COLL

SEC source: 0001062993-22-004319 · form4.xml · nonDerivative · entry 3

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 153,330

F3 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-22-004319 · form4.xml · nonDerivative · entry 2

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,297

F2 · price: On February 10, 2022, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to an aggregate of 14,341 performance share units granted in the issuer's three prior fiscal years.

SEC source: 0001062993-22-004319 · form4.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,956

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2023, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001062993-22-004320 · form4.xml · nonDerivative · entry 4

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400,941

F4 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001062993-22-004320 · form4.xml · nonDerivative · entry 3

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 429,784

F3 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-22-004320 · form4.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 453,938

F2 · price: On February 10, 2022, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to an aggregate of 65,034 performance share units granted in the issuer's three prior fiscal years.

SEC source: 0001062993-22-004320 · form4.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 388,904

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2023, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001062993-22-004326 · form4.xml · nonDerivative · entry 4

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,264

F4 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001062993-22-004326 · form4.xml · nonDerivative · entry 3

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 132,102

F3 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-22-004326 · form4.xml · nonDerivative · entry 2

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,564

F2 · price: On February 10, 2022, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to an aggregate of 6,256 performance share units granted in the issuer's two prior fiscal years.

SEC source: 0001062993-22-004326 · form4.xml · nonDerivative · entry 1

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,308

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2023, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001062993-22-004318 · form4.xml · nonDerivative · entry 4

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,785

F4 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001062993-22-004318 · form4.xml · nonDerivative · entry 3

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,801

F3 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-22-004318 · form4.xml · nonDerivative · entry 2

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,444

F2 · price: On February 10, 2022, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to an aggregate of 13,675 performance share units granted in the issuer's three prior fiscal years.

SEC source: 0001062993-22-004318 · form4.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 128,769

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2023, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001062993-22-006643 · form4a.xml · nonDerivative · entry 4

Tupper Colleen · CIK 0001862082 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,654

F4 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001062993-22-006643 · form4a.xml · nonDerivative · entry 3

Tupper Colleen · CIK 0001862082 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,891

F3 · shares: Shares withheld by the issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-22-006643 · form4a.xml · nonDerivative · entry 2

Tupper Colleen · CIK 0001862082 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,712

F2 · price: On February 10, 2022, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to an aggregate of 4,212 performance share units granted in the issuer's prior fiscal year.

SEC source: 0001062993-22-006643 · form4a.xml · nonDerivative · entry 1

Tupper Colleen · CIK 0001862082 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,500

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2023, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001879789-22-000002 · primary_doc.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,269

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001879789-22-000001 · primary_doc.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 263,904

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001879789-21-000022 · primary_doc.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,970

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 14, 2021 and amended on September 1, 2021.

F2 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $17.95 to $18.62, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2).

SEC source: 0001879789-21-000003 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,256

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000662 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · EVP & Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,694

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000661 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,994

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001104659-21-092117 · tm2122232-1_4seq1.xml · nonDerivative · entry 1

Dreyer Scott · CIK 0001746251 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,663

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000623 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,380

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000479 · edgar.xml · nonDerivative · entry 5

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 267,774

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2020.

SEC source: 0001192482-21-000479 · edgar.xml · derivative · entry 6

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,205 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: All of the 16,205 option shares are exercisable.

SEC source: 0001192482-21-000479 · edgar.xml · nonDerivative · entry 4

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,635

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2020.

F4 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.00 to $23.88, inclusive.

SEC source: 0001192482-21-000479 · edgar.xml · nonDerivative · entry 3

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284,464

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2020.

F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.79 to $22.99, inclusive. The reporting person undertakes to provide to the Issuer, any securityholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (3) and (4).

SEC source: 0001192482-21-000479 · edgar.xml · nonDerivative · entry 2

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 289,840

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001192482-21-000479 · edgar.xml · nonDerivative · entry 1

Ciaffoni Joseph · CIK 0001443841 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,635

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000452 · edgar.xml · nonDerivative · entry 1

Tupper Colleen · CIK 0001862082 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,000

F1 · security: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2022, and the balance of the restricted stock units vest in equal annual installments (in each case, rounded up to the nearest whole share of common stock) over the following three year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock.

SEC source: 0001192482-21-000456 · edgar.xml · nonDerivative · entry 1

Heffernan Michael Thomas · CIK 0001448914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,988

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000460 · edgar.xml · nonDerivative · entry 1

Freund John Gordon · CIK 0001296771 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,948

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000455 · edgar.xml · nonDerivative · entry 1

SANTINI GINO · CIK 0001276038 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,136

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000457 · edgar.xml · nonDerivative · entry 1

Fallon John A. · CIK 0001560152 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,323

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000458 · edgar.xml · nonDerivative · entry 1

Balice-Gordon Rita J. · CIK 0001825625 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,968

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000453 · edgar.xml · nonDerivative · entry 1

BOHLIN GAREN G · CIK 0001254705 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,948

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000454 · edgar.xml · nonDerivative · entry 1

Melincoff Gwen A · CIK 0001614890 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,948

F1 · shares: Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on May 20, 2022, subject to the director's continued service with the issuer. The restricted stock units will be settled on such date, or, upon the election of the director, on the earlier of the end of the director's service on the Board of Directors, the director's death or disability, or a change in control of the issuer, in shares of the issuer's common stock.

SEC source: 0001192482-21-000419 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,990

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 1, 2021.

SEC source: 0001192482-21-000309 · edgar.xml · nonDerivative · entry 2

Fleming Alison B · CIK 0001640701 · EVP & Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,080

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000309 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · EVP & Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,980

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of performance stock units.

SEC source: 0001192482-21-000322 · edgar.xml · nonDerivative · entry 1

Malamut Richard · CIK 0001772168 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,558

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000288 · edgar.xml · nonDerivative · entry 1

Fleming Alison B · CIK 0001640701 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 154,737

F1 · price: On March 30, 2021, the Compensation Committee of the Board of Directors of the issuer determined that performance-vesting criteria were met with regard to 5,984 performance share units granted on February 5, 2020.

SEC source: 0001192482-21-000251 · edgar.xml · nonDerivative · entry 1

Kuhlmann Shirley R. · CIK 0001734919 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,990

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001192482-21-000248 · edgar.xml · nonDerivative · entry 2

Heffernan Michael Thomas · CIK 0001448914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,047

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 1, 2021.

F3 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.83 to $26.03, inclusive.

SEC source: 0001192482-21-000248 · edgar.xml · nonDerivative · entry 1

Heffernan Michael Thomas · CIK 0001448914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,078

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 1, 2021.

F2 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.83 to $25.82, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0001192482-21-000211 · edgar.xml · nonDerivative · entry 12

Fleming Alison B · CIK 0001640701 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,753

F4 · kind: The sale reported in this row was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2020.