BCRX

SEC source: 0000882796-26-000065 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,340,419

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $12,500.

SEC source: 0000882796-26-000063 · form4.xml · nonDerivative · entry 1

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,226

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $12,500.

SEC source: 0000882796-26-000061 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,642

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Chair retainer of $22,500.

SEC source: 0000882796-26-000059 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,821

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $12,500.

SEC source: 0000882796-26-000057 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,747

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $12,500.

SEC source: 0000882796-26-000055 · form4.xml · derivative · entry 2

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000055 · form4.xml · nonDerivative · entry 1

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,938

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000053 · form4.xml · derivative · entry 3

Galson Steven K · CIK 0001495328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F3 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000053 · form4.xml · nonDerivative · entry 1

Galson Steven K · CIK 0001495328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,794

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000045 · form4.xml · derivative · entry 2

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000045 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,459

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000052 · form4.xml · derivative · entry 2

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000052 · form4.xml · nonDerivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,565

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000043 · form4.xml · derivative · entry 2

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000043 · form4.xml · nonDerivative · entry 1

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,936

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000041 · form4.xml · derivative · entry 2

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000041 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 108,483

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000039 · form4.xml · derivative · entry 4

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000039 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,339,775

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000035 · form4.xml · derivative · entry 2

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000035 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,646

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000037 · form4.xml · derivative · entry 2

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,540

Underlying: Common Stock · 33,540 shares

Expires 2036-06-11

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0000882796-26-000037 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,177

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0000882796-26-000033 · form4.xml · nonDerivative · entry 1

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,644

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000031 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,324,481

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000029 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,883

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000027 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,189

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Chair retainer of $20,000.

SEC source: 0000882796-26-000025 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,165

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000023 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,252

F1 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.96 to $8.985. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-26-000021 · form4.xml · derivative · entry 3

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 62,500 shares

Expires 2027-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · derivative.exercise_date: The option grant became exercisable at the rate of 25% on each of the first, second, third, and fourth anniversaries of the date of grant.

SEC source: 0000882796-26-000021 · form4.xml · nonDerivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 400,703

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-26-000021 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 463,203

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-26-000019 · form4.xml · derivative · entry 2

Menon Sandeep · CIK 0002123967 · Chief R&D Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 441,350

Underlying: Common Stock · 441,350 shares

Expires 2036-04-06

F2 · shares: Inducement grant of employee stock options pursuant to the Stock Incentive Plan, which will become exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

F2 · derivative.exercise_date: Inducement grant of employee stock options pursuant to the Stock Incentive Plan, which will become exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-26-000019 · form4.xml · nonDerivative · entry 1

Menon Sandeep · CIK 0002123967 · Chief R&D Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,150

F1 · shares: Inducement grant of restricted stock units pursuant to the BioCryst Pharmaceuticals, Inc. Stock Incentive Plan, as amended and restated (the "Stock Incentive Plan"), which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-26-000017 · form4.xml · derivative · entry 3

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 49,933 shares

Expires 2034-06-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000882796-26-000017 · form4.xml · nonDerivative · entry 2

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,352

F1 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $10.09 to $10.14. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-26-000017 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,285

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000882796-26-000015 · form4.xml · derivative · entry 3

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 150,000 shares

Expires 2027-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F3 · derivative.exercise_date: The option grant became exercisable at the rate of 25% on each of the first, second, third, and fourth anniversaries of the date of grant.

SEC source: 0000882796-26-000015 · form4.xml · nonDerivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 400,703

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.95 to $9.57. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-26-000015 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 550,703

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-26-000011 · form4.xml · derivative · entry 6

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 305,995 shares

Expires 2026-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: This transaction was made pursuant to a plan adopted by the reporting person on November 28, 2022, as modified on May 13, 2024 and further modified on May 29, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The options were originally granted to the reporting person on May 23, 2016 and would have expired on May 23, 2026. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-26-000011 · form4.xml · nonDerivative · entry 3

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,323,850

F2 · shares: This transaction was made pursuant to a plan adopted by the reporting person on November 28, 2022, as modified on May 13, 2024 and further modified on May 29, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The options were originally granted to the reporting person on May 23, 2016 and would have expired on May 23, 2026. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F3 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.54 to $8.81. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-26-000011 · form4.xml · nonDerivative · entry 2

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,629,845

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: This transaction was made pursuant to a plan adopted by the reporting person on November 28, 2022, as modified on May 13, 2024 and further modified on May 29, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The options were originally granted to the reporting person on May 23, 2016 and would have expired on May 23, 2026. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-26-000013 · form4.xml · nonDerivative · entry 1

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,382

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the prorated quarterly cash Board Member retainer of $4,625.

SEC source: 0000882796-26-000011 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,323,850

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the prorated quarterly cash Board Member retainer of $7,375.

SEC source: 0000882796-26-000009 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,067

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250 and, effective January 23, 2026, in lieu of 50% of the quarterly cash Board Chair retainer of $20,000.

SEC source: 0000882796-26-000007 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,903

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000005 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,432

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-26-000003 · form4.xml · derivative · entry 3

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,684

Underlying: Common Stock · 26,684 shares

Expires 2036-01-23

F3 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

F4 · derivative.exercise_date: The option grant vests 1/36 per month over a 3-year period measured from the date of grant.

SEC source: 0000882796-26-000003 · form4.xml · nonDerivative · entry 2

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,854

F2 · shares: Automatic non-employee director grant of restricted stock units pursuant to the BioCryst Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest in three equal annual installments beginning on the twelve-month anniversary of the date of grant.