BDSX

SEC source: 0001140361-22-018736 · form4.xml · nonDerivative · entry 1

O'Kane Kieran · CIK 0001828131 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,222

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F6 · balance_after: Includes 1,157 and 2,604 Shares acquired under the BDSX stock purchase plan on August 31, 2021 and February 28, 2022, respectively.

SEC source: 0001140361-22-018732 · form4.xml · derivative · entry 4

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,377

Underlying: Common Stock · 3,676 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-018732 · form4.xml · derivative · entry 3

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,674

Underlying: Common Stock · 1,378 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-018732 · form4.xml · nonDerivative · entry 1

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,220

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

SEC source: 0001140361-22-018731 · form4.xml · derivative · entry 4

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,090

Underlying: Common Stock · 8,418 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-018731 · form4.xml · derivative · entry 3

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,351

Underlying: Common Stock · 3,157 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-018731 · form4.xml · nonDerivative · entry 1

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,833

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock (each, a "Share").

F6 · balance_after: Includes 2,604 Shares acquired under the BDSX stock purchase plan on February 28, 2022.

SEC source: 0001567619-22-008352 · doc1.xml · nonDerivative · entry 1

SCHULER JACK W · CIK 0001021412 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jack W. Schuler Living Trust

Disclosed balance after: 11,256,460

F1 · ownership.direct: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

F1 · ownership.nature: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0001567619-22-008354 · doc1.xml · nonDerivative · entry 1

PATIENCE JOHN · CIK 0001021413 · Director · 10% owner · Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 337,926

SEC source: 0001567619-22-008353 · doc1.xml · nonDerivative · entry 2

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Birchview Fund LLC

Disclosed balance after: 769,859

F1 · ownership.direct: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F1 · ownership.nature: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0001567619-22-008353 · doc1.xml · nonDerivative · entry 1

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,545,586

SEC source: 0001140361-22-012922 · form4.xml · derivative · entry 2

Franchi Jean M. · CIK 0001653053 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,044 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These restricted stock units vested in full on March 31, 2022 and had no expiration date.

F2 · derivative.expiration_date: These restricted stock units vested in full on March 31, 2022 and had no expiration date.

SEC source: 0001140361-22-012922 · form4.xml · nonDerivative · entry 1

Franchi Jean M. · CIK 0001653053 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,044

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

SEC source: 0001140361-22-012920 · form4.xml · derivative · entry 9

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,044 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These restricted stock units vested in full on March 31, 2022 and had no expiration date.

F2 · derivative.expiration_date: These restricted stock units vested in full on March 31, 2022 and had no expiration date.

SEC source: 0001140361-22-012920 · form4.xml · nonDerivative · entry 1

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 986,927

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

SEC source: 0001567619-22-006913 · doc1.xml · derivative · entry 3

Hutton Scott · CIK 0001697361 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,875

Underlying: Common Stock · 85,875 shares

Expires 2032-03-09

SEC source: 0001567619-22-006913 · doc1.xml · derivative · entry 2

Hutton Scott · CIK 0001697361 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,846

Underlying: Common Stock · 8,423 shares

Expires 2029-03-21

F1 · shares: On March 22, 2019, the Reporting Person was granted an option to purchase 25,269 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 8,423 shares underlying the option.

F3 · shares: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 8,423 shares underlying the option.

F1 · derivative.exercise_date: On March 22, 2019, the Reporting Person was granted an option to purchase 25,269 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 8,423 shares underlying the option.

F3 · derivative.exercise_date: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 8,423 shares underlying the option.

SEC source: 0001567619-22-006923 · doc1.xml · derivative · entry 1

Siurek Ryan H · CIK 0001476512 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,887

Underlying: Common Stock · 30,887 shares

Expires 2032-03-09

SEC source: 0001567619-22-006924 · doc1.xml · derivative · entry 1

Georgantas Robert William III · CIK 0001827728 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,722

Underlying: Common Stock · 22,722 shares

Expires 2032-03-09

SEC source: 0001567619-22-006920 · doc1.xml · derivative · entry 3

O'Kane Kieran · CIK 0001828131 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,162

Underlying: Common Stock · 6,162 shares

Expires 2032-03-09

SEC source: 0001567619-22-006920 · doc1.xml · derivative · entry 2

O'Kane Kieran · CIK 0001828131 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,423

Underlying: Common Stock · 4,211 shares

Expires 2030-04-14

F1 · shares: On April 15, 2020, the Reporting Person was granted an option to purchase 8,423 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2020 and 2021 fiscal years.

F3 · shares: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 4,211 shares underlying the option.

F1 · derivative.exercise_date: On April 15, 2020, the Reporting Person was granted an option to purchase 8,423 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2020 and 2021 fiscal years.

F3 · derivative.exercise_date: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 4,211 shares underlying the option.

SEC source: 0001567619-22-006915 · doc1.xml · derivative · entry 3

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,845

Underlying: Common Stock · 5,845 shares

Expires 2032-03-09

SEC source: 0001567619-22-006915 · doc1.xml · derivative · entry 2

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,230

Underlying: Common Stock · 5,615 shares

Expires 2029-03-21

F1 · shares: On March 22, 2019, the Reporting Person was granted an option to purchase 16,845 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 5,615 shares underlying the option.

F3 · shares: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 5,615 shares underlying the option.

F1 · derivative.exercise_date: On March 22, 2019, the Reporting Person was granted an option to purchase 16,845 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 5,615 shares underlying the option.

F3 · derivative.exercise_date: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 5,615 shares underlying the option.

SEC source: 0001567619-22-006911 · doc1.xml · derivative · entry 3

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,758

Underlying: Common Stock · 27,758 shares

Expires 2032-03-09

SEC source: 0001567619-22-006911 · doc1.xml · derivative · entry 2

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,792

Underlying: Common Stock · 5,896 shares

Expires 2029-03-21

F1 · shares: On March 22, 2019, the Reporting Person was granted an option to purchase 17,688 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 5,896 shares underlying the option.

F3 · shares: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 5,896 shares underlying the option.

F1 · derivative.exercise_date: On March 22, 2019, the Reporting Person was granted an option to purchase 17,688 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2019, 2020 and 2021 fiscal years. The performance criteria was not met for fiscal year 2019, resulting in the cancellation of 5,896 shares underlying the option.

F3 · derivative.exercise_date: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 5,896 shares underlying the option.

SEC source: 0001567619-22-007219 · doc1.xml · derivative · entry 2

Georgantas Robert William III · CIK 0001827728 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,685

Underlying: Common Stock · 2,842 shares

Expires 2030-04-14

F1 · shares: On April 15, 2020, the Reporting Person was granted an option to purchase 5,685 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2020 and 2021 fiscal years.

F3 · shares: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 2,842 shares underlying the option.

F1 · derivative.exercise_date: On April 15, 2020, the Reporting Person was granted an option to purchase 5,685 shares (as-adjusted for the 0.1684664-for-1 reverse stock split effected on October 19, 2020), the vesting of which was subject to the Issuer's satisfaction of certain performance criteria for each of the 2020 and 2021 fiscal years.

F3 · derivative.exercise_date: On March 10, 2022, the Compensation Committee confirmed the performance criteria were met for fiscal year 2021, resulting in the vesting of 2,842 shares underlying the option.

SEC source: 0001140361-22-004586 · form4.xml · derivative · entry 2

Hutton Scott · CIK 0001697361 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,393

Underlying: Common Stock · 195,393 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004586 · form4.xml · derivative · entry 1

Hutton Scott · CIK 0001697361 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,392

Underlying: Common Stock · 195,392 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004590 · form4.xml · derivative · entry 2

Siurek Ryan H · CIK 0001476512 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,341

Underlying: Common Stock · 21,341 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004590 · form4.xml · derivative · entry 1

Siurek Ryan H · CIK 0001476512 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,826

Underlying: Common Stock · 30,826 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004589 · form4.xml · derivative · entry 2

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,508

Underlying: Common Stock · 50,508 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004589 · form4.xml · derivative · entry 1

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,508

Underlying: Common Stock · 50,508 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004587 · form4.xml · derivative · entry 2

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,053

Underlying: Common Stock · 22,053 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004587 · form4.xml · derivative · entry 1

Pestano Gary Anthony · CIK 0001827711 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,052

Underlying: Common Stock · 22,052 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004588 · form4.xml · derivative · entry 2

O'Kane Kieran · CIK 0001828131 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,831

Underlying: Common Stock · 23,831 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004588 · form4.xml · derivative · entry 1

O'Kane Kieran · CIK 0001828131 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,831

Underlying: Common Stock · 23,831 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004585 · form4.xml · derivative · entry 2

Georgantas Robert William III · CIK 0001827728 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,053

Underlying: Common Stock · 22,053 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F3 · derivative.expiration_date: These RSUs vest in a series of six successive quarterly installments from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001140361-22-004585 · form4.xml · derivative · entry 1

Georgantas Robert William III · CIK 0001827728 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,537

Underlying: Common Stock · 31,537 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

F2 · derivative.expiration_date: These RSUs vest in a series of sixteen successive quarterly installments measured from February 8, 2022, generally subject to the reporting person's continued service with the Issuer, and have no expiration date.

SEC source: 0001567619-22-001264 · doc1.xml · derivative · entry 4

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,210

Underlying: Common Stock · 3,159 shares

Expires 2028-04-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option vests in 60 successive, equal monthly installments measured from January 1, 2018.

SEC source: 0001567619-22-001264 · doc1.xml · derivative · entry 3

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,520 shares

Expires 2027-05-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option vested in 60 successive, equal monthly installments measured from January 1, 2017.

SEC source: 0001567619-22-001264 · doc1.xml · nonDerivative · entry 2

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-001264 · doc1.xml · nonDerivative · entry 1

Cowie Robin Harper · CIK 0001827690 · CFO, Sec'y & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,495

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-000278 · doc1.xml · nonDerivative · entry 1

SCHULER JACK W · CIK 0001021412 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jack W. Schuler Living Trust

Disclosed balance after: 8,463,164

F1 · ownership.direct: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

F1 · ownership.nature: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0001567619-22-000275 · doc1.xml · nonDerivative · entry 2

PATIENCE JOHN · CIK 0001021413 · Director · 10% owner · Chairman

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 52,988

SEC source: 0001567619-22-000275 · doc1.xml · nonDerivative · entry 1

PATIENCE JOHN · CIK 0001021413 · Director · 10% owner · Chairman

10b5-1 filing: Not disclosed

Ownership: Indirect · By Patience Enterprises LP

Disclosed balance after: 2,078,298

F1 · ownership.direct: The reporting person is the sole general partner of Patience Enterprises LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F1 · ownership.nature: The reporting person is the sole general partner of Patience Enterprises LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0001567619-22-000277 · doc1.xml · nonDerivative · entry 2

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Birchview Capital Separately Managed Account

Disclosed balance after: 19,933

F1 · ownership.direct: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The shares reported herein as held by Birchview Fund, LLC and the shares reported held by Birchview Capital Separately Managed Account were always held for each respective account, but were inadvertently reported as all being held for Birchview Fund, LLC in the Form 4 filed on November 3, 2020. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F1 · ownership.nature: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The shares reported herein as held by Birchview Fund, LLC and the shares reported held by Birchview Capital Separately Managed Account were always held for each respective account, but were inadvertently reported as all being held for Birchview Fund, LLC in the Form 4 filed on November 3, 2020. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0001567619-22-000277 · doc1.xml · nonDerivative · entry 1

Strobeck Matthew · CIK 0001377832 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Birchview Fund LLC

Disclosed balance after: 211,200

F1 · ownership.direct: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The shares reported herein as held by Birchview Fund, LLC and the shares reported held by Birchview Capital Separately Managed Account were always held for each respective account, but were inadvertently reported as all being held for Birchview Fund, LLC in the Form 4 filed on November 3, 2020. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F1 · ownership.nature: The reporting person has sole voting and dispositive power with respect to shares held by Birchview Fund, LLC and the Birchview Capital Separately Managed Account in his capacity as Managers of such entities. The shares reported herein as held by Birchview Fund, LLC and the shares reported held by Birchview Capital Separately Managed Account were always held for each respective account, but were inadvertently reported as all being held for Birchview Fund, LLC in the Form 4 filed on November 3, 2020. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0000905148-22-000138 · form4.xml · nonDerivative · entry 1

SCHULER JACK W · CIK 0001021412 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jack W. Schuler Living Trust

Disclosed balance after: 8,463,164

F1 · ownership.direct: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

F1 · ownership.nature: Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0001567619-21-022443 · doc1.xml · nonDerivative · entry 1

Watts Charles M · CIK 0001723751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,855

F1 · price: The price reported in Column 4 is a weighted average price. These shares of Common Stock were purchased in multiple transactions at prices ranging from $4.27 to $4.33, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

SEC source: 0001140361-21-040848 · form4.xml · derivative · entry 3

Kayyem Jon Faiz · CIK 0001366268 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,038

Underlying: Common Stock · 27,038 shares

Expires 2031-12-06

F4 · derivative.exercise_date: This option will vest in full on March 31, 2022, subject to the reporting person's continued service on the Board through the applicable vesting date. In the event the reporting person's continued service on the Board terminates other than for cause, the option will vest on a prorated basis based on the number of full months of service the reporting person completed during the applicable vesting period.