

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.