ARDX

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 6

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 9

Disclosed balance after: 0

F10 · kind: NEA Partners 15 made a pro rata distribution for no consideration of an aggregate of 7,164 shares of Common Stock of the Issuer to its limited partners on June 10, 2020.

F9 · ownership.nature: The Reporting Person is a director of NEA 15 GP, which is the sole general partner of NEA Partners 15, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 15 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 5

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 9

Disclosed balance after: 7,164

F8 · kind: NEA Partners 15 received 7,164 shares of Common Stock of the Issuer in the distribution by NEA 15 on June 10, 2020.

F9 · ownership.nature: The Reporting Person is a director of NEA 15 GP, which is the sole general partner of NEA Partners 15, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 15 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 4

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 7

Disclosed balance after: 2,604,582

F6 · kind: New Enterprise Associates 15, L.P. ("NEA 15") made a pro rata distribution for no consideration of an aggregate of 477,604 shares of the Common Stock of the Issuer to its general partner and its limited partners on June 10, 2020.

F7 · ownership.nature: The Reporting Person is a manager of NEA 15 GP, LLC ("NEA 15 GP"), which is the sole general partner of NEA Partners 15, L.P. ("NEA Partners 15"). NEA Partners 15 is the sole general partner of NEA 15, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 15 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 3

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 4

Disclosed balance after: 0

F5 · kind: NEA Partners 12 made a pro rata distribution for no consideration of an aggregate of 455,222 shares of Common Stock of the Issuer to its limited partners on June 10, 2020.

F4 · ownership.nature: The Reporting Person is a manager of NEA 12 GP, which is the sole general partner of NEA Partners 12, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 12 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 2

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 4

Disclosed balance after: 455,222

F3 · kind: NEA Partners 12 received 455,222 shares of Common Stock of the Issuer in the distribution by NEA 12 on June 10, 2020.

F4 · ownership.nature: The Reporting Person is a manager of NEA 12 GP, which is the sole general partner of NEA Partners 12, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 12 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036366 · doc4.xml · nonDerivative · entry 1

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 2

Disclosed balance after: 8,086,401

F1 · kind: New Enterprise Associates 12, Limited Partnership ("NEA 12") made a pro rata distribution for no consideration of an aggregate of 1,482,809 shares of Common Stock of the Issuer to its general partner and its limited partners on June 10, 2020.

F2 · ownership.nature: The Reporting Person is a manager of NEA 12 GP, LLC ("NEA 12 GP"), which is the sole general partner of NEA Partners 12, Limited Partnership ("NEA Partners 12"). NEA Partners 12 is the sole general partner of NEA 12, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 12 shares in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-20-036365 · doc4.xml · nonDerivative · entry 3

NEA Partners 12, Limited Partnership · CIK 0001383390 · 10% owner

NEA 12 GP, LLC · CIK 0001383389 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F5 · kind: NEA Partners 12 made a pro rata distribution for no consideration of an aggregate of 455,222 shares of Common Stock of the Issuer to its limited partners on June 10, 2020.

F4 · ownership.direct: The shares are directly held by NEA Partners 12 and indirectly held by NEA 12 GP, the sole general partner of NEA Partners 12, and the Managers of NEA 12 GP (NEA 12 GP and the Managers of NEA 12 GP together, the "NEA Partners 12 Indirect Reporting Persons"). The NEA Partners 12 Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 12 shares in which the NEA Partners 12 Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-20-036365 · doc4.xml · nonDerivative · entry 2

NEA Partners 12, Limited Partnership · CIK 0001383390 · 10% owner

NEA 12 GP, LLC · CIK 0001383389 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 455,222

F3 · kind: NEA Partners 12 received 455,222 shares of Common Stock of the Issuer in the distribution by NEA 12 on June 10, 2020.

F4 · ownership.direct: The shares are directly held by NEA Partners 12 and indirectly held by NEA 12 GP, the sole general partner of NEA Partners 12, and the Managers of NEA 12 GP (NEA 12 GP and the Managers of NEA 12 GP together, the "NEA Partners 12 Indirect Reporting Persons"). The NEA Partners 12 Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 12 shares in which the NEA Partners 12 Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-20-036365 · doc4.xml · nonDerivative · entry 1

NEA Partners 12, Limited Partnership · CIK 0001383390 · 10% owner

NEA 12 GP, LLC · CIK 0001383389 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 2

Disclosed balance after: 8,086,401

F1 · kind: New Enterprise Associates 12, Limited Partnership ("NEA 12") made a pro rata distribution for no consideration of an aggregate of 1,482,809 shares of Common Stock of the Issuer to its general partner and its limited partners on June 10, 2020.

F2 · ownership.nature: The shares are directly held by NEA 12 and are indirectly held by NEA Partners 12, Limited Partnership ("NEA Partners 12"), the sole general partner of NEA 12, NEA 12 GP, LLC ("NEA 12 GP"), the sole general partner of NEA Partners 12, and each of the individual managers of NEA 12 GP (NEA Partners 12, NEA 12 GP and the individual managers of NEA 12 GP (collectively, "Managers") together, the "NEA 12 Indirect Reporting Persons"). The Managers of NEA 12 GP are Forest Baskett, Patrick J. Kerins and Scott D. Sandell. The NEA 12 Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 12 shares in which the NEA 12 Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-20-036364 · doc4.xml · nonDerivative · entry 1

New Enterprise Associates 12, Limited Partnership · CIK 0001383391 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,086,401

F1 · kind: New Enterprise Associates 12, Limited Partnership ("NEA 12") made a pro rata distribution for no consideration of an aggregate of 1,482,809 shares of Common Stock of the Issuer to its general partner and its limited partners on June 10, 2020.

F2 · ownership.direct: The shares are directly held by NEA 12 and indirectly held by NEA Partners 12, Limited Partnership ("NEA Partners 12"), the sole general partner of NEA 12, NEA 12 GP, LLC ("NEA 12 GP"), the sole general partner of NEA Partners 12, and the individual managers of NEA 12 GP (NEA Partners 12, NEA 12 GP and the individual managers of NEA 12 GP together, the "Indirect Reporting Persons"). The individual managers of NEA 12 GP are Forest Baskett, Patrick J. Kerins, and Scott D. Sandell. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 12 shares in which the Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001567619-20-012107 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 47,492

F1 · kind: Pro rata distribution from NEA Partners 12, Limited Partnership, of which the reporting person is a limited partner.

F2 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-012030 · doc1.xml · derivative · entry 1

RINGOLD GORDON · CIK 0001101713 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012036 · doc1.xml · nonDerivative · entry 1

Cadoret-Manier Onaiza · CIK 0001799355 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,155

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001567619-20-012031 · doc1.xml · derivative · entry 2

Lundberg Jan M · CIK 0001480120 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F2 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F3 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012031 · doc1.xml · nonDerivative · entry 1

Lundberg Jan M · CIK 0001480120 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,618

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001567619-20-012040 · doc1.xml · derivative · entry 4

MOTT DAVID M · CIK 0001219871 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-06-09

F6 · derivative.exercise_date: The shares subject to the option vest in 36 successive, equal monthly installments from June 9, 2020, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001567619-20-012040 · doc1.xml · derivative · entry 3

MOTT DAVID M · CIK 0001219871 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F4 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F5 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012040 · doc1.xml · nonDerivative · entry 1

MOTT DAVID M · CIK 0001219871 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,561

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

F2 · balance_after: The Reporting Person holds 87,566 shares for the benefit of entities associated with New Enterprise Associates and disclaims beneficial ownership of such shares, except to the extent of his actual pecuniary interest therein.

SEC source: 0001567619-20-012034 · doc1.xml · derivative · entry 2

Bertrand William C JR · CIK 0001291937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F2 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F3 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012034 · doc1.xml · nonDerivative · entry 1

Bertrand William C JR · CIK 0001291937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,658

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001567619-20-012032 · doc1.xml · derivative · entry 1

Block Geoffrey A. · CIK 0001770782 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012029 · doc1.xml · derivative · entry 2

Rodgers Richard J · CIK 0001313397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F2 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F3 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-012029 · doc1.xml · nonDerivative · entry 1

Rodgers Richard J · CIK 0001313397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,610

F1 · shares: The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program.

SEC source: 0001567619-20-012028 · doc1.xml · derivative · entry 1

Bazemore Robert B · CIK 0001620152 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2030-06-09

F1 · shares: The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program.

F2 · derivative.exercise_date: The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date.

SEC source: 0001567619-20-011933 · doc1.xml · derivative · entry 2

Renz Justin A · CIK 0001466562 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,017

Underlying: Common Stock · 195,017 shares

Expires 2030-06-08

F3 · derivative.exercise_date: The shares subject to the option vest according to the following schedule: Twenty-five percent (25%) of the shares subject to the option vest on the first anniversary measured from June 8, 2020, and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001567619-20-011933 · doc1.xml · nonDerivative · entry 1

Renz Justin A · CIK 0001466562 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,000

F1 · shares: Restricted stock units ("RSUs"). The Reporting Person is entitled to receive one (1) share of Common Stock for each one (1) RSU upon the vesting thereof.

F2 · balance_after: Includes 10,000 RSUs.

SEC source: 0001567619-20-011554 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 46,257

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F2 · price: The transaction was executed in multiple trades in prices ranging from $7.17 to $7.50, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-010851 · doc1.xml · derivative · entry 2

Rodriguez Susan · CIK 0001812511 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,750

Underlying: Common Stock · 232,750 shares

Expires 2030-05-18

F2 · derivative.exercise_date: Twenty Five Percent (25%) of the shares subject to the option vest on May 18, 2021 and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001567619-20-010851 · doc1.xml · nonDerivative · entry 1

Rodriguez Susan · CIK 0001812511 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

F1 · shares: Restricted stock units ("RSUs"). The Reporting Person is entitled to receive one (1) share of Common Stock for each one (1) RSU upon the vesting thereof.

SEC source: 0001567619-20-009874 · doc1.xml · nonDerivative · entry 3

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · By Son

Disclosed balance after: 2,566

F1 · shares: This transaction involved a gift of securities by the Reporting Person to her son, who shares Reporting Person's household. The Reporting Person disclaims beneficial ownership of the shares held by her son, and this report should not be deemed an admission that the Reporting Person is the beneficial owner of her son's shares for purposes of Section 16 or for any other purpose.

SEC source: 0001567619-20-009874 · doc1.xml · nonDerivative · entry 2

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,108

F1 · shares: This transaction involved a gift of securities by the Reporting Person to her son, who shares Reporting Person's household. The Reporting Person disclaims beneficial ownership of the shares held by her son, and this report should not be deemed an admission that the Reporting Person is the beneficial owner of her son's shares for purposes of Section 16 or for any other purpose.

SEC source: 0001567619-20-009874 · doc1.xml · nonDerivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,608

SEC source: 0001567619-20-009078 · doc1.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 69,385

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F4 · price: The transaction was executed in multiple trades in prices ranging from $7.00 to $7.1050, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-009078 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 73,871

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F2 · price: The transaction was executed in multiple trades in prices ranging from $7.00 to $7.04, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-008549 · doc1.xml · nonDerivative · entry 4

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,608

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 27, 2020.

F6 · price: The transaction was executed in multiple trades in prices ranging from $7.31 to $7.69, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-20-008549 · doc1.xml · nonDerivative · entry 3

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,944

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 27, 2020.

F5 · price: The transaction was executed in multiple trades in prices ranging from $7.31 to $7.68, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-20-008549 · doc1.xml · nonDerivative · entry 2

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,486

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 27, 2020.

F4 · price: The transaction was executed in multiple trades in prices ranging from $7.38 to $7.68, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-20-008549 · doc1.xml · nonDerivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,986

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 27, 2020.

F2 · price: The transaction was executed in multiple trades in prices ranging from $7.48 to $7.675, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Reflects the adjusted total which includes the purchase of 1,213 shares under the Ardelyx Employee Stock Purchase Plan on February 28, 2020.

SEC source: 0001567619-20-008137 · doc1.xml · nonDerivative · entry 3

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 89,812

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F4 · price: The transaction was executed in multiple trades in prices ranging from $7.00 to $7.20, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-008137 · doc1.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 99,240

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F3 · price: The transaction was executed in multiple trades in prices ranging from $7.00 to $7.0450, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-008137 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 109,740

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F2 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-006506 · doc1.xml · derivative · entry 1

Cadoret-Manier Onaiza · CIK 0001799355 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,890

Underlying: Common Stock · 65,890 shares

Expires 2030-03-12

F1 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest in 36 successive, equal monthly installments on each monthly anniversary of March 12, 2020, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

SEC source: 0001567619-20-005668 · doc1.xml · derivative · entry 5

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,123 shares

Expires 2020-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Fully vested.

SEC source: 0001567619-20-005668 · doc1.xml · nonDerivative · entry 3

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · Family Trust

Disclosed balance after: 110,240

F3 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 21, 2019.

F4 · price: The transaction was executed in multiple trades in prices ranging from $7.00 to $7.065, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F5 · ownership.nature: The shares are directly held by Michael G. Raab, Trustee of the Michael G. Raab Living Trust dated July 25, 2012.

SEC source: 0001567619-20-005668 · doc1.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 208,057

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 23, 2019.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 1,229 shares under the Ardelyx Employee Stock Purchase Plan on February 28, 2020.

SEC source: 0001567619-20-005668 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 219,180

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 23, 2019.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 1,229 shares under the Ardelyx Employee Stock Purchase Plan on February 28, 2020.

SEC source: 0001567619-20-002467 · doc1.xml · derivative · entry 5

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,123

Underlying: Common Stock · 25,000 shares

Expires 2020-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Fully vested.

SEC source: 0001567619-20-002467 · doc1.xml · nonDerivative · entry 2

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 206,828

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 23, 2019.

F4 · price: This transaction was executed in multiple trades in prices ranging from $7.19 to $7.45, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 2,310 shares under the Ardelyx Employee Stock Purchase Plan on August 31, 2019

F3 · balance_after: Reflects the transfer of 49,837 shares previously held directly by the reporting person into a family trust.

SEC source: 0001567619-20-002467 · doc1.xml · nonDerivative · entry 1

RAAB MICHAEL · CIK 0001321402 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 231,828

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 23, 2019.

F2 · balance_after: Reflects the adjusted total which includes the purchase of 2,310 shares under the Ardelyx Employee Stock Purchase Plan on August 31, 2019

F3 · balance_after: Reflects the transfer of 49,837 shares previously held directly by the reporting person into a family trust.

SEC source: 0001567619-20-004497 · doc1.xml · derivative · entry 1

Rosenbaum David P. · CIK 0001611311 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 47,500

Underlying: Common Stock · 47,500 shares

Expires 2030-01-21

F1 · derivative.exercise_date: The option becomes exercisable as it vests and the shares subject to the option vest with respect to 1/48 of the shares subject thereto on each monthly anniversary of January 21, 2020, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

F2 · ownership.nature: The shares are directly held by the Reporting Person's wife.