ARDX

SEC source: 0001628280-24-033836 · wk-form4_1722470059.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,290,463

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction was made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

SEC source: 0001628280-24-032114 · wk-form4_1721253256.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,260,463

F1 · kind: Transaction was made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

F2 · price: Transaction was executed in multiple trades in prices ranging from $5.92 to $6.02, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-030513 · wk-form4_1719610633.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,267,963

F1 · kind: Transaction was made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

SEC source: 0001628280-24-029949 · wk-form4_1719354142.xml · nonDerivative · entry 1

Blanks Robert · CIK 0001815433 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 324,331

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2023.

F2 · price: Transaction was executed in multiple trades in prices ranging from $5.91 to $6.01, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-028598 · wk-form4_1718664608.xml · derivative · entry 1

Cadoret-Manier Onaiza · CIK 0001799355 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028604 · wk-form4_1718664869.xml · derivative · entry 2

Rodgers Richard J · CIK 0001313397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F2 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F3 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028604 · wk-form4_1718664869.xml · nonDerivative · entry 1

Rodgers Richard J · CIK 0001313397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,524

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001628280-24-028602 · wk-form4_1718664795.xml · derivative · entry 1

Bhanji Muna · CIK 0001846905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028600 · wk-form4_1718664726.xml · derivative · entry 2

Bertrand William C JR · CIK 0001291937 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F2 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F3 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028600 · wk-form4_1718664726.xml · nonDerivative · entry 1

Bertrand William C JR · CIK 0001291937 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 229,766

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001628280-24-028594 · wk-form4_1718664437.xml · derivative · entry 2

MOTT DAVID M · CIK 0001219871 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F3 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F4 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028594 · wk-form4_1718664437.xml · nonDerivative · entry 1

MOTT DAVID M · CIK 0001219871 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,209,597

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

F2 · balance_after: The Reporting Person holds 87,566 shares for the benefit of entities associated with New Enterprise Associates and disclaims beneficial ownership of such shares, except to the extent of his actual pecuniary interest therein.

SEC source: 0001628280-24-028596 · wk-form4_1718664529.xml · derivative · entry 1

Bazemore Robert B · CIK 0001620152 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,243

Underlying: Common Stock · 40,243 shares

Expires 2034-06-14

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001628280-24-028592 · wk-form4_1718664354.xml · derivative · entry 5

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 665,000

Underlying: Common Stock · 35,000 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001628280-24-028592 · wk-form4_1718664354.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,270,273

F1 · price: his transaction was executed in multiple trades in prices ranging from $6.601 to $6.73, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-028592 · wk-form4_1718664354.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,305,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-24-027351 · wk-form4_1717799368.xml · derivative · entry 4

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,000

Underlying: Common Stock · 100,000 shares

Expires 2033-01-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 5, 2023, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001628280-24-027351 · wk-form4_1717799368.xml · nonDerivative · entry 3

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 322,152

F1 · price: This transaction was executed in multiple trades in prices ranging from $7.11 to $7.145, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-027351 · wk-form4_1717799368.xml · nonDerivative · entry 2

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 422,152

F1 · price: This transaction was executed in multiple trades in prices ranging from $7.11 to $7.145, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-027351 · wk-form4_1717799368.xml · nonDerivative · entry 1

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 467,152

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-24-026948 · wk-form4_1717632047.xml · nonDerivative · entry 1

Rosenbaum David P. · CIK 0001611311 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Wife

Disclosed balance after: 158,502

F1 · ownership.nature: The shares are directly held by the Reporting Person's wife.

SEC source: 0001628280-24-026063 · wk-form4_1717187463.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,270,273

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

F2 · price: Transaction was executed in multiple trades in prices ranging from $6.65 to $6.75, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001628280-24-024949 · wk-form4_1716495453.xml · nonDerivative · entry 1

Rodriguez Susan · CIK 0001812511 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 449,092

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 3,000 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024955 · wk-form4_1716495670.xml · nonDerivative · entry 1

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 367,152

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 1,757 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024928 · wk-form4_1716494810.xml · nonDerivative · entry 1

Blanks Robert · CIK 0001815433 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 362,331

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

SEC source: 0001628280-24-024944 · wk-form4_1716495332.xml · nonDerivative · entry 1

Renz Justin A · CIK 0001466562 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,546

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 878 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024951 · wk-form4_1716495544.xml · nonDerivative · entry 2

Rosenbaum David P. · CIK 0001611311 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Wife

Disclosed balance after: 176,374

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F3 · balance_after: Reflects the adjusted total which includes the purchase of 2,636 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

F4 · ownership.nature: The shares are directly held by the Reporting Person's wife.

SEC source: 0001628280-24-024951 · wk-form4_1716495544.xml · nonDerivative · entry 1

Rosenbaum David P. · CIK 0001611311 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 376,479

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 2,349 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024938 · wk-form4_1716495196.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,277,773

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 1,324 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024930 · wk-form4_1716494897.xml · nonDerivative · entry 1

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,127

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 2,665 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001628280-24-024935 · wk-form4_1716495028.xml · nonDerivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 199,469

F1 · kind: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 2,636 shares under the Ardelyx Employee Stock Purchase Plan in February 2024.

SEC source: 0001610717-24-000238 · form4.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,307,933

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

SEC source: 0001610717-24-000236 · form4.xml · derivative · entry 6

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 40,000 shares

Expires 2033-01-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 5, 2023, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000236 · form4.xml · derivative · entry 5

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,525

Underlying: Common Stock · 79,101 shares

Expires 2032-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Twenty Five Percent (25%) of the shares subject to the option vest on February 1, 2023 and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000236 · form4.xml · nonDerivative · entry 4

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,947

SEC source: 0001610717-24-000236 · form4.xml · nonDerivative · entry 3

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,947

F1 · price: This transaction was executed in multiple trades in prices ranging from $8.63 to $9.01, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001610717-24-000236 · form4.xml · nonDerivative · entry 2

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 303,935

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001610717-24-000236 · form4.xml · nonDerivative · entry 1

Felsch Robert Ora · CIK 0001917819 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 263,935

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001610717-24-000235 · form4.xml · derivative · entry 6

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 241,313

Underlying: Common Stock · 109,687 shares

Expires 2033-01-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 5, 2023, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000235 · form4.xml · derivative · entry 5

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,750

Underlying: Common Stock · 110,250 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000235 · form4.xml · nonDerivative · entry 4

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 203,760

F1 · price: This transaction was executed in multiple trades in prices ranging from $8.63 to $9.04, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001610717-24-000235 · form4.xml · nonDerivative · entry 3

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 423,697

F1 · price: This transaction was executed in multiple trades in prices ranging from $8.63 to $9.04, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001610717-24-000235 · form4.xml · nonDerivative · entry 2

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 487,930

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001610717-24-000235 · form4.xml · nonDerivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 378,243

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001610717-24-000230 · form4.xml · derivative · entry 3

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 162,000

Underlying: Common Stock · 30,000 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000230 · form4.xml · nonDerivative · entry 2

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 370,189

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001610717-24-000230 · form4.xml · nonDerivative · entry 1

Williams Laura A · CIK 0001869194 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 410,138

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001610717-24-000233 · form4.xml · nonDerivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 267,993

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 20, 2023.

SEC source: 0001610717-24-000228 · form4.xml · derivative · entry 5

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 670,000

Underlying: Common Stock · 30,000 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001610717-24-000228 · form4.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,310,933

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 13, 2023.

F2 · price: This transaction was executed in multiple trades in prices ranging from $6.311 to $6.49, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.