CERT

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · derivative · entry 6

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,266

Underlying: Common Stock · 12,632 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · derivative · entry 5

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,663

Underlying: Common Stock · 14,663 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. Half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs are scheduled to vest and settle on April 1, 2025.

F1 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. Half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · nonDerivative · entry 4

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,218

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes 1 and 3, exempt under Rule 16b-3.

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · nonDerivative · entry 3

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,545

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · nonDerivative · entry 2

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,913

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes 1 and 3, exempt under Rule 16b-3.

SEC source: 0001415889-24-010062 · form4-04032024_090409.xml · nonDerivative · entry 1

Gallagher John E · CIK 0001628991 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,663

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each RSU was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. Half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · derivative · entry 8

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,288

Underlying: Common Stock · 6,644 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · derivative · entry 7

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,651

Underlying: Common Stock · 6,651 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 6

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,524

F6 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2023.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 5

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176,524

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 4

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 178,800

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 3

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 172,156

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 2

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,401

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010075 · form4-04032024_090439.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 167,750

F1 · kind: Each RSU was granted on April 1, 2021, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were settled on March 31, 2023. The remaining one-third of the RSUs vested and were settled on April 1, 2024.

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

F3 · balance_after: The total reported in Column 5 includes 5,495 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · derivative · entry 8

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,381

Underlying: Common Stock · 30,381 shares

Expires 2027-04-01

F6 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026 and April 1, 2027.

F6 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026 and April 1, 2027.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · derivative · entry 7

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,704

Underlying: Common Stock · 7,852 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · derivative · entry 6

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,647

Underlying: Common Stock · 8,646 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · nonDerivative · entry 5

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,518

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · nonDerivative · entry 4

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,208

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · nonDerivative · entry 3

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,356

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · nonDerivative · entry 2

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,089

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010073 · form4-04032024_090432.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,443

F1 · kind: Each RSU was granted on April 1, 2021, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were settled on March 31, 2023. The remaining one-third of the RSUs vested and were settled on April 1, 2024.

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

F3 · balance_after: The total reported in Column 5 includes 4,884 RSUs which was previously reported in Table 1 of Form 4

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · derivative · entry 8

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,381

Underlying: Common Stock · 30,381 shares

Expires 2027-04-01

F6 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026 and April 1, 2027.

F6 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026 and April 1, 2027.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · derivative · entry 7

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,704

Underlying: Common Stock · 7,852 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · derivative · entry 6

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,647

Underlying: Common Stock · 8,646 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · nonDerivative · entry 5

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 290,176

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

F3 · balance_after: The total reported in Column 5 includes 7,937 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · nonDerivative · entry 4

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 293,867

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on April 1, 2025 and April 1, 2026.

F3 · balance_after: The total reported in Column 5 includes 7,937 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · nonDerivative · entry 3

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 286,015

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

F3 · balance_after: The total reported in Column 5 includes 7,937 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · nonDerivative · entry 2

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 290,079

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2025.

F3 · balance_after: The total reported in Column 5 includes 7,937 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010061 · form4-04032024_090429.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 281,433

F1 · kind: Each RSU was granted on April 1, 2021, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents the right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were settled on March 31, 2023. The remaining one-third of the RSUs vested and were settled on April 1, 2024.

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes, 1, 4, and 5, exempt under Rule 16b-3.

F3 · balance_after: The total reported in Column 5 includes 7,937 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-24-010404 · form4a-04052024_080451.xml · derivative · entry 1

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,779

Underlying: Common Stock · 124,779 shares

Expires 2027-04-01

F1 · derivative.exercise_price: The original Form 4, filed on April 3, 2024, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported that 120,981 restricted stock units ("RSUs") were granted on April 1, 2024, when in fact, 124,779 RSUs were granted. As a result of this update, the number of shares beneficially owned by the reporting person following such transaction has been correspondingly increased by 3,798 shares. As previously disclosed, each RSU was granted on April 1, 2024, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026, and April 1, 2027.

F1 · shares: The original Form 4, filed on April 3, 2024, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported that 120,981 restricted stock units ("RSUs") were granted on April 1, 2024, when in fact, 124,779 RSUs were granted. As a result of this update, the number of shares beneficially owned by the reporting person following such transaction has been correspondingly increased by 3,798 shares. As previously disclosed, each RSU was granted on April 1, 2024, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026, and April 1, 2027.

F1 · derivative.exercise_date: The original Form 4, filed on April 3, 2024, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported that 120,981 restricted stock units ("RSUs") were granted on April 1, 2024, when in fact, 124,779 RSUs were granted. As a result of this update, the number of shares beneficially owned by the reporting person following such transaction has been correspondingly increased by 3,798 shares. As previously disclosed, each RSU was granted on April 1, 2024, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2025, April 1, 2026, and April 1, 2027.

SEC source: 0001415889-24-007049 · form4-03062024_090320.xml · nonDerivative · entry 2

SHERMAN NICOLETTE D · CIK 0001872604 · CHIEF HUMAN RESOURCES OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,717

F2 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 1.

SEC source: 0001415889-24-007049 · form4-03062024_090320.xml · nonDerivative · entry 1

SHERMAN NICOLETTE D · CIK 0001872604 · CHIEF HUMAN RESOURCES OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,090

F1 · price: Each performance stock unit ("PSU") was granted on August 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-007042 · form4-03062024_090352.xml · nonDerivative · entry 2

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,221,984

F2 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 1.

SEC source: 0001415889-24-007042 · form4-03062024_090352.xml · nonDerivative · entry 1

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,239,541

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-007044 · form4-03062024_090307.xml · nonDerivative · entry 2

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,381

F2 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 1.

SEC source: 0001415889-24-007044 · form4-03062024_090307.xml · nonDerivative · entry 1

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,431

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-007051 · form4-03062024_090348.xml · nonDerivative · entry 2

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,473

F2 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 1.

SEC source: 0001415889-24-007051 · form4-03062024_090348.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173,133

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-007036 · form4-03062024_090345.xml · nonDerivative · entry 4

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 284,303

F4 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 3.

SEC source: 0001415889-24-007036 · form4-03062024_090345.xml · nonDerivative · entry 3

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,992

F3 · price: Each PSU was granted on July 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-007036 · form4-03062024_090345.xml · nonDerivative · entry 2

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 282,403

F2 · kind: Represents shares of the issuer withheld to satisfy tax withholding obligations in connection with the vesting of PSUs described in footnote 1.

SEC source: 0001415889-24-007036 · form4-03062024_090345.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT; SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 288,025

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock. The PSUs are subject to the achievement of certain performance objectives over a three-year period from January 1, 2021 to December 31, 2023. The PSUs were vested and settled on March 5, 2024.

SEC source: 0001415889-24-006739 · form4-03052024_090309.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 162,368

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2023.

SEC source: 0001415889-24-004633 · form4-02212024_090252.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,975

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 20, 2023.

SEC source: 0001415889-24-003750 · form4-02142024_090223.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 165,368

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2023.

SEC source: 0001415889-23-016967 · form4-12272023_111200.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 171,368

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2023.

SEC source: 0001415889-23-014040 · form4-10062023_091052.xml · derivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,454

Underlying: Common Stock · 21,454 shares

Expires 2026-10-05

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") was granted on October 5, 2023, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs will vest and settle in three equal installments on October 5, 2024, October 5, 2025, and October 5, 2026.

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") was granted on October 5, 2023, under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs will vest and settle in three equal installments on October 5, 2024, October 5, 2025, and October 5, 2026.

SEC source: 0001415889-23-013171 · form4-09122023_080947.xml · nonDerivative · entry 1

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 128,883

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $14.51 to $14.84. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-012566 · form4-08232023_080847.xml · nonDerivative · entry 2

BROSHY ERAN · CIK 0001256230 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,360