CALC

SEC source: 0001209191-22-059206 · doc4.xml · nonDerivative · entry 2

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,577

SEC source: 0001209191-22-059206 · doc4.xml · nonDerivative · entry 1

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,329

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-059205 · doc4.xml · derivative · entry 3

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,250

Underlying: Common Stock · 28,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-059205 · doc4.xml · nonDerivative · entry 2

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,530

SEC source: 0001209191-22-059205 · doc4.xml · nonDerivative · entry 1

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 168,598

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-058951 · doc4.xml · derivative · entry 3

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 421,875

Underlying: Common Stock · 28,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vested as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-058951 · doc4.xml · nonDerivative · entry 2

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,294

SEC source: 0001209191-22-058951 · doc4.xml · nonDerivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,020

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-058949 · doc4.xml · derivative · entry 3

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 984,375

Underlying: Common Stock · 65,625 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vested as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-058949 · doc4.xml · nonDerivative · entry 2

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,473

SEC source: 0001209191-22-058949 · doc4.xml · nonDerivative · entry 1

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 166,297

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-058950 · doc4.xml · derivative · entry 3

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 421,875

Underlying: Common Stock · 28,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vested as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-058950 · doc4.xml · nonDerivative · entry 2

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,954

SEC source: 0001209191-22-058950 · doc4.xml · nonDerivative · entry 1

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-051242 · doc4.xml · nonDerivative · entry 2

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,895

SEC source: 0001209191-22-051242 · doc4.xml · derivative · entry 3

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 5,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/12 of the total shares on September 4, 2022, but were not settled and issued until September 23, 2022. 1/12 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on September 4, 2024, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-051242 · doc4.xml · nonDerivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,579

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-047724 · doc4.xml · derivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vest as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047723 · doc4.xml · derivative · entry 1

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vest as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047722 · doc4.xml · derivative · entry 1

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,050,000

Underlying: Common Stock · 1,050,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs shall vest as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047234 · doc4.xml · derivative · entry 3

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,313

Underlying: Common Stock · 9,937 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047234 · doc4.xml · nonDerivative · entry 2

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,579

SEC source: 0001209191-22-047234 · doc4.xml · nonDerivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,926

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-047231 · doc4.xml · derivative · entry 3

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,125

Underlying: Common Stock · 9,375 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047231 · doc4.xml · nonDerivative · entry 2

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,084

SEC source: 0001209191-22-047231 · doc4.xml · nonDerivative · entry 1

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-047229 · doc4.xml · derivative · entry 3

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 309,375

Underlying: Common Stock · 28,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-047229 · doc4.xml · nonDerivative · entry 2

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,672

SEC source: 0001209191-22-047229 · doc4.xml · nonDerivative · entry 1

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,268

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-036381 · doc4.xml · derivative · entry 2

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 5,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on September 4, 2021 but did not settle until September 22, 2021. 1/12 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on September 4, 2024, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-036381 · doc4.xml · nonDerivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,989

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-034262 · doc4.xml · derivative · entry 2

SHAFFER CHRISTY L · CIK 0001145929 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's Common Stock, subject to the reporting person's continued status as a service provider to the issuer.

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

F3 · derivative.expiration_date: These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date.

SEC source: 0001209191-22-034262 · doc4.xml · derivative · entry 1

SHAFFER CHRISTY L · CIK 0001145929 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-06-01

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

SEC source: 0001209191-22-034260 · doc4.xml · derivative · entry 2

Sauer Dirk · CIK 0001921165 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's Common Stock, subject to the reporting person's continued status as a service provider to the issuer.

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

F3 · derivative.expiration_date: These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date.

SEC source: 0001209191-22-034260 · doc4.xml · derivative · entry 1

Sauer Dirk · CIK 0001921165 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-06-01

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

SEC source: 0001209191-22-034256 · doc4.xml · derivative · entry 2

EASTLAND JULIA MARIE · CIK 0001500189 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's Common Stock, subject to the reporting person's continued status as a service provider to the issuer.

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

F3 · derivative.expiration_date: These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date.

SEC source: 0001209191-22-034256 · doc4.xml · derivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-06-01

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

SEC source: 0001209191-22-034252 · doc4.xml · derivative · entry 2

BJERKHOLT ERIC · CIK 0001197350 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's Common Stock, subject to the reporting person's continued status as a service provider to the issuer.

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

F3 · derivative.expiration_date: These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date.

SEC source: 0001209191-22-034252 · doc4.xml · derivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-06-01

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

SEC source: 0001209191-22-034247 · doc4.xml · derivative · entry 2

ACKERMANN CHRISTINA · CIK 0001681871 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's Common Stock, subject to the reporting person's continued status as a service provider to the issuer.

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

F3 · derivative.expiration_date: These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date.

SEC source: 0001209191-22-034247 · doc4.xml · derivative · entry 1

ACKERMANN CHRISTINA · CIK 0001681871 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-06-01

F1 · derivative.exercise_date: The award vests in full on the earlier of: (i) the one year anniversary of the grant date or (ii) the date of the issuer's 2023 Annual Meeting of its stockholders, subject to the reporting person's continuous service to the issuer on such date.

SEC source: 0001209191-22-031353 · doc4.xml · derivative · entry 3

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,250

Underlying: Common Stock · 39,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-031353 · doc4.xml · nonDerivative · entry 2

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,989

SEC source: 0001209191-22-031353 · doc4.xml · nonDerivative · entry 1

BREUIL ROBERT S · CIK 0001241009 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,279

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-031350 · doc4.xml · derivative · entry 3

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 37,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-031350 · doc4.xml · nonDerivative · entry 2

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,377

SEC source: 0001209191-22-031350 · doc4.xml · nonDerivative · entry 1

Zamiri Parisa · CIK 0001824806 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-031348 · doc4.xml · derivative · entry 3

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 337,500

Underlying: Common Stock · 112,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.

F2 · derivative.exercise_date: The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date.

F3 · derivative.expiration_date: The RSUs do not expire; they either vest or are canceled prior to vest date.

SEC source: 0001209191-22-031348 · doc4.xml · nonDerivative · entry 2

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,143

SEC source: 0001209191-22-031348 · doc4.xml · nonDerivative · entry 1

Guerard Frederic · CIK 0001825009 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.