BCRX

SEC source: 0000882796-26-000003 · form4.xml · nonDerivative · entry 1

Milne Jill C. · CIK 0001644246 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,582

F1 · price: Received in exchange for 4,377 shares of Astria Therapeutics, Inc. ("Astria") common stock in connection with a merger (the "Merger"), pursuant to which Astria became a wholly owned subsidiary of BioCryst Pharmaceuticals, Inc. ("BioCryst"). Pursuant to the Merger, each share of Astria common stock (subject to certain inapplicable exceptions) was converted into the right to receive (i) 0.59 of a share of common stock of BioCryst and, if applicable, cash in lieu of fractional shares, and (ii) $8.55 in cash, without interest, subject to applicable withholding taxes. On the last trading day before the effective date of the Merger, the closing price of Astria's common stock was $12.58 per share, and the closing price of BioCryst's common stock was $6.75 per share.

SEC source: 0000882796-25-000043 · form4.xml · nonDerivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 398,751

F2 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-25-000041 · form4.xml · derivative · entry 7

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2027-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option grant became exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000041 · form4.xml · derivative · entry 6

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,409

Underlying: Common Stock · 10,091 shares

Expires 2027-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option grant became exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000041 · form4.xml · derivative · entry 5

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,142 shares

Expires 2026-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option grant became exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000041 · form4.xml · nonDerivative · entry 4

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 952,583

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000882796-25-000041 · form4.xml · nonDerivative · entry 3

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 902,583

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000882796-25-000041 · form4.xml · nonDerivative · entry 2

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 892,492

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000882796-25-000045 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,323,429

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0000882796-25-000043 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 420,524

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0000882796-25-000041 · form4.xml · nonDerivative · entry 1

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 878,350

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0001171843-25-008039 · ownership.xml · nonDerivative · entry 3

Stonehouse Jon P · CIK 0001385496 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By wife as co-trustee of the Samuel Stonehouse Irrevocable Trust

Disclosed balance after: 40,000

F1 · kind: On December 18, 2025, the reporting person gifted 10,000 shares held directly by him to each of the Caroline Stonehouse Irrevocable Trust and the Samuel Stonehouse Irrevocable Trust.

SEC source: 0001171843-25-008039 · ownership.xml · nonDerivative · entry 2

Stonehouse Jon P · CIK 0001385496 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By wife as co-trustee of the Caroline Stonehouse Irrevocable Trust

Disclosed balance after: 40,000

F1 · kind: On December 18, 2025, the reporting person gifted 10,000 shares held directly by him to each of the Caroline Stonehouse Irrevocable Trust and the Samuel Stonehouse Irrevocable Trust.

SEC source: 0001171843-25-008039 · ownership.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,385,222

F1 · kind: On December 18, 2025, the reporting person gifted 10,000 shares held directly by him to each of the Caroline Stonehouse Irrevocable Trust and the Samuel Stonehouse Irrevocable Trust.

SEC source: 0001171843-25-008038 · ownership.xml · derivative · entry 2

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 986,950

Underlying: Common Stock · 986,950 shares

Expires 2035-12-17

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001171843-25-008038 · ownership.xml · nonDerivative · entry 1

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 889,827

F1 · shares: Annual award of restricted stock units which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000038 · form4.xml · derivative · entry 2

Ghias Babar · CIK 0002076862 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 355,050

Underlying: Common Stock · 355,050 shares

Expires 2035-12-17

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000038 · form4.xml · nonDerivative · entry 1

Ghias Babar · CIK 0002076862 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 268,700

F1 · shares: Annual award of restricted stock units which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001171843-25-008037 · ownership.xml · derivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 255,050

Underlying: Common Stock · 255,050 shares

Expires 2035-12-17

F2 · derivative.exercise_date: Annual Employee Option Grant becomes exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001171843-25-008037 · ownership.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 437,426

F1 · shares: Annual award of restricted stock units which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000033 · form4.xml · nonDerivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 315,726

F2 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-25-000033 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 336,936

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0000882796-25-000036 · form4.xml · nonDerivative · entry 1

Gayer Charles K · CIK 0001800110 · President and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 418,827

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0000882796-25-000031 · form4.xml · nonDerivative · entry 1

Stonehouse Jon P · CIK 0001385496 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,405,222

F1 · shares: Represents shares withheld by the Issuer to satisfy required tax withholding obligations in connection with the vesting of previously granted restricted stock units. This transaction does not represent a sale by the reporting person.

SEC source: 0000882796-25-000027 · form4.xml · nonDerivative · entry 4

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 345,476

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-25-000027 · form4.xml · nonDerivative · entry 3

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 365,246

F3 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $7.180 to $7.255. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-25-000027 · form4.xml · derivative · entry 5

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 91,004 shares

Expires 2026-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F4 · derivative.exercise_date: The option grant became exercisable at the rate of 25.0% on each of the first, second, third, and fourth anniversaries of the date of grant.

SEC source: 0000882796-25-000027 · form4.xml · nonDerivative · entry 2

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 416,152

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $7.015 to $7.190. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0000882796-25-000027 · form4.xml · nonDerivative · entry 1

Barnes Alane P · CIK 0001584348 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 507,156

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0000882796-25-000021 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,618

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-25-000023 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,790

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-25-000019 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,219

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-25-000017 · form4.xml · nonDerivative · entry 1

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,642

F1 · shares: These shares were sold pursuant to a plan adopted by the Reporting Person on August 14, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The sale occurred automatically and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0000882796-25-000013 · form4.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,007

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-25-000005 · form4.xml · nonDerivative · entry 1

Frank Steven · CIK 0001583886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,052

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 100% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0000882796-25-000003 · form4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,436

F1 · shares: Shares of Common Stock issued to the reporting person in lieu of 50% of the quarterly cash Board Member retainer of $11,250.

SEC source: 0001127602-25-020491 · form4.xml · derivative · entry 5

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 40,000 shares

Expires 2030-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-020491 · form4.xml · derivative · entry 4

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 30,000 shares

Expires 2029-05-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-020491 · form4.xml · nonDerivative · entry 3

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,352

F1 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.48 to $8.55. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0001127602-25-020491 · form4.xml · nonDerivative · entry 2

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-020491 · form4.xml · nonDerivative · entry 1

HEGGIE THERESA · CIK 0001760020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-019632 · form4.xml · derivative · entry 2

Ghias Babar · CIK 0002076862 · CFO & Head of Corp Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 305,000

Underlying: Common Stock · 305,000 shares

Expires 2035-07-24

F2 · shares: Inducement grant of employee stock options pursuant to the Stock Incentive Plan, which will become exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

F2 · derivative.exercise_date: Inducement grant of employee stock options pursuant to the Stock Incentive Plan, which will become exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001127602-25-019632 · form4.xml · nonDerivative · entry 1

Ghias Babar · CIK 0002076862 · CFO & Head of Corp Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,000

F1 · shares: Inducement grant of restricted stock units pursuant to the BioCryst Pharmaceuticals, Inc. Stock Incentive Plan, as amended and restated (the "Stock Incentive Plan"), which will vest 25% on each of the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001171843-25-003917 · ownership.xml · derivative · entry 2

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,181

Underlying: Common Stock · 27,181 shares

Expires 2035-06-12

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001171843-25-003917 · ownership.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,760

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001171843-25-003918 · ownership.xml · derivative · entry 2

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,181

Underlying: Common Stock · 27,181 shares

Expires 2035-06-12

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001171843-25-003918 · ownership.xml · nonDerivative · entry 1

SANDERS MACHELLE · CIK 0001718020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,242

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001171843-25-003916 · ownership.xml · derivative · entry 2

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,181

Underlying: Common Stock · 27,181 shares

Expires 2035-06-12

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.

SEC source: 0001171843-25-003916 · ownership.xml · nonDerivative · entry 1

McKee Amy E · CIK 0001883764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,331

F1 · shares: Automatic non-employee director grant of Restricted Stock Units pursuant to the BioCryst Pharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (the "Director Compensation Policy"), which will vest on the first anniversary of the date of grant.

SEC source: 0001171843-25-003914 · ownership.xml · derivative · entry 2

Hutson Nancy J · CIK 0001379222 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,181

Underlying: Common Stock · 27,181 shares

Expires 2035-06-12

F2 · security: Automatic non-employee director grant of stock options pursuant to the Director Compensation Policy.