BDTX

SEC source: 0001415889-24-029481 · form4-12162024_091212.xml · nonDerivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,865

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on December 12, 2024.

SEC source: 0000950170-24-108430 · ownership.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,584

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 19, 2024.

SEC source: 0001415889-24-023757 · form4-09202024_080939.xml · nonDerivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,365

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 19, 2024.

SEC source: 0001415889-24-023755 · form4-09202024_080904.xml · nonDerivative · entry 1

Raman Prakash · CIK 0002018686 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,995

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 19, 2024.

SEC source: 0000950170-24-102354 · ownership.xml · nonDerivative · entry 1

Versant Venture Capital VI, L.P. · CIK 0001687880 · 10% owner

Versant Voyageurs I, L.P. · CIK 0001745960 · 10% owner

Versant Voyageurs I Parallel, L.P. · CIK 0001745961 · 10% owner

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,726,341

F1 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $6.32 to $6.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.direct: These shares are held of record by Versant Venture Capital VI, L.P. ("VVC VI"). Versant Ventures VI GP, L.P. ("VV VI GP") is the general partner of VVC VI, and Versant Ventures VI GP-GP, LLC ("VV VI GP-GP") is the general partner of VV VI GP and each may be deemed to share voting, investment and dispositive power over the shares held by VVC VI. Each of VV VI GP-GP and VV VI GP disclaims beneficial ownership of such shares, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-24-017843 · form4-06212024_080605.xml · nonDerivative · entry 1

Raman Prakash · CIK 0002018686 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,301

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 20, 2024.

SEC source: 0000950170-24-076273 · ownership.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,577

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 20, 2024.

SEC source: 0001415889-24-017842 · form4-06212024_080631.xml · nonDerivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,011

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 20, 2024.

SEC source: 0000950170-24-070044 · ownership.xml · derivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-015828 · form4-06062024_090611.xml · derivative · entry 1

Kulkarni Samarth · CIK 0001682019 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-015823 · form4-06062024_090628.xml · derivative · entry 1

Raman Prakash · CIK 0002018686 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-015826 · form4-06062024_090630.xml · derivative · entry 1

Menzel Garry E · CIK 0001556064 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-015821 · form4-06062024_090608.xml · derivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-015819 · form4-06062024_090644.xml · derivative · entry 1

Dhingra Kapil · CIK 0001456849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,550

Underlying: Common Stock · 30,550 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 6, 2025 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-010770 · form4-04122024_090409.xml · derivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,100

Underlying: Common Stock · 61,100 shares

Expires 2034-04-09

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in thirty-six (36) equal monthly installments, with the first installment vesting on May 10, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-24-010769 · form4-04122024_090430.xml · derivative · entry 1

Raman Prakash · CIK 0002018686 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,100

Underlying: Common Stock · 61,100 shares

Expires 2034-04-09

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in thirty-six (36) equal monthly installments, with the first installment vesting on May 10, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-041554 · ownership.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,690

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on March 14, 2024.

SEC source: 0001415889-24-010213 · form4-04042024_120440.xml · nonDerivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,054

F1 · kind: These shares were issued in accordance with the Issuer's Fifth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on March 14, 2024.

SEC source: 0001415889-24-003960 · form4-02152024_100202.xml · derivative · entry 1

Jones Erika · CIK 0001895913 · SEE REMARKS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-003971 · form4-02152024_100235.xml · derivative · entry 1

Ni Fang · CIK 0001895910 · SEE REMARKS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-003965 · form4-02152024_100219.xml · derivative · entry 1

Buck Elizabeth · CIK 0001880385 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-003969 · form4-02152024_100242.xml · derivative · entry 1

Hatzis-Schoch Brent · CIK 0001637054 · SEE REMARKS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-003967 · form4-02152024_100227.xml · derivative · entry 1

Yurasov Sergey · CIK 0001686295 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-003963 · form4-02152024_100218.xml · derivative · entry 1

Velleca Mark A. · CIK 0001706847 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 537,000

Underlying: Common Stock · 537,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on February 14, 2025, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-23-058790 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,524

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on December 14, 2023.

SEC source: 0001415889-23-016532 · form4-12152023_091215.xml · nonDerivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,801

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on December 14, 2023.

SEC source: 0000950170-23-054142 · ownership.xml · nonDerivative · entry 1

BIOTECH GROWTH N V · CIK 0001259869 · 10% owner

BB BIOTECH AG · CIK 0000924223 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,517,839

SEC source: 0001415889-23-013339 · form4-09182023_090915.xml · derivative · entry 2

Velleca Mark A. · CIK 0001706847 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,000,000

Underlying: Common Stock · 1,000,000 shares

Expires 2033-09-16

F3 · derivative.exercise_date: 25% of the shares subject to this option shall vest and become exercisable on September 17, 2024, with the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-23-049791 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,069

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 14, 2023.

SEC source: 0001415889-23-013339 · form4-09182023_090915.xml · nonDerivative · entry 1

Velleca Mark A. · CIK 0001706847 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,522

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 14, 2023.

SEC source: 0001415889-23-013337 · form4-09182023_090941.xml · nonDerivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,758

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on September 14, 2023.

SEC source: 0001209191-23-041567 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 4,448,757

F1 · kind: Reports the purchase of shares in the underwritten public offering of common stock of the Issuer.

F2 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC ("NEA 16 GP"), which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001104659-23-079144 · tm2320829-1_4seq1.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director

RA Capital Healthcare Fund LP · CIK 0001315082 · Director

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director

Kolchinsky Peter · CIK 0001384859 · Director

Shah Rajeev M. · CIK 0001619841 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,213,828

F1 · price: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on June 30, 2023.

F2 · balance_after: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F1 · ownership.nature: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on June 30, 2023.

F2 · ownership.nature: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0000950170-23-031386 · ownership.xml · nonDerivative · entry 1

BIOTECH GROWTH N V · CIK 0001259869 · 10% owner

BB BIOTECH AG · CIK 0000924223 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,117,839

SEC source: 0001415889-23-010388 · form4-06282023_080616.xml · nonDerivative · entry 1

Epstein David M. · CIK 0001488668 · Director · SEE REMARKS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 671,423

F1 · kind: Shares sold pursuant to a pre-established 10b5-1 trading plan effective as of December 29, 2022.

SEC source: 0000899243-23-016705 · doc4.xml · nonDerivative · entry 1

BIOTECH GROWTH N V · CIK 0001259869 · 10% owner

BB BIOTECH AG · CIK 0000924223 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,117,839

SEC source: 0001209191-23-038084 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,770

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 15, 2023.

SEC source: 0001415889-23-009960 · form4-06162023_090654.xml · nonDerivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,772

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 15, 2023.

SEC source: 0001415889-23-009959 · form4-06162023_090615.xml · nonDerivative · entry 1

Velleca Mark A. · CIK 0001706847 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,314

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on June 15, 2023.

SEC source: 0001209191-23-030458 · doc4.xml · derivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008248 · form4-05182023_010502.xml · derivative · entry 1

Mayweg Alexander · CIK 0001786260 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008247 · form4-05182023_010525.xml · derivative · entry 1

Shah Rajeev M. · CIK 0001619841 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

F1 · ownership.nature: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: The option was awarded to Mr. Rajeev Shah in connection with his service as a director of the Issuer. Mr. Shah is a Managing Partner of the Adviser. and, under his arrangement with the Adviser, Mr. Shah holds the option for the benefit of the Fund and the Nexus Fund. Mr. Shah is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and Nexus Fund to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock.

SEC source: 0001415889-23-008246 · form4-05182023_010525.xml · derivative · entry 1

Velleca Mark A. · CIK 0001706847 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008245 · form4-05182023_010546.xml · derivative · entry 1

Menzel Garry E · CIK 0001556064 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008243 · form4-05182023_010501.xml · derivative · entry 1

Kulkarni Samarth · CIK 0001682019 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008242 · form4-05182023_010509.xml · derivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-23-008241 · form4-05182023_010514.xml · derivative · entry 1

Dhingra Kapil · CIK 0001456849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2033-05-15

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) May 16, 2024 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001209191-23-020051 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,115

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on March 16, 2023.

SEC source: 0001415889-23-005219 · form4-03202023_080355.xml · nonDerivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,653

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on March 16, 2023.

SEC source: 0001415889-23-005218 · form4-03202023_080357.xml · nonDerivative · entry 1

Velleca Mark A. · CIK 0001706847 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,385

F1 · kind: These shares were issued in accordance with the Issuer's Fourth Amended and Restated Non-Employee Director Compensation Policy, pursuant to which the Reporting Person elected to receive shares of the Issuer's common stock in lieu of cash compensation for annual services as a non-employee director of the Issuer.

F2 · price: The price reported in Column 4 is based upon the closing market price of the Issuer's common stock on March 16, 2023.