CBIO

SEC source: 0001209191-18-029616 · doc4.xml · nonDerivative · entry 2

BARRIS PETER J · CIK 0001005561 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,702,791

F2 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 216,046 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 4,006 of the warrant shares to pay the exercise price and issuing 212,040 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029616 · doc4.xml · nonDerivative · entry 1

BARRIS PETER J · CIK 0001005561 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,706,797

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · derivative · entry 6

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 298,406 shares

Expires 2019-01-16

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · derivative · entry 5

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 216,046 shares

Expires 2018-07-03

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · nonDerivative · entry 4

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,995,664

F3 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 298,406 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 5,533 of the warrant shares to pay the exercise price and issuing 292,873 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · nonDerivative · entry 3

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,001,197

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · nonDerivative · entry 2

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,702,791

F2 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 216,046 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 4,006 of the warrant shares to pay the exercise price and issuing 212,040 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029614 · doc4.xml · nonDerivative · entry 1

NEW ENTERPRISE ASSOCIATES 10 L P · CIK 0001132326 · 10% owner

NEA PARTNERS 10 L P · CIK 0001236049 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,706,797

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 10, Limited Partnership ("NEA 10") and indirectly held by NEA Partners 10, Limited Partnership ("NEA Partners 10"), the sole general partner of NEA 10, and the individual general partners of NEA Partners 10 (NEA Partners 10 and its individual general partners together, the "Indirect Reporting Persons"). The individual general partners of NEA Partners 10 are Peter J. Barris, M. James Barrett and Scott D. Sandell. Each Indirect Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which such Indirect Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · derivative · entry 7

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 0

Underlying: Common Stock · 298,406 shares

Expires 2019-01-16

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · derivative · entry 6

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 0

Underlying: Common Stock · 216,046 shares

Expires 2018-07-03

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · nonDerivative · entry 4

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,995,664

F3 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 298,406 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 5,533 of the warrant shares to pay the exercise price and issuing 292,873 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · nonDerivative · entry 3

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 5,001,197

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · nonDerivative · entry 2

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,702,791

F2 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 216,046 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 4,006 of the warrant shares to pay the exercise price and issuing 212,040 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029619 · doc4.xml · nonDerivative · entry 1

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,706,797

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · derivative · entry 7

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 0

Underlying: Common Stock · 298,406 shares

Expires 2019-01-16

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · derivative · entry 6

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 0

Underlying: Common Stock · 216,046 shares

Expires 2018-07-03

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · nonDerivative · entry 4

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,995,664

F3 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 298,406 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 5,533 of the warrant shares to pay the exercise price and issuing 292,873 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · nonDerivative · entry 3

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 5,001,197

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · nonDerivative · entry 2

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,702,791

F2 · kind: On May 10, 2018, NEA 10 exercised warrants to purchase a total of 216,046 shares of the Issuer's common stock for $0.33 a share. NEA 10 paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 4,006 of the warrant shares to pay the exercise price and issuing 212,040 shares to NEA 10. The Issuer also paid cash to NEA 10 in lieu of any fractional shares to be issued upon exercise of the warrants.

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-029615 · doc4.xml · nonDerivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 4,706,797

F1 · ownership.nature: The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"), NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-18-003393 · doc4.xml · derivative · entry 1

King Rachel K. · CIK 0001589712 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2028-01-09

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 10, 2019 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-18-003392 · doc4.xml · derivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2028-01-09

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 10, 2019 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-18-003391 · doc4.xml · derivative · entry 1

Magnani John L. · CIK 0001589713 · Director · SVP of Research, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2028-01-09

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 10, 2019 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-18-003389 · doc4.xml · derivative · entry 1

Hahn Brian M. · CIK 0001589711 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2028-01-09

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 10, 2019 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-17-065185 · doc4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,615

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b-5 trading plan adopted by the reporting person on June 19, 2017.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.00 to $15.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

SEC source: 0001209191-17-053214 · doc4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,615

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b-5 trading plan adopted by the reporting person on June 19, 2017.

SEC source: 0001209191-18-009860 · doc5.xml · nonDerivative · entry 3

King Rachel K. · CIK 0001589712 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Rachel K. King 2013 GRAT

Disclosed balance after: 0

F2 · ownership.nature: On June 7, 2013, the reporting person contributed 136,281 shares of the issuer's common stock to a grantor retained annuity trust for the benefit of herself and her two adult children. Upon termination of the trust, on September 8, 2017, a total of 46,602 shares were transferred to trusts for the benefit of the adult children. The remaining 89,679 shares were previously distributed to the reporting person and continue to be reported on this form as directly owned.

SEC source: 0001209191-18-009860 · doc5.xml · nonDerivative · entry 2

King Rachel K. · CIK 0001589712 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Langley King 2013 GRAT

Disclosed balance after: 23,301

F1 · ownership.nature: These shares are held in a trust for the benefit of the reporting person's children. The reporting person's spouse is trustee of the trust. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2 · ownership.nature: On June 7, 2013, the reporting person contributed 136,281 shares of the issuer's common stock to a grantor retained annuity trust for the benefit of herself and her two adult children. Upon termination of the trust, on September 8, 2017, a total of 46,602 shares were transferred to trusts for the benefit of the adult children. The remaining 89,679 shares were previously distributed to the reporting person and continue to be reported on this form as directly owned.

SEC source: 0001209191-18-009860 · doc5.xml · nonDerivative · entry 1

King Rachel K. · CIK 0001589712 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Connor King 2013 GRAT

Disclosed balance after: 23,301

F1 · ownership.nature: These shares are held in a trust for the benefit of the reporting person's children. The reporting person's spouse is trustee of the trust. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2 · ownership.nature: On June 7, 2013, the reporting person contributed 136,281 shares of the issuer's common stock to a grantor retained annuity trust for the benefit of herself and her two adult children. Upon termination of the trust, on September 8, 2017, a total of 46,602 shares were transferred to trusts for the benefit of the adult children. The remaining 89,679 shares were previously distributed to the reporting person and continue to be reported on this form as directly owned.

SEC source: 0001209191-17-040589 · doc4.xml · nonDerivative · entry 1

JUNIUS DANIEL M · CIK 0001094159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

F1 · price: The Reporting Person purchased the securities on the open market at purchase prices ranging from $11.24 to $11.29 per share, with a weighted average purchase price of $11.27 per share. The Reporting Person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price.

SEC source: 0001209191-17-039165 · doc4.xml · derivative · entry 1

Andrews Patricia S · CIK 0001445710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2027-06-09

F1 · derivative.exercise_date: This option grant was made pursuant to the issuer's non-employee director compensation policy. The shares underlying this option vest in three equal installments on June 9, 2018, 2019 and 2020, subject to the reporting person's continuous service with the issuer at each vesting date.

SEC source: 0001209191-17-036118 · doc4.xml · derivative · entry 1

JUNIUS DANIEL M · CIK 0001094159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2027-05-24

F1 · derivative.exercise_date: The shares underlying this option vest on May 25, 2018, subject to the reporting person's continuous service as of such vesting date.

SEC source: 0001209191-17-036146 · doc4.xml · derivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2027-05-24

F1 · derivative.exercise_date: The shares underlying this option vest on May 25, 2018, subject to the reporting person's continuous service as of such vesting date.

SEC source: 0001209191-17-036121 · doc4.xml · derivative · entry 1

PEARSON TIMOTHY R · CIK 0001528617 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2027-05-24

F1 · derivative.exercise_date: The shares underlying this option vest on May 25, 2018, subject to the reporting person's continuous service as of such vesting date.

SEC source: 0001209191-17-036120 · doc4.xml · derivative · entry 1

Koenig Scott · CIK 0001587514 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2027-05-24

F1 · derivative.exercise_date: The shares underlying this option vest on May 25, 2018, subject to the reporting person's continuous service as of such vesting date.

SEC source: 0001209191-17-036116 · doc4.xml · derivative · entry 1

Goldberg Mark Alan · CIK 0001532475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2027-05-24

F1 · derivative.exercise_date: The shares underlying this option vest on May 25, 2018, subject to the reporting person's continuous service as of such vesting date.

SEC source: 0001209191-17-036114 · doc4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,615

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b-5 trading plan adopted by the reporting person on May 31, 2016.

SEC source: 0001209191-17-034534 · doc4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 154,615

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2016.

SEC source: 0001209191-17-031515 · doc4.xml · derivative · entry 3

Magnani John L. · CIK 0001589713 · Director · SVP of Research, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,967

Underlying: Common Stock · 8,928 shares

Expires 2021-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: One-fourth of the shares underlying this option vested on January 4, 2012, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-031515 · doc4.xml · nonDerivative · entry 1

Magnani John L. · CIK 0001589713 · Director · SVP of Research, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,302

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-17-020152 · doc4.xml · derivative · entry 1

Koenig Scott · CIK 0001587514 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2027-03-09

F1 · derivative.exercise_date: This option grant was made pursuant to the issuer's non-employee director compensation policy. The shares underlying this option vest in three equal installments on March 9, 2018, 2019 and 2020, subject to the reporting person's continuous service with the issuer at each vesting date.

SEC source: 0001209191-17-001652 · doc4.xml · derivative · entry 1

Magnani John L. · CIK 0001589713 · Director · SVP of Research, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2027-01-03

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 4, 2018 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-17-001651 · doc4.xml · derivative · entry 1

Thackray Helen M. · CIK 0001589725 · SVP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2027-01-03

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 4, 2018 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-17-001650 · doc4.xml · derivative · entry 1

Hahn Brian M. · CIK 0001589711 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2027-01-03

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 4, 2018 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-17-001649 · doc4.xml · derivative · entry 1

King Rachel K. · CIK 0001589712 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2027-01-03

F1 · derivative.exercise_date: One-fourth of the shares underlying this option vest on January 4, 2018 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001209191-16-156326 · doc4.xml · nonDerivative · entry 1

JUNIUS DANIEL M · CIK 0001094159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

F1 · price: The Reporting Person purchased the securities on the open market at purchase prices ranging from $5.93 to $6.03 per share, with a weighted average purchase price of $6.01 per share. The Reporting Person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price.

F1 · balance_after: The Reporting Person purchased the securities on the open market at purchase prices ranging from $5.93 to $6.03 per share, with a weighted average purchase price of $6.01 per share. The Reporting Person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price.

SEC source: 0001209191-16-144211 · doc4.xml · nonDerivative · entry 2

Thackray Helen M. · CIK 0001589725 · VP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,615

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2016.

SEC source: 0001209191-16-144211 · doc4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · VP Clinical Development, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,715

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2016.