AUPH

SEC source: 0001600620-26-000004 · wk-form4_1767647524.xml · nonDerivative · entry 1

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 734,631

F1 · shares: Represents the number of shares earned upon certification of performance for a performance award payable solely in common shares of the Issuer that vest in two (2) equal annual installments on December 31, 2025 and December 31, 2026.

SEC source: 0001600620-25-000110 · wk-form4_1764022752.xml · nonDerivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,775

F1 · shares: Represents shares withheld to satisfy tax withholding obligations upon the vesting of restricted stock units.

SEC source: 0001370348-25-000004 · wk-form4_1764022670.xml · nonDerivative · entry 1

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,592

F1 · shares: Represents shares withheld to satisfy tax withholding obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-021066 · form4-08052025_090800.xml · nonDerivative · entry 3

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 11,329,500

F4 · price: These shares were purchased in multiple transactions ranging from $11.49 to $11.80.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 6,371,711 shares and Tang Capital Partners International, LP ("TCPI") beneficially owns 4,957,789 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCPI.

SEC source: 0001415889-25-021066 · form4-08052025_090800.xml · nonDerivative · entry 2

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 11,129,500

F3 · price: These shares were purchased in multiple transactions ranging from $11.11 to $11.48.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 6,371,711 shares and Tang Capital Partners International, LP ("TCPI") beneficially owns 4,957,789 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCPI.

SEC source: 0001415889-25-021066 · form4-08052025_090800.xml · nonDerivative · entry 1

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 11,029,500

F1 · price: The prices reported are weighted-average prices. These shares were purchased in multiple transactions at prices ranging from $9.23 to $10.50. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the SEC staff, upon request, all information regarding the number of shares purchased at each price within the ranges set forth in Footnotes 1, 3 and 4.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 6,371,711 shares and Tang Capital Partners International, LP ("TCPI") beneficially owns 4,957,789 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCPI.

SEC source: 0001600620-25-000095 · wk-form4_1754424444.xml · nonDerivative · entry 1

Keenan Greg · CIK 0002044006 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,484

F1 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.48 to $10.52, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000076 · wk-form4_1747429477.xml · derivative · entry 1

Goetz Kathleen · CIK 0001896369 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,724

Underlying: Common Shares · 63,724 shares

Expires 2035-05-16

F1 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-25-000075 · wk-form4_1747429452.xml · derivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,485

Underlying: Common Shares · 37,485 shares

Expires 2035-05-16

F1 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-25-000078 · wk-form4_1747429558.xml · derivative · entry 1

Nova Tina Susan · CIK 0001302605 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,724

Underlying: Common Shares · 63,724 shares

Expires 2035-05-16

F1 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-25-000077 · wk-form4_1747429513.xml · derivative · entry 1

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,485

Underlying: Common Shares · 37,485 shares

Expires 2035-05-16

F1 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-25-000026 · wk-form4_1741386297.xml · nonDerivative · entry 1

Keenan Greg · CIK 0002044006 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,484

F1 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units related to the March 6, 2023 grant.

F2 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.20 to $8.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 6

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 10,029,500

F7 · price: These shares were purchased in multiple transactions at prices ranging from $8.05 to $8.10.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 5

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 9,929,500

F6 · price: These shares were purchased in multiple transactions at prices ranging from $7.76 to $8.10.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 4

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 9,429,500

F5 · price: These shares were purchased in multiple transactions at prices ranging from $7.82 to $8.10.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001600620-25-000024 · wk-form4_1741140121.xml · nonDerivative · entry 4

Greenleaf Peter · CIK 0001363683 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,788,945

F6 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of RSUs related to the March 2, 2022 and March 2, 2023 grants.

F7 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.76 to $8.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000020 · wk-form4_1741139883.xml · nonDerivative · entry 4

Miller Joseph M · CIK 0001746372 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 577,361

F6 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of RSUs related to the March 2, 2022 and March 2, 2023 grants.

F7 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.76 to $8.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000019 · wk-form4_1741139835.xml · nonDerivative · entry 4

Robertson Stephen P. · CIK 0001837798 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 509,276

F6 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of RSUs related to the March 2, 2022 and March 2, 2023 grants.

F7 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.76 to $8.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000018 · wk-form4_1741139793.xml · nonDerivative · entry 4

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 680,465

F6 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of RSUs related to the March 2, 2022 and March 2, 2023 grants.

F7 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.76 to $8.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 3

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 9,281,462

F4 · price: These shares were purchased in multiple transactions at prices ranging from $7.80 to $8.10.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 2

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 8,929,500

F3 · price: These shares were purchased in multiple transactions at prices ranging from $7.80 to $8.05.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001600620-25-000022 · wk-form4_1741139983.xml · nonDerivative · entry 2

Keenan Greg · CIK 0002044006 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 161,789

F2 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units related to the January 30, 2024 grant.

F3 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.79 to $8.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000024 · wk-form4_1741140121.xml · nonDerivative · entry 3

Greenleaf Peter · CIK 0001363683 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,953,892

F4 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units (RSUs) related to the February 20, 2024 grant and March 2, 2023 performance award.

F5 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.79 to $8.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000024 · wk-form4_1741140121.xml · nonDerivative · entry 2

Greenleaf Peter · CIK 0001363683 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,149,485

F3 · shares: Represents grant of performance award payable solely in common shares of the Issuer that vest in two (2) equal annual installments on December 31, 2024 and December 31, 2025.

SEC source: 0001600620-25-000020 · wk-form4_1741139883.xml · nonDerivative · entry 3

Miller Joseph M · CIK 0001746372 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 633,515

F4 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units (RSUs) related to the February 20, 2024 grant and March 2, 2023 performance award.

F5 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.79 to $8.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000020 · wk-form4_1741139883.xml · nonDerivative · entry 2

Miller Joseph M · CIK 0001746372 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 695,374

F3 · shares: Represents grant of performance award payable solely in common shares of the Issuer that vest in two (2) equal annual installments on December 31, 2024 and December 31, 2025.

SEC source: 0001600620-25-000019 · wk-form4_1741139835.xml · nonDerivative · entry 3

Robertson Stephen P. · CIK 0001837798 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 566,883

F4 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units (RSUs) related to the February 20, 2024 grant and March 2, 2023 performance award.

F5 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.79 to $8.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000019 · wk-form4_1741139835.xml · nonDerivative · entry 2

Robertson Stephen P. · CIK 0001837798 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 631,755

F3 · shares: Represents grant of performance award payable solely in common shares of the Issuer that vest in two (2) equal annual installments on December 31, 2024 and December 31, 2025.

SEC source: 0001600620-25-000018 · wk-form4_1741139793.xml · nonDerivative · entry 3

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739,456

F4 · shares: Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of Restricted Stock Units (RSUs) related to the February 20, 2024 grant and March 2, 2023 performance award.

F5 · price: The price in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.79 to $8.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001600620-25-000018 · wk-form4_1741139793.xml · nonDerivative · entry 2

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 805,358

F3 · shares: Represents grant of performance award payable solely in common shares of the Issuer that vest in two (2) equal annual installments on December 31, 2024 and December 31, 2025.

SEC source: 0001415889-25-006589 · form4-03042025_100358.xml · nonDerivative · entry 1

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 8,828,780

F1 · price: The prices reported are weighted-average prices. These shares were purchased in multiple transactions at prices ranging from $7.47 to $7.95. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the SEC staff, upon request, all information regarding the number of shares purchased at each price within the ranges set forth in Footnotes 1, and 3 through 7.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 5,140,591 shares, Tang Capital Partners International, LP ("TCPI") beneficially owns 4,388,909 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of TCP and TCPI. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP, TCPI and TCP III.

SEC source: 0001600620-25-000022 · wk-form4_1741139983.xml · derivative · entry 3

Keenan Greg · CIK 0002044006 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,570

Underlying: Common Stock · 95,570 shares

Expires 2035-02-28

F4 · derivative.exercise_date: One-third of the shares subject to the option vests twelve months from the grant date, and the remainder vests in twenty-four equal monthly installments thereafter.

SEC source: 0001600620-25-000022 · wk-form4_1741139983.xml · nonDerivative · entry 1

Keenan Greg · CIK 0002044006 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 174,028

F1 · shares: Each performance right represents a contingent right to receive one common share of the Issuer. The performance rights vest in four tranches upon the Issuer's common shares achieving four progressively higher target prices, with respective one year retention periods per tranche achievement.

SEC source: 0001600620-25-000024 · wk-form4_1741140121.xml · derivative · entry 5

Greenleaf Peter · CIK 0001363683 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 443,973

Underlying: Common Stock · 443,973 shares

Expires 2035-02-28

F8 · derivative.exercise_date: One-third of the shares subject to the option vests twelve months from the grant date, and the remainder vests in twenty-four equal monthly installments thereafter.

SEC source: 0001600620-25-000024 · wk-form4_1741140121.xml · nonDerivative · entry 1

Greenleaf Peter · CIK 0001363683 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,815,780

F1 · shares: Each performance right represents a contingent right to receive one common share of the Issuer. The performance rights vest in four tranches upon the Issuer's common shares achieving four progressively higher target prices, with respective one year retention periods per tranche achievement.

F2 · balance_after: Includes common shares acquired by the reporting person pursuant to the Issuer's 2021 Employee Share Purchase Plan as follows: 2,500 common shares were acquired on May 31, 2024 and 438 common shares were acquired on November 29, 2024.

SEC source: 0001600620-25-000020 · wk-form4_1741139883.xml · derivative · entry 5

Miller Joseph M · CIK 0001746372 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,393

Underlying: Common Stock · 124,393 shares

Expires 2035-02-28

F8 · derivative.exercise_date: One-third of the shares subject to the option vests twelve months from the grant date, and the remainder vests in twenty-four equal monthly installments thereafter.

SEC source: 0001600620-25-000020 · wk-form4_1741139883.xml · nonDerivative · entry 1

Miller Joseph M · CIK 0001746372 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 580,663

F1 · shares: Each performance right represents a contingent right to receive one common share of the Issuer. The performance rights vest in four tranches upon the Issuer's common shares achieving four progressively higher target prices, with respective one year retention periods per tranche achievement.

F2 · balance_after: Includes common shares acquired by the reporting person pursuant to the Issuer's 2021 Employee Share Purchase Plan as follows: 1,630 common shares were acquired on May 31, 2024 and 1,648 common shares were acquired on November 29, 2024.

SEC source: 0001600620-25-000019 · wk-form4_1741139835.xml · derivative · entry 5

Robertson Stephen P. · CIK 0001837798 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,438

Underlying: Common Stock · 128,438 shares

Expires 2035-02-28

F8 · derivative.exercise_date: One-third of the shares subject to the option vests twelve months from the grant date, and the remainder vests in twenty-four equal monthly installments thereafter.

SEC source: 0001600620-25-000019 · wk-form4_1741139835.xml · nonDerivative · entry 1

Robertson Stephen P. · CIK 0001837798 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 529,349

F1 · shares: Each performance right represents a contingent right to receive one common share of the Issuer. The performance rights vest in four tranches upon the Issuer's common shares achieving four progressively higher target prices, with respective one year retention periods per tranche achievement.

F2 · balance_after: Includes common shares acquired by the reporting person pursuant to the Issuer's 2021 Employee Share Purchase Plan as follows: 513 common shares were acquired on May 31, 2024 and 506 common shares were acquired on November 29, 2024.

SEC source: 0001600620-25-000018 · wk-form4_1741139793.xml · derivative · entry 5

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,416

Underlying: Common Stock · 126,416 shares

Expires 2035-02-28

F8 · derivative.exercise_date: One-third of the shares subject to the option vests twelve months from the grant date, and the remainder vests in twenty-four equal monthly installments thereafter.

SEC source: 0001600620-25-000018 · wk-form4_1741139793.xml · nonDerivative · entry 1

Donley Matthew Maxwell · CIK 0001636642 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 669,791

F1 · shares: Each performance right represents a contingent right to receive one common share of the Issuer. The performance rights vest in four tranches upon the Issuer's common shares achieving four progressively higher target prices, with respective one year retention periods per tranche achievement.

F2 · balance_after: Includes common shares acquired by the reporting person pursuant to the Issuer's 2021 Employee Share Purchase Plan as follows: 2,500 common shares were acquired on May 31, 2024 and 438 common shares were acquired on November 29, 2024.

SEC source: 0001415889-24-028661 · form4-12092024_091246.xml · nonDerivative · entry 3

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 8,429,500

F4 · price: These shares were purchased in multiple transactions at prices ranging from $8.88 to $9.19.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 7,929,500 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC ("TCM"), which is the general partner of TCP. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCP III.

SEC source: 0001415889-24-028661 · form4-12092024_091246.xml · nonDerivative · entry 2

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 7,929,500

F3 · price: These shares were purchased in multiple transactions at prices ranging from $8.89 to $9.15.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 7,929,500 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC ("TCM"), which is the general partner of TCP. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCP III.

SEC source: 0001415889-24-028661 · form4-12092024_091246.xml · nonDerivative · entry 1

TANG KEVIN · CIK 0001178579 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LP

Disclosed balance after: 7,529,500

F1 · price: The prices reported are weighted-average prices. These shares were purchased in multiple transactions at prices ranging from $8.74 to $8.99. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the SEC staff, upon request, all information regarding the number of shares purchased at each price within the ranges set forth in Footnotes 1, 3 and 4.

F2 · ownership.nature: Tang Capital Partners, LP ("TCP") beneficially owns 7,929,500 shares and Tang Capital Partners III, Inc. ("TCP III") beneficially owns 500,000 shares. Kevin Tang is the sole manager of Tang Capital Management, LLC ("TCM"), which is the general partner of TCP. Kevin Tang is the sole director and Chief Executive Officer of TCP III, which is indirectly wholly owned by TCP. Mr. Tang has a pecuniary interest in the shares beneficially held by TCP and TCP III.

SEC source: 0001600620-24-000120 · wk-form4_1732570246.xml · derivative · entry 2

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,641

Underlying: Common Shares · 18,641 shares

Expires 2034-11-21

F2 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-24-000120 · wk-form4_1732570246.xml · nonDerivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,491

F1 · shares: Represents grant of Restricted Stock Units (RSUs) payable solely in common shares of the Issuer. The shares subject to the RSUs shall vest one year from date of grant.

SEC source: 0001600620-24-000122 · wk-form4_1732570412.xml · derivative · entry 2

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,688

Underlying: Common Shares · 31,688 shares

Expires 2034-11-21

F2 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-24-000122 · wk-form4_1732570412.xml · nonDerivative · entry 1

Johnson Craig A · CIK 0001370348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,631

F1 · shares: Represents grant of Restricted Stock Units (RSUs) payable solely in common shares of the Issuer. The shares subject to the RSUs shall vest one year from date of grant.

SEC source: 0001600620-24-000126 · wk-form4_1732570731.xml · derivative · entry 2

Smith Karen L. · CIK 0001639637 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,641

Underlying: Common Shares · 18,641 shares

Expires 2034-11-21

F2 · derivative.exercise_date: The options shall vest one year from date of grant.

SEC source: 0001600620-24-000126 · wk-form4_1732570731.xml · nonDerivative · entry 1

Smith Karen L. · CIK 0001639637 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,807

F1 · shares: Represents grant of Restricted Stock Units (RSUs) payable solely in common shares of the Issuer. The shares subject to the RSUs shall vest one year from date of grant.