CGTX

SEC source: 0001789490-26-000002 · primary_doc.xml · nonDerivative · entry 1

Fletcher Aaron G.L. · CIK 0001789490 · Director · 10% owner

BIOS Capital Management, LP · CIK 0001813845 · Director · 10% owner

BIOS Advisors GP, LLC · CIK 0001813844 · Director · 10% owner

Bios Equity Partners, LP · CIK 0001813314 · Director · 10% owner

BIOS Fund I, LP · CIK 0001697316 · Director · 10% owner

BIOS Fund II QP, LP · CIK 0001716869 · Director · 10% owner

BIOS Memory SPV I, LP · CIK 0001643749 · Director · 10% owner

Bios Equity Partners II, LP · CIK 0001813313 · Director · 10% owner

BIOS Fund II, LP · CIK 0001714576 · Director · 10% owner

BIOS Fund I QP, LP · CIK 0001700297 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,229

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

F2 · ownership.direct: Pursuant to an agreement with BP Directors, LP ("Bios Directors"), Dr. Fletcher has agreed that he will hold certain equity-based awards granted to him in connection with his services as a director of the Issuer merely as a nominee for Bios Directors. Bios Directors may be deemed the direct or indirect beneficial owner of the reported securities, and Bios Equity Partners, LP ("Bios Equity I"), Cavu Management, LP ("Cavu Management"), Bios Capital Management, LP ("Bios Management"), Cavu Advisors LLC ("Cavu Advisors"), Bios Advisors GP, LLC ("Bios Advisors"), Leslie W. Kreis, Jr. ("Mr. Kreis") and Dr. Fletcher may each be deemed the indirect beneficial owner of the reported securities through his or its respective indirect interest in Bios Directors.

SEC source: 0001104659-26-076477 · tm2618497-4_4seq1.xml · nonDerivative · entry 1

Khattar Jack A. · CIK 0001539937 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001104659-26-076475 · tm2618497-3_4seq1.xml · nonDerivative · entry 1

Monia Brett P · CIK 0001537529 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001104659-26-076472 · tm2618497-2_4seq1.xml · nonDerivative · entry 1

Wallace Peggy · CIK 0001876466 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,461

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001104659-26-076470 · tm2618497-1_4seq1.xml · nonDerivative · entry 1

RICHSTONE ELLEN B · CIK 0001281526 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001104659-26-054858 · tm2613475-1_4seq1.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 618,942

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001104659-26-045511 · tm2612247-3_4seq1.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 627,509

SEC source: 0001104659-26-045502 · tm2612247-2_4seq1.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,715,851

SEC source: 0001104659-26-045499 · tm2612247-1_4seq1.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 874,906

SEC source: 0001104659-26-017070 · tm266602-3_4seq1.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,706,676

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001104659-26-017068 · tm266602-2_4seq1.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 617,509

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001104659-26-017063 · tm266602-1_4seq1.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 864,906

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001104659-26-011074 · tm265419-2_4seq1.xml · nonDerivative · entry 2

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 619,069

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs.

SEC source: 0001104659-26-011075 · tm265419-3_4seq1.xml · nonDerivative · entry 3

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,712,526

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs.

SEC source: 0001104659-26-011073 · tm265419-1_4seq1.xml · nonDerivative · entry 3

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 869,586

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs.

SEC source: 0001104659-26-011074 · tm265419-2_4seq1.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 645,990

F1 · kind: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001104659-26-011075 · tm265419-3_4seq1.xml · nonDerivative · entry 2

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,764,230

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs.

SEC source: 0001104659-26-011075 · tm265419-3_4seq1.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,790,266

F1 · kind: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001104659-26-011073 · tm265419-1_4seq1.xml · nonDerivative · entry 2

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 896,505

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs.

SEC source: 0001104659-26-011073 · tm265419-1_4seq1.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 907,993

F1 · kind: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001104659-25-123722 · tm2534021-2_4seq1.xml · nonDerivative · entry 2

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 507,993

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001104659-25-123722 · tm2534021-2_4seq1.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 528,273

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. The remaining 50% of the total number of shares subject to the PSUs vested on December 18, 2025.

SEC source: 0001104659-25-123727 · tm2534021-3_4seq1.xml · nonDerivative · entry 2

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 990,266

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001104659-25-123727 · tm2534021-3_4seq1.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,013,666

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. The remaining 50% of the total number of shares subject to the PSUs vested on December 18, 2025.

SEC source: 0001104659-25-123721 · tm2534021-1_4seq1.xml · nonDerivative · entry 2

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 445,990

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001104659-25-123721 · tm2534021-1_4seq1.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 455,350

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. The remaining 50% of the total number of shares subject to the PSUs vested on December 18, 2025.

SEC source: 0001104659-25-092671 · tm2526822-1_4seq1.xml · derivative · entry 13

Fletcher Aaron G.L. · CIK 0001789490 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,729 shares

Expires 2025-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: The option was written and fully vested before the reporting persons became Section 16 insiders of the Issuer and therefore was reported on the reporting persons' Form 3 filed on October 7, 2021.

SEC source: 0001104659-25-092671 · tm2526822-1_4seq1.xml · nonDerivative · entry 1

Fletcher Aaron G.L. · CIK 0001789490 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,229

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Of the 56,229 shares reported as held directly by Aaron G.L. Fletcher ("Dr. Fletcher"), 7,729 shares, are held for the benefit of Dr. Fletcher and 48,500 shares, 34,000 of which represent restricted stock units, are held for the benefit of BP Directors, LP ("Bios Directors" and such securities the "Bios Directors Securities") under an agreement with Bios Directors pursuant to which Dr. Fletcher agreed that he will hold the Bios Directors Securities merely as a nominee for Bios Directors.

F1 · ownership.direct: Of the 56,229 shares reported as held directly by Aaron G.L. Fletcher ("Dr. Fletcher"), 7,729 shares, are held for the benefit of Dr. Fletcher and 48,500 shares, 34,000 of which represent restricted stock units, are held for the benefit of BP Directors, LP ("Bios Directors" and such securities the "Bios Directors Securities") under an agreement with Bios Directors pursuant to which Dr. Fletcher agreed that he will hold the Bios Directors Securities merely as a nominee for Bios Directors.

F2 · ownership.direct: Bios Directors may be deemed the direct or indirect beneficial owner of the Bios Directors Securities, and Bios Equity Partners, LP ("Bios Equity I"), Cavu Management, LP ("Cavu Management"), Bios Capital Management, LP ("Bios Management"), Cavu Advisors LLC ("Cavu Advisors"), Bios Advisors GP, LLC ("Bios Advisors"), Leslie W. Kreis, Jr. ("Mr. Kreis") and Dr. Fletcher may each be deemed the indirect beneficial owner of the Bios Directors Securities through his or its respective indirect interest in Bios Directors.

SEC source: 0001062993-25-013358 · form4.xml · nonDerivative · entry 2

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 463,273

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001062993-25-013358 · form4.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 483,554

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. 50% of the total number of shares subject to the PSUs vested on July 29, 2025.

SEC source: 0001062993-25-013357 · form4.xml · nonDerivative · entry 2

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 425,350

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001062993-25-013357 · form4.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 434,710

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. 50% of the total number of shares subject to the PSUs vested on July 29, 2025.

SEC source: 0001062993-25-013356 · form4.xml · nonDerivative · entry 2

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 938,666

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of PSUs.

SEC source: 0001062993-25-013356 · form4.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 962,066

F1 · kind: Shares earned upon the vesting of performance stock units ("PSUs") granted to the Reporting Person on February 14, 2024. Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon the achievement of certain performance goals. 50% of the total number of shares subject to the PSUs vested on July 29, 2025.

SEC source: 0001104659-25-061242 · tm2518563-2_4seq1.xml · nonDerivative · entry 1

Kreis Leslie W. · CIK 0001813316 · Director · 10% owner

Cavu Advisors, LLC · CIK 0001813310 · Director · 10% owner

Cavu Management, LP · CIK 0001813270 · Director · 10% owner

BIOS Fund II NT, LP · CIK 0001728851 · Director · 10% owner

BIOS Memory SPV II, LP · CIK 0001666485 · Director · 10% owner

BIOS Equity Partners III, LP · CIK 0001831976 · Director · 10% owner

BIOS Fund III, LP · CIK 0001791917 · Director · 10% owner

BIOS Fund III QP, LP · CIK 0001791916 · Director · 10% owner

BIOS Fund III NT, LP · CIK 0001791910 · Director · 10% owner

BP Directors, LP · CIK 0001813311 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 48,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to Aaron G.L. Fletcher's ("Dr. Fletcher") continuous service as a director as of the applicable vesting date.

F2 · ownership.nature: Pursuant to an agreement with BP Directors, LP ("Bios Directors"), Dr. Fletcher has agreed that he will hold certain equity-based awards granted to him in connection with his services as a director of the Issuer merely as a nominee for Bios Directors. Bios Directors may be deemed the direct or indirect beneficial owner of the reported securities, and Bios Equity Partners, LP ("Bios Equity I"), Cavu Management, LP ("Cavu Management"), Bios Capital Management, LP ("Bios Management"), Cavu Advisors LLC ("Cavu Advisors"), Bios Advisors GP, LLC ("Bios Advisors"), Leslie W. Kreis, Jr. ("Mr. Kreis") and Dr. Fletcher may each be deemed the indirect beneficial owner of the reported securities through his or its respective indirect interest in Bios Directors.

SEC source: 0001104659-25-061241 · tm2518563-1_4seq1.xml · nonDerivative · entry 1

Fletcher Aaron G.L. · CIK 0001789490 · Director · 10% owner

BIOS Capital Management, LP · CIK 0001813845 · Director · 10% owner

BIOS Advisors GP, LLC · CIK 0001813844 · Director · 10% owner

Bios Equity Partners, LP · CIK 0001813314 · Director · 10% owner

BIOS Fund I, LP · CIK 0001697316 · Director · 10% owner

BIOS Fund I QP, LP · CIK 0001700297 · Director · 10% owner

BIOS Memory SPV I, LP · CIK 0001643749 · Director · 10% owner

Bios Equity Partners II, LP · CIK 0001813313 · Director · 10% owner

BIOS Fund II, LP · CIK 0001714576 · Director · 10% owner

BIOS Fund II QP, LP · CIK 0001716869 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to Aaron G.L. Fletcher's ("Dr. Fletcher") continuous service as a director as of the applicable vesting date.

F2 · ownership.direct: Pursuant to an agreement with BP Directors, LP ("Bios Directors"), Dr. Fletcher has agreed that he will hold certain equity-based awards granted to him in connection with his services as a director of the Issuer merely as a nominee for Bios Directors. Bios Directors may be deemed the direct or indirect beneficial owner of the reported securities, and Bios Equity Partners, LP ("Bios Equity I"), Cavu Management, LP ("Cavu Management"), Bios Capital Management, LP ("Bios Management"), Cavu Advisors LLC ("Cavu Advisors"), Bios Advisors GP, LLC ("Bios Advisors"), Leslie W. Kreis, Jr. ("Mr. Kreis") and Dr. Fletcher may each be deemed the indirect beneficial owner of the reported securities through his or its respective indirect interest in Bios Directors.

SEC source: 0001062993-25-012082 · form4.xml · nonDerivative · entry 1

Khattar Jack A. · CIK 0001539937 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001062993-25-012081 · form4.xml · nonDerivative · entry 1

Wallace Peggy · CIK 0001876466 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,461

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001062993-25-012079 · form4.xml · nonDerivative · entry 1

RICHSTONE ELLEN B · CIK 0001281526 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001062993-25-012078 · form4.xml · nonDerivative · entry 1

Monia Brett P · CIK 0001537529 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,500

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date.

SEC source: 0001062993-25-008394 · form4.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 404,710

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001062993-25-002704 · form4.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 418,554

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001062993-25-002705 · form4.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 887,066

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001062993-25-002703 · form4.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 414,402

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001062993-25-001622 · form4.xml · nonDerivative · entry 2

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 423,850

F2 · kind: Each share is represented by an RSU. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001062993-25-001617 · form4.xml · nonDerivative · entry 3

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 893,685

F3 · kind: Each share is represented by an RSU. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001062993-25-001620 · form4.xml · nonDerivative · entry 1

Doyle John Brendan · CIK 0001840738 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 416,125

F1 · kind: Each share is represented by a restricted stock unit ("RSU"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement.

SEC source: 0001062993-25-001622 · form4.xml · nonDerivative · entry 1

Caggiano Anthony · CIK 0001892981 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,850

F1 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs").

SEC source: 0001062993-25-001617 · form4.xml · nonDerivative · entry 2

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 262,385

F2 · kind: Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs").

SEC source: 0001062993-25-001617 · form4.xml · nonDerivative · entry 1

Ricciardi Lisa · CIK 0001418200 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 38,851

F1 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $0.7602 to $0.7816, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.