BCRX

SEC source: 0001127602-23-028609 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,998

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-028607 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,861

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-023695 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,042

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-023693 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,905

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-018783 · form4.xml · nonDerivative · entry 2

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,611

SEC source: 0001127602-23-018775 · form4.xml · nonDerivative · entry 2

Hutson Nancy J · CIK 0001379222 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,818

F2 · price: The price in column 4 is a weighted average price. These shares were purchased in multiple transactions ranging from $7.89 to $8.12. The reporting person will provide to the issuer, or any security holder of the issuer, or the SEC staff upon request, full information regarding the number of shares purchased at each price within the range set forth in the footnote.

SEC source: 0001171843-23-003946 · ownership.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,014,794

F1 · kind: This transaction reflects a gift by the reporting person of shares of the issuer's common stock to a charitable donor advised fund.

SEC source: 0001127602-23-018793 · form4.xml · derivative · entry 2

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018793 · form4.xml · nonDerivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,090

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018791 · form4.xml · derivative · entry 2

LEE KENNETH B JR · CIK 0001208570 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018791 · form4.xml · nonDerivative · entry 1

LEE KENNETH B JR · CIK 0001208570 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,863

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018788 · form4.xml · derivative · entry 2

Galson Steven K · CIK 0001495328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018788 · form4.xml · nonDerivative · entry 1

Galson Steven K · CIK 0001495328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,611

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018786 · form4.xml · derivative · entry 2

ASELAGE STEVE · CIK 0001221599 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018786 · form4.xml · nonDerivative · entry 1

ASELAGE STEVE · CIK 0001221599 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,339

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018783 · form4.xml · derivative · entry 3

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018783 · form4.xml · nonDerivative · entry 1

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,611

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018779 · form4.xml · derivative · entry 2

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018779 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,251

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018775 · form4.xml · derivative · entry 3

Hutson Nancy J · CIK 0001379222 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F3 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018775 · form4.xml · nonDerivative · entry 1

Hutson Nancy J · CIK 0001379222 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,684

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018771 · form4.xml · derivative · entry 2

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018771 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,611

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018767 · form4.xml · derivative · entry 2

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018767 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,114

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-018765 · form4.xml · derivative · entry 2

ABERCROMBIE GEORGE B · CIK 0001485939 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,072

Underlying: Common Stock · 39,072 shares

Expires 2033-06-13

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001127602-23-018765 · form4.xml · nonDerivative · entry 1

ABERCROMBIE GEORGE B · CIK 0001485939 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,611

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001127602-23-017562 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,506

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-017556 · form4.xml · nonDerivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,345

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-017552 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,369

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-012587 · form4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · Chief R&D Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 207,275

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 14, 2022 to cover tax withholding obligations in connection with the vesting of 25,000 Restricted Stock Units. The sale occurred automatically to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the reporting person.

F2 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.24 to $8.31. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0001127602-23-011193 · form4.xml · derivative · entry 4

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 305,995

Underlying: Common Stock · 31,055 shares

Expires 2026-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reporting person engaged in a non-market, cash exercise and hold transaction to purchase shares of issuer common stock underlying stock options that were originally granted to the reporting person on May 23, 2016. No sales of the issuer's common stock have occurred as part of this transaction.

SEC source: 0001127602-23-011193 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,039,794

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reporting person engaged in a non-market, cash exercise and hold transaction to purchase shares of issuer common stock underlying stock options that were originally granted to the reporting person on May 23, 2016. No sales of the issuer's common stock have occurred as part of this transaction.

SEC source: 0001127602-23-008400 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,826

F1 · security: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-008391 · form4.xml · nonDerivative · entry 1

INGRAM ROBERT ALEXANDER · CIK 0001219890 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,198

F1 · security: Shares of Common Stock issued to the reporting person in lieu of quarterly cash Board Member retainer of $20,000.

SEC source: 0001127602-23-008383 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,689

F1 · security: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-008381 · form4.xml · nonDerivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,985

F1 · security: Shares of Common Stock issued to the reporting person in lieu of quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-23-003172 · form4.xml · derivative · entry 6

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 100,000 shares

Expires 2023-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 10, 2021. The options were originally granted to the reporting person on August 8, 2013 and would have expired on August 8, 2023. The shares sold subsequent to the exercise of such options represent less than 2% of the reporting person's holdings of the issuer's securities.

F4 · derivative.exercise_date: The options vested upon the achievement of performance-based vesting criteria with respect to 25,000 shares on each of May 26, 2014, December 19, 2014, May 13, 2015 and December 3, 2020.

SEC source: 0001127602-23-003172 · form4.xml · nonDerivative · entry 5

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,008,739

F2 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 10, 2021. The options were originally granted to the reporting person on August 8, 2013 and would have expired on August 8, 2023. The shares sold subsequent to the exercise of such options represent less than 2% of the reporting person's holdings of the issuer's securities.

F3 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $10.22 to $10.65. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0001127602-23-003172 · form4.xml · nonDerivative · entry 4

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,108,739

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 10, 2021. The options were originally granted to the reporting person on August 8, 2013 and would have expired on August 8, 2023. The shares sold subsequent to the exercise of such options represent less than 2% of the reporting person's holdings of the issuer's securities.

SEC source: 0001127602-23-003163 · form4.xml · derivative · entry 2

LEE KENNETH B JR · CIK 0001208570 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2023-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reporting person engaged in a non-market, cash exercise and hold transaction with respect to these stock options and the underlying shares. The options were originally granted to the reporting person on May 31, 2013 and would have expired on May 31, 2023. No sales of the issuer's common stock have occurred as part of this transaction.

SEC source: 0001127602-23-003163 · form4.xml · nonDerivative · entry 1

LEE KENNETH B JR · CIK 0001208570 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,118

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reporting person engaged in a non-market, cash exercise and hold transaction with respect to these stock options and the underlying shares. The options were originally granted to the reporting person on May 31, 2013 and would have expired on May 31, 2023. No sales of the issuer's common stock have occurred as part of this transaction.

SEC source: 0001127602-23-003172 · form4.xml · nonDerivative · entry 3

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By wife as co-trustee of the Caroline Stonehouse Irrevocable Trust

Disclosed balance after: 10,000

F1 · kind: On December 29, 2022, the reporting person gifted 5,000 shares held directly by him to each of the Samuel Stonehouse Irrevocable Trust and the Caroline Stonehouse Irrevocable Trust.

SEC source: 0001127602-23-003172 · form4.xml · nonDerivative · entry 2

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By wife as co-trustee of the Samuel Stonehouse Irrevocable Trust

Disclosed balance after: 10,000

F1 · kind: On December 29, 2022, the reporting person gifted 5,000 shares held directly by him to each of the Samuel Stonehouse Irrevocable Trust and the Caroline Stonehouse Irrevocable Trust.

SEC source: 0001127602-23-003172 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,008,739

F1 · kind: On December 29, 2022, the reporting person gifted 5,000 shares held directly by him to each of the Samuel Stonehouse Irrevocable Trust and the Caroline Stonehouse Irrevocable Trust.

SEC source: 0001127602-22-028084 · form4.xml · derivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 158,500

Underlying: Common Stock · 158,500 shares

Expires 2032-12-19

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001127602-22-028084 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,770

F1 · shares: Annual award of Restricted Stock Units which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001127602-22-028082 · form4.xml · derivative · entry 2

Thackray Helen M. · CIK 0001589725 · Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,000

Underlying: Common Stock · 238,000 shares

Expires 2032-12-19

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001127602-22-028082 · form4.xml · nonDerivative · entry 1

Thackray Helen M. · CIK 0001589725 · Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,275

F1 · shares: Annual award of Restricted Stock Units which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001127602-22-028080 · form4.xml · derivative · entry 4

Stonehouse Jon P · CIK 0001385496 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 595,000

Underlying: Common Stock · 595,000 shares

Expires 2032-12-19

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.