ARVN

SEC source: 0001655759-25-000112 · wk-form4_1751072831.xml · derivative · entry 2

Norwalk Leslie V · CIK 0001533568 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000112 · wk-form4_1751072831.xml · nonDerivative · entry 1

Norwalk Leslie V · CIK 0001533568 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,045

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000120 · wk-form4_1751073197.xml · derivative · entry 2

YOUNG JOHN D · CIK 0001551792 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000120 · wk-form4_1751073197.xml · nonDerivative · entry 1

YOUNG JOHN D · CIK 0001551792 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,045

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000114 · wk-form4_1751072923.xml · derivative · entry 2

Cunningham Everett · CIK 0001564777 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000114 · wk-form4_1751072923.xml · nonDerivative · entry 1

Cunningham Everett · CIK 0001564777 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,045

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000118 · wk-form4_1751073062.xml · derivative · entry 2

Bain Linda · CIK 0001578407 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000118 · wk-form4_1751073062.xml · nonDerivative · entry 1

Bain Linda · CIK 0001578407 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,045

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000124 · wk-form4_1751073498.xml · derivative · entry 2

Smaldone Alsup Laurie · CIK 0001589602 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000124 · wk-form4_1751073498.xml · nonDerivative · entry 1

Smaldone Alsup Laurie · CIK 0001589602 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,045

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000122 · wk-form4_1751073270.xml · derivative · entry 2

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000122 · wk-form4_1751073270.xml · nonDerivative · entry 1

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,021

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000126 · wk-form4_1751278445.xml · derivative · entry 2

AGARWAL SUNIL · CIK 0001616640 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,105

Underlying: Common Stock · 23,105 shares

Expires 2035-06-24

F2 · derivative.exercise_date: This option award was granted on June 25, 2025. The shares underlying the award shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000126 · wk-form4_1751278445.xml · nonDerivative · entry 1

AGARWAL SUNIL · CIK 0001616640 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,166

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 25, 2025 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 25, 2026 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders, subject to the reporting person's continued service with the Issuer on the vesting date.

SEC source: 0001655759-25-000109 · wk-form4_1750795707.xml · nonDerivative · entry 1

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 164,401

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of 25% of the reporting person's restricted stock units (RSUs) granted on June 24, 2024.

SEC source: 0001655759-25-000105 · wk-form4_1750284239.xml · nonDerivative · entry 1

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,248

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of 50% of the reporting person's restricted stock units (RSUs) granted on June 17, 2024.

SEC source: 0001655759-25-000089 · wk-form4_1747170997.xml · derivative · entry 2

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,000

Underlying: Common Stock · 91,000 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The option was granted by the Issuer on May 9, 2025, pursuant to the Plan. The shares underlying the option will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000089 · wk-form4_1747170997.xml · nonDerivative · entry 1

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 156,831

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on May 9, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000093 · wk-form4_1747171123.xml · derivative · entry 2

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,100

Underlying: Common Stock · 18,100 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The option was granted by the Issuer on May 9, 2025, pursuant to the Plan. The shares underlying the option will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000093 · wk-form4_1747171123.xml · nonDerivative · entry 1

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,688

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on May 9, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000087 · wk-form4_1747170938.xml · derivative · entry 2

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,000

Underlying: Common Stock · 91,000 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The option was granted by the Issuer on May 9, 2025, pursuant to the Plan. The shares underlying the option will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000087 · wk-form4_1747170938.xml · nonDerivative · entry 1

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,623

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on May 9, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000091 · wk-form4_1747171064.xml · derivative · entry 2

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,000

Underlying: Common Stock · 91,000 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The option was granted by the Issuer on May 9, 2025, pursuant to the Plan. The shares underlying the option will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000091 · wk-form4_1747171064.xml · nonDerivative · entry 1

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 170,101

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on May 9, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over two years: 1/2 of the shares underlying the award shall vest on May 9, 2026, with the remainder of the shares vesting on May 9, 2027, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000064 · wk-form4_1742386009.xml · nonDerivative · entry 1

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,023

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of 25% of the reporting person's restricted stock units (RSUs) granted on March 18, 2024.

SEC source: 0001655759-25-000052 · wk-form4_1740483329.xml · nonDerivative · entry 2

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,231

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-quarter of the reporting person's RSUs granted on February 22, 2023.

SEC source: 0001655759-25-000052 · wk-form4_1740483329.xml · nonDerivative · entry 1

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,377

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-half of the reporting person's restricted stock units (RSUs) granted on February 23, 2024.

F2 · balance_after: Includes an aggregate of 494 shares of the issuer's common stock purchased under and in accordance with the issuer's 2018 Employee Stock Purchaser Plan in transactions exempt under Rule 16b-3.

SEC source: 0001655759-25-000054 · wk-form4_1740483463.xml · nonDerivative · entry 1

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,863

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-half of the reporting person's restricted stock units (RSUs) granted on February 23, 2024.

F2 · balance_after: Includes an aggregate of 1,453 shares of the issuer's common stock purchased under and in accordance with the issuer's 2018 Employee Stock Purchaser Plan in transactions exempt under Rule 16b-3.

SEC source: 0001655759-25-000050 · wk-form4_1740483206.xml · nonDerivative · entry 2

Taylor Ian · CIK 0001753281 · President, R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 159,121

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-quarter of the reporting person's RSUs granted on February 22, 2023.

SEC source: 0001655759-25-000050 · wk-form4_1740483206.xml · nonDerivative · entry 1

Taylor Ian · CIK 0001753281 · President, R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,785

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-half of the reporting person's restricted stock units (RSUs) granted on February 23, 2024.

SEC source: 0001655759-25-000048 · wk-form4_1740483094.xml · nonDerivative · entry 2

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,157,480

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-quarter of the reporting person's RSUs granted on February 22, 2023.

SEC source: 0001655759-25-000048 · wk-form4_1740483094.xml · nonDerivative · entry 1

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,162,634

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-half of the reporting person's restricted stock units (RSUs) granted on February 23, 2024.

F2 · balance_after: Includes an aggregate of 137 shares of the issuer's common stock purchased under and in accordance with the issuer's 2018 Employee Stock Purchaser Plan in transactions exempt under Rule 16b-3.

SEC source: 0001655759-25-000021 · wk-form4_1739926615.xml · derivative · entry 2

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,960

Underlying: Common Stock · 74,960 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000021 · wk-form4_1739926615.xml · nonDerivative · entry 1

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,944

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000030 · wk-form4_1739926975.xml · derivative · entry 2

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,176

Underlying: Common Stock · 16,176 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000030 · wk-form4_1739926975.xml · nonDerivative · entry 1

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,624

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000025 · wk-form4_1739926736.xml · derivative · entry 2

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,483

Underlying: Common Stock · 31,483 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000025 · wk-form4_1739926736.xml · nonDerivative · entry 1

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,141

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000023 · wk-form4_1739926672.xml · derivative · entry 2

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,330

Underlying: Common Stock · 84,330 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000023 · wk-form4_1739926672.xml · nonDerivative · entry 1

Berkowitz Noah · CIK 0001369900 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,681

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000027 · wk-form4_1739926780.xml · derivative · entry 2

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,960

Underlying: Common Stock · 74,960 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000027 · wk-form4_1739926780.xml · nonDerivative · entry 1

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,501

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000019 · wk-form4_1739926307.xml · derivative · entry 2

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 232,000

Underlying: Common Stock · 232,000 shares

Expires 2035-02-12

F2 · derivative.exercise_date: The option was granted by the Issuer on February 13, 2025, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award will vest on February 13, 2026, with the remainder of the shares vesting in equal monthly installments following February 13, 2026 through February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-25-000019 · wk-form4_1739926307.xml · nonDerivative · entry 1

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,188,681

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on February 13, 2025, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of February 13, 2026, February 13, 2027, February 13, 2028 and February 13, 2029, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001655759-24-000133 · wk-form4_1731450837.xml · nonDerivative · entry 2

Loomis David K · CIK 0001959410 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,040

F1 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

SEC source: 0001655759-24-000105 · wk-form4_1719433252.xml · derivative · entry 2

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,418

Underlying: Common Stock · 94,418 shares

Expires 2034-06-23

F2 · derivative.exercise_date: The option was granted by the Issuer on June 24, 2024, in accordance with Nasdaq Listing Rule 5635(c)(4) and not pursuant the Plan. The shares underlying the option will vest over four years: 1/4 of the shares underlying the award shall vest on June 24, 2025, with the remainder of the shares vesting in equal monthly installments following June 24, 2025 through June 24, 2028.

SEC source: 0001655759-24-000105 · wk-form4_1719433252.xml · nonDerivative · entry 1

Saik Andrew · CIK 0001616284 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,409

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 24, 2024, in accordance with Nasdaq Listing Rule 5635(c)(4), and not pursuant to its 2018 Stock Incentive Plan (the "Plan"). Each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 25% of the RSUs will vest on each of June 24, 2025, June 24, 2026, June 24, 2027 and June 24, 2028, subject to the Reporting Person's continued service with the Issuer on each such vesting date.

SEC source: 0001655759-24-000098 · wk-form4_1718747603.xml · derivative · entry 2

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,632

Underlying: Common Stock · 24,632 shares

Expires 2034-06-16

F2 · derivative.exercise_date: The option was granted by the Issuer on June 17, 2024, pursuant to the Plan. The shares underlying the option will vest over two years: 1/2 of the shares underlying the award shall vest on June 17, 2025, with the remainder of the shares vesting on June 17, 2026.

SEC source: 0001655759-24-000098 · wk-form4_1718747603.xml · nonDerivative · entry 1

Cacace Angela M · CIK 0002026306 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,852

F1 · shares: The restricted stock units (each, an "RSU") were granted by the issuer on June 17, 2024, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs will vest over two years: 1/2 of the shares underlying the award shall vest on June 17, 2025, with the remainder of the shares vesting on June 17, 2026.

SEC source: 0001655759-24-000085 · wk-form4_1717192358.xml · derivative · entry 3

Kennedy Edward Moore Jr. · CIK 0001753859 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,070

Underlying: Common Stock · 9,070 shares

Expires 2034-05-28

F2 · derivative.exercise_date: This option award was granted on May 29, 2024. The shares underlying the award shall vest in full on the earlier of May 29, 2025 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.